ENSG00000134057

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256442 ENSG00000134057 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNB1 protein_coding protein_coding 170.3486 127.5154 230.5444 20.9355 5.670545 0.8543222 55.7591 52.77147 67.59058 11.200758 3.289179 0.357004 0.3377000 0.4074 0.2930667 -0.1143333 0.002933641 0.002048206 FALSE TRUE
ENST00000506572 ENSG00000134057 HEK293_OSMI2_2hA HEK293_TMG_2hB CCNB1 protein_coding protein_coding 170.3486 127.5154 230.5444 20.9355 5.670545 0.8543222 106.4078 67.21249 151.53137 8.187816 4.530587 1.172696 0.6102417 0.5340 0.6573000 0.1233000 0.002048206 0.002048206 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134057 E001 16.485931 0.0179765036 3.540197e-01 4.982984e-01 5 69167127 69167134 8 + 1.285 1.216 -0.241
ENSG00000134057 E002 40.735592 0.0113700959 5.309684e-03 1.677513e-02 5 69167135 69167149 15 + 1.705 1.514 -0.650
ENSG00000134057 E003 574.462577 0.0030203684 5.547369e-09 7.181934e-08 5 69167150 69167215 66 + 2.833 2.655 -0.591
ENSG00000134057 E004 713.817331 0.0012435102 7.760435e-14 2.242854e-12 5 69167216 69167262 47 + 2.921 2.762 -0.531
ENSG00000134057 E005 570.913267 0.0014001849 4.026375e-07 3.628507e-06 5 69167263 69167265 3 + 2.809 2.691 -0.392
ENSG00000134057 E006 670.579348 0.0009775189 2.612540e-09 3.585987e-08 5 69167266 69167283 18 + 2.879 2.761 -0.393
ENSG00000134057 E007 2.141246 0.0066539671 3.376193e-01 4.815105e-01 5 69167284 69167485 202 + 0.567 0.411 -0.768
ENSG00000134057 E008 1422.593331 0.0008489754 7.921652e-09 9.951151e-08 5 69167908 69168078 171 + 3.195 3.100 -0.316
ENSG00000134057 E009 1410.314888 0.0006954608 1.239715e-03 4.775525e-03 5 69168173 69168343 171 + 3.173 3.123 -0.165
ENSG00000134057 E010 1677.921083 0.0004266064 3.801208e-02 8.737502e-02 5 69171270 69171452 183 + 3.238 3.215 -0.075
ENSG00000134057 E011 713.471311 0.0001257563 6.607960e-01 7.694084e-01 5 69174251 69174256 6 + 2.858 2.861 0.010
ENSG00000134057 E012 1495.468194 0.0000726770 2.270552e-02 5.714144e-02 5 69174257 69174409 153 + 3.166 3.197 0.102
ENSG00000134057 E013 1944.303962 0.0006417517 2.182500e-06 1.683022e-05 5 69174877 69175113 237 + 3.261 3.325 0.214
ENSG00000134057 E014 1590.838773 0.0013491652 2.897574e-04 1.338250e-03 5 69175397 69175537 141 + 3.172 3.238 0.221
ENSG00000134057 E015 52.431276 0.0118434788 9.893610e-01 9.973526e-01 5 69177061 69177238 178 + 1.727 1.731 0.012
ENSG00000134057 E016 997.954713 0.0005370315 1.532736e-09 2.195798e-08 5 69177239 69177290 52 + 2.957 3.055 0.326
ENSG00000134057 E017 1072.310582 0.0009732622 1.123771e-06 9.231820e-06 5 69177291 69177349 59 + 2.991 3.080 0.298
ENSG00000134057 E018 13.481615 0.0017619102 7.289267e-03 2.197346e-02 5 69177350 69177358 9 + 1.028 1.282 0.908
ENSG00000134057 E019 1273.848645 0.0014809226 7.558172e-10 1.146783e-08 5 69177524 69178245 722 + 3.044 3.173 0.429