ENSG00000133114

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379151 ENSG00000133114 HEK293_OSMI2_2hA HEK293_TMG_2hB GPALPP1 protein_coding protein_coding 12.64274 4.490671 21.15894 0.5078661 0.5276725 2.233737 1.0735752 0.3178057 1.5093089 0.05721608 0.16963425 2.2125024 0.08795417 0.07500000 0.071400000 -0.00360000 1.000000e+00 4.58795e-12 FALSE TRUE
ENST00000479068 ENSG00000133114 HEK293_OSMI2_2hA HEK293_TMG_2hB GPALPP1 protein_coding processed_transcript 12.64274 4.490671 21.15894 0.5078661 0.5276725 2.233737 0.4310056 0.3374277 0.5568857 0.18503631 0.13362485 0.7063452 0.05545417 0.07093333 0.026100000 -0.04483333 7.130582e-01 4.58795e-12 FALSE FALSE
ENST00000497558 ENSG00000133114 HEK293_OSMI2_2hA HEK293_TMG_2hB GPALPP1 protein_coding nonsense_mediated_decay 12.64274 4.490671 21.15894 0.5078661 0.5276725 2.233737 2.8023676 0.8674273 5.2176836 0.29133427 0.32542479 2.5748203 0.20265417 0.18536667 0.246133333 0.06076667 5.744229e-01 4.58795e-12 TRUE TRUE
ENST00000611650 ENSG00000133114 HEK293_OSMI2_2hA HEK293_TMG_2hB GPALPP1 protein_coding protein_coding 12.64274 4.490671 21.15894 0.5078661 0.5276725 2.233737 0.4962018 0.4955086 0.1874474 0.05003800 0.03917509 -1.3562670 0.08805833 0.11083333 0.008966667 -0.10186667 4.587950e-12 4.58795e-12   FALSE
MSTRG.8686.1 ENSG00000133114 HEK293_OSMI2_2hA HEK293_TMG_2hB GPALPP1 protein_coding   12.64274 4.490671 21.15894 0.5078661 0.5276725 2.233737 6.7113171 2.1118943 10.7567906 0.27860365 0.22479636 2.3431635 0.48237917 0.47323333 0.508533333 0.03530000 7.756041e-01 4.58795e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133114 E001 0.7331366 0.0180549755 8.962659e-01 9.377047e-01 13 44989518 44989528 11 + 0.198 0.239 0.345
ENSG00000133114 E002 0.7331366 0.0180549755 8.962659e-01 9.377047e-01 13 44989529 44989537 9 + 0.198 0.239 0.345
ENSG00000133114 E003 1.2490799 0.0940292431 6.049356e-01 7.253690e-01 13 44989538 44989549 12 + 0.271 0.393 0.765
ENSG00000133114 E004 9.0856409 0.1010578236 4.764635e-01 6.150824e-01 13 44989550 44989557 8 + 0.873 1.029 0.585
ENSG00000133114 E005 16.9917096 0.0343685960 6.533131e-01 7.638268e-01 13 44989558 44989563 6 + 1.136 1.220 0.299
ENSG00000133114 E006 47.6792406 0.0005815355 4.612305e-01 6.012146e-01 13 44989564 44989614 51 + 1.587 1.568 -0.066
ENSG00000133114 E007 47.6719674 0.0005787511 3.739160e-01 5.183430e-01 13 44989615 44989619 5 + 1.589 1.559 -0.102
ENSG00000133114 E008 88.4460035 0.0077770409 5.194287e-01 6.535389e-01 13 44989620 44989742 123 + 1.851 1.833 -0.059
ENSG00000133114 E009 6.6749298 0.0025737433 8.802508e-16 3.351304e-14 13 44989743 44990427 685 + 0.362 1.362 4.083
ENSG00000133114 E010 3.6139437 0.0116127680 3.937890e-04 1.750895e-03 13 45001703 45002040 338 + 0.388 0.959 2.488
ENSG00000133114 E011 43.1279361 0.0039950595 1.816218e-01 3.032732e-01 13 45004305 45004310 6 + 1.555 1.483 -0.249
ENSG00000133114 E012 100.3514378 0.0014055228 6.808456e-04 2.828972e-03 13 45004311 45004437 127 + 1.928 1.786 -0.479
ENSG00000133114 E013 0.0000000       13 45005110 45005241 132 +      
ENSG00000133114 E014 104.7987213 0.0002760493 7.787684e-06 5.303974e-05 13 45006202 45006303 102 + 1.953 1.771 -0.615
ENSG00000133114 E015 101.0335733 0.0003267635 1.422061e-07 1.403152e-06 13 45008795 45008879 85 + 1.945 1.713 -0.782
ENSG00000133114 E016 131.4409516 0.0002457505 3.536823e-06 2.605944e-05 13 45014952 45015083 132 + 2.048 1.884 -0.551
ENSG00000133114 E017 140.2502067 0.0002669412 4.337594e-01 5.761652e-01 13 45015432 45015596 165 + 2.048 2.048 0.001
ENSG00000133114 E018 107.9680943 0.0009299923 1.397399e-01 2.476640e-01 13 45020330 45020413 84 + 1.917 2.009 0.309
ENSG00000133114 E019 51.5160549 0.0004666712 3.455109e-04 1.561972e-03 13 45020414 45020428 15 + 1.567 1.797 0.778
ENSG00000133114 E020 108.2272936 0.0003339322 3.075003e-03 1.048714e-02 13 45027785 45028003 219 + 1.904 2.051 0.496
ENSG00000133114 E021 19.6070814 0.0210590119 3.042390e-02 7.279258e-02 13 45028004 45029238 1235 + 1.151 1.404 0.890
ENSG00000133114 E022 179.7316208 0.0002811954 6.311475e-03 1.943264e-02 13 45029239 45030435 1197 + 2.167 2.104 -0.210
ENSG00000133114 E023 53.9413633 0.0004642385 6.920262e-01 7.933477e-01 13 45030436 45031091 656 + 1.641 1.646 0.019
ENSG00000133114 E024 17.9810779 0.0009994678 1.869740e-01 3.099278e-01 13 45031092 45031203 112 + 1.150 1.303 0.539
ENSG00000133114 E025 62.3337928 0.0003752471 2.804624e-01 4.203142e-01 13 45031204 45031665 462 + 1.683 1.771 0.297
ENSG00000133114 E026 88.7393229 0.0010682322 2.536574e-01 3.902185e-01 13 45031666 45032107 442 + 1.836 1.920 0.281
ENSG00000133114 E027 66.5423215 0.0778890202 1.124554e-03 4.385504e-03 13 45033236 45033813 578 + 1.571 2.091 1.753
ENSG00000133114 E028 13.0598491 0.0019302618 8.242477e-01 8.892795e-01 13 45033814 45036129 2316 + 1.051 1.052 0.004
ENSG00000133114 E029 12.2878773 0.0017030595 7.411812e-01 8.304475e-01 13 45036130 45037669 1540 + 1.034 1.023 -0.041