ENSG00000133704

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256079 ENSG00000133704 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO8 protein_coding protein_coding 18.11197 6.83799 31.07418 0.6345167 0.8961123 2.182428 14.870355 6.2395898 24.479173 0.6448965 0.2896471 1.970311 0.8405833 0.91213333 0.7885333 -0.12360000 0.03191134 0.03191134 FALSE TRUE
ENST00000535598 ENSG00000133704 HEK293_OSMI2_2hA HEK293_TMG_2hB IPO8 protein_coding protein_coding 18.11197 6.83799 31.07418 0.6345167 0.8961123 2.182428 2.394221 0.5983998 4.519358 0.2055186 0.5063904 2.896215 0.1293542 0.08786667 0.1460000 0.05813333 0.34802662 0.03191134 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133704 E001 662.1725560 0.0113423093 8.534654e-22 6.634651e-20 12 30628988 30630471 1484 - 2.553 3.084 1.767
ENSG00000133704 E002 63.9328009 0.0003690129 3.143840e-15 1.114922e-13 12 30630472 30630511 40 - 1.575 2.039 1.570
ENSG00000133704 E003 95.7708657 0.0003210363 7.517453e-10 1.141427e-08 12 30630512 30630592 81 - 1.792 2.133 1.144
ENSG00000133704 E004 70.5587894 0.0037405071 3.889734e-03 1.283527e-02 12 30630593 30630614 22 - 1.690 1.941 0.849
ENSG00000133704 E005 93.6884970 0.0003328279 1.089816e-03 4.269370e-03 12 30630615 30630664 50 - 1.817 2.048 0.776
ENSG00000133704 E006 203.3201943 0.0001744570 3.273894e-03 1.107355e-02 12 30630665 30630955 291 - 2.164 2.343 0.599
ENSG00000133704 E007 73.1183604 0.0003284325 5.422439e-01 6.730293e-01 12 30630956 30630957 2 - 1.738 1.861 0.415
ENSG00000133704 E008 30.7858954 0.0006378407 6.154039e-01 7.336863e-01 12 30631626 30631894 269 - 1.386 1.437 0.177
ENSG00000133704 E009 142.2490709 0.0002936156 2.074858e-01 3.354836e-01 12 30631895 30632011 117 - 2.018 2.157 0.463
ENSG00000133704 E010 215.0278366 0.0001810274 5.310827e-01 6.635802e-01 12 30634083 30634286 204 - 2.211 2.286 0.249
ENSG00000133704 E011 209.1843738 0.0004100657 2.070009e-02 5.295627e-02 12 30636982 30637187 206 - 2.209 2.228 0.064
ENSG00000133704 E012 187.6304673 0.0002322696 2.642806e-03 9.199128e-03 12 30639515 30639735 221 - 2.168 2.161 -0.023
ENSG00000133704 E013 111.1459352 0.0008155858 2.391222e-02 5.962538e-02 12 30649137 30649232 96 - 1.943 1.935 -0.027
ENSG00000133704 E014 91.8288771 0.0003697664 2.425437e-06 1.852416e-05 12 30652192 30652289 98 - 1.884 1.736 -0.497
ENSG00000133704 E015 101.1166591 0.0003037886 4.244699e-06 3.068672e-05 12 30652967 30653092 126 - 1.921 1.793 -0.432
ENSG00000133704 E016 79.0283506 0.0003349359 1.388666e-03 5.269476e-03 12 30656684 30656750 67 - 1.807 1.730 -0.259
ENSG00000133704 E017 106.0406142 0.0002845460 1.616622e-03 6.013790e-03 12 30661141 30661266 126 - 1.928 1.879 -0.167
ENSG00000133704 E018 81.3698185 0.0003176350 1.111810e-01 2.072855e-01 12 30662327 30662389 63 - 1.805 1.818 0.045
ENSG00000133704 E019 103.1934905 0.0007528881 4.655583e-03 1.497354e-02 12 30662390 30662487 98 - 1.915 1.874 -0.137
ENSG00000133704 E020 127.0887636 0.0006323352 3.683457e-04 1.651840e-03 12 30663489 30663654 166 - 2.009 1.950 -0.199
ENSG00000133704 E021 92.8938545 0.0003040009 2.073496e-04 9.954072e-04 12 30665220 30665306 87 - 1.881 1.792 -0.299
ENSG00000133704 E022 49.6665483 0.0011011786 2.002661e-01 3.265544e-01 12 30665307 30665309 3 - 1.595 1.604 0.030
ENSG00000133704 E023 107.5722736 0.0002483765 1.421198e-02 3.870750e-02 12 30665729 30665845 117 - 1.930 1.916 -0.049
ENSG00000133704 E024 74.7168762 0.0003248717 2.199883e-03 7.841669e-03 12 30666175 30666251 77 - 1.784 1.712 -0.246
ENSG00000133704 E025 63.5178776 0.0003620796 4.906025e-02 1.074860e-01 12 30669183 30669267 85 - 1.705 1.685 -0.068
ENSG00000133704 E026 35.3942400 0.0005864842 1.824085e-01 3.042448e-01 12 30669268 30669282 15 - 1.458 1.449 -0.030
ENSG00000133704 E027 74.2451412 0.0014842288 4.171101e-02 9.420856e-02 12 30670962 30671096 135 - 1.774 1.753 -0.070
ENSG00000133704 E028 77.8080162 0.0003169507 5.068393e-04 2.185935e-03 12 30673990 30674074 85 - 1.805 1.712 -0.316
ENSG00000133704 E029 104.9239803 0.0002764744 5.120521e-11 9.498359e-10 12 30674659 30674753 95 - 1.951 1.718 -0.787
ENSG00000133704 E030 104.2693600 0.0002764284 1.442851e-12 3.442618e-11 12 30676498 30676587 90 - 1.952 1.685 -0.899
ENSG00000133704 E031 0.1515154 0.0426350869 1.000000e+00   12 30676896 30677045 150 - 0.057 0.000 -9.599
ENSG00000133704 E032 0.0000000       12 30677046 30677244 199 -      
ENSG00000133704 E033 0.0000000       12 30680372 30680481 110 -      
ENSG00000133704 E034 62.5909799 0.0034894306 6.957369e-05 3.779688e-04 12 30680482 30680521 40 - 1.725 1.542 -0.622
ENSG00000133704 E035 89.9013789 0.0004199101 5.506291e-10 8.568073e-09 12 30680522 30680638 117 - 1.887 1.643 -0.824
ENSG00000133704 E036 115.3593208 0.0062743142 3.250164e-07 2.984942e-06 12 30681659 30681817 159 - 1.991 1.760 -0.777
ENSG00000133704 E037 76.4240622 0.0014606874 1.476458e-08 1.763956e-07 12 30684301 30684336 36 - 1.818 1.561 -0.871
ENSG00000133704 E038 109.8271500 0.0003785646 7.190145e-16 2.768600e-14 12 30684337 30684434 98 - 1.979 1.658 -1.085
ENSG00000133704 E039 65.0142615 0.0021706643 8.877780e-11 1.580407e-09 12 30684435 30684457 23 - 1.760 1.387 -1.275
ENSG00000133704 E040 0.1472490 0.0434410768 1.000000e+00   12 30686321 30686523 203 - 0.057 0.000 -9.598
ENSG00000133704 E041 0.2987644 0.0294506359 1.000000e+00   12 30686524 30686659 136 - 0.108 0.000 -10.598
ENSG00000133704 E042 0.1472490 0.0434410768 1.000000e+00   12 30688360 30688692 333 - 0.057 0.000 -9.598
ENSG00000133704 E043 0.4439371 0.0215704378 6.883538e-01 7.905105e-01 12 30688693 30688759 67 - 0.153 0.000 -11.183
ENSG00000133704 E044 81.1704097 0.0005265819 3.549015e-14 1.076105e-12 12 30690496 30690548 53 - 1.855 1.483 -1.264
ENSG00000133704 E045 58.2631450 0.0014459591 5.613446e-08 5.982508e-07 12 30690549 30690577 29 - 1.705 1.413 -1.000
ENSG00000133704 E046 0.2903454 0.2921292367 1.000000e+00   12 30694978 30695111 134 - 0.107 0.000 -10.598
ENSG00000133704 E047 80.1569381 0.0003698329 4.663570e-10 7.337476e-09 12 30695564 30695869 306 - 1.839 1.570 -0.911