ENSG00000133895

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312049 ENSG00000133895 HEK293_OSMI2_2hA HEK293_TMG_2hB MEN1 protein_coding protein_coding 88.25637 117.8843 66.24831 6.219167 0.6421675 -0.8313201 4.017597 7.117428 0.000000 3.6165981 0.0000000 -9.4772378 0.04078333 0.06320000 0.0000000 -0.06320000 4.536589e-08 1.133939e-10 FALSE TRUE
ENST00000315422 ENSG00000133895 HEK293_OSMI2_2hA HEK293_TMG_2hB MEN1 protein_coding protein_coding 88.25637 117.8843 66.24831 6.219167 0.6421675 -0.8313201 18.345767 20.011732 16.044861 2.3095704 1.0744187 -0.3185566 0.21248333 0.16870000 0.2419333 0.07323333 2.582642e-02 1.133939e-10 FALSE TRUE
ENST00000394376 ENSG00000133895 HEK293_OSMI2_2hA HEK293_TMG_2hB MEN1 protein_coding protein_coding 88.25637 117.8843 66.24831 6.219167 0.6421675 -0.8313201 3.940939 14.077327 0.000000 6.1905152 0.0000000 -10.4601821 0.03702083 0.12170000 0.0000000 -0.12170000 2.631491e-07 1.133939e-10 FALSE TRUE
ENST00000440873 ENSG00000133895 HEK293_OSMI2_2hA HEK293_TMG_2hB MEN1 protein_coding protein_coding 88.25637 117.8843 66.24831 6.219167 0.6421675 -0.8313201 25.443756 29.172347 21.973903 6.6220237 0.5734404 -0.4086484 0.29336250 0.24306667 0.3318333 0.08876667 3.554958e-01 1.133939e-10 FALSE TRUE
ENST00000450708 ENSG00000133895 HEK293_OSMI2_2hA HEK293_TMG_2hB MEN1 protein_coding protein_coding 88.25637 117.8843 66.24831 6.219167 0.6421675 -0.8313201 15.143905 27.809809 7.752188 6.3069225 1.4710747 -1.8415771 0.15852500 0.23780000 0.1174000 -0.12040000 1.903754e-01 1.133939e-10 FALSE TRUE
ENST00000478548 ENSG00000133895 HEK293_OSMI2_2hA HEK293_TMG_2hB MEN1 protein_coding retained_intron 88.25637 117.8843 66.24831 6.219167 0.6421675 -0.8313201 4.817814 3.336769 4.893112 0.4406862 0.3244674 0.5509285 0.06079583 0.02806667 0.0738000 0.04573333 1.615272e-08 1.133939e-10 TRUE TRUE
ENST00000671939 ENSG00000133895 HEK293_OSMI2_2hA HEK293_TMG_2hB MEN1 protein_coding retained_intron 88.25637 117.8843 66.24831 6.219167 0.6421675 -0.8313201 5.107926 2.805407 5.493513 0.3939560 0.4231746 0.9670096 0.06516667 0.02366667 0.0829000 0.05923333 1.133939e-10 1.133939e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133895 E001 0.5931727 0.7753202736 4.950760e-01 6.319401e-01 11 64803510 64803513 4 - 0.000 0.276 12.475
ENSG00000133895 E002 0.5931727 0.7753202736 4.950760e-01 6.319401e-01 11 64803514 64803515 2 - 0.000 0.276 12.551
ENSG00000133895 E003 7.7532372 0.0497405297 1.192459e-03 4.615451e-03 11 64803516 64803535 20 - 0.438 1.042 2.525
ENSG00000133895 E004 11.2155793 0.0186953332 7.249630e-02 1.475069e-01 11 64803536 64803541 6 - 0.877 1.132 0.941
ENSG00000133895 E005 85.5587670 0.0060582218 9.570836e-05 5.018728e-04 11 64803542 64803577 36 - 1.716 1.974 0.871
ENSG00000133895 E006 110.5022343 0.0063057225 5.216022e-06 3.695851e-05 11 64803578 64803584 7 - 1.804 2.089 0.956
ENSG00000133895 E007 164.9556352 0.0087648842 9.995572e-08 1.014862e-06 11 64803585 64803593 9 - 1.934 2.271 1.127
ENSG00000133895 E008 3129.0907426 0.0033056396 2.076108e-05 1.282945e-04 11 64803594 64804489 896 - 3.368 3.502 0.446
ENSG00000133895 E009 500.4494632 0.0020298079 2.815152e-01 4.214148e-01 11 64804490 64804541 52 - 2.621 2.684 0.212
ENSG00000133895 E010 619.8373020 0.0026092769 2.367854e-01 3.704632e-01 11 64804542 64804710 169 - 2.710 2.779 0.229
ENSG00000133895 E011 420.4014618 0.0024050461 1.103901e-01 2.061051e-01 11 64804711 64804795 85 - 2.532 2.614 0.272
ENSG00000133895 E012 273.0971901 0.0008687601 1.283689e-01 2.318755e-01 11 64804796 64804807 12 - 2.350 2.422 0.239
ENSG00000133895 E013 280.4505083 0.0010872817 2.557137e-01 3.926294e-01 11 64804808 64804816 9 - 2.369 2.432 0.207
ENSG00000133895 E014 688.5667258 0.0007344947 1.655601e-01 2.824389e-01 11 64805034 64805198 165 - 2.763 2.821 0.192
ENSG00000133895 E015 790.1096451 0.0004689526 1.037580e-01 1.962341e-01 11 64805635 64805770 136 - 2.825 2.882 0.192
ENSG00000133895 E016 32.2079526 0.0048762259 3.047588e-05 1.810349e-04 11 64805771 64805887 117 - 1.645 1.384 -0.895
ENSG00000133895 E017 36.8939233 0.0006280112 5.344304e-05 2.989437e-04 11 64805888 64806013 126 - 1.674 1.466 -0.711
ENSG00000133895 E018 20.5290591 0.0008885228 5.375362e-11 9.924434e-10 11 64806014 64806082 69 - 1.560 1.094 -1.627
ENSG00000133895 E019 36.8767176 0.0005635965 2.838278e-16 1.154613e-14 11 64806083 64806231 149 - 1.792 1.350 -1.511
ENSG00000133895 E020 792.8039881 0.0013025681 4.225838e-01 5.657156e-01 11 64806232 64806368 137 - 2.857 2.872 0.050
ENSG00000133895 E021 30.9770889 0.0009144122 4.286288e-10 6.794615e-09 11 64806369 64807010 642 - 1.682 1.316 -1.256
ENSG00000133895 E022 544.1032923 0.0008417502 3.736379e-01 5.180522e-01 11 64807011 64807098 88 - 2.695 2.707 0.041
ENSG00000133895 E023 11.4720166 0.0021804696 1.262106e-02 3.501688e-02 11 64807099 64807178 80 - 1.199 0.978 -0.799
ENSG00000133895 E024 384.8582807 0.0010455100 3.492495e-01 4.934797e-01 11 64807179 64807219 41 - 2.546 2.554 0.026
ENSG00000133895 E025 649.5291476 0.0001438893 2.893872e-03 9.953257e-03 11 64807552 64807680 129 - 2.788 2.772 -0.054
ENSG00000133895 E026 40.2951313 0.0005553215 2.338493e-18 1.230012e-16 11 64807681 64807890 210 - 1.836 1.382 -1.548
ENSG00000133895 E027 381.4537980 0.0001425614 1.027666e-03 4.054231e-03 11 64807891 64807904 14 - 2.571 2.536 -0.116
ENSG00000133895 E028 677.6719542 0.0001699365 7.204883e-08 7.520349e-07 11 64807905 64807995 91 - 2.831 2.779 -0.172
ENSG00000133895 E029 758.3121972 0.0020362613 5.426679e-03 1.708861e-02 11 64807996 64808099 104 - 2.871 2.835 -0.120
ENSG00000133895 E030 16.4572407 0.0348865835 6.365726e-01 7.505589e-01 11 64809650 64809664 15 - 1.233 1.200 -0.115
ENSG00000133895 E031 412.1990147 0.0001981519 6.399920e-10 9.846075e-09 11 64809665 64809669 5 - 2.638 2.551 -0.292
ENSG00000133895 E032 1212.3398402 0.0009275033 1.547473e-07 1.515452e-06 11 64809670 64810132 463 - 3.088 3.031 -0.188
ENSG00000133895 E033 13.3577761 0.0014239743 1.167188e-02 3.275128e-02 11 64810133 64810267 135 - 1.255 1.050 -0.735
ENSG00000133895 E034 155.3973265 0.0002566834 1.471290e-08 1.758575e-07 11 64810268 64810457 190 - 2.247 2.107 -0.467
ENSG00000133895 E035 44.4031970 0.0007480452 9.386110e-06 6.279072e-05 11 64810458 64810513 56 - 1.751 1.539 -0.721
ENSG00000133895 E036 55.7329263 0.0231233684 2.068001e-01 3.347202e-01 11 64810514 64810525 12 - 1.771 1.694 -0.261
ENSG00000133895 E037 64.8155978 0.0153940714 6.904064e-01 7.921058e-01 11 64810526 64810608 83 - 1.777 1.784 0.024
ENSG00000133895 E038 6.5120795 0.0025466823 5.129895e-01 6.478495e-01 11 64810630 64810686 57 - 0.877 0.819 -0.224
ENSG00000133895 E039 0.4815130 0.0219717886 1.000000e+00 1.000000e+00 11 64810814 64810905 92 - 0.157 0.172 0.156
ENSG00000133895 E040 0.1817044 0.0392908854 9.258218e-01   11 64810906 64811033 128 - 0.000 0.095 10.677
ENSG00000133895 E041 0.0000000       11 64811034 64811294 261 -