ENSG00000133226

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000323848 ENSG00000133226 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM1 protein_coding protein_coding 65.55286 52.46006 81.53854 0.7565832 3.262253 0.6361645 34.573243 35.1651240 35.919641 0.98227491 4.4382838 0.030619 0.54171250 0.670200000 0.43760000 -0.23260000 1.294553e-04 4.89423e-16 FALSE TRUE
ENST00000462710 ENSG00000133226 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM1 protein_coding retained_intron 65.55286 52.46006 81.53854 0.7565832 3.262253 0.6361645 2.844258 0.3305656 4.773536 0.05496225 0.5726058 3.812073 0.03990833 0.006266667 0.05840000 0.05213333 4.894230e-16 4.89423e-16   FALSE
MSTRG.568.19 ENSG00000133226 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM1 protein_coding   65.55286 52.46006 81.53854 0.7565832 3.262253 0.6361645 3.023043 4.7404497 2.327972 0.89104463 0.3299956 -1.022806 0.04993333 0.090866667 0.02853333 -0.06233333 1.424797e-03 4.89423e-16 FALSE TRUE
MSTRG.568.20 ENSG00000133226 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM1 protein_coding   65.55286 52.46006 81.53854 0.7565832 3.262253 0.6361645 2.044441 2.9491532 0.000000 1.63848804 0.0000000 -8.209041 0.03118333 0.055700000 0.00000000 -0.05570000 1.457597e-01 4.89423e-16 FALSE TRUE
MSTRG.568.23 ENSG00000133226 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM1 protein_coding   65.55286 52.46006 81.53854 0.7565832 3.262253 0.6361645 3.468625 1.5141765 5.516327 0.10167343 0.3235922 1.858291 0.05103750 0.028900000 0.06820000 0.03930000 6.935862e-05 4.89423e-16 FALSE TRUE
MSTRG.568.6 ENSG00000133226 HEK293_OSMI2_2hA HEK293_TMG_2hB SRRM1 protein_coding   65.55286 52.46006 81.53854 0.7565832 3.262253 0.6361645 4.008998 4.7314173 1.941508 0.61716453 1.9415077 -1.280729 0.06147083 0.090500000 0.02293333 -0.06756667 1.027243e-01 4.89423e-16 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133226 E001 0.0000000       1 24631716 24631777 62 +      
ENSG00000133226 E002 0.0000000       1 24633019 24633065 47 +      
ENSG00000133226 E003 0.0000000       1 24633066 24633099 34 +      
ENSG00000133226 E004 0.0000000       1 24635644 24635877 234 +      
ENSG00000133226 E005 0.0000000       1 24641231 24641392 162 +      
ENSG00000133226 E006 0.1472490 0.0438163130 6.621623e-01   1 24643133 24643168 36 + 0.098 0.000 -11.882
ENSG00000133226 E007 0.2924217 0.0272524731 3.086873e-01   1 24643169 24643187 19 + 0.178 0.000 -12.876
ENSG00000133226 E008 0.7353267 0.0751823386 3.359279e-01 4.797411e-01 1 24643188 24643189 2 + 0.304 0.151 -1.280
ENSG00000133226 E009 0.7353267 0.0751823386 3.359279e-01 4.797411e-01 1 24643190 24643191 2 + 0.304 0.151 -1.280
ENSG00000133226 E010 0.9170311 0.0300372345 6.856294e-01 7.883328e-01 1 24643192 24643192 1 + 0.304 0.264 -0.276
ENSG00000133226 E011 1.0642801 0.0124392430 4.780398e-01 6.164914e-01 1 24643193 24643201 9 + 0.355 0.264 -0.597
ENSG00000133226 E012 3.4009346 0.0045376604 1.656193e-01 2.825122e-01 1 24643202 24643213 12 + 0.703 0.545 -0.690
ENSG00000133226 E013 4.0620506 0.0038652240 1.226417e-01 2.237233e-01 1 24643214 24643216 3 + 0.764 0.594 -0.715
ENSG00000133226 E014 5.9400062 0.0026958187 1.091633e-01 2.043099e-01 1 24643217 24643240 24 + 0.894 0.748 -0.570
ENSG00000133226 E015 7.2632823 0.0022902863 1.211280e-01 2.215497e-01 1 24643241 24643261 21 + 0.959 0.836 -0.467
ENSG00000133226 E016 10.0960206 0.0059881298 7.634358e-02 1.536515e-01 1 24643262 24643271 10 + 1.084 0.953 -0.482
ENSG00000133226 E017 9.9883987 0.0310595186 1.643506e-01 2.808407e-01 1 24643272 24643274 3 + 1.074 0.956 -0.435
ENSG00000133226 E018 15.4230682 0.0026664928 1.077553e-01 2.022202e-01 1 24643275 24643287 13 + 1.235 1.159 -0.273
ENSG00000133226 E019 24.9663109 0.0027174441 3.091193e-02 7.374418e-02 1 24643288 24643292 5 + 1.440 1.350 -0.314
ENSG00000133226 E020 27.8365259 0.0025969332 2.436344e-02 6.056874e-02 1 24643293 24643298 6 + 1.486 1.396 -0.309
ENSG00000133226 E021 37.6182823 0.0017385569 2.790045e-03 9.644654e-03 1 24643299 24643301 3 + 1.623 1.511 -0.384
ENSG00000133226 E022 42.3882964 0.0015807908 2.277962e-02 5.728946e-02 1 24643302 24643304 3 + 1.656 1.597 -0.202
ENSG00000133226 E023 45.3733814 0.0033178576 1.781452e-02 4.673870e-02 1 24643305 24643307 3 + 1.689 1.619 -0.236
ENSG00000133226 E024 205.0681553 0.0007982261 1.507460e-09 2.161875e-08 1 24643308 24643347 40 + 2.346 2.245 -0.338
ENSG00000133226 E025 1.1008118 0.0113178264 9.507162e-01 9.731538e-01 1 24643559 24643732 174 + 0.304 0.353 0.310
ENSG00000133226 E026 302.0192720 0.0005957117 2.329868e-10 3.856252e-09 1 24645984 24646073 90 + 2.506 2.428 -0.260
ENSG00000133226 E027 388.4100286 0.0004831302 5.960756e-11 1.090639e-09 1 24646667 24646789 123 + 2.610 2.546 -0.215
ENSG00000133226 E028 11.1725229 0.0014985482 6.474237e-14 1.890160e-12 1 24646790 24647078 289 + 1.284 0.353 -3.859
ENSG00000133226 E029 52.1876325 0.0004189766 8.916313e-33 1.836053e-30 1 24647079 24647208 130 + 1.890 1.259 -2.160
ENSG00000133226 E030 75.9397863 0.0123483951 3.589730e-31 6.520265e-29 1 24647209 24648023 815 + 2.079 1.186 -3.052
ENSG00000133226 E031 30.2667558 0.0306165953 7.807434e-10 1.181578e-08 1 24648024 24648166 143 + 1.662 0.995 -2.335
ENSG00000133226 E032 48.8962200 0.0030590865 7.622501e-36 1.964707e-33 1 24648167 24648533 367 + 1.886 1.043 -2.917
ENSG00000133226 E033 21.1647960 0.0008806672 2.388777e-16 9.816632e-15 1 24648534 24648617 84 + 1.517 0.836 -2.444
ENSG00000133226 E034 37.1288326 0.0024919707 5.693827e-25 6.220753e-23 1 24648618 24648858 241 + 1.755 1.043 -2.477
ENSG00000133226 E035 406.8219742 0.0015291781 3.872177e-05 2.239232e-04 1 24648859 24649029 171 + 2.618 2.584 -0.113
ENSG00000133226 E036 192.5662793 0.0021285375 1.159752e-03 4.504315e-03 1 24649971 24649987 17 + 2.297 2.258 -0.131
ENSG00000133226 E037 313.5047268 0.0004092308 6.817006e-08 7.151740e-07 1 24649988 24650086 99 + 2.511 2.463 -0.160
ENSG00000133226 E038 4.1008610 0.0040019155 4.973133e-02 1.086836e-01 1 24650565 24650627 63 + 0.783 0.546 -1.011
ENSG00000133226 E039 284.1886997 0.0013442899 3.799978e-03 1.258161e-02 1 24651409 24651498 90 + 2.453 2.446 -0.023
ENSG00000133226 E040 207.0176777 0.0002553253 2.062580e-02 5.279743e-02 1 24651499 24651519 21 + 2.306 2.319 0.043
ENSG00000133226 E041 294.8255066 0.0003865073 1.045401e-03 4.116056e-03 1 24651520 24651612 93 + 2.466 2.465 -0.005
ENSG00000133226 E042 236.8320013 0.0007547673 3.592096e-04 1.615813e-03 1 24652434 24652496 63 + 2.381 2.359 -0.073
ENSG00000133226 E043 284.5417730 0.0029051664 6.908716e-03 2.098805e-02 1 24652497 24652628 132 + 2.457 2.439 -0.059
ENSG00000133226 E044 150.2651293 0.0039963797 8.086648e-02 1.608913e-01 1 24652913 24652927 15 + 2.173 2.172 -0.005
ENSG00000133226 E045 295.8184658 0.0023347482 2.590376e-03 9.036386e-03 1 24652928 24653032 105 + 2.475 2.453 -0.072
ENSG00000133226 E046 4.1917360 0.1367355355 9.306992e-04 3.721755e-03 1 24654306 24654343 38 + 0.893 0.153 -4.011
ENSG00000133226 E047 133.0584457 0.0034729241 2.704500e-02 6.608883e-02 1 24654855 24654857 3 + 2.129 2.108 -0.072
ENSG00000133226 E048 435.1868844 0.0002546907 5.820550e-10 9.020662e-09 1 24654858 24655010 153 + 2.651 2.609 -0.141
ENSG00000133226 E049 251.0206766 0.0018637946 5.181044e-03 1.642129e-02 1 24655011 24655021 11 + 2.402 2.388 -0.049
ENSG00000133226 E050 300.6827919 0.0023720579 1.749646e-03 6.439094e-03 1 24655022 24655053 32 + 2.485 2.458 -0.092
ENSG00000133226 E051 372.9151059 0.0009755117 4.099723e-04 1.812542e-03 1 24655054 24655123 70 + 2.571 2.559 -0.040
ENSG00000133226 E052 149.5006812 0.0007267021 8.847603e-03 2.590163e-02 1 24655124 24655129 6 + 2.175 2.163 -0.039
ENSG00000133226 E053 336.0671439 0.0006521801 4.157962e-01 5.591339e-01 1 24660719 24660799 81 + 2.498 2.551 0.178
ENSG00000133226 E054 1.0414660 0.0127560836 1.208644e-02 3.374211e-02 1 24660800 24660975 176 + 0.443 0.000 -14.684
ENSG00000133226 E055 147.1764416 0.0002295191 7.380066e-01 8.280120e-01 1 24661310 24661312 3 + 2.130 2.212 0.275
ENSG00000133226 E056 319.9239834 0.0001565764 1.978836e-01 3.235724e-01 1 24661313 24661396 84 + 2.457 2.555 0.329
ENSG00000133226 E057 360.2029422 0.0011325958 4.119207e-01 5.554719e-01 1 24662660 24662804 145 + 2.511 2.604 0.311
ENSG00000133226 E058 7.0327697 0.0047555296 4.141495e-04 1.828592e-03 1 24662805 24663068 264 + 1.036 0.638 -1.562
ENSG00000133226 E059 76.8499639 0.0096961206 4.502306e-02 1.002454e-01 1 24663183 24663224 42 + 1.910 1.859 -0.172
ENSG00000133226 E060 8.3455580 0.0271923419 1.820272e-01 3.037533e-01 1 24666555 24666814 260 + 1.005 0.889 -0.435
ENSG00000133226 E061 323.8747229 0.0018222555 7.033357e-01 8.020226e-01 1 24666815 24666925 111 + 2.479 2.542 0.209
ENSG00000133226 E062 947.9671678 0.0015711888 8.907486e-01 9.342225e-01 1 24669123 24669582 460 + 2.938 3.014 0.255
ENSG00000133226 E063 209.5870441 0.0056882829 3.280548e-01 4.715080e-01 1 24669583 24669587 5 + 2.267 2.381 0.381
ENSG00000133226 E064 16.7099956 0.0115156971 6.884642e-03 2.092498e-02 1 24669588 24670119 532 + 1.317 1.118 -0.704
ENSG00000133226 E065 559.4597595 0.0022710974 8.180142e-01 8.849431e-01 1 24670120 24670315 196 + 2.708 2.787 0.262
ENSG00000133226 E066 556.0439975 0.0010225087 2.850368e-02 6.902113e-02 1 24671386 24671595 210 + 2.686 2.804 0.395
ENSG00000133226 E067 1911.3435609 0.0056493242 6.823073e-32 1.303035e-29 1 24672182 24673281 1100 + 3.024 3.481 1.521