ENSG00000133065

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367137 ENSG00000133065 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A1 protein_coding protein_coding 26.36103 28.65959 21.00135 1.497707 0.5410008 -0.4483522 16.040541 12.39756 15.495133 1.2951093 0.8273047 0.3215265 0.6266833 0.4301 0.7408667 0.3107667 0.0039734105 0.0003612502 FALSE TRUE
ENST00000468057 ENSG00000133065 HEK293_OSMI2_2hA HEK293_TMG_2hB SLC41A1 protein_coding processed_transcript 26.36103 28.65959 21.00135 1.497707 0.5410008 -0.4483522 8.580632 15.18551 3.488215 0.2903096 1.0210893 -2.1189542 0.3049042 0.5331 0.1638000 -0.3693000 0.0003612502 0.0003612502 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133065 E001 0.2214452 0.0387338017 6.367043e-01   1 205789094 205789094 1 - 0.000 0.115 9.098
ENSG00000133065 E002 1593.4858006 0.0049815687 7.899999e-12 1.672027e-10 1 205789095 205790919 1825 - 3.044 3.279 0.782
ENSG00000133065 E003 419.6851223 0.0001963154 1.632225e-01 2.793619e-01 1 205790920 205791323 404 - 2.557 2.650 0.310
ENSG00000133065 E004 189.1267392 0.0002115760 9.014023e-02 1.753409e-01 1 205791324 205791431 108 - 2.256 2.280 0.078
ENSG00000133065 E005 248.2482044 0.0003072353 5.252434e-01 6.586429e-01 1 205791432 205791718 287 - 2.356 2.409 0.177
ENSG00000133065 E006 5.4518808 0.0074698965 8.909024e-01 9.343275e-01 1 205792285 205792349 65 - 0.771 0.847 0.298
ENSG00000133065 E007 144.1692159 0.0008948222 3.781314e-02 8.698740e-02 1 205794870 205795018 149 - 2.150 2.150 0.003
ENSG00000133065 E008 145.8072943 0.0021306502 3.284406e-02 7.749860e-02 1 205795344 205795478 135 - 2.161 2.153 -0.027
ENSG00000133065 E009 6.4792571 0.0060583029 4.313560e-04 1.894935e-03 1 205795479 205796616 1138 - 1.048 0.665 -1.486
ENSG00000133065 E010 125.1031121 0.0088003409 1.491405e-01 2.605012e-01 1 205796924 205797003 80 - 2.097 2.091 -0.020
ENSG00000133065 E011 172.5406099 0.0038939241 1.854598e-03 6.771929e-03 1 205797904 205798051 148 - 2.262 2.209 -0.175
ENSG00000133065 E012 140.8335931 0.0003174087 8.502295e-10 1.276031e-08 1 205798669 205798815 147 - 2.207 2.090 -0.393
ENSG00000133065 E013 134.6781458 0.0002778871 6.400778e-04 2.680567e-03 1 205798957 205799101 145 - 2.144 2.106 -0.127
ENSG00000133065 E014 116.4970306 0.0010921163 1.668074e-02 4.423640e-02 1 205799759 205799830 72 - 2.069 2.051 -0.060
ENSG00000133065 E015 135.8960411 0.0002788473 3.434746e-02 8.042796e-02 1 205800953 205801060 108 - 2.125 2.127 0.007
ENSG00000133065 E016 0.3729606 0.0299216706 8.264921e-01 8.908182e-01 1 205801321 205801488 168 - 0.130 0.115 -0.210
ENSG00000133065 E017 198.1031852 0.0018121718 1.326289e-06 1.072896e-05 1 205810070 205810298 229 - 2.337 2.252 -0.281
ENSG00000133065 E018 346.8543403 0.0009468997 2.062053e-18 1.092324e-16 1 205810299 205811087 789 - 2.604 2.473 -0.437
ENSG00000133065 E019 102.8090677 0.0011868285 1.460600e-07 1.437137e-06 1 205812808 205813198 391 - 2.078 1.947 -0.440
ENSG00000133065 E020 11.3987476 0.0214670862 2.651877e-03 9.228498e-03 1 205813695 205813948 254 - 1.225 0.936 -1.048