ENSG00000133104

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000491805 ENSG00000133104 HEK293_OSMI2_2hA HEK293_TMG_2hB SPART protein_coding processed_transcript 26.68082 7.731523 44.69003 0.5365675 2.348292 2.529586 3.569236 0.000000 5.128569 0.0000000 0.2837893 9.005223 0.1178792 0.0000000 0.1157333 0.1157333 3.060496e-16 3.060496e-16 FALSE TRUE
ENST00000494062 ENSG00000133104 HEK293_OSMI2_2hA HEK293_TMG_2hB SPART protein_coding protein_coding 26.68082 7.731523 44.69003 0.5365675 2.348292 2.529586 13.092203 5.448463 21.496132 0.3622749 0.4969074 1.978181 0.5546792 0.7059000 0.4826333 -0.2232667 7.022636e-06 3.060496e-16 FALSE TRUE
ENST00000494703 ENSG00000133104 HEK293_OSMI2_2hA HEK293_TMG_2hB SPART protein_coding processed_transcript 26.68082 7.731523 44.69003 0.5365675 2.348292 2.529586 6.622435 1.017811 11.748230 0.5089125 0.9108880 3.516024 0.1901917 0.1268667 0.2623000 0.1354333 5.927183e-01 3.060496e-16 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133104 E001 0.0000000       13 36301638 36301639 2 -      
ENSG00000133104 E002 0.0000000       13 36301640 36301651 12 -      
ENSG00000133104 E003 39.2235600 0.0511129853 8.077058e-01 8.778166e-01 13 36301652 36303185 1534 - 1.514 1.602 0.299
ENSG00000133104 E004 18.6892803 0.0867673430 1.132624e-01 2.102820e-01 13 36303186 36303601 416 - 1.129 1.461 1.162
ENSG00000133104 E005 267.4900024 0.0018766451 2.643294e-31 4.842980e-29 13 36303602 36304321 720 - 2.247 2.598 1.172
ENSG00000133104 E006 175.9645182 0.0008424509 7.890986e-03 2.350583e-02 13 36304322 36304450 129 - 2.149 2.250 0.339
ENSG00000133104 E007 103.9163418 0.0002651951 9.519383e-01 9.739101e-01 13 36304451 36304456 6 - 1.944 1.961 0.057
ENSG00000133104 E008 217.7931291 0.0001866749 3.562543e-01 5.006402e-01 13 36304457 36304632 176 - 2.268 2.257 -0.039
ENSG00000133104 E009 0.5922303 0.0180073638 8.185142e-01 8.852969e-01 13 36308419 36308444 26 - 0.172 0.219 0.433
ENSG00000133104 E010 0.0000000       13 36312142 36312144 3 -      
ENSG00000133104 E011 132.0457171 0.0009692224 3.508033e-01 4.949774e-01 13 36312145 36312235 91 - 2.037 2.087 0.168
ENSG00000133104 E012 145.2275511 0.0002567129 7.904975e-01 8.659899e-01 13 36312319 36312477 159 - 2.084 2.108 0.079
ENSG00000133104 E013 0.5911862 0.0172671820 4.065180e-01 5.501515e-01 13 36312478 36312584 107 - 0.217 0.000 -10.469
ENSG00000133104 E014 1.7810446 0.0134979426 8.621303e-01 9.151189e-01 13 36313968 36314082 115 - 0.390 0.364 -0.147
ENSG00000133104 E015 0.1451727 0.0428029756 1.000000e+00   13 36314222 36314226 5 - 0.065 0.000 -8.469
ENSG00000133104 E016 227.0210591 0.0002092802 5.425862e-01 6.733086e-01 13 36314227 36314421 195 - 2.283 2.280 -0.009
ENSG00000133104 E017 1.3233924 0.0106525978 8.825330e-02 1.724530e-01 13 36314422 36314441 20 - 0.390 0.000 -11.639
ENSG00000133104 E018 1.9530848 0.0079645644 8.114151e-01 8.803449e-01 13 36325923 36326574 652 - 0.418 0.472 0.282
ENSG00000133104 E019 204.3115115 0.0002401273 1.794577e-01 3.004528e-01 13 36326575 36326698 124 - 2.243 2.217 -0.087
ENSG00000133104 E020 130.5159879 0.0004249089 2.298428e-02 5.771494e-02 13 36329362 36329391 30 - 2.059 1.985 -0.247
ENSG00000133104 E021 185.7025243 0.0001856578 2.321041e-01 3.649383e-01 13 36329392 36329517 126 - 2.202 2.179 -0.076
ENSG00000133104 E022 193.9023432 0.0024297553 9.221693e-03 2.683845e-02 13 36331399 36331596 198 - 2.236 2.150 -0.285
ENSG00000133104 E023 177.6160055 0.0002223779 2.186334e-04 1.043600e-03 13 36335021 36335232 212 - 2.200 2.092 -0.362
ENSG00000133104 E024 233.7048842 0.0004180880 1.159854e-03 4.504621e-03 13 36335233 36335580 348 - 2.312 2.231 -0.272
ENSG00000133104 E025 203.4842072 0.0010546638 1.258637e-04 6.406333e-04 13 36335581 36335832 252 - 2.260 2.142 -0.393
ENSG00000133104 E026 17.4176078 0.0115150566 3.138120e-01 4.564391e-01 13 36336287 36336358 72 - 1.213 1.108 -0.375
ENSG00000133104 E027 0.4427912 0.1970863677 6.002567e-01 7.215291e-01 13 36345525 36345634 110 - 0.122 0.217 1.005
ENSG00000133104 E028 15.2861416 0.0025880098 5.890679e-03 1.832345e-02 13 36346225 36346313 89 - 1.196 0.878 -1.165
ENSG00000133104 E029 15.6500298 0.0010967437 2.081715e-02 5.320687e-02 13 36346314 36346581 268 - 1.196 0.948 -0.903
ENSG00000133104 E030 77.7559189 0.0003659400 3.094484e-04 1.417924e-03 13 36346582 36346914 333 - 1.856 1.683 -0.585
ENSG00000133104 E031 0.0000000       13 36368874 36368990 117 -      
ENSG00000133104 E032 0.0000000       13 36370089 36370180 92 -