ENSG00000134333

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000422447 ENSG00000134333 HEK293_OSMI2_2hA HEK293_TMG_2hB LDHA protein_coding protein_coding 604.7361 576.2715 677.4126 83.46001 18.56414 0.2332826 471.16027 532.210223 444.81075 87.122824 22.404259 -0.2587993 0.79249583 0.91873333 0.6558000 -0.26293333 5.326983e-08 8.266524e-38 FALSE TRUE
ENST00000486690 ENSG00000134333 HEK293_OSMI2_2hA HEK293_TMG_2hB LDHA protein_coding nonsense_mediated_decay 604.7361 576.2715 677.4126 83.46001 18.56414 0.2332826 68.31194 33.338096 101.91333 3.088116 7.993910 1.6118080 0.10954583 0.06170000 0.1506667 0.08896667 8.040338e-03 8.266524e-38 FALSE FALSE
ENST00000543445 ENSG00000134333 HEK293_OSMI2_2hA HEK293_TMG_2hB LDHA protein_coding protein_coding 604.7361 576.2715 677.4126 83.46001 18.56414 0.2332826 47.65045 6.957702 81.97194 1.201808 8.154105 3.5565511 0.07091667 0.01286667 0.1212333 0.10836667 7.359860e-10 8.266524e-38 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134333 E001 2.194689e+01 9.429427e-03 8.615519e-02 1.692435e-01 11 18394560 18394560 1 + 1.427 1.297 -0.452
ENSG00000134333 E002 2.275319e+01 1.621047e-02 2.224425e-01 3.533180e-01 11 18394561 18394561 1 + 1.427 1.324 -0.357
ENSG00000134333 E003 2.356686e+01 1.486466e-02 1.933869e-01 3.180313e-01 11 18394562 18394562 1 + 1.443 1.337 -0.370
ENSG00000134333 E004 9.132938e+02 5.462501e-03 5.029176e-09 6.561272e-08 11 18394563 18394585 23 + 3.069 2.850 -0.729
ENSG00000134333 E005 1.947407e+03 4.118264e-03 4.652171e-06 3.335629e-05 11 18394586 18394611 26 + 3.361 3.220 -0.468
ENSG00000134333 E006 2.357201e+03 4.596409e-03 1.130731e-04 5.819283e-04 11 18394612 18394636 25 + 3.435 3.311 -0.412
ENSG00000134333 E007 2.132611e+00 8.740724e-03 3.975402e-01 5.412929e-01 11 18394637 18394641 5 + 0.573 0.455 -0.571
ENSG00000134333 E008 4.751703e-01 2.053969e-02 6.697576e-01 7.764234e-01 11 18394642 18394703 62 + 0.128 0.209 0.845
ENSG00000134333 E009 1.222036e+00 1.111189e-02 8.049920e-01 8.759172e-01 11 18394704 18394886 183 + 0.375 0.349 -0.156
ENSG00000134333 E010 1.430883e+00 2.859185e-01 9.372855e-01 9.646007e-01 11 18395124 18395273 150 + 0.374 0.361 -0.078
ENSG00000134333 E011 7.384326e-01 1.074513e-01 4.097835e-01 5.534132e-01 11 18396266 18396277 12 + 0.128 0.286 1.444
ENSG00000134333 E012 1.436391e+01 1.821169e-03 1.317638e-09 1.910036e-08 11 18396278 18396479 202 + 1.410 0.874 -1.931
ENSG00000134333 E013 1.668165e+01 2.359354e-03 1.580179e-09 2.258640e-08 11 18396480 18396553 74 + 1.459 0.955 -1.793
ENSG00000134333 E014 1.624605e+01 1.094941e-03 2.145416e-06 1.657461e-05 11 18396554 18396610 57 + 1.410 1.036 -1.324
ENSG00000134333 E015 7.405115e-01 3.506219e-01 5.289980e-02 1.143078e-01 11 18396611 18396817 207 + 0.434 0.000 -11.260
ENSG00000134333 E016 5.326770e+00 4.210557e-03 8.647732e-01 9.168421e-01 11 18396818 18396818 1 + 0.812 0.816 0.013
ENSG00000134333 E017 2.610717e+03 4.025326e-03 1.208277e-04 6.178090e-04 11 18396819 18396842 24 + 3.475 3.360 -0.381
ENSG00000134333 E018 4.351716e+03 8.224928e-04 2.718060e-11 5.272124e-10 11 18396843 18396954 112 + 3.682 3.598 -0.280
ENSG00000134333 E019 2.802357e+03 6.226735e-04 3.526062e-09 4.721195e-08 11 18396955 18396968 14 + 3.482 3.417 -0.217
ENSG00000134333 E020 9.625472e+00 3.394714e-02 3.594176e-02 8.347300e-02 11 18396969 18397398 430 + 1.159 0.889 -0.990
ENSG00000134333 E021 4.427912e-01 1.900325e-01 5.135591e-01 6.483642e-01 11 18398630 18398797 168 + 0.227 0.116 -1.168
ENSG00000134333 E022 3.289534e-01 2.720160e-02 9.124064e-01   11 18398798 18398865 68 + 0.128 0.117 -0.153
ENSG00000134333 E023 1.623099e+00 9.182364e-03 7.295021e-02 1.482440e-01 11 18398866 18398988 123 + 0.573 0.284 -1.571
ENSG00000134333 E024 7.118058e+00 2.400056e-03 1.958855e-01 3.210868e-01 11 18398989 18399430 442 + 0.981 0.855 -0.476
ENSG00000134333 E025 5.313154e+03 4.572900e-04 1.707777e-15 6.266380e-14 11 18399431 18399548 118 + 3.763 3.690 -0.244
ENSG00000134333 E026 1.735466e+01 1.998214e-02 4.931135e-12 1.079661e-10 11 18399549 18399725 177 + 1.543 0.751 -2.871
ENSG00000134333 E027 5.072771e+01 7.708443e-04 2.254216e-44 1.011978e-41 11 18399726 18400629 904 + 1.986 1.232 -2.577
ENSG00000134333 E028 1.280888e+01 2.617813e-03 2.126159e-09 2.963249e-08 11 18400630 18400745 116 + 1.368 0.796 -2.087
ENSG00000134333 E029 1.781143e+01 1.002358e-03 8.009157e-05 4.282801e-04 11 18400746 18400836 91 + 1.416 1.125 -1.022
ENSG00000134333 E030 4.205974e+03 3.944497e-04 8.130736e-10 1.225705e-08 11 18400837 18400906 70 + 3.650 3.600 -0.168
ENSG00000134333 E031 4.844077e+03 1.935194e-04 6.036581e-05 3.332301e-04 11 18400907 18401010 104 + 3.692 3.679 -0.046
ENSG00000134333 E032 5.212538e-01 1.985583e-02 6.690146e-01 7.759304e-01 11 18401011 18401025 15 + 0.128 0.209 0.847
ENSG00000134333 E033 8.353408e+00 1.709673e-01 4.304410e-01 5.730753e-01 11 18402535 18402839 305 + 1.042 0.895 -0.546
ENSG00000134333 E034 6.760566e+03 3.826247e-05 1.459348e-03 5.504976e-03 11 18402840 18403013 174 + 3.827 3.835 0.028
ENSG00000134333 E035 4.769249e+03 3.192096e-04 9.449975e-01 9.694949e-01 11 18403694 18403737 44 + 3.666 3.685 0.064
ENSG00000134333 E036 5.141273e+03 4.406439e-04 7.633702e-01 8.466859e-01 11 18403738 18403788 51 + 3.696 3.719 0.074
ENSG00000134333 E037 3.812779e+03 2.129921e-04 5.051635e-01 6.410071e-01 11 18403789 18403811 23 + 3.565 3.594 0.094
ENSG00000134333 E038 5.832240e+03 4.966452e-04 2.175348e-08 2.519029e-07 11 18405449 18405572 124 + 3.714 3.797 0.275
ENSG00000134333 E039 1.049932e+01 1.589992e-02 4.171889e-01 5.605665e-01 11 18405573 18405574 2 + 1.103 1.034 -0.252
ENSG00000134333 E040 6.130086e+03 5.040259e-04 7.110140e-20 4.444061e-18 11 18407117 18407238 122 + 3.712 3.833 0.402
ENSG00000134333 E041 1.267761e+04 1.759647e-03 2.877239e-18 1.495430e-16 11 18407239 18408425 1187 + 3.990 4.165 0.579