ENSG00000134243

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256637 ENSG00000134243 HEK293_OSMI2_2hA HEK293_TMG_2hB SORT1 protein_coding protein_coding 20.22324 12.87676 23.61962 1.993068 0.4827789 0.8747069 14.057752 9.216224 15.1990012 1.3072093 0.08722543 0.7211131 0.7067458 0.72183333 0.643966667 -0.07786667 0.3186673619 0.0001352302 FALSE TRUE
ENST00000538502 ENSG00000134243 HEK293_OSMI2_2hA HEK293_TMG_2hB SORT1 protein_coding protein_coding 20.22324 12.87676 23.61962 1.993068 0.4827789 0.8747069 1.683794 2.327575 0.1800631 0.3089053 0.12754766 -3.6204625 0.1033833 0.18250000 0.007666667 -0.17483333 0.0001352302 0.0001352302 FALSE TRUE
MSTRG.1749.3 ENSG00000134243 HEK293_OSMI2_2hA HEK293_TMG_2hB SORT1 protein_coding   20.22324 12.87676 23.61962 1.993068 0.4827789 0.8747069 4.197275 1.074445 7.8170510 0.6589860 0.52913311 2.8515122 0.1745250 0.07356667 0.330333333 0.25676667 0.1483556770 0.0001352302 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134243 E001 0.5117019 0.0236020000 4.382484e-02 9.806393e-02 1 109309568 109309574 7 - 0.000 0.343 12.200
ENSG00000134243 E002 1480.1415859 0.0010182991 3.542439e-16 1.420327e-14 1 109309575 109313630 4056 - 3.106 3.240 0.446
ENSG00000134243 E003 54.0509705 0.0010693386 6.454022e-04 2.699523e-03 1 109313631 109313654 24 - 1.797 1.654 -0.484
ENSG00000134243 E004 85.9841974 0.0003281212 6.514111e-05 3.566083e-04 1 109313655 109313800 146 - 1.990 1.866 -0.418
ENSG00000134243 E005 128.7097845 0.0002741566 6.159896e-01 7.341305e-01 1 109313801 109314057 257 - 2.097 2.145 0.162
ENSG00000134243 E006 133.7992113 0.0002973082 3.242955e-06 2.408248e-05 1 109314261 109314384 124 - 2.048 2.224 0.586
ENSG00000134243 E007 155.2437853 0.0059874152 2.254125e-04 1.072123e-03 1 109314672 109314778 107 - 2.096 2.296 0.671
ENSG00000134243 E008 199.3863294 0.0099380308 8.350546e-02 1.650395e-01 1 109316850 109316958 109 - 2.246 2.364 0.396
ENSG00000134243 E009 179.9672014 0.0023336894 1.308996e-02 3.611793e-02 1 109317853 109317969 117 - 2.206 2.321 0.384
ENSG00000134243 E010 241.0634903 0.0002005323 2.787422e-02 6.776615e-02 1 109322932 109323121 190 - 2.350 2.433 0.276
ENSG00000134243 E011 231.6669779 0.0002066849 5.234419e-01 6.571407e-01 1 109324899 109325089 191 - 2.349 2.396 0.157
ENSG00000134243 E012 0.1451727 0.0446406671 6.955752e-01   1 109326806 109326991 186 - 0.102 0.000 -12.516
ENSG00000134243 E013 176.5283550 0.0010512941 8.288191e-01 8.924580e-01 1 109326992 109327160 169 - 2.241 2.263 0.075
ENSG00000134243 E014 132.4456553 0.0066476896 2.810026e-01 4.208707e-01 1 109327499 109327601 103 - 2.137 2.112 -0.084
ENSG00000134243 E015 158.6439559 0.0041600100 2.210036e-01 3.516289e-01 1 109336240 109336346 107 - 2.215 2.192 -0.076
ENSG00000134243 E016 170.4263423 0.0007398392 3.662583e-04 1.643705e-03 1 109340724 109340879 156 - 2.268 2.192 -0.254
ENSG00000134243 E017 164.6838700 0.0013174946 1.590808e-02 4.252846e-02 1 109342014 109342158 145 - 2.241 2.191 -0.168
ENSG00000134243 E018 171.0092282 0.0002010795 5.503689e-05 3.068444e-04 1 109345751 109345878 128 - 2.273 2.195 -0.261
ENSG00000134243 E019 52.3690796 0.0004256900 2.215799e-02 5.600456e-02 1 109345879 109345881 3 - 1.766 1.687 -0.269
ENSG00000134243 E020 118.8278049 0.0003362111 1.676242e-05 1.057895e-04 1 109347483 109347532 50 - 2.129 2.018 -0.372
ENSG00000134243 E021 93.5375099 0.0014267573 1.806849e-04 8.809281e-04 1 109350929 109350946 18 - 2.030 1.909 -0.404
ENSG00000134243 E022 116.0687938 0.0003775624 1.117781e-04 5.759675e-04 1 109350947 109351002 56 - 2.114 2.016 -0.329
ENSG00000134243 E023 130.2608236 0.0013512901 1.091602e-01 2.043061e-01 1 109354367 109354484 118 - 2.133 2.108 -0.085
ENSG00000134243 E024 106.6828147 0.0002945308 2.096864e-05 1.294462e-04 1 109354485 109354531 47 - 2.082 1.965 -0.393
ENSG00000134243 E025 117.4498996 0.0008389953 8.615668e-06 5.810860e-05 1 109355367 109355440 74 - 2.127 2.000 -0.425
ENSG00000134243 E026 85.2154066 0.0092934524 1.114623e-03 4.352689e-03 1 109355441 109355469 29 - 2.005 1.837 -0.566
ENSG00000134243 E027 3.7054660 0.0239252070 4.946116e-04 2.139369e-03 1 109366783 109367407 625 - 0.313 0.894 2.691
ENSG00000134243 E028 97.6232938 0.0019733078 6.262159e-08 6.617893e-07 1 109367408 109367481 74 - 2.073 1.872 -0.674
ENSG00000134243 E029 0.0000000       1 109368478 109368808 331 -      
ENSG00000134243 E030 69.8622722 0.0004435650 3.739947e-12 8.352254e-11 1 109369530 109369589 60 - 1.955 1.676 -0.941
ENSG00000134243 E031 0.0000000       1 109389775 109389899 125 -      
ENSG00000134243 E032 1.4393170 0.0092755343 6.177194e-01 7.354703e-01 1 109392591 109393026 436 - 0.413 0.343 -0.401
ENSG00000134243 E033 0.4502799 0.0321610523 1.595947e-01 2.745793e-01 1 109393027 109393357 331 - 0.254 0.000 -14.261
ENSG00000134243 E034 0.2944980 0.4290041776 4.492766e-01   1 109397207 109397293 87 - 0.184 0.000 -12.523
ENSG00000134243 E035 0.1472490 0.0451610406 6.952355e-01   1 109397294 109397340 47 - 0.102 0.000 -12.511
ENSG00000134243 E036 67.8515355 0.0003633645 9.785253e-20 6.032499e-18 1 109397587 109397946 360 - 1.971 1.578 -1.329