ENSG00000133313

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000324262 ENSG00000133313 HEK293_OSMI2_2hA HEK293_TMG_2hB CNDP2 protein_coding protein_coding 55.45867 75.68597 50.88982 7.008464 0.9355926 -0.5725558 8.507138 16.176171 5.071924 1.0958012 0.7258135 -1.6713150 0.14340417 0.21733333 0.09996667 -0.117366667 0.008224111 3.902387e-13 FALSE TRUE
ENST00000579847 ENSG00000133313 HEK293_OSMI2_2hA HEK293_TMG_2hB CNDP2 protein_coding protein_coding 55.45867 75.68597 50.88982 7.008464 0.9355926 -0.5725558 7.753570 12.270544 5.880633 0.9137168 0.3689409 -1.0598798 0.13772917 0.16343333 0.11536667 -0.048066667 0.050971494 3.902387e-13 FALSE TRUE
ENST00000583216 ENSG00000133313 HEK293_OSMI2_2hA HEK293_TMG_2hB CNDP2 protein_coding protein_coding 55.45867 75.68597 50.88982 7.008464 0.9355926 -0.5725558 3.033840 2.257290 4.052735 2.2572896 2.0281601 0.8414826 0.05567500 0.03336667 0.07826667 0.044900000 0.470300085 3.902387e-13 FALSE FALSE
ENST00000583399 ENSG00000133313 HEK293_OSMI2_2hA HEK293_TMG_2hB CNDP2 protein_coding retained_intron 55.45867 75.68597 50.88982 7.008464 0.9355926 -0.5725558 13.065057 17.994982 11.488184 5.7065146 1.0998836 -0.6469901 0.23660833 0.22900000 0.22646667 -0.002533333 1.000000000 3.902387e-13 FALSE FALSE
ENST00000583695 ENSG00000133313 HEK293_OSMI2_2hA HEK293_TMG_2hB CNDP2 protein_coding processed_transcript 55.45867 75.68597 50.88982 7.008464 0.9355926 -0.5725558 9.007761 12.439039 9.999670 0.8698441 0.7246765 -0.3146400 0.16065833 0.16666667 0.19663333 0.029966667 0.618685844 3.902387e-13 FALSE FALSE
ENST00000583938 ENSG00000133313 HEK293_OSMI2_2hA HEK293_TMG_2hB CNDP2 protein_coding retained_intron 55.45867 75.68597 50.88982 7.008464 0.9355926 -0.5725558 3.638995 2.285571 3.551478 1.2776765 0.3424151 0.6336231 0.07141667 0.03016667 0.06993333 0.039766667 0.590199146 3.902387e-13 FALSE TRUE
MSTRG.15914.18 ENSG00000133313 HEK293_OSMI2_2hA HEK293_TMG_2hB CNDP2 protein_coding   55.45867 75.68597 50.88982 7.008464 0.9355926 -0.5725558 6.918114 8.046228 6.548537 2.1664260 1.0315833 -0.2967304 0.12896250 0.10306667 0.12883333 0.025766667 0.719676444 3.902387e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133313 E001 0.2214452 0.0391812457 1.000000e+00   18 74495816 74495923 108 + 0.000 0.086 9.556
ENSG00000133313 E002 0.0000000       18 74496234 74496285 52 +      
ENSG00000133313 E003 0.2944980 0.3288918762 1.011064e-01   18 74496286 74496306 21 + 0.294 0.000 -13.538
ENSG00000133313 E004 2.0533158 0.0594338697 2.045488e-01 3.318503e-01 18 74496307 74496316 10 + 0.592 0.367 -1.132
ENSG00000133313 E005 2.2350202 0.1143440944 3.143774e-01 4.570966e-01 18 74496317 74496318 2 + 0.592 0.408 -0.897
ENSG00000133313 E006 2.8961361 0.1508050538 1.613297e-01 2.768176e-01 18 74496319 74496321 3 + 0.729 0.448 -1.272
ENSG00000133313 E007 25.1486475 0.0083610162 8.299787e-01 8.932602e-01 18 74496322 74496358 37 + 1.339 1.370 0.108
ENSG00000133313 E008 28.8605475 0.0110438474 8.031204e-01 8.746745e-01 18 74496359 74496361 3 + 1.426 1.418 -0.029
ENSG00000133313 E009 29.0088406 0.0091029460 8.286227e-01 8.923125e-01 18 74496362 74496362 1 + 1.426 1.421 -0.019
ENSG00000133313 E010 43.4147211 0.0153144169 1.942095e-01 3.190490e-01 18 74496363 74496371 9 + 1.658 1.567 -0.311
ENSG00000133313 E011 46.3601856 0.0182990690 2.648771e-01 4.028796e-01 18 74496372 74496373 2 + 1.676 1.599 -0.263
ENSG00000133313 E012 78.1749070 0.0127452609 4.505624e-01 5.916566e-01 18 74496374 74496382 9 + 1.870 1.835 -0.118
ENSG00000133313 E013 156.5712574 0.0104051847 8.039998e-02 1.601869e-01 18 74496383 74496431 49 + 2.205 2.120 -0.284
ENSG00000133313 E014 2.0648568 0.0070251926 8.451626e-02 1.666235e-01 18 74497509 74497595 87 + 0.643 0.364 -1.371
ENSG00000133313 E015 1.3639869 0.0314177408 3.873443e-01 5.314827e-01 18 74497596 74497726 131 + 0.468 0.319 -0.836
ENSG00000133313 E016 1.9551586 0.0138573503 1.695911e-01 2.876632e-01 18 74497727 74498024 298 + 0.592 0.364 -1.149
ENSG00000133313 E017 0.1515154 0.0422820032 2.141216e-01   18 74499342 74499357 16 + 0.172 0.000 -13.732
ENSG00000133313 E018 0.1515154 0.0422820032 2.141216e-01   18 74499358 74499375 18 + 0.172 0.000 -13.732
ENSG00000133313 E019 0.2987644 0.0292729701 5.748444e-02   18 74499376 74499420 45 + 0.294 0.000 -14.958
ENSG00000133313 E020 0.6319842 0.0230116035 7.109796e-02 1.451589e-01 18 74499421 74499482 62 + 0.390 0.086 -2.733
ENSG00000133313 E021 0.6621732 0.0199106592 4.208101e-01 5.639907e-01 18 74499483 74499587 105 + 0.294 0.158 -1.148
ENSG00000133313 E022 0.4762024 0.2296861753 2.613051e-01 3.989448e-01 18 74499588 74499706 119 + 0.294 0.086 -2.143
ENSG00000133313 E023 0.5975289 0.0269063287 4.380062e-03 1.420612e-02 18 74499707 74499860 154 + 0.468 0.000 -15.997
ENSG00000133313 E024 15.6472399 0.0438633056 6.852511e-01 7.880460e-01 18 74499861 74499881 21 + 1.191 1.166 -0.091
ENSG00000133313 E025 153.0121315 0.0136763115 2.074860e-01 3.354836e-01 18 74499882 74499928 47 + 2.181 2.119 -0.208
ENSG00000133313 E026 112.6280631 0.0225449638 2.371909e-01 3.709261e-01 18 74499929 74499936 8 + 2.059 1.982 -0.256
ENSG00000133313 E027 147.2073055 0.0118278243 3.130232e-02 7.448696e-02 18 74499937 74499940 4 + 2.200 2.085 -0.387
ENSG00000133313 E028 294.5872243 0.0046437670 3.347066e-02 7.871926e-02 18 74499941 74500033 93 + 2.468 2.399 -0.230
ENSG00000133313 E029 0.0000000       18 74501090 74501101 12 +      
ENSG00000133313 E030 0.0000000       18 74501102 74501211 110 +      
ENSG00000133313 E031 2.5034914 0.0064026371 4.509013e-01 5.919263e-01 18 74501212 74501238 27 + 0.390 0.532 0.728
ENSG00000133313 E032 2.6486641 0.0057084597 7.465215e-01 8.342501e-01 18 74501239 74501328 90 + 0.468 0.532 0.313
ENSG00000133313 E033 271.6643045 0.0030906002 6.577159e-02 1.363204e-01 18 74501329 74501385 57 + 2.421 2.369 -0.172
ENSG00000133313 E034 346.2875207 0.0008195186 5.063891e-01 6.420505e-01 18 74501386 74501472 87 + 2.492 2.489 -0.011
ENSG00000133313 E035 390.6029224 0.0003844814 7.898847e-01 8.655890e-01 18 74505849 74506011 163 + 2.538 2.545 0.024
ENSG00000133313 E036 0.9899927 0.0194703129 7.589464e-02 1.529364e-01 18 74506012 74506028 17 + 0.000 0.363 14.491
ENSG00000133313 E037 14.1998411 0.0012584875 2.030968e-01 3.301052e-01 18 74507067 74508839 1773 + 1.029 1.169 0.507
ENSG00000133313 E038 186.1465238 0.0002305767 7.550641e-02 1.523177e-01 18 74508840 74508844 5 + 2.250 2.212 -0.127
ENSG00000133313 E039 296.1632150 0.0002054654 1.039425e-01 1.965150e-01 18 74508845 74508928 84 + 2.439 2.414 -0.083
ENSG00000133313 E040 6.3688036 0.0025521885 4.834189e-02 1.062304e-01 18 74508929 74509138 210 + 0.592 0.891 1.221
ENSG00000133313 E041 6.7362647 0.0084818041 3.036090e-02 7.267397e-02 18 74509139 74509632 494 + 0.592 0.925 1.350
ENSG00000133313 E042 151.6519044 0.0002632846 8.105020e-01 8.797529e-01 18 74510813 74510823 11 + 2.128 2.133 0.016
ENSG00000133313 E043 219.6816270 0.0002003449 7.989781e-01 8.717317e-01 18 74510824 74510875 52 + 2.288 2.294 0.019
ENSG00000133313 E044 363.3861673 0.0001427042 5.783533e-01 7.034683e-01 18 74510876 74510986 111 + 2.510 2.511 0.004
ENSG00000133313 E045 224.0831525 0.0002217645 9.564754e-01 9.767269e-01 18 74510987 74511013 27 + 2.294 2.305 0.037
ENSG00000133313 E046 7.9209605 0.1359513186 1.145607e-01 2.121994e-01 18 74511014 74511233 220 + 1.101 0.820 -1.050
ENSG00000133313 E047 0.0000000       18 74512013 74512100 88 +      
ENSG00000133313 E048 329.4671669 0.0009235422 7.474008e-01 8.349339e-01 18 74512448 74512532 85 + 2.466 2.471 0.016
ENSG00000133313 E049 222.8790128 0.0002083276 1.220875e-01 2.229086e-01 18 74513559 74513576 18 + 2.321 2.293 -0.093
ENSG00000133313 E050 445.2819396 0.0005741293 1.099120e-01 2.054155e-01 18 74513577 74513719 143 + 2.615 2.594 -0.069
ENSG00000133313 E051 4.2761325 0.0136074809 2.010902e-03 7.259965e-03 18 74513720 74513818 99 + 0.942 0.504 -1.822
ENSG00000133313 E052 188.4476763 0.0014718893 4.742932e-01 6.131414e-01 18 74516228 74516231 4 + 2.236 2.224 -0.037
ENSG00000133313 E053 377.0773006 0.0003192564 5.578783e-01 6.862034e-01 18 74516232 74516330 99 + 2.528 2.528 0.002
ENSG00000133313 E054 330.4547814 0.0003333224 4.379309e-01 5.798118e-01 18 74516331 74516392 62 + 2.473 2.468 -0.016
ENSG00000133313 E055 22.6762538 0.0008277650 1.800853e-04 8.783664e-04 18 74516393 74518498 2106 + 1.499 1.235 -0.916
ENSG00000133313 E056 475.8555817 0.0002365302 3.911706e-01 5.351085e-01 18 74518499 74518640 142 + 2.631 2.628 -0.010
ENSG00000133313 E057 12.7737126 0.0138054806 3.706263e-03 1.231523e-02 18 74518641 74518948 308 + 1.288 0.988 -1.076
ENSG00000133313 E058 432.5154474 0.0002210084 4.536034e-03 1.464312e-02 18 74518949 74519096 148 + 2.536 2.605 0.230
ENSG00000133313 E059 522.8755228 0.0006427496 7.773955e-02 1.558388e-01 18 74519999 74520151 153 + 2.633 2.682 0.163
ENSG00000133313 E060 1585.8273324 0.0037253397 5.305026e-06 3.753581e-05 18 74520152 74523454 3303 + 3.048 3.183 0.449
ENSG00000133313 E061 0.1472490 0.0425046193 2.142704e-01   18 74531475 74531541 67 + 0.172 0.000 -13.728