ENSG00000134294

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256689 ENSG00000134294 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A2 protein_coding protein_coding 52.39777 9.90869 69.86748 1.395457 2.901586 2.816606 37.414019 9.582745 46.77541 1.451839 1.3334516 2.286043 0.79672500 0.9642 0.6702667 -0.2939333 2.020935e-07 1.667614e-35 FALSE TRUE
ENST00000612232 ENSG00000134294 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC38A2 protein_coding protein_coding 52.39777 9.90869 69.86748 1.395457 2.901586 2.816606 6.448362 0.000000 11.91784 0.000000 0.4038245 10.220117 0.07255417 0.0000 0.1708000 0.1708000 1.667614e-35 1.667614e-35 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134294 E001 201.7762455 0.0108457359 1.159421e-26 1.452705e-24 12 46358188 46358480 293 - 1.942 2.677 2.455
ENSG00000134294 E002 894.7554265 0.0066207716 1.662942e-27 2.263214e-25 12 46358481 46359384 904 - 2.673 3.190 1.719
ENSG00000134294 E003 1231.8444454 0.0008934687 1.080145e-21 8.294700e-20 12 46359385 46360959 1575 - 2.882 3.160 0.926
ENSG00000134294 E004 245.4970019 0.0002208026 6.487884e-02 1.348389e-01 12 46360960 46361110 151 - 2.224 2.289 0.217
ENSG00000134294 E005 143.7325269 0.0009081973 1.252659e-03 4.818527e-03 12 46361111 46361117 7 - 2.006 1.984 -0.073
ENSG00000134294 E006 221.5045999 0.0001742728 3.556362e-07 3.239768e-06 12 46361118 46361209 92 - 2.196 2.141 -0.184
ENSG00000134294 E007 8.5053668 0.0305066357 3.720469e-02 8.586189e-02 12 46361853 46362283 431 - 0.870 0.564 -1.267
ENSG00000134294 E008 127.5148572 0.0021579911 1.172997e-07 1.176332e-06 12 46362284 46362289 6 - 1.970 1.802 -0.565
ENSG00000134294 E009 138.8115478 0.0060562805 5.284116e-04 2.265662e-03 12 46362290 46362324 35 - 1.997 1.906 -0.307
ENSG00000134294 E010 160.4394538 0.0021093711 2.530468e-04 1.187990e-03 12 46362325 46362381 57 - 2.056 2.004 -0.173
ENSG00000134294 E011 3.9065875 0.0391429792 3.030891e-01 4.449938e-01 12 46362382 46362493 112 - 0.585 0.445 -0.673
ENSG00000134294 E012 268.9007412 0.0002124527 5.075997e-09 6.615978e-08 12 46362494 46362638 145 - 2.281 2.215 -0.218
ENSG00000134294 E013 4.4287743 0.0035427183 1.591205e-01 2.739325e-01 12 46362639 46362904 266 - 0.636 0.445 -0.898
ENSG00000134294 E014 238.1926478 0.0001783638 1.051243e-09 1.552865e-08 12 46363021 46363114 94 - 2.231 2.144 -0.291
ENSG00000134294 E015 157.3933436 0.0002408077 1.352823e-07 1.340139e-06 12 46363115 46363145 31 - 2.054 1.951 -0.345
ENSG00000134294 E016 259.9078666 0.0057314597 1.532326e-06 1.222602e-05 12 46363726 46363826 101 - 2.272 2.142 -0.435
ENSG00000134294 E017 208.0683274 0.0008810697 1.589690e-10 2.710241e-09 12 46363924 46364003 80 - 2.178 2.041 -0.458
ENSG00000134294 E018 186.0569164 0.0010379546 3.150354e-11 6.042990e-10 12 46364389 46364441 53 - 2.132 1.964 -0.565
ENSG00000134294 E019 248.2649231 0.0035205617 5.059342e-08 5.449298e-07 12 46364442 46364556 115 - 2.253 2.123 -0.434
ENSG00000134294 E020 4.6714257 0.0033146628 3.110244e-02 7.410534e-02 12 46364557 46364641 85 - 0.659 0.277 -1.997
ENSG00000134294 E021 2.6190614 0.1770235279 8.466093e-01 9.046766e-01 12 46364642 46364643 2 - 0.446 0.445 -0.003
ENSG00000134294 E022 183.3086080 0.0004985228 2.552244e-09 3.509072e-08 12 46364644 46364702 59 - 2.122 2.000 -0.409
ENSG00000134294 E023 1.6263095 0.0083770370 1.221774e-01 2.230503e-01 12 46364703 46364832 130 - 0.363 0.000 -11.769
ENSG00000134294 E024 213.4336222 0.0002327570 2.279039e-11 4.479273e-10 12 46365107 46365189 83 - 2.188 2.061 -0.424
ENSG00000134294 E025 6.1594940 0.0028351521 9.445479e-01 9.691961e-01 12 46365190 46365307 118 - 0.712 0.803 0.365
ENSG00000134294 E026 176.5388024 0.0002043626 3.696617e-08 4.088226e-07 12 46366864 46366945 82 - 2.103 2.004 -0.331
ENSG00000134294 E027 186.1264644 0.0082392110 8.616965e-04 3.479460e-03 12 46367076 46367168 93 - 2.124 2.035 -0.297
ENSG00000134294 E028 146.7957465 0.0130519011 1.021497e-03 4.033215e-03 12 46367267 46367340 74 - 2.026 1.897 -0.435
ENSG00000134294 E029 7.4181163 0.0022721901 1.184296e-02 3.315571e-02 12 46367341 46367410 70 - 0.826 0.445 -1.675
ENSG00000134294 E030 186.2703084 0.0002268627 2.870150e-18 1.492565e-16 12 46370512 46370627 116 - 2.141 1.891 -0.839
ENSG00000134294 E031 107.2999461 0.0003014292 3.721875e-09 4.961636e-08 12 46370776 46370798 23 - 1.899 1.700 -0.673
ENSG00000134294 E032 160.3330244 0.0018528947 1.933215e-16 8.014366e-15 12 46370799 46370857 59 - 2.081 1.770 -1.046
ENSG00000134294 E033 1.2210941 0.0106711359 8.710021e-01 9.210543e-01 12 46370858 46371177 320 - 0.263 0.277 0.103
ENSG00000134294 E034 226.3720733 0.0043474946 7.724282e-15 2.584497e-13 12 46371178 46371379 202 - 2.228 1.938 -0.972
ENSG00000134294 E035 1.0308569 0.0237344389 2.972762e-01 4.385973e-01 12 46371380 46371433 54 - 0.263 0.000 -11.106
ENSG00000134294 E036 0.7279398 0.2649078171 6.294894e-01 7.448539e-01 12 46372321 46372508 188 - 0.202 0.000 -9.507
ENSG00000134294 E037 142.1904252 0.0002944362 5.753470e-10 8.922541e-09 12 46372509 46372773 265 - 2.016 1.849 -0.563