ENSG00000133422

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000397641 ENSG00000133422 HEK293_OSMI2_2hA HEK293_TMG_2hB MORC2 protein_coding protein_coding 26.86409 27.81058 20.7652 0.5032804 0.8057845 -0.4212899 3.0528827 4.0950987 2.429178 0.2129817 0.2135627 -0.7510219 0.11436250 0.1471333 0.11706667 -0.03006667 3.157502e-01 2.247838e-37 FALSE TRUE
ENST00000429468 ENSG00000133422 HEK293_OSMI2_2hA HEK293_TMG_2hB MORC2 protein_coding processed_transcript 26.86409 27.81058 20.7652 0.5032804 0.8057845 -0.4212899 2.3288077 0.0000000 2.505507 0.0000000 0.4105223 7.9747056 0.08858750 0.0000000 0.11950000 0.11950000 7.529845e-25 2.247838e-37   FALSE
ENST00000445980 ENSG00000133422 HEK293_OSMI2_2hA HEK293_TMG_2hB MORC2 protein_coding protein_coding 26.86409 27.81058 20.7652 0.5032804 0.8057845 -0.4212899 1.1169327 3.7666896 0.000000 0.2229061 0.0000000 -8.5609784 0.04031667 0.1353667 0.00000000 -0.13536667 2.247838e-37 2.247838e-37 FALSE TRUE
ENST00000675601 ENSG00000133422 HEK293_OSMI2_2hA HEK293_TMG_2hB MORC2 protein_coding processed_transcript 26.86409 27.81058 20.7652 0.5032804 0.8057845 -0.4212899 1.6856467 3.4622304 0.000000 0.8734916 0.0000000 -8.4397189 0.05741667 0.1236667 0.00000000 -0.12366667 2.474820e-13 2.247838e-37 FALSE TRUE
ENST00000676263 ENSG00000133422 HEK293_OSMI2_2hA HEK293_TMG_2hB MORC2 protein_coding retained_intron 26.86409 27.81058 20.7652 0.5032804 0.8057845 -0.4212899 5.8139550 8.1094616 2.368972 0.3297038 0.2383151 -1.7710456 0.20678333 0.2914667 0.11356667 -0.17790000 1.630548e-13 2.247838e-37 FALSE TRUE
MSTRG.21944.6 ENSG00000133422 HEK293_OSMI2_2hA HEK293_TMG_2hB MORC2 protein_coding   26.86409 27.81058 20.7652 0.5032804 0.8057845 -0.4212899 0.8068085 0.2837281 1.888967 0.2837281 0.5486068 2.6926616 0.03307500 0.0104000 0.09143333 0.08103333 7.495728e-02 2.247838e-37 TRUE TRUE
MSTRG.21944.7 ENSG00000133422 HEK293_OSMI2_2hA HEK293_TMG_2hB MORC2 protein_coding   26.86409 27.81058 20.7652 0.5032804 0.8057845 -0.4212899 6.9112825 4.3177247 6.861770 0.7788093 0.6755282 0.6670729 0.26375833 0.1562333 0.33080000 0.17456667 1.496211e-02 2.247838e-37 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133422 E001 3.9042161 0.0086237667 1.317653e-01 2.365804e-01 22 30890023 30890110 88 - 0.805 0.575 -0.965
ENSG00000133422 E002 3.8988157 0.0041232321 7.392620e-01 8.289590e-01 22 30890111 30890190 80 - 0.718 0.661 -0.240
ENSG00000133422 E003 0.1472490 0.0434947271 3.694728e-01   22 30895863 30895910 48 - 0.141 0.000 -11.035
ENSG00000133422 E004 3.6984634 0.0149555169 2.601658e-01 3.976477e-01 22 30904016 30904141 126 - 0.778 0.604 -0.730
ENSG00000133422 E005 3.9417708 0.0040872549 4.211764e-04 1.855596e-03 22 30904239 30904349 111 - 0.939 0.424 -2.218
ENSG00000133422 E006 8.2393560 0.0438008649 6.520768e-02 1.353797e-01 22 30911298 30911388 91 - 1.111 0.830 -1.048
ENSG00000133422 E007 5.3714066 0.0189751177 4.053388e-02 9.200265e-02 22 30911389 30911431 43 - 0.958 0.660 -1.174
ENSG00000133422 E008 0.4720498 0.2474764258 4.844128e-01 6.224264e-01 22 30911690 30911861 172 - 0.247 0.106 -1.472
ENSG00000133422 E009 123.0753778 0.0010092796 2.248945e-06 1.729965e-05 22 30925130 30926610 1481 - 1.973 2.134 0.538
ENSG00000133422 E010 5.3390712 0.0032889319 5.754630e-02 1.224116e-01 22 30926611 30926636 26 - 0.610 0.866 1.043
ENSG00000133422 E011 83.4191950 0.0038012873 2.836988e-07 2.639001e-06 22 30926637 30926712 76 - 1.742 1.995 0.852
ENSG00000133422 E012 82.9302926 0.0027175655 1.409375e-08 1.690634e-07 22 30926713 30926724 12 - 1.730 1.996 0.897
ENSG00000133422 E013 91.1071006 0.0024347888 1.431245e-07 1.411332e-06 22 30926725 30926732 8 - 1.796 2.027 0.778
ENSG00000133422 E014 172.8828214 0.0013749021 5.670203e-12 1.228503e-10 22 30926733 30926871 139 - 2.078 2.298 0.733
ENSG00000133422 E015 6.4137412 0.0026886636 1.660370e-04 8.181021e-04 22 30926872 30927529 658 - 0.466 0.992 2.197
ENSG00000133422 E016 4.2143285 0.0681420309 5.346564e-01 6.666645e-01 22 30927530 30927803 274 - 0.650 0.749 0.412
ENSG00000133422 E017 2.3000316 0.0127407574 9.719065e-01 9.864343e-01 22 30927804 30928018 215 - 0.519 0.505 -0.067
ENSG00000133422 E018 68.1917340 0.0010392911 6.714269e-05 3.663062e-04 22 30928019 30928027 9 - 1.711 1.886 0.593
ENSG00000133422 E019 216.3546298 0.0002405012 9.601970e-11 1.698949e-09 22 30928028 30928207 180 - 2.221 2.375 0.515
ENSG00000133422 E020 0.1451727 0.0436891510 3.694275e-01   22 30928208 30928228 21 - 0.141 0.000 -11.034
ENSG00000133422 E021 162.5513477 0.0002557467 5.625711e-04 2.394137e-03 22 30932359 30932452 94 - 2.143 2.231 0.296
ENSG00000133422 E022 256.4911895 0.0002147847 2.711445e-06 2.049863e-05 22 30932545 30932769 225 - 2.332 2.429 0.324
ENSG00000133422 E023 0.9974562 0.0124670806 7.128345e-01 8.094244e-01 22 30932770 30932888 119 - 0.333 0.262 -0.480
ENSG00000133422 E024 215.2613366 0.0004133171 6.219469e-13 1.578802e-11 22 30932889 30933030 142 - 2.197 2.378 0.603
ENSG00000133422 E025 0.8856962 0.0141591029 2.359139e-01 3.694438e-01 22 30933031 30933095 65 - 0.404 0.190 -1.483
ENSG00000133422 E026 151.0980010 0.0020196969 8.234149e-08 8.501934e-07 22 30933466 30933520 55 - 2.039 2.226 0.627
ENSG00000133422 E027 0.5922303 0.0179830268 1.910062e-01 3.150103e-01 22 30933521 30933597 77 - 0.333 0.106 -2.067
ENSG00000133422 E028 0.6589510 0.0248198946 4.764533e-01 6.150735e-01 22 30933694 30933777 84 - 0.141 0.261 1.103
ENSG00000133422 E029 192.2173884 0.0002081772 7.624606e-07 6.498960e-06 22 30934060 30934191 132 - 2.192 2.313 0.403
ENSG00000133422 E030 269.7728580 0.0001646570 1.414551e-01 2.500187e-01 22 30934781 30935161 381 - 2.405 2.425 0.069
ENSG00000133422 E031 0.8512514 0.0136968632 2.952042e-01 4.363376e-01 22 30935162 30935218 57 - 0.141 0.323 1.519
ENSG00000133422 E032 108.0459968 0.0004797812 1.595493e-02 4.262967e-02 22 30935248 30935322 75 - 1.973 2.048 0.252
ENSG00000133422 E033 125.3956205 0.0003536366 2.203597e-01 3.508410e-01 22 30936511 30936577 67 - 2.070 2.099 0.096
ENSG00000133422 E034 113.0864512 0.0020388757 3.827141e-01 5.268960e-01 22 30936578 30936643 66 - 2.028 2.051 0.077
ENSG00000133422 E035 0.7363694 0.0537029584 4.773717e-01 6.159275e-01 22 30936644 30936668 25 - 0.141 0.263 1.111
ENSG00000133422 E036 105.7582738 0.0003483139 4.557099e-01 5.962174e-01 22 30936932 30937002 71 - 2.041 2.003 -0.126
ENSG00000133422 E037 89.7847634 0.0019433277 9.984119e-01 1.000000e+00 22 30937003 30937037 35 - 1.955 1.944 -0.036
ENSG00000133422 E038 130.4775957 0.0018526509 7.930214e-01 8.676460e-01 22 30937583 30937711 129 - 2.121 2.101 -0.068
ENSG00000133422 E039 127.0509742 0.0004298481 6.309867e-01 7.460993e-01 22 30937815 30937969 155 - 2.112 2.085 -0.090
ENSG00000133422 E040 79.1407571 0.0003641992 1.545958e-01 2.678759e-01 22 30938065 30938115 51 - 1.934 1.866 -0.230
ENSG00000133422 E041 102.2776521 0.0003945284 4.532279e-03 1.463360e-02 22 30938116 30938205 90 - 2.066 1.953 -0.378
ENSG00000133422 E042 4.9424468 0.0032738880 1.492493e-02 4.031890e-02 22 30938206 30939620 1415 - 0.939 0.605 -1.343
ENSG00000133422 E043 106.9500894 0.0038219705 3.719039e-03 1.235205e-02 22 30939621 30939706 86 - 2.100 1.956 -0.482
ENSG00000133422 E044 1.9844316 0.0476453259 2.042681e-01 3.315009e-01 22 30939707 30939958 252 - 0.610 0.374 -1.167
ENSG00000133422 E045 115.8562010 0.0003094466 5.454978e-05 3.044781e-04 22 30939959 30940041 83 - 2.137 1.991 -0.489
ENSG00000133422 E046 0.2214452 0.0411458098 6.334761e-01   22 30940042 30940724 683 - 0.000 0.106 9.494
ENSG00000133422 E047 112.8519417 0.0003086114 1.049213e-04 5.447403e-04 22 30940758 30940837 80 - 2.125 1.983 -0.476
ENSG00000133422 E048 120.1025226 0.0002597110 1.212641e-04 6.197561e-04 22 30941433 30941558 126 - 2.149 2.013 -0.457
ENSG00000133422 E049 56.9376881 0.0006354838 9.565715e-05 5.016321e-04 22 30941891 30941899 9 - 1.858 1.662 -0.663
ENSG00000133422 E050 117.3827168 0.0038550877 5.278292e-05 2.956702e-04 22 30941900 30942002 103 - 2.166 1.975 -0.640
ENSG00000133422 E051 155.9103896 0.0033922250 3.527111e-05 2.060439e-04 22 30942112 30942271 160 - 2.282 2.105 -0.590
ENSG00000133422 E052 119.9161204 0.0047641729 6.674764e-05 3.643713e-04 22 30946341 30946449 109 - 2.180 1.982 -0.663
ENSG00000133422 E053 0.0000000       22 30947014 30947172 159 -      
ENSG00000133422 E054 114.9129295 0.0003725566 1.198747e-07 1.199932e-06 22 30949752 30949842 91 - 2.158 1.970 -0.632
ENSG00000133422 E055 103.8432156 0.0003041002 2.176090e-07 2.071419e-06 22 30950377 30950445 69 - 2.117 1.925 -0.643
ENSG00000133422 E056 4.1921548 0.0158812321 7.151322e-01 8.111533e-01 22 30950446 30950469 24 - 0.749 0.686 -0.261
ENSG00000133422 E057 75.1743229 0.0015422408 2.222964e-04 1.059136e-03 22 30956763 30956797 35 - 1.970 1.795 -0.588
ENSG00000133422 E058 91.5117290 0.0004879491 1.582495e-04 7.838905e-04 22 30958641 30958694 54 - 2.042 1.888 -0.517
ENSG00000133422 E059 3.4919809 0.0412402270 1.704387e-01 2.887286e-01 22 30958695 30958884 190 - 0.779 0.540 -1.020
ENSG00000133422 E060 1.7693146 0.0078386841 4.254404e-01 5.683870e-01 22 30963225 30963334 110 - 0.519 0.376 -0.744
ENSG00000133422 E061 18.1892673 0.0114941625 6.089336e-03 1.884608e-02 22 30967066 30967821 756 - 1.414 1.146 -0.943
ENSG00000133422 E062 326.1246225 0.0043499686 7.289958e-11 1.316048e-09 22 30967822 30968774 953 - 2.638 2.390 -0.826