ENSG00000133872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256255 ENSG00000133872 HEK293_OSMI2_2hA HEK293_TMG_2hB SARAF protein_coding protein_coding 59.03573 35.71356 88.35232 4.870132 1.259513 1.306555 38.758761 21.475214 60.744819 2.7361758 0.5727951 1.4996547 0.6312833 0.60266667 0.6878667 0.08520000 0.01259921 3.931815e-07 FALSE TRUE
ENST00000518174 ENSG00000133872 HEK293_OSMI2_2hA HEK293_TMG_2hB SARAF protein_coding nonsense_mediated_decay 59.03573 35.71356 88.35232 4.870132 1.259513 1.306555 4.751623 1.284478 6.553053 0.7151744 1.1451207 2.3419970 0.0905250 0.04216667 0.0740000 0.03183333 0.70161660 3.931815e-07 FALSE TRUE
ENST00000520303 ENSG00000133872 HEK293_OSMI2_2hA HEK293_TMG_2hB SARAF protein_coding nonsense_mediated_decay 59.03573 35.71356 88.35232 4.870132 1.259513 1.306555 12.056182 12.156396 16.108000 2.8394881 2.1166182 0.4057708 0.2231167 0.33200000 0.1821000 -0.14990000 0.01552032 3.931815e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133872 E001 0.0000000       8 30063003 30063011 9 -      
ENSG00000133872 E002 1.8038586 0.0127370768 6.862130e-01 7.887645e-01 8 30063012 30063097 86 - 0.396 0.476 0.419
ENSG00000133872 E003 29.0621009 0.0012684408 3.384681e-06 2.505148e-05 8 30063098 30063125 28 - 1.327 1.646 1.096
ENSG00000133872 E004 29.2835461 0.0011746885 2.049028e-06 1.590259e-05 8 30063126 30063129 4 - 1.327 1.651 1.113
ENSG00000133872 E005 1169.5217811 0.0023721853 3.471972e-10 5.589824e-09 8 30063130 30063794 665 - 2.989 3.140 0.502
ENSG00000133872 E006 396.1916314 0.0001424031 2.947928e-02 7.092840e-02 8 30063795 30063852 58 - 2.559 2.615 0.185
ENSG00000133872 E007 487.5123529 0.0001403998 1.579427e-01 2.723924e-01 8 30063853 30063897 45 - 2.657 2.696 0.130
ENSG00000133872 E008 376.2385803 0.0001526129 3.755111e-01 5.199378e-01 8 30063898 30063913 16 - 2.546 2.578 0.107
ENSG00000133872 E009 6.2579892 0.0028442036 6.117081e-02 1.285939e-01 8 30065712 30065873 162 - 0.904 0.652 -1.012
ENSG00000133872 E010 6.5376249 0.0029515725 4.113916e-02 9.314352e-02 8 30065874 30065987 114 - 0.927 0.652 -1.096
ENSG00000133872 E011 495.3596096 0.0001263374 7.277281e-01 8.203342e-01 8 30065988 30066027 40 - 2.669 2.689 0.068
ENSG00000133872 E012 481.7120584 0.0001249597 5.729294e-01 6.989564e-01 8 30066028 30066067 40 - 2.663 2.667 0.016
ENSG00000133872 E013 560.2749628 0.0003145970 6.714065e-01 7.776334e-01 8 30066068 30066139 72 - 2.722 2.743 0.069
ENSG00000133872 E014 744.7354503 0.0002052100 1.182297e-01 2.173912e-01 8 30066777 30066903 127 - 2.857 2.848 -0.028
ENSG00000133872 E015 362.3259258 0.0004086514 3.024681e-01 4.443333e-01 8 30066904 30066918 15 - 2.545 2.538 -0.023
ENSG00000133872 E016 2.4292846 0.0097217809 2.038257e-01 3.309890e-01 8 30066919 30067053 135 - 0.432 0.652 1.032
ENSG00000133872 E017 645.3945237 0.0001525467 4.547114e-01 5.953157e-01 8 30069642 30069792 151 - 2.791 2.794 0.011
ENSG00000133872 E018 355.4570691 0.0001432376 2.888651e-01 4.295058e-01 8 30069793 30069873 81 - 2.521 2.557 0.120
ENSG00000133872 E019 486.2593705 0.0001217851 5.752719e-03 1.796215e-02 8 30069874 30070059 186 - 2.680 2.647 -0.111
ENSG00000133872 E020 1.7672278 0.0089635740 2.687522e-01 4.072363e-01 8 30073694 30073876 183 - 0.495 0.300 -1.098
ENSG00000133872 E021 212.9019216 0.0003544061 1.360604e-10 2.349681e-09 8 30073877 30073878 2 - 2.360 2.193 -0.557
ENSG00000133872 E022 345.9550295 0.0015310346 1.592874e-06 1.265900e-05 8 30073879 30073988 110 - 2.558 2.431 -0.422
ENSG00000133872 E023 214.1435263 0.0012949387 7.614334e-04 3.120363e-03 8 30073989 30074028 40 - 2.341 2.245 -0.321
ENSG00000133872 E024 162.2292271 0.0007507808 4.775382e-05 2.703852e-04 8 30074029 30074051 23 - 2.229 2.106 -0.409
ENSG00000133872 E025 122.7232279 0.0005390691 9.388945e-04 3.750332e-03 8 30074052 30074055 4 - 2.105 1.998 -0.358
ENSG00000133872 E026 0.4375944 0.0284763566 3.160630e-01 4.588254e-01 8 30078212 30078256 45 - 0.214 0.000 -9.403
ENSG00000133872 E027 1.6982363 0.0084412587 1.501577e-03 5.640761e-03 8 30082229 30082424 196 - 0.154 0.697 3.224
ENSG00000133872 E028 155.2867658 0.0011454369 1.077682e-04 5.578396e-04 8 30082847 30082861 15 - 2.211 2.086 -0.420
ENSG00000133872 E029 218.9696937 0.0054612724 5.678795e-03 1.776412e-02 8 30082862 30083208 347 - 2.358 2.235 -0.410