ENSG00000134278

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000410092 ENSG00000134278 HEK293_OSMI2_2hA HEK293_TMG_2hB SPIRE1 protein_coding protein_coding 8.059124 4.113322 10.55155 0.1568669 0.3946022 1.356943 5.2786781 3.710493 7.898711 0.1884999 0.01812868 1.087949 0.7181542 0.9026 0.7506667 -0.1519333 0.02670649 0.02670649 FALSE TRUE
MSTRG.15521.6 ENSG00000134278 HEK293_OSMI2_2hA HEK293_TMG_2hB SPIRE1 protein_coding   8.059124 4.113322 10.55155 0.1568669 0.3946022 1.356943 0.8381788 0.000000 1.088163 0.0000000 0.55227735 6.778948 0.0725375 0.0000 0.1005333 0.1005333 0.29711015 0.02670649 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134278 E001 0.0000000       18 12446512 12446512 1 -      
ENSG00000134278 E002 526.2422971 0.0129047603 8.896910e-05 4.701922e-04 18 12446513 12449503 2991 - 2.610 2.830 0.732
ENSG00000134278 E003 20.8479621 0.0012583308 1.792926e-01 3.002258e-01 18 12449504 12449505 2 - 1.257 1.422 0.578
ENSG00000134278 E004 20.8082198 0.0036003122 1.285290e-01 2.321072e-01 18 12449506 12449508 3 - 1.246 1.431 0.641
ENSG00000134278 E005 35.9831182 0.0006097850 7.581123e-01 8.427686e-01 18 12449509 12449572 64 - 1.516 1.599 0.282
ENSG00000134278 E006 42.3889246 0.0033683525 2.529653e-01 3.894117e-01 18 12449573 12449665 93 - 1.616 1.609 -0.024
ENSG00000134278 E007 25.3425034 0.0011334688 2.745761e-01 4.137512e-01 18 12449666 12449667 2 - 1.404 1.388 -0.055
ENSG00000134278 E008 58.3941989 0.0010957754 8.047841e-02 1.603044e-01 18 12449668 12449809 142 - 1.755 1.732 -0.079
ENSG00000134278 E009 45.0727552 0.0006228366 6.740178e-02 1.390367e-01 18 12449810 12449896 87 - 1.648 1.610 -0.130
ENSG00000134278 E010 59.9403422 0.0008760071 2.963009e-01 4.375058e-01 18 12452255 12452391 137 - 1.757 1.771 0.048
ENSG00000134278 E011 0.6266857 0.0172671820 4.677532e-01 6.072436e-01 18 12452392 12452443 52 - 0.151 0.305 1.291
ENSG00000134278 E012 32.0058479 0.0032354829 5.745315e-02 1.222691e-01 18 12452485 12452512 28 - 1.521 1.454 -0.233
ENSG00000134278 E013 2.5998177 0.1055781504 5.175936e-01 6.519479e-01 18 12452513 12452610 98 - 0.569 0.480 -0.425
ENSG00000134278 E014 44.7899916 0.0053213655 7.954298e-02 1.588152e-01 18 12453068 12453138 71 - 1.656 1.608 -0.164
ENSG00000134278 E015 52.7242109 0.0005052302 5.412235e-01 6.722473e-01 18 12454346 12454483 138 - 1.694 1.728 0.114
ENSG00000134278 E016 0.7384326 0.0445288983 8.725821e-02 1.709795e-01 18 12454484 12454506 23 - 0.082 0.404 2.882
ENSG00000134278 E017 3.3956215 0.0046366191 5.743149e-01 7.001476e-01 18 12459755 12459928 174 - 0.569 0.705 0.592
ENSG00000134278 E018 54.8147772 0.0004874376 3.152560e-01 4.580049e-01 18 12463351 12463493 143 - 1.714 1.728 0.048
ENSG00000134278 E019 36.6817896 0.0126388216 3.090404e-01 4.513336e-01 18 12464868 12464958 91 - 1.553 1.530 -0.078
ENSG00000134278 E020 51.6104809 0.0038033515 6.991613e-01 7.989747e-01 18 12479699 12479871 173 - 1.677 1.717 0.134
ENSG00000134278 E021 1.1814393 0.2835045086 9.031307e-01 9.423834e-01 18 12485959 12486000 42 - 0.309 0.313 0.022
ENSG00000134278 E022 32.8326336 0.0019744880 2.777375e-01 4.173498e-01 18 12493072 12493138 67 - 1.454 1.588 0.457
ENSG00000134278 E023 39.6094643 0.0031022737 5.661157e-01 6.931269e-01 18 12493139 12493201 63 - 1.551 1.650 0.341
ENSG00000134278 E024 42.9254821 0.0007302719 8.663553e-01 9.179596e-01 18 12496016 12496102 87 - 1.601 1.656 0.187
ENSG00000134278 E025 28.7235020 0.0006670655 6.020858e-01 7.231010e-01 18 12506477 12506495 19 - 1.441 1.470 0.099
ENSG00000134278 E026 61.0041835 0.0032880374 5.700911e-01 6.965986e-01 18 12506496 12506641 146 - 1.756 1.789 0.114
ENSG00000134278 E027 42.2241255 0.0005346553 3.511650e-02 8.186456e-02 18 12512454 12512512 59 - 1.627 1.570 -0.195
ENSG00000134278 E028 24.0895776 0.0007747378 2.043611e-02 5.240831e-02 18 12512513 12512531 19 - 1.411 1.297 -0.394
ENSG00000134278 E029 0.0000000       18 12516071 12516225 155 -      
ENSG00000134278 E030 19.8162976 0.0009159703 3.027425e-02 7.250409e-02 18 12535476 12535477 2 - 1.330 1.212 -0.416
ENSG00000134278 E031 54.0715089 0.0004901046 1.735507e-05 1.091589e-04 18 12535478 12535601 124 - 1.762 1.599 -0.553
ENSG00000134278 E032 60.8035057 0.0104452563 5.624714e-05 3.129013e-04 18 12546674 12546904 231 - 1.827 1.605 -0.753
ENSG00000134278 E033 0.1482932 0.0411070542 2.325028e-01   18 12588376 12588419 44 - 0.000 0.178 12.735
ENSG00000134278 E034 15.2931237 0.0070463978 3.899946e-03 1.286292e-02 18 12635062 12635096 35 - 1.252 1.008 -0.876
ENSG00000134278 E035 0.1482932 0.0411070542 2.325028e-01   18 12636324 12636340 17 - 0.000 0.178 12.735
ENSG00000134278 E036 0.0000000       18 12647795 12647865 71 -      
ENSG00000134278 E037 0.1817044 0.0403588317 2.306393e-01   18 12653001 12653085 85 - 0.000 0.179 12.739
ENSG00000134278 E038 0.0000000       18 12653384 12653440 57 -      
ENSG00000134278 E039 0.0000000       18 12656575 12656650 76 -      
ENSG00000134278 E040 0.0000000       18 12656651 12656736 86 -      
ENSG00000134278 E041 36.4640073 0.0033730109 5.609715e-11 1.032291e-09 18 12657530 12658107 578 - 1.650 1.212 -1.515