ENSG00000133678

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000372277 ENSG00000133678 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM254 protein_coding protein_coding 30.61917 33.4748 31.62715 0.3130462 0.7628252 -0.08188661 4.612044 2.717886 8.759649 0.5440690 0.6383706 1.6847357 0.1439125 0.08150000 0.27640000 0.1949000 2.634190e-06 2.63419e-06 FALSE FALSE
ENST00000372281 ENSG00000133678 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM254 protein_coding protein_coding 30.61917 33.4748 31.62715 0.3130462 0.7628252 -0.08188661 17.076400 19.248431 13.957563 0.4379192 0.7804119 -0.4634099 0.5660292 0.57516667 0.44300000 -0.1321667 5.063735e-02 2.63419e-06 FALSE FALSE
ENST00000463209 ENSG00000133678 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM254 protein_coding processed_transcript 30.61917 33.4748 31.62715 0.3130462 0.7628252 -0.08188661 3.306333 4.987875 3.083369 0.4322120 0.3519832 -0.6921361 0.1077333 0.14880000 0.09710000 -0.0517000 1.056389e-01 2.63419e-06   FALSE
ENST00000467529 ENSG00000133678 HEK293_OSMI2_2hA HEK293_TMG_2hB TMEM254 protein_coding processed_transcript 30.61917 33.4748 31.62715 0.3130462 0.7628252 -0.08188661 2.220762 2.722836 2.513956 0.1853765 0.1618754 -0.1147123 0.0716250 0.08126667 0.07936667 -0.0019000 9.731899e-01 2.63419e-06 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133678 E001 0.5911836 0.0380610158 1.413733e-01 2.499230e-01 10 80078646 80078664 19 + 0.000 0.277 9.648
ENSG00000133678 E002 13.7329875 0.0012984568 1.064287e-06 8.781234e-06 10 80078665 80078681 17 + 1.352 0.954 -1.426
ENSG00000133678 E003 47.0633452 0.0005019996 6.222578e-05 3.424298e-04 10 80078682 80078691 10 + 1.760 1.603 -0.533
ENSG00000133678 E004 129.2712918 0.0015795356 1.036527e-04 5.388477e-04 10 80078692 80078786 95 + 2.158 2.067 -0.302
ENSG00000133678 E005 2.5453125 0.0058119433 2.807761e-01 4.206532e-01 10 80079036 80079184 149 + 0.625 0.487 -0.637
ENSG00000133678 E006 1.7671245 0.0106473997 4.372652e-01 5.792472e-01 10 80079270 80079272 3 + 0.498 0.394 -0.537
ENSG00000133678 E007 4.9937271 0.0060555199 4.300485e-02 9.655068e-02 10 80079273 80079294 22 + 0.892 0.658 -0.937
ENSG00000133678 E008 16.5558636 0.0010743618 8.141404e-03 2.414207e-02 10 80079295 80079307 13 + 1.330 1.156 -0.615
ENSG00000133678 E009 10.5713137 0.0280878473 2.346251e-02 5.870802e-02 10 80079328 80079692 365 + 1.175 0.930 -0.894
ENSG00000133678 E010 11.0799661 0.0017882924 6.540557e-01 7.643567e-01 10 80081640 80081702 63 + 1.070 1.067 -0.011
ENSG00000133678 E011 10.8122564 0.0016552138 6.456612e-02 1.343183e-01 10 80081703 80081722 20 + 0.912 1.147 0.863
ENSG00000133678 E012 9.0751078 0.0018823727 2.575983e-02 6.344744e-02 10 80081723 80081734 12 + 0.804 1.098 1.104
ENSG00000133678 E013 3.3923211 0.0065222776 2.522948e-01 3.886210e-01 10 80081735 80081741 7 + 0.498 0.711 0.948
ENSG00000133678 E014 206.0888016 0.0030034995 1.186568e-03 4.595745e-03 10 80081841 80081944 104 + 2.344 2.280 -0.212
ENSG00000133678 E015 159.0327303 0.0006389301 7.241557e-03 2.185201e-02 10 80082145 80082204 60 + 2.214 2.182 -0.109
ENSG00000133678 E016 5.0637812 0.0038035837 6.661438e-01 7.736429e-01 10 80082205 80082217 13 + 0.779 0.759 -0.081
ENSG00000133678 E017 23.0592730 0.0099382753 2.150348e-01 3.444816e-01 10 80086231 80086258 28 + 1.276 1.431 0.538
ENSG00000133678 E018 26.3133434 0.0008712775 6.925909e-02 1.421444e-01 10 80086259 80086441 183 + 1.323 1.494 0.590
ENSG00000133678 E019 6.2814390 0.0026669946 2.842319e-01 4.244540e-01 10 80090380 80090431 52 + 0.912 0.821 -0.349
ENSG00000133678 E020 1089.1326317 0.0027052998 1.434970e-07 1.414490e-06 10 80090797 80092557 1761 + 2.961 3.072 0.370