ENSG00000134202

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000486823 ENSG00000134202 HEK293_OSMI2_2hA HEK293_TMG_2hB GSTM3 protein_coding processed_transcript 90.90572 156.1923 58.46899 23.55812 0.843113 -1.417425 15.45312 29.10239 7.684341 5.272472 0.1852961 -1.919764 0.1593125 0.1843667 0.1313667 -0.05300000 0.0006400812 0.0006400812 FALSE  
MSTRG.1767.1 ENSG00000134202 HEK293_OSMI2_2hA HEK293_TMG_2hB GSTM3 protein_coding   90.90572 156.1923 58.46899 23.55812 0.843113 -1.417425 72.46660 124.43100 47.397795 18.193581 0.8705229 -1.392266 0.8002250 0.7980333 0.8105667 0.01253333 0.7027929307 0.0006400812 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134202 E001 0.147249 4.451186e-02 1.562468e-01   1 109727122 109727151 30 - 0.197 0.000 -10.855
ENSG00000134202 E002 1.108174 1.224620e-02 1.051777e-02 3.001792e-02 1 109733932 109733936 5 - 0.588 0.136 -2.965
ENSG00000134202 E003 105.862939 1.265645e-02 3.261042e-27 4.296207e-25 1 109733937 109736929 2993 - 2.387 1.664 -2.427
ENSG00000134202 E004 30.566150 2.664877e-03 9.441463e-06 6.312312e-05 1 109736930 109736974 45 - 1.650 1.334 -1.088
ENSG00000134202 E005 31.691920 2.423635e-03 1.258634e-02 3.493691e-02 1 109736975 109736975 1 - 1.578 1.392 -0.637
ENSG00000134202 E006 169.655702 2.375107e-04 1.255653e-02 3.486592e-02 1 109736976 109737020 45 - 2.098 2.169 0.239
ENSG00000134202 E007 766.693096 9.988131e-05 9.543438e-12 1.995778e-10 1 109737021 109737169 149 - 2.730 2.824 0.311
ENSG00000134202 E008 11.246239 1.821049e-03 4.191436e-01 5.623898e-01 1 109737170 109737456 287 - 1.097 1.000 -0.353
ENSG00000134202 E009 991.148410 9.686904e-05 1.424266e-14 4.591166e-13 1 109737457 109737567 111 - 2.843 2.935 0.306
ENSG00000134202 E010 965.992101 9.012018e-05 5.682256e-06 3.993050e-05 1 109737656 109737751 96 - 2.867 2.916 0.162
ENSG00000134202 E011 1054.952401 3.860059e-04 8.195620e-02 1.626186e-01 1 109738091 109738191 101 - 2.933 2.945 0.038
ENSG00000134202 E012 949.007690 1.233318e-04 1.816606e-01 3.033205e-01 1 109738285 109738366 82 - 2.922 2.892 -0.100
ENSG00000134202 E013 903.946685 9.187107e-05 2.415620e-02 6.013388e-02 1 109739429 109739493 65 - 2.910 2.868 -0.141
ENSG00000134202 E014 809.601731 5.957671e-04 1.810221e-02 4.735183e-02 1 109739833 109739908 76 - 2.871 2.812 -0.196
ENSG00000134202 E015 43.972900 5.111678e-04 8.408509e-09 1.050908e-07 1 109739909 109740239 331 - 1.808 1.478 -1.122
ENSG00000134202 E016 618.911870 2.045538e-03 5.104827e-03 1.621580e-02 1 109740240 109740511 272 - 2.780 2.684 -0.319
ENSG00000134202 E017 0.000000       1 109740512 109740516 5 -      
ENSG00000134202 E018 2.805494 9.420612e-03 6.415694e-03 1.970229e-02 1 109740953 109741038 86 - 0.829 0.393 -1.968