ENSG00000133103

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000455146 ENSG00000133103 HEK293_OSMI2_2hA HEK293_TMG_2hB COG6 protein_coding protein_coding 7.272118 1.697505 12.03119 0.02643829 0.3510673 2.818017 6.2087622 1.48672 10.4011869 0.1105701 0.4168994 2.798258 0.82655417 0.8752667 0.86456667 -0.01070000 0.89336927 0.02911197 FALSE  
ENST00000460701 ENSG00000133103 HEK293_OSMI2_2hA HEK293_TMG_2hB COG6 protein_coding processed_transcript 7.272118 1.697505 12.03119 0.02643829 0.3510673 2.818017 0.4257492 0.00000 0.6028911 0.0000000 0.1630593 5.937559 0.08635417 0.0000000 0.05093333 0.05093333 0.02911197 0.02911197    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133103 E001 0.0000000       13 39655627 39655650 24 +      
ENSG00000133103 E002 0.0000000       13 39655651 39655661 11 +      
ENSG00000133103 E003 9.3808772 0.0017511177 6.907009e-01 7.923383e-01 13 39655662 39655723 62 + 0.883 0.854 -0.114
ENSG00000133103 E004 9.5260499 0.0017247299 6.564598e-01 7.660178e-01 13 39655724 39655726 3 + 0.890 0.854 -0.140
ENSG00000133103 E005 30.7537597 0.0016601679 1.001766e-02 2.880627e-02 13 39655727 39655879 153 + 1.379 1.151 -0.804
ENSG00000133103 E006 0.0000000       13 39656117 39656275 159 +      
ENSG00000133103 E007 0.6633060 0.0198320779 4.908708e-01 6.281978e-01 13 39656826 39656890 65 + 0.134 0.274 1.277
ENSG00000133103 E008 20.0919831 0.0011525493 1.561798e-01 2.700430e-01 13 39659364 39659395 32 + 1.194 1.062 -0.474
ENSG00000133103 E009 19.5655550 0.0010703975 4.663910e-01 6.059410e-01 13 39659396 39659413 18 + 1.173 1.123 -0.178
ENSG00000133103 E010 40.9967876 0.0019215261 6.139140e-02 1.289775e-01 13 39659414 39659507 94 + 1.487 1.360 -0.438
ENSG00000133103 E011 44.6049774 0.0027425499 1.966704e-02 5.077627e-02 13 39660810 39660881 72 + 1.527 1.361 -0.572
ENSG00000133103 E012 43.7974040 0.0006410001 6.262182e-03 1.929968e-02 13 39665096 39665154 59 + 1.522 1.326 -0.677
ENSG00000133103 E013 54.1584626 0.0012084576 9.731067e-04 3.867176e-03 13 39677468 39677579 112 + 1.615 1.392 -0.765
ENSG00000133103 E014 0.1472490 0.0442935721 8.204748e-01   13 39678092 39678144 53 + 0.050 0.001 -6.265
ENSG00000133103 E015 0.4804688 0.0224117365 3.302270e-01 4.738141e-01 13 39679347 39679537 191 + 0.094 0.273 1.860
ENSG00000133103 E016 46.7460948 0.0006783581 1.811895e-02 4.738515e-02 13 39679538 39679595 58 + 1.546 1.392 -0.530
ENSG00000133103 E017 36.4626585 0.0005489329 2.561206e-03 8.945992e-03 13 39679596 39679620 25 + 1.452 1.202 -0.873
ENSG00000133103 E018 0.3289534 0.0299300852 1.685277e-01   13 39679621 39679974 354 + 0.050 0.273 2.860
ENSG00000133103 E019 47.7531900 0.0005735089 4.883637e-02 1.070908e-01 13 39679975 39680045 71 + 1.554 1.436 -0.404
ENSG00000133103 E020 46.4680112 0.0022029102 3.198294e-01 4.629075e-01 13 39682171 39682264 94 + 1.533 1.489 -0.151
ENSG00000133103 E021 1.1480412 0.0307416777 2.807051e-01 4.205781e-01 13 39682265 39682473 209 + 0.205 0.441 1.541
ENSG00000133103 E022 25.7506787 0.0298999918 2.194561e-01 3.497367e-01 13 39687503 39687542 40 + 1.296 1.153 -0.507
ENSG00000133103 E023 31.5858354 0.0096482934 3.707757e-01 5.151922e-01 13 39687543 39687631 89 + 1.370 1.309 -0.213
ENSG00000133103 E024 1.3254687 0.0100131572 2.435157e-01 3.783031e-01 13 39687632 39687707 76 + 0.320 0.001 -9.435
ENSG00000133103 E025 32.4577143 0.0124344616 8.640626e-01 9.163397e-01 13 39687708 39687799 92 + 1.370 1.379 0.032
ENSG00000133103 E026 26.2376005 0.0063917425 2.145471e-01 3.439126e-01 13 39689760 39689824 65 + 1.262 1.408 0.509
ENSG00000133103 E027 25.0274969 0.0028421237 5.343330e-01 6.663931e-01 13 39694634 39694725 92 + 1.253 1.343 0.315
ENSG00000133103 E028 38.1431594 0.0005594183 9.221816e-01 9.549148e-01 13 39699501 39699618 118 + 1.439 1.463 0.085
ENSG00000133103 E029 58.6298971 0.0004548387 6.102016e-01 7.295501e-01 13 39719236 39719367 132 + 1.625 1.625 0.000
ENSG00000133103 E030 70.9440593 0.0003438089 3.696374e-01 5.140367e-01 13 39719660 39719827 168 + 1.693 1.776 0.282
ENSG00000133103 E031 64.1318051 0.0004497281 5.043763e-01 6.402741e-01 13 39723333 39723440 108 + 1.649 1.722 0.247
ENSG00000133103 E032 45.4435629 0.0005456116 8.154415e-02 1.619658e-01 13 39724508 39724561 54 + 1.492 1.643 0.514
ENSG00000133103 E033 53.1226898 0.0007773763 1.673177e-01 2.847068e-01 13 39727469 39727548 80 + 1.562 1.684 0.415
ENSG00000133103 E034 217.7775496 0.0084149160 1.564263e-06 1.245356e-05 13 39750946 39752628 1683 + 2.141 2.392 0.839
ENSG00000133103 E035 3.5805376 0.0044954040 2.498701e-01 3.857498e-01 13 39788335 39791665 3331 + 0.502 0.731 1.012