ENSG00000133247

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000255613 ENSG00000133247 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5C protein_coding protein_coding 21.81398 29.36956 14.72438 2.614197 0.5004378 -0.9956262 6.733463 10.2537312 4.6936178 1.63685963 0.3565808 -1.12571256 0.30014167 0.34553333 0.32120000 -0.02433333 8.747076e-01 9.488764e-20 FALSE TRUE
ENST00000402499 ENSG00000133247 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5C protein_coding processed_transcript 21.81398 29.36956 14.72438 2.614197 0.5004378 -0.9956262 1.675779 0.7827658 1.1777689 0.28302910 0.3193312 0.58328745 0.08417083 0.02523333 0.07893333 0.05370000 8.698187e-02 9.488764e-20 FALSE FALSE
ENST00000445196 ENSG00000133247 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5C protein_coding nonsense_mediated_decay 21.81398 29.36956 14.72438 2.614197 0.5004378 -0.9956262 1.213893 1.7330242 0.0000000 1.73302424 0.0000000 -7.44544882 0.05483333 0.07166667 0.00000000 -0.07166667 9.097840e-01 9.488764e-20 FALSE TRUE
ENST00000460956 ENSG00000133247 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5C protein_coding processed_transcript 21.81398 29.36956 14.72438 2.614197 0.5004378 -0.9956262 1.430191 3.2086017 0.1168872 1.60711771 0.1168872 -4.66481559 0.06538750 0.11796667 0.00770000 -0.11026667 4.475458e-01 9.488764e-20 FALSE FALSE
ENST00000498738 ENSG00000133247 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5C protein_coding retained_intron 21.81398 29.36956 14.72438 2.614197 0.5004378 -0.9956262 1.076292 1.1341472 1.3648100 0.22388973 0.1667494 0.26495958 0.05551667 0.03800000 0.09243333 0.05443333 1.501484e-03 9.488764e-20   FALSE
ENST00000592631 ENSG00000133247 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5C protein_coding nonsense_mediated_decay 21.81398 29.36956 14.72438 2.614197 0.5004378 -0.9956262 3.543830 3.7619366 3.6020966 2.10246814 0.3605477 -0.06246896 0.16701250 0.11710000 0.24366667 0.12656667 6.470522e-01 9.488764e-20 FALSE FALSE
MSTRG.17712.4 ENSG00000133247 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5C protein_coding   21.81398 29.36956 14.72438 2.614197 0.5004378 -0.9956262 2.472155 5.6371540 0.0000000 1.26129884 0.0000000 -9.14138017 0.09475000 0.18703333 0.00000000 -0.18703333 9.488764e-20 9.488764e-20 FALSE TRUE
MSTRG.17712.9 ENSG00000133247 HEK293_OSMI2_2hA HEK293_TMG_2hB KMT5C protein_coding   21.81398 29.36956 14.72438 2.614197 0.5004378 -0.9956262 1.282387 1.3046078 1.0354893 0.06394043 0.3581600 -0.33045414 0.06117500 0.04510000 0.06943333 0.02433333 6.644263e-01 9.488764e-20 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133247 E001 2.224790 0.1389662626 3.144496e-01 4.571630e-01 19 55339853 55339875 23 + 0.609 0.420 -0.910
ENSG00000133247 E002 1.776688 0.0237267179 2.494841e-01 3.853034e-01 19 55339876 55339884 9 + 0.550 0.351 -1.033
ENSG00000133247 E003 4.054584 0.0038309193 4.279086e-02 9.616598e-02 19 55339885 55339885 1 + 0.852 0.568 -1.178
ENSG00000133247 E004 56.656336 0.0109216960 2.983459e-01 4.397842e-01 19 55339886 55339917 32 + 1.621 1.715 0.321
ENSG00000133247 E005 85.272434 0.0054710426 2.989076e-02 7.175077e-02 19 55339918 55339957 40 + 1.760 1.899 0.469
ENSG00000133247 E006 20.365823 0.0010152399 1.623457e-03 6.036368e-03 19 55340337 55340603 267 + 1.431 1.192 -0.836
ENSG00000133247 E007 15.545865 0.0037217023 1.232172e-02 3.430644e-02 19 55340604 55340714 111 + 1.309 1.088 -0.784
ENSG00000133247 E008 3.536439 0.0045131221 1.200364e-02 3.353962e-02 19 55341616 55341793 178 + 0.852 0.488 -1.557
ENSG00000133247 E009 129.320698 0.0019535421 2.210827e-02 5.589753e-02 19 55341794 55341840 47 + 1.965 2.071 0.356
ENSG00000133247 E010 237.965188 0.0002548235 5.175227e-01 6.519042e-01 19 55341841 55342046 206 + 2.289 2.316 0.088
ENSG00000133247 E011 8.554240 0.0019786083 2.649923e-05 1.596959e-04 19 55342047 55342214 168 + 1.212 0.762 -1.677
ENSG00000133247 E012 69.520781 0.0008903172 6.617064e-01 7.701397e-01 19 55342215 55342321 107 + 1.786 1.775 -0.038
ENSG00000133247 E013 53.564606 0.0004637372 1.826673e-01 3.045318e-01 19 55342322 55342380 59 + 1.711 1.650 -0.207
ENSG00000133247 E014 5.793709 0.0029161252 1.381324e-02 3.780357e-02 19 55342618 55342647 30 + 0.985 0.676 -1.210
ENSG00000133247 E015 106.283386 0.0003122820 1.775680e-01 2.980845e-01 19 55342742 55342774 33 + 1.995 1.953 -0.139
ENSG00000133247 E016 147.055785 0.0002863238 2.215231e-01 3.522248e-01 19 55342775 55342851 77 + 2.125 2.096 -0.100
ENSG00000133247 E017 12.838546 0.0020514405 1.674308e-04 8.241553e-04 19 55342852 55343679 828 + 1.309 0.960 -1.255
ENSG00000133247 E018 117.071411 0.0003183824 2.450278e-01 3.800508e-01 19 55343680 55343723 44 + 1.967 2.020 0.176
ENSG00000133247 E019 172.269775 0.0002602949 1.062384e-01 1.999856e-01 19 55343724 55343843 120 + 2.129 2.187 0.196
ENSG00000133247 E020 5.557499 0.0030529304 1.868611e-01 3.097896e-01 19 55343844 55343977 134 + 0.882 0.713 -0.671
ENSG00000133247 E021 80.543374 0.0003413082 3.780388e-01 5.223382e-01 19 55343978 55343997 20 + 1.865 1.836 -0.098
ENSG00000133247 E022 7.893074 0.0021468124 6.749759e-07 5.813957e-06 19 55343998 55344379 382 + 1.225 0.676 -2.077
ENSG00000133247 E023 24.617228 0.0365342091 6.896215e-04 2.861232e-03 19 55344631 55345193 563 + 1.598 1.211 -1.341
ENSG00000133247 E024 10.572897 0.0016901267 2.054006e-04 9.871014e-04 19 55346073 55346212 140 + 1.251 0.884 -1.338
ENSG00000133247 E025 168.785105 0.0002285650 3.795711e-01 5.238365e-01 19 55346213 55346349 137 + 2.137 2.173 0.121
ENSG00000133247 E026 142.344682 0.0002372739 5.048607e-01 6.407251e-01 19 55346500 55346687 188 + 2.100 2.087 -0.041
ENSG00000133247 E027 0.000000       19 55346688 55346731 44 +      
ENSG00000133247 E028 488.244349 0.0050657622 4.703425e-02 1.038846e-01 19 55346956 55348286 1331 + 2.567 2.646 0.263