ENSG00000133030

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000341712 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding protein_coding 56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 15.989118 23.993717 9.9415444 0.84539824 0.5041430 -1.2702655 0.27645833 0.31613333 0.24380000 -0.07233333 6.165980e-02 1.022679e-67 FALSE TRUE
ENST00000395811 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding protein_coding 56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 8.898260 6.759881 9.7768440 0.63941803 0.1116246 0.5317132 0.17617500 0.08833333 0.23940000 0.15106667 2.285938e-33 1.022679e-67 FALSE TRUE
ENST00000429184 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding protein_coding 56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 1.854692 5.664314 0.0000000 1.27672651 0.0000000 -9.1483023 0.02617500 0.07733333 0.00000000 -0.07733333 6.780108e-14 1.022679e-67 FALSE TRUE
ENST00000462033 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding protein_coding 56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 3.140174 1.637114 1.6064779 1.23187415 0.4222616 -0.0270865 0.06146250 0.02033333 0.03956667 0.01923333 6.072193e-01 1.022679e-67   FALSE
ENST00000577514 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding protein_coding 56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 5.717564 4.742420 7.2294205 2.37177635 1.8839848 0.6072120 0.11287083 0.05856667 0.17616667 0.11760000 5.890800e-01 1.022679e-67 FALSE FALSE
ENST00000581989 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding processed_transcript 56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 2.270000 5.152905 0.0000000 0.90085837 0.0000000 -9.0120393 0.03366667 0.06983333 0.00000000 -0.06983333 3.252490e-15 1.022679e-67   FALSE
ENST00000584067 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding protein_coding 56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 6.925456 15.383061 0.0000000 1.28133483 0.0000000 -10.5880644 0.10470000 0.20180000 0.00000000 -0.20180000 1.022679e-67 1.022679e-67 FALSE TRUE
MSTRG.13749.4 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding   56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 1.260178 0.216796 4.3129284 0.08133262 0.1872374 4.2525418 0.02603333 0.00270000 0.10553333 0.10283333 3.752127e-39 1.022679e-67 FALSE TRUE
MSTRG.13749.8 ENSG00000133030 HEK293_OSMI2_2hA HEK293_TMG_2hB MPRIP protein_coding   56.12821 76.26003 40.84312 5.163826 0.5135506 -0.9006699 3.223343 5.199921 0.9172745 0.99839700 0.1974607 -2.4901929 0.05427083 0.06700000 0.02236667 -0.04463333 3.261904e-03 1.022679e-67 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000133030 E001 3.0968702 0.0051300980 5.379106e-02 1.158913e-01 17 17042449 17042456 8 + 0.761 0.470 -1.290
ENSG00000133030 E002 5.5252375 0.0036378956 7.433138e-03 2.234435e-02 17 17042457 17042474 18 + 0.986 0.645 -1.344
ENSG00000133030 E003 13.0820805 0.0030826440 7.225773e-14 2.094722e-12 17 17042475 17042537 63 + 1.465 0.751 -2.604
ENSG00000133030 E004 13.2668934 0.0375318863 2.760617e-08 3.130496e-07 17 17042538 17042544 7 + 1.472 0.754 -2.615
ENSG00000133030 E005 15.3477491 0.0316899878 6.560933e-11 1.192964e-09 17 17042545 17042596 52 + 1.553 0.754 -2.895
ENSG00000133030 E006 19.7387757 0.0202146630 1.607789e-25 1.857261e-23 17 17042597 17042759 163 + 1.732 0.506 -4.584
ENSG00000133030 E007 8.4260574 0.0033891135 7.047772e-22 5.528693e-20 17 17042760 17042774 15 + 1.396 0.173 -5.612
ENSG00000133030 E008 10.0890243 0.0016685274 1.818177e-22 1.527486e-20 17 17042775 17042786 12 + 1.452 0.346 -4.486
ENSG00000133030 E009 18.8228894 0.0009450825 3.910811e-17 1.765709e-15 17 17042787 17042806 20 + 1.598 0.933 -2.352
ENSG00000133030 E010 33.6619216 0.0400224347 1.408018e-05 9.035459e-05 17 17042807 17042848 42 + 1.766 1.294 -1.618
ENSG00000133030 E011 201.8399628 0.0002226438 2.817003e-09 3.844073e-08 17 17042849 17042971 123 + 2.370 2.220 -0.502
ENSG00000133030 E012 8.3208824 0.0029788957 4.015908e-01 5.452875e-01 17 17057636 17057950 315 + 0.876 0.979 0.391
ENSG00000133030 E013 294.7469475 0.0008784995 2.407744e-07 2.272518e-06 17 17075710 17075787 78 + 2.518 2.394 -0.416
ENSG00000133030 E014 314.7127450 0.0005352314 2.189473e-13 5.931490e-12 17 17078011 17078076 66 + 2.570 2.407 -0.542
ENSG00000133030 E015 23.2653418 0.0008191203 7.783527e-04 3.181303e-03 17 17096768 17097337 570 + 1.147 1.425 0.977
ENSG00000133030 E016 393.5353010 0.0009546813 3.827169e-07 3.462988e-06 17 17126702 17126853 152 + 2.637 2.524 -0.374
ENSG00000133030 E017 188.8055703 0.0019458308 3.666919e-01 5.110359e-01 17 17131617 17131665 49 + 2.263 2.238 -0.083
ENSG00000133030 E018 190.0089797 0.0036187066 8.747928e-01 9.235340e-01 17 17131666 17131701 36 + 2.241 2.253 0.043
ENSG00000133030 E019 241.0884634 0.0001872442 4.004620e-01 5.441645e-01 17 17136219 17136337 119 + 2.362 2.346 -0.054
ENSG00000133030 E020 240.2182218 0.0002450913 9.191493e-01 9.529333e-01 17 17136338 17136450 113 + 2.348 2.350 0.006
ENSG00000133030 E021 302.3698964 0.0001881332 3.456639e-01 4.897869e-01 17 17137916 17138075 160 + 2.460 2.443 -0.055
ENSG00000133030 E022 11.2749286 0.0016161637 5.620490e-01 6.897437e-01 17 17138076 17138131 56 + 1.005 1.070 0.238
ENSG00000133030 E023 18.1491002 0.0016599369 6.435743e-01 7.560862e-01 17 17138132 17138246 115 + 1.274 1.239 -0.122
ENSG00000133030 E024 27.2235276 0.0007447184 7.763398e-01 8.559745e-01 17 17138247 17138429 183 + 1.425 1.409 -0.054
ENSG00000133030 E025 1.1049513 0.0675953716 2.907117e-01 4.315183e-01 17 17141495 17141760 266 + 0.437 0.238 -1.249
ENSG00000133030 E026 3.0871929 0.0418910986 5.205462e-02 1.128122e-01 17 17142010 17142312 303 + 0.793 0.468 -1.425
ENSG00000133030 E027 335.2109556 0.0013022750 8.852875e-01 9.306467e-01 17 17142627 17142765 139 + 2.491 2.493 0.007
ENSG00000133030 E028 320.3960736 0.0001687448 7.410375e-01 8.303406e-01 17 17143556 17143669 114 + 2.464 2.475 0.039
ENSG00000133030 E029 288.7757466 0.0010081737 8.437033e-02 1.664047e-01 17 17146036 17146092 57 + 2.456 2.416 -0.133
ENSG00000133030 E030 307.9174857 0.0037466991 5.393517e-01 6.706317e-01 17 17147319 17147387 69 + 2.467 2.453 -0.045
ENSG00000133030 E031 1.3464834 0.6181259586 4.255414e-01 5.684858e-01 17 17149760 17150143 384 + 0.504 0.279 -1.280
ENSG00000133030 E032 378.4982234 0.0011246789 7.640236e-01 8.471924e-01 17 17150144 17150233 90 + 2.547 2.546 -0.004
ENSG00000133030 E033 314.1880874 0.0006330951 7.283279e-01 8.208161e-01 17 17154306 17154351 46 + 2.455 2.468 0.045
ENSG00000133030 E034 378.2405719 0.0032298599 8.587989e-01 9.129091e-01 17 17154352 17154415 64 + 2.536 2.550 0.047
ENSG00000133030 E035 375.7390435 0.0026948256 3.657232e-01 5.100122e-01 17 17158432 17158496 65 + 2.558 2.536 -0.073
ENSG00000133030 E036 867.5629011 0.0009444556 5.463563e-02 1.173639e-01 17 17158497 17159002 506 + 2.874 2.919 0.148
ENSG00000133030 E037 347.1278370 0.0040421264 8.930545e-03 2.610500e-02 17 17161240 17161356 117 + 2.431 2.539 0.359
ENSG00000133030 E038 62.5372556 0.0182197379 4.679804e-02 1.034643e-01 17 17164109 17165555 1447 + 1.867 1.713 -0.519
ENSG00000133030 E039 121.3096837 0.0002455835 5.865734e-01 7.101202e-01 17 17165556 17167915 2360 + 2.063 2.049 -0.048
ENSG00000133030 E040 5.2305824 0.0453821304 7.145922e-01 8.107350e-01 17 17170860 17171490 631 + 0.793 0.737 -0.223
ENSG00000133030 E041 186.3427589 0.0105686450 1.282548e-01 2.317115e-01 17 17171718 17171719 2 + 2.164 2.269 0.350
ENSG00000133030 E042 499.6058343 0.0015417206 2.596994e-03 9.056804e-03 17 17171720 17171865 146 + 2.606 2.690 0.281
ENSG00000133030 E043 303.9709097 0.0001824323 3.253729e-02 7.687626e-02 17 17172698 17172720 23 + 2.413 2.465 0.175
ENSG00000133030 E044 426.0872991 0.0003278510 6.372297e-02 1.328988e-01 17 17172721 17172815 95 + 2.567 2.609 0.140
ENSG00000133030 E045 498.6153264 0.0003885101 1.165650e-06 9.544818e-06 17 17173916 17174075 160 + 2.592 2.692 0.332
ENSG00000133030 E046 358.7181328 0.0019195338 6.370085e-04 2.669897e-03 17 17175293 17175363 71 + 2.445 2.553 0.359
ENSG00000133030 E047 289.4252660 0.0019805952 2.413657e-04 1.139107e-03 17 17175364 17175412 49 + 2.342 2.464 0.406
ENSG00000133030 E048 499.0612454 0.0003599595 1.456515e-08 1.741997e-07 17 17176426 17176512 87 + 2.583 2.697 0.382
ENSG00000133030 E049 286.4187670 0.0001508539 1.830457e-07 1.767274e-06 17 17177250 17177251 2 + 2.334 2.460 0.421
ENSG00000133030 E050 655.7520947 0.0001091205 5.600903e-19 3.179725e-17 17 17177252 17177412 161 + 2.680 2.824 0.480
ENSG00000133030 E051 0.5483223 0.0203037527 9.496159e-01 9.724531e-01 17 17179558 17179577 20 + 0.157 0.173 0.172
ENSG00000133030 E052 487.0301871 0.0008634544 1.097461e-13 3.099907e-12 17 17180003 17180088 86 + 2.530 2.704 0.579
ENSG00000133030 E053 4.7272425 0.0036139115 8.074078e-03 2.396831e-02 17 17180089 17180150 62 + 0.945 0.594 -1.416
ENSG00000133030 E054 110.7986248 0.0046109250 2.179311e-01 3.479387e-01 17 17180607 17180669 63 + 1.972 2.037 0.217
ENSG00000133030 E055 371.9414338 0.0015115070 8.345281e-13 2.075605e-11 17 17184823 17184861 39 + 2.389 2.595 0.688
ENSG00000133030 E056 1630.1496838 0.0051057740 6.067575e-08 6.426724e-07 17 17184862 17186464 1603 + 3.043 3.233 0.634
ENSG00000133030 E057 64.0220792 0.0003907148 7.652766e-19 4.288061e-17 17 17186465 17186648 184 + 2.004 1.616 -1.309
ENSG00000133030 E058 600.1318165 0.0006004309 2.304624e-123 1.364388e-119 17 17186649 17189240 2592 + 2.988 2.561 -1.419
ENSG00000133030 E059 1114.2307294 0.0070552643 1.419628e-04 7.119634e-04 17 17189241 17192648 3408 + 3.109 2.965 -0.479
ENSG00000133030 E060 1.8455871 0.0077352381 5.155806e-01 6.502356e-01 17 17201458 17201633 176 + 0.501 0.392 -0.567
ENSG00000133030 E061 10.6535271 0.0015677646 3.999489e-04 1.774203e-03 17 17204498 17206410 1913 + 1.243 0.894 -1.271
ENSG00000133030 E062 2.1527826 0.0648516328 8.626807e-01 9.154568e-01 17 17217490 17217679 190 + 0.502 0.469 -0.160