ENSG00000134030

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256413 ENSG00000134030 HEK293_OSMI2_2hA HEK293_TMG_2hB CTIF protein_coding protein_coding 7.29557 9.874008 6.839092 1.03068 0.2101621 -0.5291835 4.5147344 7.4397907 3.5450583 0.71710892 0.158670254 -1.0673267 0.59640417 0.75610000 0.5200667 -0.23603333 0.00156814 0.00156814 FALSE TRUE
ENST00000382998 ENSG00000134030 HEK293_OSMI2_2hA HEK293_TMG_2hB CTIF protein_coding protein_coding 7.29557 9.874008 6.839092 1.03068 0.2101621 -0.5291835 1.2770576 0.6296183 1.9165523 0.62961831 0.345926553 1.5907382 0.19014583 0.05576667 0.2777000 0.22193333 0.09478380 0.00156814 FALSE TRUE
ENST00000587860 ENSG00000134030 HEK293_OSMI2_2hA HEK293_TMG_2hB CTIF protein_coding retained_intron 7.29557 9.874008 6.839092 1.03068 0.2101621 -0.5291835 0.6767877 0.5258623 0.6716629 0.04314048 0.008319211 0.3471963 0.09890417 0.05403333 0.0984000 0.04436667 0.06283729 0.00156814 FALSE TRUE
MSTRG.15760.7 ENSG00000134030 HEK293_OSMI2_2hA HEK293_TMG_2hB CTIF protein_coding   7.29557 9.874008 6.839092 1.03068 0.2101621 -0.5291835 0.2602839 0.8349390 0.0000000 0.42006860 0.000000000 -6.4007753 0.03330000 0.09376667 0.0000000 -0.09376667 0.20660115 0.00156814 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000134030 E001 0.2214452 0.0381164173 8.630576e-01   18 48539031 48539133 103 + 0.000 0.095 8.624
ENSG00000134030 E002 0.1817044 0.0394998895 8.635139e-01   18 48539134 48539135 2 + 0.000 0.095 10.909
ENSG00000134030 E003 1.2845899 0.0106892261 2.682517e-02 6.562857e-02 18 48539136 48539146 11 + 0.000 0.433 13.837
ENSG00000134030 E004 1.9843259 0.0074499702 3.917621e-03 1.291216e-02 18 48539147 48539157 11 + 0.000 0.566 14.463
ENSG00000134030 E005 2.7937481 0.0057461378 1.505746e-01 2.624641e-01 18 48539158 48539171 14 + 0.362 0.620 1.282
ENSG00000134030 E006 3.1634865 0.0051176390 8.284334e-02 1.640012e-01 18 48539172 48539174 3 + 0.362 0.668 1.489
ENSG00000134030 E007 7.6296370 0.0022621025 1.480038e-01 2.589623e-01 18 48539175 48539209 35 + 0.762 0.957 0.752
ENSG00000134030 E008 13.1528061 0.0015489863 3.627049e-01 5.071240e-01 18 48539210 48539312 103 + 1.041 1.144 0.372
ENSG00000134030 E009 1.3901235 0.1916150930 8.643317e-01 9.165423e-01 18 48539415 48539654 240 + 0.362 0.350 -0.070
ENSG00000134030 E010 3.3661201 0.2107130582 8.232494e-01 8.886174e-01 18 48539655 48539748 94 + 0.606 0.608 0.011
ENSG00000134030 E011 3.2649546 0.1649321260 9.836900e-01 9.938878e-01 18 48539749 48539757 9 + 0.557 0.608 0.232
ENSG00000134030 E012 6.6688063 0.0024875585 3.509046e-01 4.950909e-01 18 48539758 48539831 74 + 0.924 0.820 -0.397
ENSG00000134030 E013 0.5149242 0.2171592077 1.000000e+00 1.000000e+00 18 48539988 48540058 71 + 0.157 0.173 0.171
ENSG00000134030 E014 1.1278802 0.3993642944 3.762017e-01 5.205554e-01 18 48540095 48540337 243 + 0.436 0.240 -1.227
ENSG00000134030 E015 47.2782240 0.0004994689 4.303828e-02 9.661544e-02 18 48619538 48619745 208 + 1.711 1.618 -0.316
ENSG00000134030 E016 0.4428904 0.4124436792 5.326731e-01 6.650016e-01 18 48621444 48621641 198 + 0.000 0.179 10.964
ENSG00000134030 E017 0.2987644 0.0271303507 8.159672e-02   18 48625189 48625236 48 + 0.272 0.000 -13.969
ENSG00000134030 E018 30.1783114 0.0006578057 5.634315e-02 1.203251e-01 18 48636614 48636685 72 + 1.532 1.421 -0.381
ENSG00000134030 E019 41.9795015 0.0005827701 1.170278e-03 4.539985e-03 18 48663752 48663825 74 + 1.707 1.543 -0.560
ENSG00000134030 E020 50.0698017 0.0029178313 8.997710e-04 3.613255e-03 18 48664447 48664551 105 + 1.782 1.611 -0.579
ENSG00000134030 E021 52.6301805 0.0017949479 6.502162e-05 3.560262e-04 18 48670669 48670744 76 + 1.815 1.621 -0.655
ENSG00000134030 E022 0.0000000       18 48692512 48692670 159 +      
ENSG00000134030 E023 59.9651023 0.0009236280 8.987720e-04 3.610009e-03 18 48711619 48711695 77 + 1.840 1.696 -0.489
ENSG00000134030 E024 144.9063002 0.0002686546 7.083260e-07 6.075255e-06 18 48757919 48758405 487 + 2.215 2.080 -0.449
ENSG00000134030 E025 15.3475168 0.0018066915 1.953982e-02 5.049943e-02 18 48758406 48758411 6 + 1.304 1.112 -0.678
ENSG00000134030 E026 20.9843799 0.0009181978 9.025783e-06 6.062857e-05 18 48760182 48761389 1208 + 1.503 1.187 -1.101
ENSG00000134030 E027 109.2333347 0.0023116662 2.164160e-03 7.732811e-03 18 48761390 48761689 300 + 2.079 1.971 -0.364
ENSG00000134030 E028 62.9012810 0.0004425864 5.328630e-01 6.651648e-01 18 48817221 48817376 156 + 1.782 1.766 -0.054
ENSG00000134030 E029 35.5192338 0.0006055027 1.901327e-01 3.139497e-01 18 48857588 48857641 54 + 1.459 1.555 0.327
ENSG00000134030 E030 119.2214462 0.0002780993 5.329032e-01 6.651809e-01 18 48859344 48859881 538 + 2.020 2.055 0.115
ENSG00000134030 E031 68.0860045 0.0004507514 9.958649e-01 1.000000e+00 18 48859882 48860074 193 + 1.794 1.807 0.045
ENSG00000134030 E032 80.2379100 0.0008890689 6.167752e-01 7.347552e-01 18 48860075 48860273 199 + 1.854 1.888 0.117
ENSG00000134030 E033 86.4076798 0.0003408390 9.597591e-01 9.787039e-01 18 48860274 48860429 156 + 1.896 1.907 0.037
ENSG00000134030 E034 237.5948409 0.0029995214 9.246364e-01 9.565419e-01 18 48860430 48861216 787 + 2.335 2.348 0.043
ENSG00000134030 E035 58.8388855 0.0035525176 8.763239e-01 9.246220e-01 18 48861217 48861292 76 + 1.725 1.747 0.075
ENSG00000134030 E036 201.7036382 0.0021935850 5.873366e-02 1.244622e-01 18 48861293 48862008 716 + 2.216 2.294 0.262
ENSG00000134030 E037 26.0209005 0.0007619308 2.569983e-02 6.331776e-02 18 48862009 48862027 19 + 1.264 1.445 0.627
ENSG00000134030 E038 33.2841882 0.0006092722 2.238507e-01 3.550140e-01 18 48862028 48862066 39 + 1.432 1.524 0.316
ENSG00000134030 E039 157.1691242 0.0023597817 8.460335e-05 4.498541e-04 18 48862067 48862543 477 + 2.048 2.211 0.544
ENSG00000134030 E040 66.3571456 0.0057433077 3.499268e-02 8.163910e-02 18 48862544 48862625 82 + 1.696 1.835 0.471
ENSG00000134030 E041 107.4259545 0.0072704014 8.920237e-03 2.608169e-02 18 48862626 48862878 253 + 1.887 2.047 0.537
ENSG00000134030 E042 100.4503271 0.0134482108 4.599312e-05 2.614710e-04 18 48862879 48863305 427 + 1.750 2.049 1.007