ENSG00000134138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000314177 ENSG00000134138 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS2 protein_coding nonsense_mediated_decay 6.774853 4.704989 7.247123 0.2356127 0.1382839 0.6221433 0.83165264 0.7650587 0.0000000 0.05313835 0.00000000 -6.2762337 0.12338750 0.16443333 0.0000000 -0.16443333 3.726746e-16 4.808033e-23 TRUE TRUE
ENST00000340545 ENSG00000134138 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS2 protein_coding protein_coding 6.774853 4.704989 7.247123 0.2356127 0.1382839 0.6221433 1.10670561 0.8668911 1.0494696 0.23036232 0.34235202 0.2728726 0.17033750 0.18920000 0.1433333 -0.04586667 8.049605e-01 4.808033e-23 FALSE TRUE
ENST00000397624 ENSG00000134138 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS2 protein_coding protein_coding 6.774853 4.704989 7.247123 0.2356127 0.1382839 0.6221433 0.99549380 1.6564082 0.8937985 0.10194307 0.28675658 -0.8826687 0.18155833 0.35183333 0.1249667 -0.22686667 6.932116e-03 4.808033e-23 FALSE TRUE
ENST00000559561 ENSG00000134138 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS2 protein_coding protein_coding 6.774853 4.704989 7.247123 0.2356127 0.1382839 0.6221433 0.37348139 0.0000000 1.7248172 0.00000000 0.03964826 7.4386398 0.04948750 0.00000000 0.2380000 0.23800000 4.808033e-23 4.808033e-23 FALSE TRUE
ENST00000559972 ENSG00000134138 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS2 protein_coding retained_intron 6.774853 4.704989 7.247123 0.2356127 0.1382839 0.6221433 0.60378328 0.1629986 0.7983275 0.16299855 0.44207073 2.2241800 0.08310000 0.03426667 0.1080667 0.07380000 6.196054e-01 4.808033e-23 FALSE TRUE
ENST00000560570 ENSG00000134138 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS2 protein_coding nonsense_mediated_decay 6.774853 4.704989 7.247123 0.2356127 0.1382839 0.6221433 1.21005049 0.7090082 1.8145699 0.26401767 0.30712219 1.3434763 0.16758333 0.14660000 0.2489333 0.10233333 4.789949e-01 4.808033e-23 FALSE TRUE
ENST00000606653 ENSG00000134138 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS2 protein_coding protein_coding 6.774853 4.704989 7.247123 0.2356127 0.1382839 0.6221433 0.05168597 0.2566574 0.0000000 0.12697681 0.00000000 -4.7369153 0.00996250 0.05263333 0.0000000 -0.05263333 3.476895e-04 4.808033e-23 FALSE TRUE
ENST00000607277 ENSG00000134138 HEK293_OSMI2_2hA HEK293_TMG_2hB MEIS2 protein_coding protein_coding 6.774853 4.704989 7.247123 0.2356127 0.1382839 0.6221433 0.77837474 0.0000000 0.5241986 0.00000000 0.52419863 5.7393044 0.09595833 0.00000000 0.0752000 0.07520000 9.051458e-01 4.808033e-23 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134138 E001 3.9554953 0.0042108632 4.826293e-01 6.207621e-01 15 36889204 36891020 1817 - 0.635 0.746 0.462
ENSG00000134138 E002 0.1515154 0.0426300789 5.518663e-01   15 36891021 36891021 1 - 0.114 0.000 -12.787
ENSG00000134138 E003 0.8178402 0.0167698793 1.349419e-01 2.410138e-01 15 36891022 36891031 10 - 0.114 0.381 2.219
ENSG00000134138 E004 13.4514623 0.0013741672 2.717140e-02 6.634367e-02 15 36891032 36891084 53 - 1.039 1.252 0.762
ENSG00000134138 E005 37.6015289 0.0006409988 2.494390e-15 8.956686e-14 15 36891085 36891255 171 - 1.281 1.765 1.663
ENSG00000134138 E006 51.1316175 0.0131489145 9.593279e-07 7.988650e-06 15 36891256 36891409 154 - 1.493 1.859 1.244
ENSG00000134138 E007 97.2164035 0.0077670122 3.144823e-05 1.861687e-04 15 36891410 36891847 438 - 1.862 2.089 0.763
ENSG00000134138 E008 17.4283689 0.0030532156 4.183957e-01 5.616648e-01 15 36891848 36891849 2 - 1.222 1.301 0.276
ENSG00000134138 E009 51.0624276 0.0005078062 3.721391e-04 1.666485e-03 15 36891850 36892055 206 - 1.614 1.798 0.626
ENSG00000134138 E010 29.8045103 0.0007183893 1.056982e-03 4.156641e-03 15 36892056 36892129 74 - 1.367 1.586 0.753
ENSG00000134138 E011 22.4561316 0.0049743824 8.693749e-02 1.704921e-01 15 36892130 36892148 19 - 1.294 1.441 0.511
ENSG00000134138 E012 34.5604375 0.0043098008 9.509441e-02 1.830177e-01 15 36892149 36892218 70 - 1.489 1.612 0.419
ENSG00000134138 E013 45.5498847 0.0010306485 9.738853e-01 9.877173e-01 15 36892219 36892435 217 - 1.665 1.675 0.036
ENSG00000134138 E014 17.7837209 0.0012139236 1.360095e-02 3.730829e-02 15 36892436 36892459 24 - 1.356 1.168 -0.662
ENSG00000134138 E015 0.1472490 0.0429893847 5.520168e-01   15 36894418 36894706 289 - 0.114 0.000 -12.787
ENSG00000134138 E016 0.1515154 0.0426300789 5.518663e-01   15 36894707 36894716 10 - 0.114 0.000 -12.787
ENSG00000134138 E017 14.7428354 0.0012995570 3.516835e-02 8.196417e-02 15 36894717 36894751 35 - 1.274 1.100 -0.616
ENSG00000134138 E018 16.8258151 0.0011365928 7.281311e-02 1.480208e-01 15 36894752 36894783 32 - 1.314 1.178 -0.479
ENSG00000134138 E019 15.7353072 0.0012318477 5.523876e-01 6.816671e-01 15 36894784 36894812 29 - 1.245 1.207 -0.134
ENSG00000134138 E020 0.0000000       15 36895149 36895150 2 -      
ENSG00000134138 E021 30.4297299 0.0006859826 3.040144e-01 4.459928e-01 15 36895151 36895236 86 - 1.526 1.474 -0.176
ENSG00000134138 E022 16.2897749 0.0012393281 1.509562e-01 2.629599e-01 15 36895237 36895240 4 - 1.294 1.188 -0.376
ENSG00000134138 E023 7.9146956 0.0116204115 4.355722e-01 5.777954e-01 15 36895241 36895261 21 - 1.002 0.921 -0.300
ENSG00000134138 E024 0.0000000       15 36895262 36895302 41 -      
ENSG00000134138 E025 0.0000000       15 36896624 36896627 4 -      
ENSG00000134138 E026 24.4867086 0.0017026974 1.686974e-01 2.864680e-01 15 36896628 36896686 59 - 1.449 1.364 -0.293
ENSG00000134138 E027 0.1472490 0.0429893847 5.520168e-01   15 36896687 36896719 33 - 0.114 0.000 -12.787
ENSG00000134138 E028 0.4375944 0.0243284362 1.069171e-01 2.009876e-01 15 36896720 36898339 1620 - 0.280 0.000 -14.371
ENSG00000134138 E029 0.1515154 0.0426300789 5.518663e-01   15 36898364 36898420 57 - 0.114 0.000 -12.787
ENSG00000134138 E030 0.1515154 0.0426300789 5.518663e-01   15 36898421 36898435 15 - 0.114 0.000 -12.787
ENSG00000134138 E031 0.0000000       15 36898727 36898768 42 -      
ENSG00000134138 E032 0.0000000       15 36901000 36901156 157 -      
ENSG00000134138 E033 0.0000000       15 36903941 36904067 127 -      
ENSG00000134138 E034 31.1751634 0.0027296379 5.247820e-02 1.135743e-01 15 36950324 36950400 77 - 1.563 1.448 -0.394
ENSG00000134138 E035 0.0000000       15 37036391 37036813 423 -      
ENSG00000134138 E036 45.2940209 0.0071699433 1.154435e-02 3.245256e-02 15 37036814 37036959 146 - 1.737 1.586 -0.514
ENSG00000134138 E037 1.2929087 0.0143040910 1.136153e-03 4.424837e-03 15 37066297 37066537 241 - 0.000 0.580 15.950
ENSG00000134138 E038 0.2214452 0.0390896133 4.298105e-01   15 37083770 37083770 1 - 0.000 0.131 12.959
ENSG00000134138 E039 19.5500117 0.0130098904 5.533037e-02 1.185605e-01 15 37083771 37083771 1 - 1.389 1.218 -0.598
ENSG00000134138 E040 23.3655363 0.0093343062 1.879910e-02 4.889458e-02 15 37083772 37083789 18 - 1.472 1.285 -0.646
ENSG00000134138 E041 23.8074065 0.0009499868 3.568958e-02 8.298293e-02 15 37083790 37083803 14 - 1.458 1.323 -0.469
ENSG00000134138 E042 36.8103895 0.0092750952 2.221086e-02 5.611049e-02 15 37083804 37083885 82 - 1.653 1.498 -0.529
ENSG00000134138 E043 41.0070993 0.0107145997 1.115738e-01 2.078655e-01 15 37093581 37093730 150 - 1.676 1.573 -0.351
ENSG00000134138 E044 0.2955422 0.0287787985 9.320078e-01   15 37093731 37094029 299 - 0.114 0.131 0.219
ENSG00000134138 E045 0.0000000       15 37094516 37094526 11 -      
ENSG00000134138 E046 20.7480287 0.0047388147 1.533462e-02 4.124743e-02 15 37094527 37094577 51 - 1.425 1.243 -0.635
ENSG00000134138 E047 0.0000000       15 37095007 37095021 15 -      
ENSG00000134138 E048 18.7606314 0.0013094271 4.195934e-03 1.369349e-02 15 37095564 37095614 51 - 1.400 1.187 -0.744
ENSG00000134138 E049 0.1482932 0.0410558843 4.335058e-01   15 37095753 37096288 536 - 0.000 0.131 12.952
ENSG00000134138 E050 18.2610802 0.0050473582 1.249956e-02 3.473317e-02 15 37096289 37096407 119 - 1.378 1.177 -0.705
ENSG00000134138 E051 8.3509707 0.0020046300 1.443557e-02 3.921274e-02 15 37096408 37096430 23 - 1.085 0.821 -0.988
ENSG00000134138 E052 0.1515154 0.0426300789 5.518663e-01   15 37096431 37096506 76 - 0.114 0.000 -12.787
ENSG00000134138 E053 0.0000000       15 37097271 37097367 97 -      
ENSG00000134138 E054 31.2405072 0.0007928127 1.519082e-01 2.642562e-01 15 37097967 37098199 233 - 1.541 1.464 -0.263
ENSG00000134138 E055 6.7103963 0.0208918048 1.967379e-01 3.221662e-01 15 37098200 37098531 332 - 0.787 0.973 0.714
ENSG00000134138 E056 2.5252638 0.0585905809 3.518880e-01 4.960940e-01 15 37098901 37099454 554 - 0.448 0.621 0.815
ENSG00000134138 E057 12.5278767 0.0014805598 1.439852e-03 5.439085e-03 15 37099455 37099599 145 - 1.252 0.958 -1.062
ENSG00000134138 E058 34.7535440 0.0006445706 7.945622e-06 5.399893e-05 15 37099600 37100549 950 - 1.662 1.408 -0.868
ENSG00000134138 E059 4.7857189 0.0085856574 8.394065e-01 8.996446e-01 15 37100892 37101299 408 - 0.765 0.746 -0.076