ENSG00000134255

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357172 ENSG00000134255 HEK293_OSMI2_2hA HEK293_TMG_2hB CEPT1 protein_coding protein_coding 24.17788 10.12904 33.07804 2.319283 1.407136 1.706389 18.3543717 7.1386370 23.3407707 2.3588275 1.5501715 1.707730 0.7280833 0.68373333 0.704666667 0.02093333 1.000000e+00 2.728461e-13 FALSE TRUE
ENST00000460443 ENSG00000134255 HEK293_OSMI2_2hA HEK293_TMG_2hB CEPT1 protein_coding processed_transcript 24.17788 10.12904 33.07804 2.319283 1.407136 1.706389 1.5185341 0.0000000 3.6426140 0.0000000 0.6663963 8.512786 0.0414750 0.00000000 0.109800000 0.10980000 2.728461e-13 2.728461e-13 FALSE FALSE
ENST00000473474 ENSG00000134255 HEK293_OSMI2_2hA HEK293_TMG_2hB CEPT1 protein_coding processed_transcript 24.17788 10.12904 33.07804 2.319283 1.407136 1.706389 0.4282094 1.1739143 0.0000000 0.6256487 0.0000000 -6.887421 0.0398750 0.10550000 0.000000000 -0.10550000 4.939777e-02 2.728461e-13 FALSE TRUE
MSTRG.1799.9 ENSG00000134255 HEK293_OSMI2_2hA HEK293_TMG_2hB CEPT1 protein_coding   24.17788 10.12904 33.07804 2.319283 1.407136 1.706389 0.2400476 0.5470663 0.2674856 0.5470663 0.2674856 -1.005436 0.0314375 0.06783333 0.008833333 -0.05900000 9.002754e-01 2.728461e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134255 E001 5.0368331 0.0056946141 9.286611e-01 9.591010e-01 1 111139501 111139626 126 + 0.744 0.780 0.144
ENSG00000134255 E002 3.9211563 0.0040072467 3.046440e-01 4.466676e-01 1 111139627 111139654 28 + 0.605 0.780 0.730
ENSG00000134255 E003 6.0173243 0.0027953193 5.630758e-01 6.905921e-01 1 111139655 111139733 79 + 0.786 0.887 0.390
ENSG00000134255 E004 5.5421541 0.0030933155 8.716453e-01 9.214346e-01 1 111139734 111139761 28 + 0.773 0.819 0.182
ENSG00000134255 E005 0.1451727 0.0447211208 1.000000e+00   1 111139762 111139835 74 + 0.075 0.000 -9.457
ENSG00000134255 E006 2.0178309 0.1950759124 8.623948e-01 9.152733e-01 1 111139836 111139914 79 + 0.461 0.429 -0.165
ENSG00000134255 E007 17.9607225 0.0131985157 1.556294e-01 2.692559e-01 1 111140223 111140265 43 + 1.279 1.155 -0.436
ENSG00000134255 E008 34.1691230 0.0006447286 3.316475e-01 4.752834e-01 1 111140266 111140307 42 + 1.524 1.486 -0.130
ENSG00000134255 E009 1.0436561 0.0154745654 8.367564e-02 1.653086e-01 1 111140545 111140608 64 + 0.367 0.000 -12.225
ENSG00000134255 E010 0.1472490 0.0477166748 1.000000e+00   1 111141970 111142006 37 + 0.075 0.000 -9.460
ENSG00000134255 E011 0.0000000       1 111143482 111143545 64 +      
ENSG00000134255 E012 38.9019709 0.0006018002 1.296754e-01 2.336963e-01 1 111147642 111147646 5 + 1.586 1.516 -0.236
ENSG00000134255 E013 119.2784563 0.0008985597 3.740585e-02 8.623385e-02 1 111147647 111147825 179 + 2.060 2.008 -0.173
ENSG00000134255 E014 207.6552874 0.0002563952 6.029638e-05 3.328759e-04 1 111147826 111148053 228 + 2.307 2.225 -0.274
ENSG00000134255 E015 161.0911837 0.0002417241 1.000995e-03 3.961595e-03 1 111159380 111159527 148 + 2.195 2.120 -0.251
ENSG00000134255 E016 1.8436020 0.0073679353 1.172187e-01 2.159767e-01 1 111159528 111160970 1443 + 0.489 0.193 -1.898
ENSG00000134255 E017 170.1869277 0.0002868054 5.304286e-01 6.630427e-01 1 111161155 111161296 142 + 2.194 2.202 0.025
ENSG00000134255 E018 3.3446076 0.0673041469 9.763691e-01 9.892195e-01 1 111167106 111167190 85 + 0.606 0.634 0.124
ENSG00000134255 E019 3.7936775 0.0456263805 9.692727e-01 9.847894e-01 1 111173114 111173137 24 + 0.644 0.640 -0.016
ENSG00000134255 E020 7.9865178 0.0021127259 8.746088e-01 9.233684e-01 1 111173138 111173258 121 + 0.914 0.917 0.014
ENSG00000134255 E021 144.9146128 0.0002253943 2.577473e-01 3.949196e-01 1 111174879 111174963 85 + 2.131 2.121 -0.031
ENSG00000134255 E022 86.7206063 0.0090706529 5.240001e-19 2.983776e-17 1 111178214 111182186 3973 + 2.014 1.347 -2.266
ENSG00000134255 E023 167.0185545 0.0004495725 8.636744e-01 9.160928e-01 1 111182187 111182318 132 + 2.184 2.206 0.072
ENSG00000134255 E024 1.9281944 0.0221475522 9.278824e-02 1.794837e-01 1 111182537 111182798 262 + 0.515 0.193 -2.026
ENSG00000134255 E025 158.3365366 0.0004971257 5.584874e-01 6.867208e-01 1 111182799 111182957 159 + 2.156 2.201 0.151
ENSG00000134255 E026 151.5697798 0.0009183813 2.904525e-01 4.312637e-01 1 111183462 111183587 126 + 2.131 2.191 0.201
ENSG00000134255 E027 434.9006265 0.0032466317 1.197464e-14 3.893318e-13 1 111184191 111185104 914 + 2.524 2.746 0.737