ENSG00000133943

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256324 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding protein_coding 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.8690585 1.3750815 0.47099839 0.22625831 0.16230392 -1.525866885 0.11900417 0.13653333 0.08696667 -0.049566667 5.233350e-01 4.608016e-06 FALSE TRUE
ENST00000298858 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding protein_coding 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.1893366 0.5254553 0.03450693 0.28556569 0.03450693 -3.588664322 0.02045833 0.05520000 0.00520000 -0.050000000 4.945852e-01 4.608016e-06 FALSE TRUE
ENST00000412671 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding protein_coding 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 1.2571828 1.5208401 1.52717303 0.30803629 0.19789075 0.005956011 0.18168333 0.15460000 0.26243333 0.107833333 1.822090e-01 4.608016e-06 FALSE TRUE
ENST00000428926 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding protein_coding 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.1061331 0.6990660 0.00000000 0.26761776 0.00000000 -6.147847948 0.01219583 0.06686667 0.00000000 -0.066866667 1.458217e-05 4.608016e-06 FALSE TRUE
ENST00000518649 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding processed_transcript 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.1137495 0.0000000 0.33367072 0.00000000 0.07888417 5.102955018 0.01792917 0.00000000 0.06070000 0.060700000 4.608016e-06 4.608016e-06 FALSE FALSE
ENST00000521334 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding protein_coding 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.5083636 0.4538560 0.58844401 0.22941439 0.29621320 0.367539349 0.07305417 0.04346667 0.09500000 0.051533333 8.761389e-01 4.608016e-06 FALSE FALSE
ENST00000522816 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding protein_coding 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.5468254 0.3483327 0.23509263 0.08476342 0.07554189 -0.547972482 0.07413750 0.03393333 0.04296667 0.009033333 9.165708e-01 4.608016e-06 FALSE FALSE
ENST00000523461 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding nonsense_mediated_decay 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.5616302 0.9605665 0.19267031 0.07905305 0.04047058 -2.259692327 0.06904583 0.09580000 0.03503333 -0.060766667 1.175434e-02 4.608016e-06 TRUE TRUE
ENST00000523576 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding processed_transcript 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.5544793 0.4390868 0.34164209 0.10235380 0.09884646 -0.352886542 0.08092917 0.04273333 0.06286667 0.020133333 7.785759e-01 4.608016e-06   FALSE
ENST00000557303 ENSG00000133943 HEK293_OSMI2_2hA HEK293_TMG_2hB DGLUCY protein_coding processed_transcript 7.189732 10.07802 5.779685 0.5951507 0.4923916 -0.8010859 0.4655455 0.7140115 0.54025244 0.32744393 0.15294710 -0.395918949 0.06649167 0.06790000 0.09066667 0.022766667 7.549612e-01 4.608016e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133943 E001 10.8638030 0.0589726589 0.2409264109 0.3752623615 14 91060333 91060704 372 + 1.154 0.970 -0.668
ENSG00000133943 E002 0.2214452 0.0392806023 1.0000000000   14 91060832 91060880 49 + 0.000 0.088 10.769
ENSG00000133943 E003 0.1817044 0.0405284691 1.0000000000   14 91107986 91108061 76 + 0.000 0.088 10.763
ENSG00000133943 E004 0.2924217 0.0290785164 0.0647374364   14 91114054 91114062 9 + 0.290 0.000 -14.274
ENSG00000133943 E005 0.2924217 0.0290785164 0.0647374364   14 91114063 91114064 2 + 0.290 0.000 -14.274
ENSG00000133943 E006 0.5138669 0.0205307810 0.2246588253 0.3560201205 14 91114065 91114066 2 + 0.290 0.088 -2.085
ENSG00000133943 E007 0.8136755 0.0145401845 0.2038196435 0.3309848193 14 91114067 91114072 6 + 0.384 0.160 -1.672
ENSG00000133943 E008 0.8136755 0.0145401845 0.2038196435 0.3309848193 14 91114073 91114073 1 + 0.384 0.160 -1.672
ENSG00000133943 E009 1.1436731 0.0110293000 0.5513414631 0.6808196311 14 91114074 91114079 6 + 0.384 0.277 -0.672
ENSG00000133943 E010 1.6241419 0.0085677132 0.2443861453 0.3793350491 14 91114080 91114082 3 + 0.528 0.326 -1.087
ENSG00000133943 E011 4.1308293 0.0086178236 0.5797671983 0.7045999655 14 91114083 91114084 2 + 0.722 0.639 -0.348
ENSG00000133943 E012 4.7930025 0.0035363495 0.4232107347 0.5663091845 14 91114085 91114086 2 + 0.794 0.681 -0.458
ENSG00000133943 E013 9.3141318 0.0030976874 0.7088978820 0.8064353211 14 91114087 91114098 12 + 0.934 0.977 0.162
ENSG00000133943 E014 10.7868574 0.0027410674 0.6149591724 0.7333545489 14 91114099 91114119 21 + 0.979 1.035 0.204
ENSG00000133943 E015 20.8386077 0.0019740782 0.8168989108 0.8841680359 14 91114120 91114283 164 + 1.300 1.281 -0.067
ENSG00000133943 E016 0.5921286 0.3022290669 0.9163610861 0.9511284047 14 91114284 91114369 86 + 0.169 0.216 0.440
ENSG00000133943 E017 0.0000000       14 91114370 91114375 6 +      
ENSG00000133943 E018 0.2998086 0.0291826054 0.5815303815   14 91114376 91114387 12 + 0.169 0.087 -1.090
ENSG00000133943 E019 0.5943067 0.0224092040 0.0819332573 0.1625937232 14 91114388 91114389 2 + 0.384 0.087 -2.674
ENSG00000133943 E020 2.7343907 0.0276017339 0.2167578099 0.3465033906 14 91114390 91114400 11 + 0.681 0.477 -0.922
ENSG00000133943 E021 4.9799052 0.0034845485 0.3609628337 0.5053268137 14 91114401 91114441 41 + 0.826 0.701 -0.502
ENSG00000133943 E022 5.3088586 0.0031464568 0.3098762125 0.4522213829 14 91114442 91114448 7 + 0.855 0.719 -0.540
ENSG00000133943 E023 8.6700196 0.0119465289 0.4580156048 0.5983409795 14 91114449 91114528 80 + 1.000 0.912 -0.332
ENSG00000133943 E024 0.2998086 0.0291826054 0.5815303815   14 91114670 91114685 16 + 0.169 0.087 -1.090
ENSG00000133943 E025 0.2998086 0.0291826054 0.5815303815   14 91114686 91114699 14 + 0.169 0.087 -1.090
ENSG00000133943 E026 0.1515154 0.0426615422 0.2318165940   14 91114700 91114994 295 + 0.169 0.000 -13.265
ENSG00000133943 E027 0.0000000       14 91114995 91115221 227 +      
ENSG00000133943 E028 0.0000000       14 91125539 91125624 86 +      
ENSG00000133943 E029 0.0000000       14 91128778 91128912 135 +      
ENSG00000133943 E030 7.4147264 0.0023150367 0.3583635637 0.5027540549 14 91145221 91145313 93 + 0.957 0.847 -0.419
ENSG00000133943 E031 0.0000000       14 91147778 91147780 3 +      
ENSG00000133943 E032 6.4701751 0.0028711972 0.4005631369 0.5442472646 14 91147781 91147858 78 + 0.909 0.803 -0.409
ENSG00000133943 E033 0.0000000       14 91148574 91148852 279 +      
ENSG00000133943 E034 22.6703911 0.0014689734 0.5367062286 0.6684376307 14 91157639 91157665 27 + 1.358 1.311 -0.166
ENSG00000133943 E035 23.1729850 0.0009043289 0.1987125895 0.3245749754 14 91157666 91157690 25 + 1.401 1.306 -0.333
ENSG00000133943 E036 0.0000000       14 91158856 91158972 117 +      
ENSG00000133943 E037 28.9883316 0.0009156304 0.4581694937 0.5984956080 14 91160266 91160340 75 + 1.462 1.412 -0.174
ENSG00000133943 E038 24.9404312 0.0014982984 0.5599311592 0.6880036585 14 91160341 91160397 57 + 1.340 1.384 0.154
ENSG00000133943 E039 0.1482932 0.0414615583 1.0000000000   14 91165247 91165337 91 + 0.000 0.087 10.758
ENSG00000133943 E040 33.0765007 0.0051777294 0.4989827542 0.6353449829 14 91167225 91167378 154 + 1.455 1.505 0.171
ENSG00000133943 E041 1.1738620 0.0112658830 0.8462738420 0.9044365534 14 91167379 91167468 90 + 0.290 0.326 0.235
ENSG00000133943 E042 5.5455656 0.0071066552 0.0830163222 0.1642732582 14 91167469 91167523 55 + 0.585 0.846 1.080
ENSG00000133943 E043 6.6673660 0.0438316040 0.0488436486 0.1071006585 14 91167524 91167721 198 + 0.585 0.928 1.392
ENSG00000133943 E044 14.0602606 0.0017226921 0.7403245152 0.8297722729 14 91170003 91170040 38 + 1.155 1.123 -0.112
ENSG00000133943 E045 25.3259667 0.0158087993 0.5895559226 0.7126060770 14 91170041 91170186 146 + 1.409 1.360 -0.171
ENSG00000133943 E046 13.7840901 0.0252619847 0.2272788117 0.3591489406 14 91170187 91170201 15 + 1.222 1.084 -0.493
ENSG00000133943 E047 30.3275566 0.0133209493 0.6828359076 0.7861992880 14 91173289 91173403 115 + 1.476 1.447 -0.101
ENSG00000133943 E048 18.8469107 0.0024263100 0.6114961257 0.7306061973 14 91173404 91173439 36 + 1.290 1.248 -0.146
ENSG00000133943 E049 0.5848540 0.0541924788 0.2789372109 0.4186182226 14 91173664 91173753 90 + 0.000 0.224 12.223
ENSG00000133943 E050 0.0000000       14 91175749 91175933 185 +      
ENSG00000133943 E051 32.2817396 0.0106438901 0.0321211938 0.0760924298 14 91175934 91176056 123 + 1.590 1.430 -0.549
ENSG00000133943 E052 47.3620965 0.0005355745 0.0142620082 0.0388214413 14 91181186 91181389 204 + 1.730 1.603 -0.431
ENSG00000133943 E053 0.0000000       14 91185470 91185575 106 +      
ENSG00000133943 E054 31.0921624 0.0035461968 0.5000040023 0.6362670578 14 91188910 91188987 78 + 1.490 1.442 -0.166
ENSG00000133943 E055 50.4751309 0.0005938315 0.1886651793 0.3120568221 14 91188988 91189170 183 + 1.714 1.647 -0.229
ENSG00000133943 E056 0.1482932 0.0414615583 1.0000000000   14 91189787 91189807 21 + 0.000 0.087 10.758
ENSG00000133943 E057 26.7569655 0.0008326320 0.5965857387 0.7185038775 14 91196375 91196392 18 + 1.425 1.388 -0.128
ENSG00000133943 E058 38.6215456 0.0007365669 0.5338492181 0.6659774953 14 91196393 91196474 82 + 1.580 1.543 -0.125
ENSG00000133943 E059 52.6084778 0.0005341331 0.0783569258 0.1568454897 14 91199757 91199905 149 + 1.616 1.710 0.317
ENSG00000133943 E060 44.3770773 0.0007541755 0.0783713991 0.1568678307 14 91204706 91204825 120 + 1.528 1.631 0.353
ENSG00000133943 E061 0.3299976 0.0274424043 0.4931171770   14 91204826 91204867 42 + 0.000 0.160 11.745
ENSG00000133943 E062 47.5674761 0.0005063809 0.2411728617 0.3755566846 14 91215405 91215556 152 + 1.590 1.655 0.221
ENSG00000133943 E063 5.9993203 0.0174834833 0.1249474081 0.2270460369 14 91215557 91215793 237 + 0.934 0.722 -0.829
ENSG00000133943 E064 6.9730717 0.0024993356 0.0071427687 0.0215944992 14 91215857 91216460 604 + 1.058 0.738 -1.224
ENSG00000133943 E065 6.2720855 0.0027398398 0.2812540071 0.4211474090 14 91220443 91220766 324 + 0.909 0.772 -0.534
ENSG00000133943 E066 11.3101985 0.0016425079 0.1153687961 0.2133922294 14 91223679 91223795 117 + 0.909 1.085 0.651
ENSG00000133943 E067 74.0404122 0.0119777531 0.0448490011 0.0999221173 14 91224684 91224939 256 + 1.726 1.860 0.450
ENSG00000133943 E068 59.8324038 0.0005300050 0.0032513777 0.0110052484 14 91224940 91225107 168 + 1.626 1.776 0.509
ENSG00000133943 E069 50.7181292 0.0004984071 0.0001364693 0.0006878544 14 91225108 91225415 308 + 1.503 1.719 0.736
ENSG00000133943 E070 0.2998086 0.0291826054 0.5815303815   14 91225416 91225633 218 + 0.169 0.087 -1.090
ENSG00000133943 E071 0.0000000       14 91226785 91226848 64 +      
ENSG00000133943 E072 0.0000000       14 91230549 91230598 50 +