ENSG00000133059

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367161 ENSG00000133059 HEK293_OSMI2_2hA HEK293_TMG_2hB DSTYK protein_coding protein_coding 6.350176 5.015833 7.740087 0.6123365 0.06088082 0.6248498 1.6455385 1.07027988 2.4137626 0.55342500 0.1153347 1.1658433 0.25525833 0.1916333 0.3118333 0.12020000 0.67462243 0.01062408 FALSE  
ENST00000367162 ENSG00000133059 HEK293_OSMI2_2hA HEK293_TMG_2hB DSTYK protein_coding protein_coding 6.350176 5.015833 7.740087 0.6123365 0.06088082 0.6248498 4.1453184 3.83856236 4.1691397 0.20403728 0.2910861 0.1188864 0.66555417 0.7896000 0.5382000 -0.25140000 0.48603658 0.01062408 FALSE  
MSTRG.2916.5 ENSG00000133059 HEK293_OSMI2_2hA HEK293_TMG_2hB DSTYK protein_coding   6.350176 5.015833 7.740087 0.6123365 0.06088082 0.6248498 0.3652661 0.05195812 0.7824935 0.02789579 0.2775918 3.6770339 0.05182083 0.0092000 0.1016667 0.09246667 0.01062408 0.01062408 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133059 E001 518.6099117 0.0135840524 2.307990e-08 2.658813e-07 1 205142505 205145062 2558 - 2.549 2.862 1.041
ENSG00000133059 E002 321.8022057 0.0003319577 1.069413e-01 2.010210e-01 1 205145063 205147217 2155 - 2.489 2.533 0.146
ENSG00000133059 E003 29.9429093 0.0058994464 7.699978e-03 2.302592e-02 1 205147218 205147269 52 - 1.537 1.414 -0.425
ENSG00000133059 E004 34.0546953 0.0008428164 2.723133e-01 4.111786e-01 1 205147270 205147377 108 - 1.540 1.548 0.026
ENSG00000133059 E005 45.9726032 0.0006475147 2.941166e-01 4.351964e-01 1 205147378 205147494 117 - 1.609 1.737 0.433
ENSG00000133059 E006 73.6854119 0.0003778889 6.028443e-01 7.237364e-01 1 205147495 205147745 251 - 1.828 1.924 0.322
ENSG00000133059 E007 37.9907056 0.0005649278 9.947608e-01 1.000000e+00 1 205148205 205148339 135 - 1.556 1.630 0.252
ENSG00000133059 E008 50.4479681 0.0004770980 4.641182e-01 6.038860e-01 1 205150680 205150794 115 - 1.692 1.730 0.129
ENSG00000133059 E009 54.3514175 0.0132264522 1.873711e-01 3.104327e-01 1 205157273 205157386 114 - 1.751 1.722 -0.100
ENSG00000133059 E010 51.5250846 0.0156596175 2.350065e-01 3.683585e-01 1 205159547 205159679 133 - 1.726 1.702 -0.084
ENSG00000133059 E011 0.1451727 0.0438708919 6.438864e-01   1 205160006 205160113 108 - 0.100 0.000 -8.349
ENSG00000133059 E012 51.7652826 0.0043374686 4.475148e-03 1.447233e-02 1 205160114 205160270 157 - 1.758 1.666 -0.310
ENSG00000133059 E013 49.9902251 0.0028473448 5.339901e-05 2.987591e-04 1 205161258 205161387 130 - 1.764 1.609 -0.524
ENSG00000133059 E014 55.6214456 0.0004546449 2.800596e-04 1.298812e-03 1 205162036 205162212 177 - 1.794 1.696 -0.332
ENSG00000133059 E015 40.9834796 0.0006115386 3.609370e-03 1.203697e-02 1 205162923 205163006 84 - 1.659 1.572 -0.294
ENSG00000133059 E016 30.3270159 0.0007165471 4.296991e-03 1.397562e-02 1 205163723 205163751 29 - 1.537 1.427 -0.377
ENSG00000133059 E017 60.6504962 0.0023649796 3.559527e-04 1.603209e-03 1 205163752 205163955 204 - 1.830 1.723 -0.361
ENSG00000133059 E018 100.8923261 0.0242948741 2.059176e-02 5.273181e-02 1 205169163 205169645 483 - 2.049 1.937 -0.376
ENSG00000133059 E019 44.0611439 0.0202230583 1.914696e-03 6.961452e-03 1 205169646 205169832 187 - 1.723 1.529 -0.659
ENSG00000133059 E020 0.5546650 0.0223536891 4.132275e-01 5.567467e-01 1 205173037 205173393 357 - 0.100 0.260 1.660
ENSG00000133059 E021 12.8330246 0.0016092520 2.820709e-03 9.736088e-03 1 205187418 205187444 27 - 1.219 1.000 -0.791
ENSG00000133059 E022 43.4041843 0.0160198702 1.441548e-02 3.916772e-02 1 205187445 205187774 330 - 1.696 1.564 -0.448
ENSG00000133059 E023 12.9825835 0.0241595597 3.404472e-01 4.843986e-01 1 205187775 205187806 32 - 1.160 1.122 -0.136
ENSG00000133059 E024 28.0662984 0.0007329322 1.451650e-03 5.479066e-03 1 205211271 205211702 432 - 1.517 1.378 -0.478