ENSG00000134152

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256544 ENSG00000134152 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNBL1 protein_coding protein_coding 15.99585 3.126446 26.62618 0.2461459 2.02756 3.086185 2.5380804 0.92534986 4.378224 0.15528943 0.08143501 2.2300593 0.21220417 0.29286667 0.16603333 -0.126833333 0.009446575 0.001540092 FALSE TRUE
ENST00000559760 ENSG00000134152 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNBL1 protein_coding protein_coding 15.99585 3.126446 26.62618 0.2461459 2.02756 3.086185 1.6574860 0.13111099 3.023867 0.07744623 0.36856904 4.4262555 0.09565417 0.03846667 0.11283333 0.074366667 0.047680186 0.001540092 FALSE TRUE
ENST00000560108 ENSG00000134152 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNBL1 protein_coding protein_coding 15.99585 3.126446 26.62618 0.2461459 2.02756 3.086185 0.5760876 0.00000000 1.555184 0.00000000 0.47721584 7.2901888 0.02060000 0.00000000 0.05853333 0.058533333 0.001540092 0.001540092 FALSE FALSE
ENST00000560310 ENSG00000134152 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNBL1 protein_coding protein_coding 15.99585 3.126446 26.62618 0.2461459 2.02756 3.086185 1.2467238 0.22528484 1.261966 0.22528484 1.26196560 2.4345794 0.05200000 0.08390000 0.04133333 -0.042566667 0.818129311 0.001540092 FALSE FALSE
ENST00000560671 ENSG00000134152 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNBL1 protein_coding retained_intron 15.99585 3.126446 26.62618 0.2461459 2.02756 3.086185 2.0149896 0.03884573 3.238759 0.03884573 0.92613860 6.0555124 0.09620417 0.01446667 0.12780000 0.113333333 0.070939738 0.001540092 FALSE TRUE
ENST00000561270 ENSG00000134152 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNBL1 protein_coding protein_coding 15.99585 3.126446 26.62618 0.2461459 2.02756 3.086185 0.4290149 0.35760917 0.457357 0.18034286 0.45735704 0.3463523 0.02615000 0.10670000 0.01786667 -0.088833333 0.328869785 0.001540092 FALSE TRUE
ENST00000561371 ENSG00000134152 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNBL1 protein_coding protein_coding 15.99585 3.126446 26.62618 0.2461459 2.02756 3.086185 1.0574759 0.19669450 1.618186 0.07047125 0.29765773 2.9776938 0.08907083 0.06236667 0.05993333 -0.002433333 1.000000000 0.001540092 FALSE FALSE
MSTRG.10431.2 ENSG00000134152 HEK293_OSMI2_2hA HEK293_TMG_2hB KATNBL1 protein_coding   15.99585 3.126446 26.62618 0.2461459 2.02756 3.086185 4.7683463 0.91342877 7.949501 0.06310470 0.53396018 3.1076054 0.29144167 0.29400000 0.29946667 0.005466667 0.926971368 0.001540092 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134152 E001 61.8938544 0.0042156457 9.629503e-06 6.426691e-05 15 34140674 34141886 1213 - 1.617 1.886 0.910
ENSG00000134152 E002 16.9413080 0.0016648712 2.736202e-03 9.481886e-03 15 34141887 34141961 75 - 1.068 1.361 1.038
ENSG00000134152 E003 22.7915734 0.0009074622 8.307495e-06 5.622629e-05 15 34141962 34142035 74 - 1.167 1.535 1.284
ENSG00000134152 E004 32.9669847 0.0006802387 2.787196e-07 2.595742e-06 15 34142036 34142090 55 - 1.324 1.682 1.231
ENSG00000134152 E005 89.3681429 0.0005407944 3.461903e-05 2.026722e-04 15 34142091 34142371 281 - 1.791 1.982 0.643
ENSG00000134152 E006 10.9058699 0.0180220131 3.544541e-01 4.987579e-01 15 34142669 34143024 356 - 0.976 0.826 -0.570
ENSG00000134152 E007 10.7493210 0.0016039789 5.121172e-01 6.470439e-01 15 34144964 34145252 289 - 0.964 0.875 -0.337
ENSG00000134152 E008 51.8812358 0.0005070998 1.917247e-01 3.159258e-01 15 34145398 34145491 94 - 1.583 1.667 0.288
ENSG00000134152 E009 3.9001430 0.0535206625 8.324570e-01 8.950178e-01 15 34145492 34145855 364 - 0.587 0.627 0.176
ENSG00000134152 E010 8.0314486 0.0025174868 5.782668e-01 7.034038e-01 15 34146070 34146659 590 - 0.853 0.769 -0.329
ENSG00000134152 E011 1.5813693 0.0092156706 5.953872e-01 7.174939e-01 15 34146660 34146760 101 - 0.310 0.419 0.642
ENSG00000134152 E012 59.6808957 0.0003802262 9.283744e-01 9.589321e-01 15 34146761 34146850 90 - 1.655 1.652 -0.010
ENSG00000134152 E013 7.4865891 0.0107107816 8.316323e-02 1.645193e-01 15 34146851 34147199 349 - 0.853 0.536 -1.330
ENSG00000134152 E014 32.7032623 0.0006195990 8.392637e-01 8.995632e-01 15 34147200 34147202 3 - 1.404 1.390 -0.048
ENSG00000134152 E015 43.9902990 0.0004897041 4.408418e-01 5.824860e-01 15 34147203 34147229 27 - 1.534 1.481 -0.184
ENSG00000134152 E016 51.3320119 0.0004182751 3.230357e-01 4.663782e-01 15 34147230 34147289 60 - 1.600 1.536 -0.221
ENSG00000134152 E017 52.2586314 0.0018807062 1.181306e-01 2.172598e-01 15 34147380 34147430 51 - 1.614 1.504 -0.378
ENSG00000134152 E018 2.1173874 0.0308852188 4.472215e-01 5.886344e-01 15 34148390 34148542 153 - 0.431 0.258 -1.060
ENSG00000134152 E019 1.0822641 0.2239023565 9.335470e-01 9.621242e-01 15 34148543 34148631 89 - 0.252 0.259 0.053
ENSG00000134152 E020 43.1222269 0.0005548977 9.444245e-01 9.691728e-01 15 34148632 34148652 21 - 1.518 1.525 0.026
ENSG00000134152 E021 39.8676214 0.0005971252 9.256013e-01 9.571600e-01 15 34148653 34148655 3 - 1.485 1.481 -0.016
ENSG00000134152 E022 39.8665892 0.0006109659 9.316657e-01 9.609486e-01 15 34148656 34148657 2 - 1.484 1.492 0.030
ENSG00000134152 E023 69.7925744 0.0003837307 1.539629e-01 2.670581e-01 15 34148658 34148750 93 - 1.734 1.652 -0.277
ENSG00000134152 E024 84.9833453 0.0003444832 8.794707e-03 2.577115e-02 15 34152790 34152973 184 - 1.825 1.682 -0.481
ENSG00000134152 E025 38.5504297 0.0005611638 2.876875e-02 6.954032e-02 15 34152974 34153004 31 - 1.493 1.312 -0.626
ENSG00000134152 E026 48.8212470 0.0004519574 3.339862e-03 1.126249e-02 15 34153005 34153069 65 - 1.597 1.376 -0.761
ENSG00000134152 E027 41.4680153 0.0005123876 3.893570e-02 8.906986e-02 15 34154644 34154684 41 - 1.523 1.361 -0.559
ENSG00000134152 E028 0.0000000       15 34154685 34154785 101 -      
ENSG00000134152 E029 0.0000000       15 34154786 34154831 46 -      
ENSG00000134152 E030 70.8667091 0.0038336056 4.083866e-04 1.806599e-03 15 34163560 34163690 131 - 1.759 1.514 -0.835
ENSG00000134152 E031 0.1482932 0.0411597534 5.758630e-02   15 34165930 34166115 186 - 0.000 0.258 12.660
ENSG00000134152 E032 3.7952047 0.0444720653 3.996456e-01 5.433903e-01 15 34177821 34177999 179 - 0.602 0.419 -0.885
ENSG00000134152 E033 0.3030308 0.4017853497 1.000000e+00   15 34198260 34198331 72 - 0.101 0.000 -9.112
ENSG00000134152 E034 0.2987644 0.0295860707 1.000000e+00   15 34199579 34199840 262 - 0.101 0.000 -9.103
ENSG00000134152 E035 4.5897583 0.0250906415 5.119640e-04 2.204520e-03 15 34208517 34209950 1434 - 0.489 1.032 2.228
ENSG00000134152 E036 45.9123478 0.0041436438 2.461934e-04 1.159522e-03 15 34209951 34210096 146 - 1.581 1.257 -1.122