ENSG00000132906

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000333868 ENSG00000132906 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP9 protein_coding protein_coding 14.46964 21.8749 7.765154 0.8053263 0.4285409 -1.492993 0.9797627 1.4336604 1.0016266 0.06499499 0.1280949 -0.5130544 0.07507917 0.06573333 0.13130000 0.065566667 0.03756625 0.001624661 FALSE  
ENST00000348549 ENSG00000132906 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP9 protein_coding protein_coding 14.46964 21.8749 7.765154 0.8053263 0.4285409 -1.492993 6.7188486 10.8607941 3.6462414 0.32260084 0.3928090 -1.5720241 0.46154167 0.49700000 0.46726667 -0.029733333 0.77155313 0.001624661 FALSE  
ENST00000400777 ENSG00000132906 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP9 protein_coding nonsense_mediated_decay 14.46964 21.8749 7.765154 0.8053263 0.4285409 -1.492993 0.8181655 0.6547805 0.2486623 0.45482066 0.1251312 -1.3618085 0.05487083 0.02960000 0.03066667 0.001066667 0.95908982 0.001624661 FALSE  
ENST00000447522 ENSG00000132906 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP9 protein_coding protein_coding 14.46964 21.8749 7.765154 0.8053263 0.4285409 -1.492993 0.6911976 0.0000000 0.0000000 0.00000000 0.0000000 0.0000000 0.05421667 0.00000000 0.00000000 0.000000000   0.001624661 FALSE  
MSTRG.357.5 ENSG00000132906 HEK293_OSMI2_2hA HEK293_TMG_2hB CASP9 protein_coding   14.46964 21.8749 7.765154 0.8053263 0.4285409 -1.492993 4.4373650 8.0375063 2.1802745 0.35014943 0.1008793 -1.8774301 0.29077083 0.36740000 0.28380000 -0.083600000 0.17460171 0.001624661 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132906 E001 13.0265999 0.0016682730 8.177190e-11 1.464496e-09 1 15490832 15491400 569 - 1.455 0.862 -2.129
ENSG00000132906 E002 29.2610561 0.0010633432 9.120406e-08 9.326534e-07 1 15491401 15492269 869 - 1.649 1.294 -1.221
ENSG00000132906 E003 29.5388178 0.0007707950 2.061134e-02 5.277120e-02 1 15492270 15492365 96 - 1.246 1.435 0.661
ENSG00000132906 E004 148.8279836 0.0024303785 9.952743e-02 1.897643e-01 1 15492366 15492566 201 - 2.031 2.101 0.234
ENSG00000132906 E005 204.1168454 0.0034842874 5.329617e-02 1.150161e-01 1 15492567 15492797 231 - 2.161 2.239 0.261
ENSG00000132906 E006 107.3244157 0.0006705029 2.922748e-01 4.332258e-01 1 15492798 15492854 57 - 1.906 1.953 0.156
ENSG00000132906 E007 114.4988094 0.0003394639 8.178294e-01 8.848148e-01 1 15492855 15492942 88 - 1.961 1.973 0.038
ENSG00000132906 E008 112.2727414 0.0002966367 9.775337e-01 9.900372e-01 1 15492943 15493035 93 - 1.961 1.965 0.011
ENSG00000132906 E009 2.9870927 0.0051188652 1.965032e-01 3.218598e-01 1 15493036 15493891 856 - 0.332 0.577 1.276
ENSG00000132906 E010 118.6725900 0.0005801027 2.306783e-01 3.632664e-01 1 15493892 15494001 110 - 1.950 2.000 0.166
ENSG00000132906 E011 137.9148858 0.0019370362 6.624419e-01 7.707483e-01 1 15495273 15495452 180 - 2.041 2.061 0.068
ENSG00000132906 E012 45.3328139 0.0007757014 3.176085e-01 4.605000e-01 1 15504611 15504624 14 - 1.527 1.592 0.223
ENSG00000132906 E013 74.0101890 0.0004338175 4.207364e-01 5.639278e-01 1 15504625 15504758 134 - 1.752 1.794 0.141
ENSG00000132906 E014 56.2258398 0.0029699650 3.556696e-01 5.000374e-01 1 15505990 15506079 90 - 1.620 1.679 0.201
ENSG00000132906 E015 86.5452175 0.0003231683 4.102665e-01 5.538665e-01 1 15506899 15507075 177 - 1.821 1.861 0.133
ENSG00000132906 E016 0.9556391 0.0133718879 1.796991e-01 3.007798e-01 1 15507076 15507133 58 - 0.434 0.192 -1.631
ENSG00000132906 E017 1.1007972 0.1905601236 6.903249e-01 7.920426e-01 1 15507772 15507872 101 - 0.331 0.245 -0.592
ENSG00000132906 E018 52.4625279 0.0073947791 6.162865e-01 7.343769e-01 1 15507873 15507907 35 - 1.660 1.630 -0.100
ENSG00000132906 E019 65.9586589 0.0003950671 3.665079e-01 5.108470e-01 1 15518110 15518135 26 - 1.770 1.727 -0.144
ENSG00000132906 E020 110.8511779 0.0002908695 1.161650e-02 3.262121e-02 1 15518136 15518249 114 - 2.031 1.939 -0.309
ENSG00000132906 E021 120.8018747 0.0004608560 6.542189e-02 1.357486e-01 1 15518250 15518395 146 - 2.045 1.980 -0.220
ENSG00000132906 E022 0.0000000       1 15519881 15520001 121 -      
ENSG00000132906 E023 78.1767381 0.0084612479 3.579417e-01 5.023482e-01 1 15524069 15524445 377 - 1.850 1.796 -0.182
ENSG00000132906 E024 2.4713278 0.0138109283 1.408721e-01 2.492229e-01 1 15524583 15524851 269 - 0.647 0.395 -1.211
ENSG00000132906 E025 1.2501346 0.0108148335 5.180078e-01 6.523025e-01 1 15524852 15524889 38 - 0.197 0.324 0.955
ENSG00000132906 E026 2.5056814 0.0063003667 7.988998e-01 8.716965e-01 1 15526191 15526534 344 - 0.434 0.482 0.245