ENSG00000133731

1 Isoform Switch

Summary Plot
Results

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Rows: 1-7 / 7
Columns:
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isoform_id
gene_id
condition_1
condition_2
gene_name
gene_biotype
iso_biotype
gene_overall_mean
gene_value_1
gene_value_2
gene_stderr_1
gene_stderr_2
gene_log2_fold_change
iso_overall_mean
iso_value_1
iso_value_2
iso_stderr_1
iso_stderr_2
iso_log2_fold_change
IF_overall
IF1
IF2
dIF
isoform_switch_q_value
gene_switch_q_value
PTC
codingPotential
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isoform_id	gene_id	condition_1	condition_2	gene_name	gene_biotype	iso_biotype	gene_overall_mean	gene_value_1	gene_value_2	gene_stderr_1	gene_stderr_2	gene_log2_fold_change	iso_overall_mean	iso_value_1	iso_value_2	iso_stderr_1	iso_stderr_2	iso_log2_fold_change	IF_overall	IF1	IF2	dIF	isoform_switch_q_value	gene_switch_q_value	PTC	codingPotential

ENST00000256108	ENSG00000133731	HEK293_OSMI2_2hA	HEK293_TMG_2hB	IMPA1	protein_coding	protein_coding	16.63507	4.369849	26.12914	0.5329286	1.266699	2.577258	4.9174081	2.77180704	7.0094120	0.55078315	0.1727738	1.3353278	0.38700417	0.62343333	0.26910000	-0.35433333	5.945866e-08	1.067866e-09	FALSE	TRUE
ENST00000311489	ENSG00000133731	HEK293_OSMI2_2hA	HEK293_TMG_2hB	IMPA1	protein_coding	protein_coding	16.63507	4.369849	26.12914	0.5329286	1.266699	2.577258	3.2922811	0.36550556	4.9032548	0.18748818	0.9978205	3.7097729	0.15018750	0.08803333	0.18650000	0.09846667	4.849290e-01	1.067866e-09	FALSE	TRUE
ENST00000449740	ENSG00000133731	HEK293_OSMI2_2hA	HEK293_TMG_2hB	IMPA1	protein_coding	protein_coding	16.63507	4.369849	26.12914	0.5329286	1.266699	2.577258	0.7971530	0.09481470	2.1390606	0.06961893	0.3743976	4.3577932	0.04080000	0.02163333	0.08140000	0.05976667	1.228214e-01	1.067866e-09	FALSE	TRUE
ENST00000518202	ENSG00000133731	HEK293_OSMI2_2hA	HEK293_TMG_2hB	IMPA1	protein_coding	protein_coding	16.63507	4.369849	26.12914	0.5329286	1.266699	2.577258	0.6981629	0.60590308	0.7930965	0.14747300	0.3849038	0.3828699	0.08182083	0.14270000	0.03006667	-0.11263333	5.069958e-02	1.067866e-09	FALSE	FALSE
ENST00000519816	ENSG00000133731	HEK293_OSMI2_2hA	HEK293_TMG_2hB	IMPA1	protein_coding	nonsense_mediated_decay	16.63507	4.369849	26.12914	0.5329286	1.266699	2.577258	1.0150113	0.26803062	2.0372686	0.15705610	0.1863337	2.8803847	0.06049167	0.05926667	0.07773333	0.01846667	7.209100e-01	1.067866e-09	TRUE	TRUE
ENST00000520065	ENSG00000133731	HEK293_OSMI2_2hA	HEK293_TMG_2hB	IMPA1	protein_coding	retained_intron	16.63507	4.369849	26.12914	0.5329286	1.266699	2.577258	1.1413184	0.08637058	1.4368403	0.04943274	0.4146784	3.9081692	0.08797083	0.02310000	0.05403333	0.03093333	3.144856e-01	1.067866e-09		FALSE
MSTRG.31737.3	ENSG00000133731	HEK293_OSMI2_2hA	HEK293_TMG_2hB	IMPA1	protein_coding		16.63507	4.369849	26.12914	0.5329286	1.266699	2.577258	3.3222861	0.00000000	5.7616025	0.00000000	1.0701705	9.1728281	0.12463750	0.00000000	0.22376667	0.22376667	1.067866e-09	1.067866e-09	FALSE	TRUE

Note:
- The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

All exons whithin this gene region are shown and numbering below.

All isoforms whithin this gene region are shown below.

Rows: 1-10 / 27
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groupID
featureID
exonBaseMean
dispersion
pvalue
padj
seqnames
start
end
width
strand
HEK293_TMG_2hB
HEK293_OSMI2_2hA
log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
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groupID	featureID	exonBaseMean	dispersion	pvalue	padj	seqnames	start	end	width	strand	HEK293_TMG_2hB	HEK293_OSMI2_2hA	log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB

ENSG00000133731	E001	261.589897	0.0141913959	9.386836e-11	1.663992e-09	8	81656914	81659043	2130	-	2.199	2.620	1.402
ENSG00000133731	E002	60.757249	0.0004442620	9.912629e-01	9.986442e-01	8	81659044	81659148	105	-	1.678	1.755	0.262
ENSG00000133731	E003	73.076140	0.0063957693	7.616360e-01	8.454554e-01	8	81659149	81659261	113	-	1.751	1.851	0.337
ENSG00000133731	E004	115.392722	0.0010384622	3.499382e-01	4.941311e-01	8	81659262	81659466	205	-	1.957	1.995	0.126
ENSG00000133731	E005	0.000000				8	81660514	81660515	2	-
ENSG00000133731	E006	71.977203	0.0011454117	3.036019e-02	7.267320e-02	8	81660516	81660572	57	-	1.769	1.726	-0.143
ENSG00000133731	E007	93.960152	0.0005916611	2.763790e-03	9.564192e-03	8	81660573	81660667	95	-	1.887	1.823	-0.216
ENSG00000133731	E008	38.716864	0.0011534562	2.611485e-02	6.417683e-02	8	81670939	81670939	1	-	1.516	1.427	-0.304
ENSG00000133731	E009	48.025621	0.0013522707	4.543637e-03	1.466428e-02	8	81670940	81670977	38	-	1.611	1.494	-0.402
ENSG00000133731	E010	46.285575	0.0014922835	4.551805e-03	1.468664e-02	8	81670978	81671007	30	-	1.596	1.473	-0.420
ENSG00000133731	E011	46.651936	0.0005224055	6.908330e-06	4.764160e-05	8	81671008	81671047	40	-	1.614	1.363	-0.862
ENSG00000133731	E012	46.072085	0.0006039707	5.331135e-04	2.283694e-03	8	81673841	81673867	27	-	1.596	1.428	-0.576
ENSG00000133731	E013	51.207867	0.0010138583	3.183590e-03	1.080747e-02	8	81673868	81673895	28	-	1.634	1.514	-0.408
ENSG00000133731	E014	55.245775	0.0036503254	6.495399e-03	1.991091e-02	8	81673896	81673949	54	-	1.666	1.552	-0.389
ENSG00000133731	E015	10.294829	0.0851922878	1.433052e-01	2.525127e-01	8	81673950	81674421	472	-	0.992	0.740	-0.969
ENSG00000133731	E016	10.371538	0.0018635632	3.893333e-01	5.334387e-01	8	81674672	81674831	160	-	0.964	0.922	-0.155
ENSG00000133731	E017	42.164050	0.0005385823	4.282992e-02	9.623285e-02	8	81676234	81676265	32	-	1.547	1.483	-0.218
ENSG00000133731	E018	33.676244	0.0006351675	1.516182e-01	2.638561e-01	8	81676266	81676279	14	-	1.448	1.415	-0.113
ENSG00000133731	E019	5.276720	0.0032385691	3.841611e-06	2.805989e-05	8	81678583	81678689	107	-	0.479	1.154	2.717
ENSG00000133731	E020	78.790800	0.0003884008	2.255156e-01	3.570179e-01	8	81679126	81679230	105	-	1.795	1.813	0.060
ENSG00000133731	E021	86.167713	0.0023881973	1.813607e-01	3.029533e-01	8	81680650	81680779	130	-	1.836	1.842	0.020
ENSG00000133731	E022	31.281601	0.0006924752	7.662969e-01	8.488407e-01	8	81680780	81680783	4	-	1.386	1.484	0.337
ENSG00000133731	E023	57.312926	0.0004587820	2.820558e-01	4.220144e-01	8	81681498	81681563	66	-	1.660	1.676	0.051
ENSG00000133731	E024	40.531606	0.0006411061	2.559644e-01	3.929220e-01	8	81681564	81681584	21	-	1.516	1.514	-0.007
ENSG00000133731	E025	8.899743	0.0022331010	2.489645e-02	6.166048e-02	8	81685763	81685963	201	-	0.943	0.670	-1.078
ENSG00000133731	E026	2.432623	0.0058525582	9.821470e-01	9.928857e-01	8	81685964	81686051	88	-	0.458	0.506	0.239
ENSG00000133731	E027	39.594312	0.0005916155	4.224840e-01	5.656219e-01	8	81686252	81686339	88	-	1.502	1.524	0.073

Isoforom Switch Analysis

WANG Ziyi

Date: 19 5月 2022

ENSG00000133731

1 Isoform Switch

TableFilter v0.7.3

2 Differential Exon Usage

TableFilter v0.7.3