ENSG00000133884

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000528416 ENSG00000133884 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF2 protein_coding protein_coding 63.01802 74.48115 51.58269 4.213097 0.8630979 -0.5299023 35.87867 54.84942 23.36396 0.881227 0.3631600 -1.230837 0.5552417 0.7402000 0.4532000 -0.2870000 3.896852e-06 2.602724e-06 FALSE TRUE
ENST00000532264 ENSG00000133884 HEK293_OSMI2_2hA HEK293_TMG_2hB DPF2 protein_coding processed_transcript 63.01802 74.48115 51.58269 4.213097 0.8630979 -0.5299023 19.28483 13.83593 19.62443 3.668968 0.8116958 0.503923 0.3137833 0.1813333 0.3801667 0.1988333 1.731470e-02 2.602724e-06   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133884 E001 20.010190 0.0152434147 1.089189e-01 2.039392e-01 11 65333413 65333851 439 + 1.124 1.327 0.718
ENSG00000133884 E002 17.846322 0.0215980401 2.084315e-01 3.365901e-01 11 65333852 65333854 3 + 1.093 1.273 0.641
ENSG00000133884 E003 26.191216 0.0358717878 7.244583e-01 8.179614e-01 11 65333855 65333861 7 + 1.333 1.413 0.278
ENSG00000133884 E004 31.809464 0.0292451826 6.721814e-01 7.782408e-01 11 65333862 65333866 5 + 1.480 1.470 -0.034
ENSG00000133884 E005 37.915363 0.0138315872 1.932103e-01 3.178099e-01 11 65333867 65333872 6 + 1.594 1.523 -0.243
ENSG00000133884 E006 38.547246 0.0126386693 1.992575e-01 3.253052e-01 11 65333873 65333874 2 + 1.599 1.531 -0.231
ENSG00000133884 E007 55.724010 0.0053535754 4.627881e-02 1.025473e-01 11 65333875 65333876 2 + 1.770 1.683 -0.293
ENSG00000133884 E008 244.768672 0.0007086962 4.269577e-01 5.697952e-01 11 65333877 65333918 42 + 2.308 2.365 0.189
ENSG00000133884 E009 444.456359 0.0005582845 4.013235e-01 5.450172e-01 11 65340385 65340545 161 + 2.596 2.613 0.058
ENSG00000133884 E010 454.117281 0.0024904527 4.014501e-03 1.318245e-02 11 65340966 65341073 108 + 2.651 2.603 -0.162
ENSG00000133884 E011 489.449766 0.0018547344 3.003243e-05 1.787088e-04 11 65341399 65341486 88 + 2.701 2.627 -0.245
ENSG00000133884 E012 479.210585 0.0009484900 4.662756e-05 2.646727e-04 11 65341487 65341562 76 + 2.679 2.624 -0.181
ENSG00000133884 E013 3.656909 0.0213217094 1.279723e-03 4.909357e-03 11 65341563 65342002 440 + 0.894 0.421 -2.061
ENSG00000133884 E014 7.527552 0.0271908447 3.337267e-03 1.125474e-02 11 65343505 65343744 240 + 1.124 0.766 -1.347
ENSG00000133884 E015 261.875902 0.0001967583 1.454146e-02 3.945852e-02 11 65343745 65343754 10 + 2.396 2.373 -0.078
ENSG00000133884 E016 447.339855 0.0001392651 2.825088e-02 6.850517e-02 11 65343755 65343837 83 + 2.615 2.610 -0.017
ENSG00000133884 E017 394.419553 0.0001558183 1.697389e-01 2.878629e-01 11 65343991 65344069 79 + 2.550 2.558 0.026
ENSG00000133884 E018 5.489646 0.0029626910 2.170837e-01 3.468751e-01 11 65344070 65344095 26 + 0.868 0.734 -0.530
ENSG00000133884 E019 8.065430 0.0023182573 3.215547e-07 2.956446e-06 11 65344260 65344579 320 + 1.217 0.674 -2.057
ENSG00000133884 E020 10.712583 0.0035144607 4.631469e-03 1.490661e-02 11 65344580 65344621 42 + 1.205 0.949 -0.930
ENSG00000133884 E021 22.090083 0.0009823374 2.721601e-05 1.635473e-04 11 65344622 65345665 1044 + 1.505 1.231 -0.951
ENSG00000133884 E022 444.921737 0.0001649502 3.494383e-02 8.154723e-02 11 65345666 65345740 75 + 2.611 2.607 -0.014
ENSG00000133884 E023 451.087957 0.0001309022 5.292684e-02 1.143467e-01 11 65345741 65345803 63 + 2.615 2.615 -0.001
ENSG00000133884 E024 9.010942 0.0018840855 1.286130e-09 1.868508e-08 11 65345804 65345929 126 + 1.294 0.674 -2.328
ENSG00000133884 E025 610.548936 0.0001092130 2.802156e-02 6.805549e-02 11 65345930 65346058 129 + 2.746 2.747 0.003
ENSG00000133884 E026 8.583620 0.0946912120 2.624250e-01 4.002095e-01 11 65346059 65346246 188 + 1.043 0.887 -0.583
ENSG00000133884 E027 589.591741 0.0001440817 8.051576e-01 8.760421e-01 11 65346247 65346359 113 + 2.704 2.743 0.130
ENSG00000133884 E028 85.719539 0.0038656506 2.126110e-19 1.272221e-17 11 65346360 65348849 2490 + 2.135 1.734 -1.345
ENSG00000133884 E029 517.409104 0.0001166567 9.391145e-01 9.657654e-01 11 65348850 65348931 82 + 2.649 2.685 0.121
ENSG00000133884 E030 2869.204142 0.0025569336 1.674652e-10 2.845872e-09 11 65351683 65354262 2580 + 3.302 3.460 0.523