ENSG00000133710

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256084 ENSG00000133710 HEK293_OSMI2_2hA HEK293_TMG_2hB SPINK5 protein_coding protein_coding 0.1693043 0.1062408 0.1769224 0.02416378 0.08438588 0.6853232 0.059262994 0.09526868 0.01042533 0.02773231 0.01042533 -2.365645 0.45833333 0.8906333 0.1245333 -0.7661000 0.008518646 0.008518646 FALSE TRUE
ENST00000359874 ENSG00000133710 HEK293_OSMI2_2hA HEK293_TMG_2hB SPINK5 protein_coding protein_coding 0.1693043 0.1062408 0.1769224 0.02416378 0.08438588 0.6853232 0.043574358 0.00000000 0.00000000 0.00000000 0.00000000 0.000000 0.24523750 0.0000000 0.0000000 0.0000000   0.008518646 FALSE TRUE
ENST00000398454 ENSG00000133710 HEK293_OSMI2_2hA HEK293_TMG_2hB SPINK5 protein_coding protein_coding 0.1693043 0.1062408 0.1769224 0.02416378 0.08438588 0.6853232 0.013973734 0.01097212 0.00000000 0.01097212 0.00000000 -1.068473 0.07995833 0.1093667 0.0000000 -0.1093667 0.711526302 0.008518646 FALSE TRUE
ENST00000507988 ENSG00000133710 HEK293_OSMI2_2hA HEK293_TMG_2hB SPINK5 protein_coding retained_intron 0.1693043 0.1062408 0.1769224 0.02416378 0.08438588 0.6853232 0.007466876 0.00000000 0.05137214 0.00000000 0.02935804 2.617584 0.06873750 0.0000000 0.5421333 0.5421333 0.574612446 0.008518646 FALSE TRUE
ENST00000508733 ENSG00000133710 HEK293_OSMI2_2hA HEK293_TMG_2hB SPINK5 protein_coding protein_coding 0.1693043 0.1062408 0.1769224 0.02416378 0.08438588 0.6853232 0.015433225 0.00000000 0.03663491 0.00000000 0.03663491 2.221410 0.10095417 0.0000000 0.1060667 0.1060667 0.731148711 0.008518646 FALSE TRUE
ENST00000521206 ENSG00000133710 HEK293_OSMI2_2hA HEK293_TMG_2hB SPINK5 protein_coding protein_coding 0.1693043 0.1062408 0.1769224 0.02416378 0.08438588 0.6853232 0.029593142 0.00000000 0.07849006 0.00000000 0.07849006 3.145515 0.04677917 0.0000000 0.2272667 0.2272667 0.799620420 0.008518646   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133710 E001 0.0000000       5 148025683 148025786 104 +      
ENSG00000133710 E002 0.4502799 0.026330189 0.05914002 0.12515805 5 148063863 148063971 109 + 0.332 0.000 -12.154
ENSG00000133710 E003 0.4502799 0.026330189 0.05914002 0.12515805 5 148063972 148063979 8 + 0.332 0.000 -14.912
ENSG00000133710 E004 0.4502799 0.026330189 0.05914002 0.12515805 5 148063980 148063983 4 + 0.332 0.000 -14.912
ENSG00000133710 E005 0.6717251 0.020135420 0.23093643 0.36359735 5 148063984 148064099 116 + 0.332 0.106 -2.048
ENSG00000133710 E006 0.3729606 0.027138281 0.89358152 0.93593965 5 148065347 148065372 26 + 0.141 0.106 -0.462
ENSG00000133710 E007 0.0000000       5 148065373 148065475 103 +      
ENSG00000133710 E008 0.0000000       5 148070323 148070379 57 +      
ENSG00000133710 E009 0.2214452 0.037093220 0.56657356   5 148070380 148070450 71 + 0.000 0.106 11.753
ENSG00000133710 E010 0.2214452 0.037093220 0.56657356   5 148072148 148072220 73 + 0.000 0.106 11.753
ENSG00000133710 E011 0.1451727 0.048477778 0.41496586   5 148086405 148086532 128 + 0.141 0.000 -13.589
ENSG00000133710 E012 0.1451727 0.048477778 0.41496586   5 148088542 148088605 64 + 0.141 0.000 -13.589
ENSG00000133710 E013 0.0000000       5 148089019 148089093 75 +      
ENSG00000133710 E014 0.0000000       5 148089217 148089272 56 +      
ENSG00000133710 E015 0.2944980 0.389714982 0.24077814   5 148089494 148089621 128 + 0.246 0.000 -14.362
ENSG00000133710 E016 0.0000000       5 148090653 148090700 48 +      
ENSG00000133710 E017 0.0000000       5 148090928 148091045 118 +      
ENSG00000133710 E018 0.8126314 0.015990308 0.11148648 0.20773447 5 148091165 148091228 64 + 0.403 0.106 -2.463
ENSG00000133710 E019 0.9609246 0.013947219 0.29209061 0.43303745 5 148094354 148094481 128 + 0.403 0.191 -1.464
ENSG00000133710 E020 0.5943067 0.022670871 0.23361685 0.36669604 5 148095818 148095905 88 + 0.332 0.106 -2.052
ENSG00000133710 E021 0.4439371 0.022537296 0.05820629 0.12355743 5 148097867 148097994 128 + 0.332 0.000 -14.912
ENSG00000133710 E022 0.0000000       5 148097995 148098003 9 +      
ENSG00000133710 E023 0.4439371 0.022537296 0.05820629 0.12355743 5 148099234 148099315 82 + 0.332 0.000 -14.912
ENSG00000133710 E024 0.1451727 0.048477778 0.41496586   5 148100454 148100581 128 + 0.141 0.000 -13.589
ENSG00000133710 E025 0.3697384 0.028066859 0.24946114 0.38527738 5 148101355 148101436 82 + 0.000 0.192 12.649
ENSG00000133710 E026 0.8449086 0.016968179 0.23149178 0.36424771 5 148101781 148101908 128 + 0.141 0.324 1.535
ENSG00000133710 E027 0.6966155 0.018009155 0.39852457 0.54227083 5 148104952 148105000 49 + 0.141 0.263 1.121
ENSG00000133710 E028 0.8115992 0.018077468 0.51252670 0.64744046 5 148107037 148107164 128 + 0.332 0.191 -1.049
ENSG00000133710 E029 1.2534455 0.014489993 0.52454954 0.65803914 5 148108753 148108837 85 + 0.403 0.263 -0.875
ENSG00000133710 E030 1.1082728 0.015308047 0.81382497 0.88199250 5 148111768 148111895 128 + 0.332 0.263 -0.460
ENSG00000133710 E031 0.8115846 0.022380982 0.40791877 0.55150822 5 148112868 148112934 67 + 0.141 0.264 1.127
ENSG00000133710 E032 0.8825612 0.018999749 0.50770708 0.64315765 5 148114362 148114489 128 + 0.332 0.192 -1.045
ENSG00000133710 E033 1.7672237 0.008817329 0.72401294 0.81766258 5 148116370 148116466 97 + 0.403 0.426 0.123
ENSG00000133710 E034 2.2530031 0.007243862 0.59703773 0.71886978 5 148118437 148118564 128 + 0.464 0.508 0.215
ENSG00000133710 E035 2.1380194 0.008562469 0.13217355 0.23713240 5 148118986 148119058 73 + 0.332 0.544 1.122
ENSG00000133710 E036 0.8147328 0.023415185 0.79473340 0.86887690 5 148120009 148120136 128 + 0.247 0.263 0.119
ENSG00000133710 E037 0.7331471 0.017712971 0.05219572 0.11306496 5 148120295 148120391 97 + 0.000 0.324 13.597
ENSG00000133710 E038 0.9578146 0.015903082 0.23261542 0.36556029 5 148123833 148123960 128 + 0.141 0.325 1.539
ENSG00000133710 E039 0.1817044 0.043621305 0.56353354   5 148124765 148124837 73 + 0.000 0.106 11.749
ENSG00000133710 E040 0.1817044 0.043621305 0.56353354   5 148124838 148124940 103 + 0.000 0.106 11.749
ENSG00000133710 E041 0.0000000       5 148125524 148125613 90 +      
ENSG00000133710 E042 0.5483223 0.022369889 0.67593434 0.78104404 5 148125723 148125850 128 + 0.141 0.192 0.538
ENSG00000133710 E043 0.6966155 0.018009155 0.39852457 0.54227083 5 148126983 148127079 97 + 0.141 0.263 1.121
ENSG00000133710 E044 0.9932018 0.044447925 0.14012314 0.24818538 5 148131259 148131389 131 + 0.141 0.377 1.852
ENSG00000133710 E045 0.8480291 0.048670905 0.02780757 0.06763549 5 148133797 148133887 91 + 0.000 0.376 13.896
ENSG00000133710 E046 0.6632043 0.022264936 0.39986391 0.54358711 5 148136983 148137382 400 + 0.141 0.263 1.119