ENSG00000134262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256658 ENSG00000134262 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4B1 protein_coding protein_coding 17.85892 15.5964 16.81618 1.021679 0.6027292 0.1085699 4.505081 5.0884811 4.1426575 0.65077598 0.7793965 -0.2960326 0.25789583 0.32413333 0.24703333 -0.077100000 4.873953e-01 5.070001e-05 FALSE TRUE
ENST00000369567 ENSG00000134262 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4B1 protein_coding protein_coding 17.85892 15.5964 16.81618 1.021679 0.6027292 0.1085699 1.772426 3.4285412 0.2589478 0.21435021 0.2589478 -3.6763987 0.10340000 0.22236667 0.01643333 -0.205933333 2.204587e-02 5.070001e-05 FALSE TRUE
ENST00000460653 ENSG00000134262 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4B1 protein_coding processed_transcript 17.85892 15.5964 16.81618 1.021679 0.6027292 0.1085699 1.169179 0.3225498 1.3155453 0.18740779 0.3950196 1.9949437 0.06112083 0.01953333 0.07676667 0.057233333 1.961136e-01 5.070001e-05   FALSE
ENST00000472122 ENSG00000134262 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4B1 protein_coding processed_transcript 17.85892 15.5964 16.81618 1.021679 0.6027292 0.1085699 1.478108 0.4802014 1.7057554 0.06004355 0.1548197 1.8073975 0.07835417 0.03160000 0.10170000 0.070100000 5.070001e-05 5.070001e-05 FALSE FALSE
ENST00000479285 ENSG00000134262 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4B1 protein_coding processed_transcript 17.85892 15.5964 16.81618 1.021679 0.6027292 0.1085699 1.004757 0.5610720 0.7184298 0.12397940 0.1916035 0.3511175 0.05272083 0.03533333 0.04346667 0.008133333 8.888313e-01 5.070001e-05 FALSE TRUE
ENST00000489499 ENSG00000134262 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4B1 protein_coding processed_transcript 17.85892 15.5964 16.81618 1.021679 0.6027292 0.1085699 2.548062 1.0344584 3.2411698 0.57324103 0.3519966 1.6382038 0.14221667 0.06803333 0.19233333 0.124300000 4.835095e-01 5.070001e-05 FALSE TRUE
MSTRG.1852.6 ENSG00000134262 HEK293_OSMI2_2hA HEK293_TMG_2hB AP4B1 protein_coding   17.85892 15.5964 16.81618 1.021679 0.6027292 0.1085699 3.175046 2.8036274 3.0773249 0.07909531 0.3363183 0.1339260 0.17934583 0.18120000 0.18306667 0.001866667 1.000000e+00 5.070001e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134262 E001 5.319482 0.0031548112 6.143805e-01 7.328705e-01 1 113894194 113894747 554 - 0.833 0.772 -0.242
ENSG00000134262 E002 6.731313 0.1035784519 8.127146e-01 8.812478e-01 1 113894748 113895055 308 - 0.880 0.891 0.042
ENSG00000134262 E003 1.659415 0.6396537691 9.732089e-01 9.872902e-01 1 113895056 113895059 4 - 0.467 0.400 -0.352
ENSG00000134262 E004 31.955270 0.0006680406 2.569177e-02 6.330285e-02 1 113895060 113895130 71 - 1.412 1.559 0.506
ENSG00000134262 E005 69.511102 0.0010476077 8.799519e-02 1.720711e-01 1 113895131 113895184 54 - 1.789 1.871 0.278
ENSG00000134262 E006 95.338283 0.0003357562 5.771769e-04 2.449143e-03 1 113895185 113895242 58 - 1.886 2.020 0.450
ENSG00000134262 E007 183.467466 0.0042751853 2.056146e-05 1.271854e-04 1 113895243 113895492 250 - 2.134 2.313 0.596
ENSG00000134262 E008 6.938138 0.0063396626 7.648689e-01 8.478223e-01 1 113895493 113895756 264 - 0.922 0.892 -0.114
ENSG00000134262 E009 186.086979 0.0008105988 1.355744e-05 8.735518e-05 1 113895757 113896038 282 - 2.178 2.308 0.435
ENSG00000134262 E010 3.202277 0.0120479582 1.260365e-02 3.497777e-02 1 113896039 113896044 6 - 0.808 0.422 -1.724
ENSG00000134262 E011 9.000806 0.0500990417 4.338497e-02 9.726578e-02 1 113896045 113896257 213 - 1.151 0.848 -1.122
ENSG00000134262 E012 108.461168 0.0082308123 1.945121e-01 3.194020e-01 1 113896258 113896348 91 - 1.978 2.056 0.260
ENSG00000134262 E013 125.718801 0.0085720432 4.193664e-01 5.626169e-01 1 113896349 113896465 117 - 2.059 2.108 0.165
ENSG00000134262 E014 20.210137 0.0010247440 2.683782e-07 2.508310e-06 1 113896466 113897839 1374 - 1.510 1.124 -1.352
ENSG00000134262 E015 103.755436 0.0004037246 2.064354e-01 3.342499e-01 1 113897840 113897943 104 - 1.977 2.026 0.165
ENSG00000134262 E016 2.961366 0.0059927949 9.457901e-04 3.774136e-03 1 113897944 113897975 32 - 0.833 0.321 -2.411
ENSG00000134262 E017 75.369008 0.0004027434 5.560046e-01 6.847568e-01 1 113898718 113898763 46 - 1.854 1.883 0.096
ENSG00000134262 E018 64.561346 0.0005130087 1.735658e-01 2.928163e-01 1 113898764 113898801 38 - 1.763 1.828 0.220
ENSG00000134262 E019 6.246274 0.0026119053 2.015060e-06 1.566528e-05 1 113899128 113899352 225 - 1.127 0.539 -2.335
ENSG00000134262 E020 68.982123 0.0004551513 6.840638e-01 7.871202e-01 1 113899904 113899941 38 - 1.818 1.839 0.072
ENSG00000134262 E021 73.635736 0.0005289338 7.842027e-01 8.615631e-01 1 113899942 113899987 46 - 1.864 1.856 -0.027
ENSG00000134262 E022 71.367090 0.0003987541 8.465637e-01 9.046509e-01 1 113899988 113900024 37 - 1.850 1.846 -0.014
ENSG00000134262 E023 61.151334 0.0006416106 7.741628e-01 8.543859e-01 1 113900025 113900061 37 - 1.769 1.786 0.058
ENSG00000134262 E024 122.736149 0.0012663138 3.006507e-01 4.423804e-01 1 113900062 113900230 169 - 2.100 2.065 -0.116
ENSG00000134262 E025 70.419285 0.0101905056 8.740560e-01 9.230270e-01 1 113900231 113900269 39 - 1.845 1.831 -0.047
ENSG00000134262 E026 78.492049 0.0071214227 6.484653e-01 7.599659e-01 1 113900270 113900330 61 - 1.901 1.872 -0.098
ENSG00000134262 E027 76.079348 0.0065102386 1.769453e-01 2.972604e-01 1 113900331 113900400 70 - 1.918 1.839 -0.266
ENSG00000134262 E028 92.744619 0.0006704576 4.872796e-04 2.111522e-03 1 113901236 113901383 148 - 2.035 1.907 -0.429
ENSG00000134262 E029 75.556867 0.0004047140 2.269387e-03 8.057321e-03 1 113901755 113901885 131 - 1.945 1.827 -0.400
ENSG00000134262 E030 8.956792 0.0020976679 3.698582e-06 2.714108e-05 1 113901886 113902119 234 - 1.228 0.730 -1.862
ENSG00000134262 E031 75.210091 0.0054057920 7.255979e-02 1.476122e-01 1 113902638 113902734 97 - 1.928 1.839 -0.300
ENSG00000134262 E032 84.863667 0.0028271964 6.465275e-02 1.344649e-01 1 113902735 113902862 128 - 1.973 1.894 -0.266
ENSG00000134262 E033 105.945171 0.0054225216 6.019245e-03 1.866269e-02 1 113904605 113904793 189 - 2.096 1.964 -0.441
ENSG00000134262 E034 25.715791 0.0102863948 2.557872e-01 3.927105e-01 1 113904794 113904920 127 - 1.472 1.378 -0.324
ENSG00000134262 E035 1.286656 0.0133561440 6.177928e-01 7.355253e-01 1 113904921 113904941 21 - 0.407 0.321 -0.504
ENSG00000134262 E036 27.806454 0.0139883516 7.412667e-03 2.229130e-02 1 113904942 113905201 260 - 1.578 1.347 -0.794