ENSG00000133606

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000255977 ENSG00000133606 HEK293_OSMI2_2hA HEK293_TMG_2hB MKRN1 protein_coding protein_coding 54.22041 48.58134 61.17058 5.508447 1.363415 0.3323747 38.490499 43.6207687 37.130400 4.8616565 0.3380890 -0.2323566 0.71602917 0.8983 0.60776667 -0.29053333 1.869202e-36 1.007063e-49 FALSE TRUE
ENST00000443720 ENSG00000133606 HEK293_OSMI2_2hA HEK293_TMG_2hB MKRN1 protein_coding protein_coding 54.22041 48.58134 61.17058 5.508447 1.363415 0.3323747 4.381016 2.8930156 4.246237 0.6591737 0.1759641 0.5520261 0.07990000 0.0581 0.06960000 0.01150000 6.436632e-01 1.007063e-49 FALSE TRUE
ENST00000463142 ENSG00000133606 HEK293_OSMI2_2hA HEK293_TMG_2hB MKRN1 protein_coding protein_coding 54.22041 48.58134 61.17058 5.508447 1.363415 0.3323747 7.033103 0.0000000 12.175656 0.0000000 1.3297590 10.2509682 0.12576250 0.0000 0.19840000 0.19840000 1.007063e-49 1.007063e-49 FALSE FALSE
ENST00000468447 ENSG00000133606 HEK293_OSMI2_2hA HEK293_TMG_2hB MKRN1 protein_coding retained_intron 54.22041 48.58134 61.17058 5.508447 1.363415 0.3323747 2.475246 0.4115301 5.998353 0.2544015 0.8414100 3.8332618 0.04366667 0.0100 0.09766667 0.08766667 6.166363e-02 1.007063e-49 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133606 E001 0.2955422 0.0282901024 9.002019e-01   7 140453033 140453046 14 - 0.129 0.116 -0.171
ENSG00000133606 E002 1563.8126280 0.0013233628 3.618827e-21 2.648034e-19 7 140453047 140454142 1096 - 3.081 3.259 0.592
ENSG00000133606 E003 327.5130696 0.0016949247 1.612719e-03 6.001155e-03 7 140454143 140454267 125 - 2.450 2.556 0.353
ENSG00000133606 E004 401.8369965 0.0010370889 7.838167e-06 5.335096e-05 7 140454268 140454463 196 - 2.528 2.652 0.412
ENSG00000133606 E005 554.4880850 0.0001464286 6.732918e-01 7.790169e-01 7 140454464 140454664 201 - 2.734 2.753 0.062
ENSG00000133606 E006 360.6637752 0.0001619342 3.468597e-03 1.163510e-02 7 140454665 140454729 65 - 2.577 2.548 -0.097
ENSG00000133606 E007 484.6414029 0.0001756569 2.184441e-03 7.793957e-03 7 140455095 140455233 139 - 2.702 2.677 -0.084
ENSG00000133606 E008 15.7561130 0.0118398721 2.209939e-02 5.588387e-02 7 140455234 140455789 556 - 1.330 1.139 -0.674
ENSG00000133606 E009 317.0882015 0.0007194292 1.168000e-03 4.532167e-03 7 140455790 140455856 67 - 2.531 2.478 -0.176
ENSG00000133606 E010 239.0558134 0.0001910345 4.962448e-04 2.145660e-03 7 140455857 140455900 44 - 2.411 2.356 -0.183
ENSG00000133606 E011 1.0350216 0.0185020643 1.723221e-01 2.912291e-01 7 140455901 140455911 11 - 0.435 0.208 -1.493
ENSG00000133606 E012 0.4375944 0.0259663252 6.313446e-02 1.319328e-01 7 140456180 140456185 6 - 0.308 0.000 -13.913
ENSG00000133606 E013 1.0975895 0.0124616425 8.887358e-01 9.328260e-01 7 140456186 140456191 6 - 0.309 0.348 0.245
ENSG00000133606 E014 83.3700048 0.0050175345 3.597421e-01 5.040720e-01 7 140456192 140456651 460 - 1.884 1.962 0.261
ENSG00000133606 E015 449.7817440 0.0001262817 3.846421e-02 8.821949e-02 7 140456652 140456866 215 - 2.660 2.651 -0.030
ENSG00000133606 E016 1.5103927 0.0180324474 2.219814e-01 3.527729e-01 7 140456867 140456919 53 - 0.487 0.284 -1.164
ENSG00000133606 E017 257.3939681 0.0001953452 1.288023e-01 2.324877e-01 7 140459007 140459090 84 - 2.380 2.440 0.202
ENSG00000133606 E018 311.1665756 0.0009498448 1.659315e-01 2.829020e-01 7 140459091 140459177 87 - 2.501 2.493 -0.025
ENSG00000133606 E019 245.0791210 0.0010856918 1.246219e-02 3.464668e-02 7 140459178 140459233 56 - 2.417 2.376 -0.137
ENSG00000133606 E020 274.5053419 0.0002114374 1.721598e-04 8.444930e-04 7 140459707 140459771 65 - 2.474 2.418 -0.185
ENSG00000133606 E021 190.5296916 0.0001935019 8.558736e-05 4.544103e-04 7 140459772 140459797 26 - 2.325 2.250 -0.250
ENSG00000133606 E022 252.2221364 0.0002432806 1.428320e-07 1.408741e-06 7 140459798 140459840 43 - 2.456 2.362 -0.314
ENSG00000133606 E023 309.3168424 0.0001696262 1.189929e-07 1.192238e-06 7 140459841 140459928 88 - 2.537 2.455 -0.274
ENSG00000133606 E024 166.5015393 0.0038804315 1.689493e-02 4.470180e-02 7 140459929 140459936 8 - 2.264 2.185 -0.267
ENSG00000133606 E025 1.2501346 0.0105687186 7.958628e-02 1.588899e-01 7 140460122 140460243 122 - 0.129 0.454 2.418
ENSG00000133606 E026 263.5783751 0.0015933865 9.843585e-05 5.145941e-04 7 140471883 140472011 129 - 2.470 2.379 -0.305
ENSG00000133606 E027 0.4417591 0.0435045510 6.888911e-01 7.909118e-01 7 140472203 140472405 203 - 0.129 0.207 0.825
ENSG00000133606 E028 0.2214452 0.0501082876 5.565727e-01   7 140473244 140473332 89 - 0.000 0.117 10.983
ENSG00000133606 E029 0.2214452 0.0501082876 5.565727e-01   7 140473775 140473827 53 - 0.000 0.117 10.983
ENSG00000133606 E030 1.7120452 0.1624718369 5.953320e-02 1.258229e-01 7 140474381 140474489 109 - 0.614 0.208 -2.339
ENSG00000133606 E031 0.1451727 0.0435994986 4.259107e-01   7 140475218 140475335 118 - 0.129 0.000 -11.991
ENSG00000133606 E032 1.0672868 0.3950123765 8.174160e-01 8.845535e-01 7 140478135 140478599 465 - 0.376 0.277 -0.624
ENSG00000133606 E033 2.5035826 0.0089650473 2.801536e-01 4.199743e-01 7 140478600 140478836 237 - 0.613 0.454 -0.751
ENSG00000133606 E034 1.5416153 0.0109164277 2.830297e-02 6.861140e-02 7 140478837 140479159 323 - 0.575 0.208 -2.168
ENSG00000133606 E035 168.2486203 0.0128736943 3.037919e-02 7.270856e-02 7 140479160 140479536 377 - 2.289 2.167 -0.408