ENSG00000133739

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360375 ENSG00000133739 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRCC1 protein_coding protein_coding 2.260118 0.5455 4.059111 0.09675924 0.06463147 2.872855 0.7403638 0.3507372 1.6123349 0.1402941 0.26268501 2.169052 0.39130417 0.7166 0.3954000 -0.3212000 0.35371172 0.03800799 FALSE TRUE
ENST00000517875 ENSG00000133739 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRCC1 protein_coding nonsense_mediated_decay 2.260118 0.5455 4.059111 0.09675924 0.06463147 2.872855 0.5033298 0.0000000 0.4778264 0.0000000 0.25883043 5.608296 0.12907917 0.0000 0.1160667 0.1160667 0.56841670 0.03800799 FALSE TRUE
ENST00000522567 ENSG00000133739 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRCC1 protein_coding nonsense_mediated_decay 2.260118 0.5455 4.059111 0.09675924 0.06463147 2.872855 0.1942094 0.0000000 0.4226459 0.0000000 0.06601119 5.435115 0.05973333 0.0000 0.1043333 0.1043333 0.03800799 0.03800799 FALSE TRUE
MSTRG.31754.1 ENSG00000133739 HEK293_OSMI2_2hA HEK293_TMG_2hB LRRCC1 protein_coding   2.260118 0.5455 4.059111 0.09675924 0.06463147 2.872855 0.7363993 0.1947629 1.4985979 0.1947629 0.43842013 2.881182 0.38280417 0.2834 0.3725000 0.0891000 0.60246140 0.03800799 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133739 E001 0.1515154 0.0425624974 0.9198107566   8 85107139 85107214 76 + 0.054 0.001 -6.156
ENSG00000133739 E002 1.4928892 0.0143315704 0.5108397277 0.64599431 8 85107215 85107237 23 + 0.283 0.418 0.813
ENSG00000133739 E003 7.4770982 0.0022873472 0.0775961833 0.15560069 8 85107238 85107399 162 + 0.848 0.534 -1.320
ENSG00000133739 E004 0.0000000       8 85107400 85107718 319 +      
ENSG00000133739 E005 0.0000000       8 85108662 85109594 933 +      
ENSG00000133739 E006 5.2948892 0.0031283704 0.6523960002 0.76310780 8 85109595 85109800 206 + 0.705 0.626 -0.337
ENSG00000133739 E007 8.8527290 0.0019652296 0.0788833586 0.15772759 8 85110115 85110180 66 + 0.915 0.626 -1.164
ENSG00000133739 E008 17.1791266 0.0079468032 0.6583918346 0.76755369 8 85112932 85113099 168 + 1.142 1.090 -0.187
ENSG00000133739 E009 21.7580508 0.0009501134 0.4293062547 0.57205102 8 85115100 85115275 176 + 1.217 1.291 0.259
ENSG00000133739 E010 18.6555289 0.0033688895 0.4105231228 0.55411584 8 85115375 85115584 210 + 1.182 1.090 -0.329
ENSG00000133739 E011 17.0744769 0.0013674874 0.0211783131 0.05397297 8 85123413 85123606 194 + 1.166 0.872 -1.082
ENSG00000133739 E012 17.6539356 0.0011719960 0.0132683548 0.03654358 8 85124792 85124939 148 + 1.185 0.872 -1.150
ENSG00000133739 E013 18.0992360 0.0065176632 0.8954264546 0.93720949 8 85126689 85126837 149 + 1.158 1.144 -0.052
ENSG00000133739 E014 18.8169224 0.0014338883 0.5273902173 0.66046362 8 85129175 85129379 205 + 1.185 1.117 -0.243
ENSG00000133739 E015 16.2794692 0.0195864549 0.5998465513 0.72117487 8 85129919 85130058 140 + 1.107 1.167 0.214
ENSG00000133739 E016 24.7926353 0.0009619591 0.3644921755 0.50884790 8 85131760 85131961 202 + 1.299 1.213 -0.304
ENSG00000133739 E017 22.8217163 0.0010024096 0.4801012595 0.61841125 8 85134847 85135032 186 + 1.260 1.191 -0.245
ENSG00000133739 E018 23.0399487 0.0008377749 0.3297474732 0.47328844 8 85135789 85135963 175 + 1.238 1.326 0.308
ENSG00000133739 E019 23.1952875 0.0010010554 0.0329571705 0.07771808 8 85137464 85137627 164 + 1.218 1.401 0.643
ENSG00000133739 E020 28.1352618 0.0007052389 0.3308065350 0.47437614 8 85138035 85138243 209 + 1.321 1.401 0.277
ENSG00000133739 E021 25.6157741 0.0008301528 0.7249043859 0.81829611 8 85138338 85138475 138 + 1.305 1.273 -0.112
ENSG00000133739 E022 20.5674990 0.0009932082 0.4425039070 0.58411922 8 85141382 85141517 136 + 1.200 1.273 0.257
ENSG00000133739 E023 20.9152981 0.0010715620 0.0009855013 0.00390938 8 85145389 85146080 692 + 1.158 1.441 0.989