ENSG00000132849

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000307297 ENSG00000132849 HEK293_OSMI2_2hA HEK293_TMG_2hB PATJ protein_coding protein_coding 3.641954 2.015655 5.892259 0.5849112 0.1448726 1.542879 0.08151595 0.20837760 0.03829522 0.17565995 0.03829522 -2.1768726 0.04413750 0.08566667 0.00680000 -0.07886667 0.35598881 0.01298105 FALSE TRUE
ENST00000371158 ENSG00000132849 HEK293_OSMI2_2hA HEK293_TMG_2hB PATJ protein_coding protein_coding 3.641954 2.015655 5.892259 0.5849112 0.1448726 1.542879 1.21677794 0.32219574 2.42460864 0.16122014 0.17817589 2.8735844 0.28425417 0.12530000 0.41290000 0.28760000 0.01298105 0.01298105 FALSE TRUE
ENST00000465798 ENSG00000132849 HEK293_OSMI2_2hA HEK293_TMG_2hB PATJ protein_coding protein_coding 3.641954 2.015655 5.892259 0.5849112 0.1448726 1.542879 0.55989384 0.42731287 0.54617139 0.42731287 0.04435380 0.3468637 0.14363750 0.15353333 0.09316667 -0.06036667 0.70801620 0.01298105 FALSE FALSE
ENST00000494842 ENSG00000132849 HEK293_OSMI2_2hA HEK293_TMG_2hB PATJ protein_coding protein_coding 3.641954 2.015655 5.892259 0.5849112 0.1448726 1.542879 0.28283789 0.22295380 0.34900080 0.15414331 0.05240257 0.6239432 0.08706667 0.09013333 0.05893333 -0.03120000 0.83038634 0.01298105 FALSE TRUE
ENST00000635214 ENSG00000132849 HEK293_OSMI2_2hA HEK293_TMG_2hB PATJ protein_coding retained_intron 3.641954 2.015655 5.892259 0.5849112 0.1448726 1.542879 0.24547174 0.04251596 0.41431232 0.04251596 0.17964119 3.0142986 0.07453333 0.04900000 0.06950000 0.02050000 0.57632876 0.01298105 FALSE TRUE
ENST00000642238 ENSG00000132849 HEK293_OSMI2_2hA HEK293_TMG_2hB PATJ protein_coding protein_coding 3.641954 2.015655 5.892259 0.5849112 0.1448726 1.542879 0.08432928 0.20177746 0.00000000 0.20177746 0.00000000 -4.4044772 0.07577083 0.23263333 0.00000000 -0.23263333 0.73348856 0.01298105 FALSE TRUE
MSTRG.1311.1 ENSG00000132849 HEK293_OSMI2_2hA HEK293_TMG_2hB PATJ protein_coding   3.641954 2.015655 5.892259 0.5849112 0.1448726 1.542879 0.66352729 0.25419754 1.66443142 0.07339783 0.19695975 2.6639823 0.14581250 0.13156667 0.28256667 0.15100000 0.02882057 0.01298105 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132849 E001 0.1451727 0.0441087627 1.000000000   1 61742113 61742345 233 + 0.065 0.000 -8.213
ENSG00000132849 E002 3.3904378 0.0048797982 0.162195523 0.277970863 1 61742346 61742476 131 + 0.516 0.745 1.001
ENSG00000132849 E003 3.3904378 0.0048797982 0.162195523 0.277970863 1 61742477 61742479 3 + 0.516 0.745 1.001
ENSG00000132849 E004 6.8311144 0.0295301947 0.434661011 0.576974506 1 61742480 61742544 65 + 0.793 0.914 0.468
ENSG00000132849 E005 5.9173175 0.0370065987 0.363674299 0.508093753 1 61742545 61742555 11 + 0.732 0.879 0.577
ENSG00000132849 E006 7.0986577 0.0035360460 0.488910354 0.626416701 1 61762858 61762914 57 + 0.815 0.912 0.373
ENSG00000132849 E007 15.8117376 0.0100037817 0.102581270 0.194440191 1 61763013 61763179 167 + 1.194 1.005 -0.684
ENSG00000132849 E008 24.9681603 0.0007780981 0.023908340 0.059616495 1 61766279 61766473 195 + 1.382 1.185 -0.690
ENSG00000132849 E009 20.3223315 0.0010836292 0.308567511 0.450853310 1 61769283 61769422 140 + 1.276 1.185 -0.321
ENSG00000132849 E010 29.4139830 0.0006651209 0.045117846 0.100414226 1 61771431 61771626 196 + 1.442 1.284 -0.550
ENSG00000132849 E011 25.3212409 0.0065095703 0.120465121 0.220627956 1 61775206 61775334 129 + 1.379 1.237 -0.497
ENSG00000132849 E012 29.0165715 0.0044444176 0.293637807 0.434695102 1 61787754 61787972 219 + 1.424 1.339 -0.295
ENSG00000132849 E013 17.3203795 0.0011014607 0.539869467 0.671089042 1 61791348 61791447 100 + 1.203 1.147 -0.201
ENSG00000132849 E014 20.2473029 0.0011379188 0.453645459 0.594394872 1 61795467 61795558 92 + 1.269 1.203 -0.231
ENSG00000132849 E015 26.2053833 0.0009186313 0.408306590 0.551904400 1 61797287 61797428 142 + 1.376 1.312 -0.222
ENSG00000132849 E016 26.8729182 0.0068335588 0.194967339 0.319947138 1 61801623 61801769 147 + 1.399 1.284 -0.400
ENSG00000132849 E017 19.2262254 0.0010005775 0.142035639 0.250822388 1 61805448 61805509 62 + 1.265 1.126 -0.493
ENSG00000132849 E018 12.5287382 0.0015629734 0.512768759 0.647668501 1 61805510 61805524 15 + 1.051 1.126 0.270
ENSG00000132849 E019 16.3222158 0.0014515961 0.573696508 0.699614306 1 61808474 61808530 57 + 1.161 1.220 0.209
ENSG00000132849 E020 21.9454354 0.0039377409 0.322446676 0.465744290 1 61822945 61823079 135 + 1.273 1.363 0.317
ENSG00000132849 E021 26.1885696 0.0007557862 0.406365155 0.550026029 1 61827422 61827583 162 + 1.376 1.312 -0.222
ENSG00000132849 E022 0.0000000       1 61833358 61833377 20 +      
ENSG00000132849 E023 28.5405481 0.0007510824 0.868899770 0.919746345 1 61833654 61833785 132 + 1.394 1.411 0.058
ENSG00000132849 E024 30.3138787 0.0006928771 0.662812609 0.771036132 1 61856030 61856239 210 + 1.416 1.452 0.126
ENSG00000132849 E025 20.0404044 0.0009462382 0.753711833 0.839551766 1 61861551 61861667 117 + 1.261 1.237 -0.084
ENSG00000132849 E026 21.3791203 0.0009230437 0.970395101 0.985464705 1 61864238 61864390 153 + 1.276 1.284 0.026
ENSG00000132849 E027 11.4501999 0.0054332186 0.637312220 0.751234386 1 61864391 61864430 40 + 1.032 0.977 -0.203
ENSG00000132849 E028 29.1068482 0.0009161691 0.348662690 0.492893125 1 61864431 61864633 203 + 1.421 1.352 -0.240
ENSG00000132849 E029 0.3634088 0.3539720114 0.045966218   1 61865241 61865611 371 + 0.000 0.364 12.929
ENSG00000132849 E030 25.7804547 0.0023328129 0.027195469 0.066388764 1 61875243 61875366 124 + 1.397 1.203 -0.677
ENSG00000132849 E031 0.2903454 0.3893217119 1.000000000   1 61875367 61875531 165 + 0.122 0.000 -9.188
ENSG00000132849 E032 34.0953724 0.0011787507 0.224862866 0.356270008 1 61884237 61884408 172 + 1.495 1.410 -0.292
ENSG00000132849 E033 26.4732904 0.0007831182 0.578795659 0.703793974 1 61899583 61899654 72 + 1.379 1.339 -0.139
ENSG00000132849 E034 29.2255150 0.0044141387 0.962593460 0.980389144 1 61901282 61901459 178 + 1.410 1.410 0.000
ENSG00000132849 E035 20.6797511 0.0070134039 0.448651652 0.589924344 1 61908372 61908454 83 + 1.287 1.219 -0.239
ENSG00000132849 E036 15.6055400 0.0016289754 0.774800028 0.854868819 1 61908455 61908482 28 + 1.152 1.185 0.119
ENSG00000132849 E037 18.7820081 0.0010256906 0.631744765 0.746702045 1 61914587 61914646 60 + 1.221 1.269 0.170
ENSG00000132849 E038 12.9054741 0.0019686792 0.630493102 0.745673892 1 61914647 61914664 18 + 1.070 1.126 0.203
ENSG00000132849 E039 23.2424183 0.0017037233 0.431141278 0.573731499 1 61927730 61927829 100 + 1.305 1.376 0.245
ENSG00000132849 E040 0.0000000       1 61952053 61952074 22 +      
ENSG00000132849 E041 0.0000000       1 61952075 61952311 237 +      
ENSG00000132849 E042 0.0000000       1 61952312 61952411 100 +      
ENSG00000132849 E043 26.6750440 0.0054832140 0.978322447 0.990594616 1 61990168 61990364 197 + 1.376 1.386 0.033
ENSG00000132849 E044 0.2955422 0.0292455323 0.315733251   1 61990365 61990436 72 + 0.065 0.217 1.998
ENSG00000132849 E045 2.2517595 0.0632453512 0.054145332 0.116506822 1 61991482 61991779 298 + 0.362 0.738 1.781
ENSG00000132849 E046 13.2999921 0.0234562040 0.700100594 0.799643189 1 62017856 62017947 92 + 1.076 1.125 0.177
ENSG00000132849 E047 11.7999435 0.0015279197 0.897359233 0.938443395 1 62037977 62038049 73 + 1.038 1.057 0.069
ENSG00000132849 E048 15.3062319 0.0011848056 0.092977554 0.179787479 1 62050966 62051058 93 + 1.104 1.269 0.585
ENSG00000132849 E049 18.6346613 0.0009707572 0.001120043 0.004370612 1 62079450 62079567 118 + 1.142 1.421 0.982
ENSG00000132849 E050 18.2055786 0.0009588539 0.039014774 0.089224059 1 62084515 62084648 134 + 1.166 1.352 0.652
ENSG00000132849 E051 3.3422543 0.0382908317 0.841317024 0.901019742 1 62100319 62100360 42 + 0.594 0.556 -0.169
ENSG00000132849 E052 2.1787844 0.0438081305 0.608322226 0.728088883 1 62100361 62100408 48 + 0.470 0.363 -0.579
ENSG00000132849 E053 15.2794129 0.0068158816 0.353244248 0.497473001 1 62108437 62108520 84 + 1.120 1.220 0.356
ENSG00000132849 E054 12.2400997 0.0014999151 0.033630491 0.079025521 1 62114053 62114089 37 + 0.998 1.220 0.803
ENSG00000132849 E055 24.8175021 0.0113016958 0.001212472 0.004683439 1 62114090 62114246 157 + 1.257 1.542 0.987
ENSG00000132849 E056 2.4376906 0.2238481031 0.094729721 0.182467861 1 62114247 62114925 679 + 0.362 0.744 1.807
ENSG00000132849 E057 27.5387136 0.0007909974 0.000662165 0.002760131 1 62116532 62116679 148 + 1.319 1.566 0.850
ENSG00000132849 E058 21.1290803 0.0009446936 0.063375093 0.132314540 1 62117132 62117218 87 + 1.241 1.399 0.550
ENSG00000132849 E059 5.2628409 0.1612583758 0.005774802 0.018020705 1 62117219 62117395 177 + 0.494 1.133 2.572
ENSG00000132849 E060 0.2955422 0.0292455323 0.315733251   1 62120874 62121180 307 + 0.065 0.217 1.998
ENSG00000132849 E061 8.1388670 0.0020481121 0.757700829 0.842429848 1 62121181 62121185 5 + 0.912 0.875 -0.138
ENSG00000132849 E062 16.6297685 0.0011359576 0.074591098 0.150880978 1 62121186 62121295 110 + 1.216 1.032 -0.663
ENSG00000132849 E063 10.7712541 0.0015726168 0.312532966 0.455064429 1 62123021 62123058 38 + 1.032 0.912 -0.448
ENSG00000132849 E064 15.8883251 0.0011011258 0.130243917 0.234504408 1 62127972 62128094 123 + 1.190 1.032 -0.569
ENSG00000132849 E065 0.0000000       1 62128095 62128457 363 +      
ENSG00000132849 E066 14.9000926 0.0024548854 0.020278665 0.052070809 1 62128841 62128945 105 + 1.181 0.912 -0.983
ENSG00000132849 E067 13.9017165 0.0012468070 0.019895870 0.051265765 1 62148284 62148390 107 + 1.152 0.876 -1.017
ENSG00000132849 E068 7.3867894 0.0022572372 0.539888699 0.671104119 1 62153358 62153481 124 + 0.876 0.793 -0.321
ENSG00000132849 E069 29.2970746 0.0007093751 0.105533858 0.198916340 1 62160908 62161389 482 + 1.437 1.312 -0.433
ENSG00000132849 E070 60.5956118 0.0051695068 0.474052013 0.612917681 1 62161390 62162882 1493 + 1.725 1.681 -0.149
ENSG00000132849 E071 22.7745490 0.0018515610 0.055434906 0.118733483 1 62162883 62163950 1068 + 1.261 1.421 0.558
ENSG00000132849 E072 0.0000000       1 62178423 62178675 253 +