ENSG00000134352

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336909 ENSG00000134352 HEK293_OSMI2_2hA HEK293_TMG_2hB IL6ST protein_coding protein_coding 9.140614 0.7568735 13.46794 0.03979162 0.9809892 4.135468 0.5589346 0.3921092 0.5172206 0.1754287 0.5172206 0.3908194 0.19882917 0.5138667 0.04483333 -0.469033333 0.0738587684 0.0001774033 FALSE TRUE
ENST00000381294 ENSG00000134352 HEK293_OSMI2_2hA HEK293_TMG_2hB IL6ST protein_coding protein_coding 9.140614 0.7568735 13.46794 0.03979162 0.9809892 4.135468 0.8102503 0.0000000 0.7690296 0.0000000 0.1588911 6.2836063 0.04638333 0.0000000 0.05603333 0.056033333 0.0699140468 0.0001774033 FALSE TRUE
ENST00000502326 ENSG00000134352 HEK293_OSMI2_2hA HEK293_TMG_2hB IL6ST protein_coding protein_coding 9.140614 0.7568735 13.46794 0.03979162 0.9809892 4.135468 1.6944453 0.0000000 3.1479390 0.0000000 0.4021466 8.3028395 0.10090833 0.0000000 0.24093333 0.240933333 0.0001774033 0.0001774033 FALSE TRUE
ENST00000583149 ENSG00000134352 HEK293_OSMI2_2hA HEK293_TMG_2hB IL6ST protein_coding retained_intron 9.140614 0.7568735 13.46794 0.03979162 0.9809892 4.135468 1.5389744 0.0000000 1.7592137 0.0000000 0.9108455 7.4669645 0.09201667 0.0000000 0.12153333 0.121533333 0.5785411063 0.0001774033 FALSE FALSE
ENST00000651614 ENSG00000134352 HEK293_OSMI2_2hA HEK293_TMG_2hB IL6ST protein_coding nonsense_mediated_decay 9.140614 0.7568735 13.46794 0.03979162 0.9809892 4.135468 4.0418042 0.3647643 6.6704483 0.1662545 0.6580687 4.1558895 0.46634583 0.4861333 0.49336667 0.007233333 0.9882441226 0.0001774033 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134352 E001 0.0000000       5 55935095 55935098 4 -      
ENSG00000134352 E002 0.2955422 0.0292045847 6.368947e-02   5 55935099 55935124 26 - 0.025 0.442 4.884
ENSG00000134352 E003 6.9862777 0.1726599827 1.583846e-03 5.906474e-03 5 55935125 55936649 1525 - 0.437 1.469 4.032
ENSG00000134352 E004 552.9661096 0.0576647275 1.258329e-07 1.253941e-06 5 55936650 55940965 4316 - 2.278 2.931 2.175
ENSG00000134352 E005 21.7966872 0.0009410619 1.410765e-03 5.342207e-03 5 55940966 55941027 62 - 0.986 0.657 -1.293
ENSG00000134352 E006 27.0306974 0.0074401671 1.335795e-03 5.095714e-03 5 55941028 55941081 54 - 1.069 0.800 -1.014
ENSG00000134352 E007 107.0728420 0.0003398638 6.084478e-07 5.294108e-06 5 55941082 55941522 441 - 1.632 1.561 -0.240
ENSG00000134352 E008 62.6157993 0.0022107462 7.936063e-03 2.361745e-02 5 55941523 55941693 171 - 1.401 1.467 0.229
ENSG00000134352 E009 36.8592060 0.0035471829 3.236019e-02 7.655424e-02 5 55941694 55941764 71 - 1.183 1.229 0.163
ENSG00000134352 E010 31.6656481 0.0006444603 2.275177e-02 5.723501e-02 5 55941765 55941819 55 - 1.123 1.127 0.015
ENSG00000134352 E011 36.0487672 0.0005819951 1.571145e-02 4.208774e-02 5 55942670 55942751 82 - 1.174 1.181 0.023
ENSG00000134352 E012 28.2204506 0.0006883125 2.544920e-02 6.280318e-02 5 55947493 55947560 68 - 1.077 1.065 -0.044
ENSG00000134352 E013 16.1926974 0.0010750858 1.568626e-01 2.709243e-01 5 55947561 55947564 4 - 0.859 0.907 0.187
ENSG00000134352 E014 19.9151760 0.0009497322 1.230796e-01 2.243458e-01 5 55947565 55947589 25 - 0.937 0.994 0.209
ENSG00000134352 E015 0.1515154 0.0432405233 4.481426e-01   5 55947590 55947594 5 - 0.025 0.000 -18.404
ENSG00000134352 E016 0.1472490 0.0439535502 4.485159e-01   5 55948102 55948897 796 - 0.025 0.000 -18.404
ENSG00000134352 E017 0.1472490 0.0439535502 4.485159e-01   5 55948898 55948982 85 - 0.025 0.000 -18.404
ENSG00000134352 E018 32.3959423 0.0038838326 2.113112e-02 5.387416e-02 5 55951464 55951604 141 - 1.133 1.127 -0.020
ENSG00000134352 E019 0.1451727 0.0433290830 4.476282e-01   5 55951605 55951637 33 - 0.025 0.000 -18.403
ENSG00000134352 E020 37.3324162 0.0012930539 1.057719e-02 3.015526e-02 5 55951929 55952075 147 - 1.191 1.181 -0.038
ENSG00000134352 E021 34.6808365 0.0155862102 1.866839e-02 4.860333e-02 5 55952250 55952351 102 - 1.163 1.126 -0.131
ENSG00000134352 E022 50.9441658 0.0004771259 8.012886e-06 5.440532e-05 5 55954810 55954992 183 - 1.326 1.065 -0.925
ENSG00000134352 E023 0.0000000       5 55955980 55956024 45 -      
ENSG00000134352 E024 55.8690745 0.0012510818 8.934087e-05 4.718923e-04 5 55956025 55956235 211 - 1.360 1.229 -0.459
ENSG00000134352 E025 40.2916779 0.0007107112 1.635747e-01 2.797827e-01 5 55957209 55957291 83 - 1.213 1.380 0.588
ENSG00000134352 E026 0.1515154 0.0432405233 4.481426e-01   5 55959626 55959671 46 - 0.025 0.000 -18.404
ENSG00000134352 E027 40.0152922 0.0005239516 5.297492e-02 1.144375e-01 5 55960402 55960561 160 - 1.214 1.311 0.341
ENSG00000134352 E028 30.6898650 0.0029488755 1.236861e-03 4.765736e-03 5 55963352 55963506 155 - 1.117 0.908 -0.771
ENSG00000134352 E029 21.7704354 0.0008203005 6.921869e-03 2.101996e-02 5 55964146 55964208 63 - 0.983 0.800 -0.698
ENSG00000134352 E030 29.8684734 0.0006703736 2.903472e-04 1.340582e-03 5 55964209 55964312 104 - 1.109 0.800 -1.158
ENSG00000134352 E031 34.2314811 0.0006090536 1.015128e-02 2.913656e-02 5 55968276 55968396 121 - 1.157 1.127 -0.107
ENSG00000134352 E032 45.4920020 0.0004680361 5.235532e-02 1.133550e-01 5 55969550 55969759 210 - 1.266 1.380 0.397
ENSG00000134352 E033 31.0782503 0.0006268885 9.973712e-03 2.869864e-02 5 55969760 55969855 96 - 1.119 1.065 -0.194
ENSG00000134352 E034 24.8042902 0.0007692137 2.192537e-03 7.818870e-03 5 55976215 55976293 79 - 1.034 0.800 -0.886
ENSG00000134352 E035 0.1515154 0.0432405233 4.481426e-01   5 55976294 55976314 21 - 0.025 0.000 -18.404
ENSG00000134352 E036 23.8528920 0.0085093157 9.172792e-04 3.675383e-03 5 55982724 55982811 88 - 1.022 0.657 -1.427
ENSG00000134352 E037 21.0043305 0.0053474131 1.693979e-05 1.067915e-04 5 55994784 55995022 239 - 0.978 0.000 -25.553