ENSG00000134324

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256720 ENSG00000134324 HEK293_OSMI2_2hA HEK293_TMG_2hB LPIN1 protein_coding protein_coding 5.273891 4.491996 5.616478 0.5264861 0.2341904 0.3216671 2.5305412 1.6054903 3.0500719 0.05855747 0.2890459 0.9215935 0.47172500 0.36450000 0.5417333 0.1772333 3.498985e-02 3.020139e-33 FALSE TRUE
ENST00000460096 ENSG00000134324 HEK293_OSMI2_2hA HEK293_TMG_2hB LPIN1 protein_coding retained_intron 5.273891 4.491996 5.616478 0.5264861 0.2341904 0.3216671 0.4754421 0.2813486 0.4953068 0.14075787 0.2645913 0.7944134 0.08813333 0.07040000 0.0885000 0.0181000 9.877441e-01 3.020139e-33   FALSE
ENST00000475286 ENSG00000134324 HEK293_OSMI2_2hA HEK293_TMG_2hB LPIN1 protein_coding processed_transcript 5.273891 4.491996 5.616478 0.5264861 0.2341904 0.3216671 0.6758960 0.4116201 1.2109021 0.21724298 0.1721778 1.5339317 0.11897083 0.08233333 0.2153000 0.1329667 4.130832e-01 3.020139e-33   FALSE
ENST00000487576 ENSG00000134324 HEK293_OSMI2_2hA HEK293_TMG_2hB LPIN1 protein_coding processed_transcript 5.273891 4.491996 5.616478 0.5264861 0.2341904 0.3216671 0.7023582 1.6936617 0.0000000 0.17099071 0.0000000 -7.4124951 0.15258333 0.37893333 0.0000000 -0.3789333 3.020139e-33 3.020139e-33 FALSE FALSE
ENST00000674199 ENSG00000134324 HEK293_OSMI2_2hA HEK293_TMG_2hB LPIN1 protein_coding protein_coding 5.273891 4.491996 5.616478 0.5264861 0.2341904 0.3216671 0.4751578 0.2087167 0.6616510 0.10973534 0.1907821 1.6186488 0.08816667 0.04286667 0.1201667 0.0773000 2.929916e-01 3.020139e-33 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134324 E001 0.0000000       2 11677595 11677728 134 +      
ENSG00000134324 E002 0.0000000       2 11713756 11713812 57 +      
ENSG00000134324 E003 0.0000000       2 11724334 11724348 15 +      
ENSG00000134324 E004 0.0000000       2 11724349 11724349 1 +      
ENSG00000134324 E005 0.0000000       2 11724350 11724351 2 +      
ENSG00000134324 E006 0.0000000       2 11724352 11724539 188 +      
ENSG00000134324 E007 0.0000000       2 11724540 11724642 103 +      
ENSG00000134324 E008 0.0000000       2 11741349 11741428 80 +      
ENSG00000134324 E009 0.0000000       2 11742015 11742151 137 +      
ENSG00000134324 E010 0.0000000       2 11745907 11745960 54 +      
ENSG00000134324 E011 0.0000000       2 11745961 11746130 170 +      
ENSG00000134324 E012 1.0329332 0.1226309991 2.196984e-02 5.561008e-02 2 11746588 11746631 44 + 0.475 0.000 -13.144
ENSG00000134324 E013 1.0329332 0.1226309991 2.196984e-02 5.561008e-02 2 11746632 11746633 2 + 0.475 0.000 -15.251
ENSG00000134324 E014 1.1844487 0.0593808592 8.607349e-03 2.530629e-02 2 11746634 11746637 4 + 0.515 0.000 -15.654
ENSG00000134324 E015 6.7816843 0.0617962213 2.194233e-02 5.555583e-02 2 11746638 11746671 34 + 1.038 0.640 -1.561
ENSG00000134324 E016 0.5848540 0.1282148593 5.654507e-02 1.206698e-01 2 11755799 11755864 66 + 0.000 0.329 13.589
ENSG00000134324 E017 1.1468953 0.0113985141 9.993846e-01 1.000000e+00 2 11763023 11763286 264 + 0.329 0.326 -0.019
ENSG00000134324 E018 0.0000000       2 11764204 11764289 86 +      
ENSG00000134324 E019 15.3640195 0.0656999361 8.809346e-03 2.580766e-02 2 11765533 11765733 201 + 1.364 0.962 -1.436
ENSG00000134324 E020 15.7529093 0.0012564620 3.580230e-03 1.195526e-02 2 11767763 11767858 96 + 1.331 1.073 -0.916
ENSG00000134324 E021 30.1354710 0.0006928780 9.278202e-04 3.712359e-03 2 11771372 11771679 308 + 1.585 1.369 -0.742
ENSG00000134324 E022 18.4803780 0.0010392915 2.179743e-02 5.525319e-02 2 11773620 11773745 126 + 1.369 1.181 -0.660
ENSG00000134324 E023 3.5274579 0.0097808668 1.023637e-01 1.941249e-01 2 11776086 11776193 108 + 0.765 0.510 -1.109
ENSG00000134324 E024 0.1451727 0.0429387962 6.477571e-01   2 11777207 11777521 315 + 0.108 0.000 -12.913
ENSG00000134324 E025 20.9551475 0.0010080343 1.361815e-03 5.182640e-03 2 11779519 11779645 127 + 1.442 1.192 -0.873
ENSG00000134324 E026 26.6603630 0.0055859360 5.065198e-02 1.103163e-01 2 11782201 11782363 163 + 1.512 1.361 -0.519
ENSG00000134324 E027 26.6556773 0.0007575109 1.836770e-01 3.058168e-01 2 11782364 11782507 144 + 1.488 1.396 -0.319
ENSG00000134324 E028 15.0677239 0.0012321501 6.312623e-01 7.462947e-01 2 11783829 11783868 40 + 1.228 1.181 -0.164
ENSG00000134324 E029 15.3998708 0.0012558357 9.581277e-01 9.777472e-01 2 11783869 11783922 54 + 1.213 1.212 -0.001
ENSG00000134324 E030 4.2145930 0.0135249155 6.103908e-01 7.297119e-01 2 11783923 11784313 391 + 0.671 0.740 0.284
ENSG00000134324 E031 5.3831591 0.0031212316 7.679242e-01 8.500452e-01 2 11784712 11784885 174 + 0.786 0.820 0.133
ENSG00000134324 E032 25.0250913 0.0009962987 2.357706e-01 3.692904e-01 2 11784886 11785076 191 + 1.455 1.369 -0.298
ENSG00000134324 E033 0.0000000       2 11787047 11787073 27 +      
ENSG00000134324 E034 12.3041742 0.0014785478 6.401193e-01 7.534135e-01 2 11787074 11787129 56 + 1.148 1.099 -0.174
ENSG00000134324 E035 11.1971360 0.0016540553 1.896226e-01 3.132776e-01 2 11787130 11787167 38 + 1.148 1.014 -0.484
ENSG00000134324 E036 16.2392519 0.0258859791 2.046702e-01 3.319791e-01 2 11788387 11788456 70 + 1.301 1.157 -0.510
ENSG00000134324 E037 0.0000000       2 11791708 11791785 78 +      
ENSG00000134324 E038 22.9600738 0.0008699795 2.569343e-02 6.330445e-02 2 11791914 11792006 93 + 1.451 1.285 -0.574
ENSG00000134324 E039 0.0000000       2 11792007 11792349 343 +      
ENSG00000134324 E040 22.3534289 0.0008654985 7.965057e-01 8.701115e-01 2 11795408 11795487 80 + 1.385 1.362 -0.080
ENSG00000134324 E041 24.4347734 0.0009792895 7.287274e-01 8.211268e-01 2 11802907 11803033 127 + 1.424 1.396 -0.097
ENSG00000134324 E042 12.1985545 0.0014427523 8.076571e-01 8.777978e-01 2 11804423 11804427 5 + 1.139 1.112 -0.097
ENSG00000134324 E043 14.0357105 0.0013328811 7.062514e-01 8.044361e-01 2 11804428 11804439 12 + 1.197 1.159 -0.135
ENSG00000134324 E044 26.1796581 0.0007707264 6.841738e-01 7.871990e-01 2 11804440 11804571 132 + 1.428 1.451 0.077
ENSG00000134324 E045 19.8593341 0.0010259929 6.357074e-01 7.499129e-01 2 11805070 11805156 87 + 1.342 1.302 -0.142
ENSG00000134324 E046 0.9932018 0.0129571037 4.403897e-02 9.845702e-02 2 11805157 11805515 359 + 0.108 0.457 2.716
ENSG00000134324 E047 20.5965467 0.0009563878 9.727319e-01 9.870019e-01 2 11815088 11815240 153 + 1.342 1.340 -0.007
ENSG00000134324 E048 3.2847919 0.0048071594 6.553254e-01 7.652398e-01 2 11816153 11819483 3331 + 0.671 0.600 -0.305
ENSG00000134324 E049 25.5997530 0.0008056214 6.334347e-01 7.481447e-01 2 11819484 11819598 115 + 1.451 1.415 -0.124
ENSG00000134324 E050 24.6451577 0.0007921951 6.312540e-01 7.462947e-01 2 11820411 11820514 104 + 1.433 1.396 -0.129
ENSG00000134324 E051 0.2214452 0.0421409142 3.658797e-01   2 11823080 11823175 96 + 0.000 0.138 12.391
ENSG00000134324 E052 280.2134993 0.0002888858 9.164248e-25 9.803158e-23 2 11824632 11827409 2778 + 2.362 2.536 0.582