ENSG00000133466

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000337843 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding protein_coding 3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.4296926 1.1786155 0.00000000 0.43250999 0.00000000 -6.89313826 0.10542500 0.28100000 0.00000000 -0.281000000 3.903478e-07 3.903478e-07 FALSE TRUE
ENST00000467564 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding processed_transcript 3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.1970289 0.1606400 0.16836552 0.16064004 0.08865091 0.06388054 0.05099583 0.03900000 0.04346667 0.004466667 7.725435e-01 3.903478e-07   FALSE
ENST00000470655 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding processed_transcript 3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.5054192 0.4013959 0.67008101 0.11451542 0.02545215 0.72517932 0.14552083 0.09993333 0.17060000 0.070666667 3.083927e-01 3.903478e-07 FALSE TRUE
ENST00000493023 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding retained_intron 3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.5212140 0.3818196 0.68420203 0.20900072 0.12243171 0.82516607 0.14181667 0.10336667 0.17263333 0.069266667 6.398106e-01 3.903478e-07 FALSE TRUE
ENST00000497071 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding processed_transcript 3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.2796857 0.3945322 0.42031951 0.19880679 0.21898049 0.08915375 0.08529583 0.10006667 0.10620000 0.006133333 1.000000e+00 3.903478e-07   FALSE
MSTRG.22066.10 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding   3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.1789881 0.1511919 0.42956458 0.15119191 0.34872221 1.44729581 0.05777083 0.03393333 0.11216667 0.078233333 7.160779e-01 3.903478e-07 FALSE TRUE
MSTRG.22066.4 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding   3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.5647407 0.2456163 0.76893832 0.12708956 0.06778631 1.60752910 0.16312083 0.06596667 0.19493333 0.128966667 2.322557e-01 3.903478e-07 FALSE TRUE
MSTRG.22066.6 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding   3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.3474102 0.6201408 0.09534261 0.22095138 0.05876341 -2.58058516 0.08695833 0.15270000 0.02360000 -0.129100000 5.110696e-02 3.903478e-07 FALSE TRUE
MSTRG.22066.8 ENSG00000133466 HEK293_OSMI2_2hA HEK293_TMG_2hB C1QTNF6 protein_coding   3.624026 4.01914 3.9367 0.2868814 0.08364556 -0.02982506 0.4990221 0.3171179 0.54115202 0.09534507 0.28777801 0.75263977 0.13652917 0.08170000 0.13563333 0.053933333 9.795656e-01 3.903478e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133466 E001 0.0000000       22 37180166 37180166 1 -      
ENSG00000133466 E002 0.0000000       22 37180167 37180170 4 -      
ENSG00000133466 E003 2.7594660 0.2949100595 7.638083e-02 1.537118e-01 22 37180171 37180202 32 - 0.225 0.703 2.575
ENSG00000133466 E004 17.7023111 0.0165541817 2.367683e-03 8.360679e-03 22 37180203 37180332 130 - 1.062 1.368 1.084
ENSG00000133466 E005 42.9452695 0.0019720197 4.616146e-10 7.271265e-09 22 37180333 37180648 316 - 1.406 1.761 1.213
ENSG00000133466 E006 29.0027792 0.0144413910 4.037322e-04 1.788933e-03 22 37180649 37180749 101 - 1.279 1.586 1.062
ENSG00000133466 E007 32.1599280 0.0105016399 7.209590e-04 2.973797e-03 22 37180750 37180867 118 - 1.357 1.617 0.895
ENSG00000133466 E008 76.0632998 0.0037856529 4.346155e-02 9.740057e-02 22 37180868 37182151 1284 - 1.832 1.918 0.291
ENSG00000133466 E009 13.1189880 0.0177518385 4.487889e-01 5.900406e-01 22 37182152 37182173 22 - 1.110 1.190 0.286
ENSG00000133466 E010 45.2438641 0.0005621526 1.625728e-01 2.785015e-01 22 37182174 37182582 409 - 1.621 1.685 0.219
ENSG00000133466 E011 23.0512857 0.0008738542 8.214881e-02 1.629106e-01 22 37182583 37182735 153 - 1.301 1.419 0.410
ENSG00000133466 E012 0.2934659 0.0292046723 9.583299e-01   22 37182736 37182827 92 - 0.127 0.118 -0.125
ENSG00000133466 E013 1.4758462 0.0094275928 3.268942e-02 7.718180e-02 22 37184337 37184437 101 - 0.127 0.503 2.686
ENSG00000133466 E014 27.4013357 0.0010022520 6.382790e-01 7.519379e-01 22 37185218 37185455 238 - 1.475 1.439 -0.124
ENSG00000133466 E015 4.7304793 0.0050752549 3.135310e-02 7.459188e-02 22 37185456 37185870 415 - 0.910 0.614 -1.195
ENSG00000133466 E016 2.2456031 0.0086427181 8.806837e-01 9.274741e-01 22 37185871 37186046 176 - 0.482 0.503 0.102
ENSG00000133466 E017 1.9293377 0.0075487879 6.180431e-02 1.296609e-01 22 37188163 37188476 314 - 0.608 0.287 -1.707
ENSG00000133466 E018 5.4823725 0.0190693499 7.534138e-01 8.393639e-01 22 37190553 37190677 125 - 0.785 0.821 0.143
ENSG00000133466 E019 17.6304080 0.0011106821 4.526292e-01 5.934738e-01 22 37190865 37190928 64 - 1.301 1.236 -0.230
ENSG00000133466 E020 13.5469324 0.0012979534 3.863415e-01 5.305367e-01 22 37191672 37191737 66 - 1.203 1.119 -0.297
ENSG00000133466 E021 13.8581663 0.0070693743 1.332576e-01 2.386559e-01 22 37195381 37195458 78 - 1.238 1.089 -0.532
ENSG00000133466 E022 8.2932141 0.0031070615 2.820336e-01 4.219903e-01 22 37195459 37195473 15 - 1.021 0.896 -0.469
ENSG00000133466 E023 7.2601828 0.0024342139 2.620298e-01 3.997516e-01 22 37195474 37195512 39 - 0.977 0.841 -0.518
ENSG00000133466 E024 54.8542295 0.0138306417 1.877079e-05 1.171609e-04 22 37195513 37197602 2090 - 1.887 1.582 -1.033
ENSG00000133466 E025 17.2649371 0.0013131522 1.856127e-01 3.082594e-01 22 37197603 37197684 82 - 1.316 1.203 -0.396
ENSG00000133466 E026 25.5333302 0.0077066088 2.836513e-03 9.783507e-03 22 37197685 37197841 157 - 1.535 1.296 -0.824
ENSG00000133466 E027 11.0078680 0.0245210970 2.203988e-03 7.854972e-03 22 37197842 37197861 20 - 1.246 0.863 -1.403
ENSG00000133466 E028 23.2474528 0.0106970926 3.176539e-05 1.878819e-04 22 37197862 37198301 440 - 1.548 1.187 -1.255
ENSG00000133466 E029 4.9415799 0.0603813407 2.747936e-03 9.515936e-03 22 37199269 37199323 55 - 0.977 0.463 -2.156
ENSG00000133466 E030 7.3459993 0.0023526482 1.379539e-03 5.239776e-03 22 37199324 37199407 84 - 1.087 0.704 -1.466