ENSG00000132824

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000255175 ENSG00000132824 HEK293_OSMI2_2hA HEK293_TMG_2hB SERINC3 protein_coding protein_coding 51.76182 39.04706 59.75272 3.790971 0.9113491 0.6136625 9.373044 5.7767895 13.6595773 1.8457579 1.3070974 1.2401336 0.18199583 0.15460000 0.228100000 0.07350000 0.54649345 0.00194066 FALSE TRUE
ENST00000342374 ENSG00000132824 HEK293_OSMI2_2hA HEK293_TMG_2hB SERINC3 protein_coding protein_coding 51.76182 39.04706 59.75272 3.790971 0.9113491 0.6136625 22.403593 16.3417698 22.2390024 2.1857688 0.6278255 0.4442939 0.43150000 0.41623333 0.372666667 -0.04356667 0.49794779 0.00194066 FALSE TRUE
ENST00000411544 ENSG00000132824 HEK293_OSMI2_2hA HEK293_TMG_2hB SERINC3 protein_coding protein_coding 51.76182 39.04706 59.75272 3.790971 0.9113491 0.6136625 3.109960 8.4955677 0.2135288 2.9437209 0.2135288 -5.2498752 0.07524167 0.20756667 0.003633333 -0.20393333 0.00194066 0.00194066 FALSE TRUE
MSTRG.20745.6 ENSG00000132824 HEK293_OSMI2_2hA HEK293_TMG_2hB SERINC3 protein_coding   51.76182 39.04706 59.75272 3.790971 0.9113491 0.6136625 2.979419 0.6139958 5.1225869 0.6139958 2.5613783 3.0400780 0.04787917 0.01893333 0.085266667 0.06633333 0.48198656 0.00194066 TRUE TRUE
MSTRG.20745.8 ENSG00000132824 HEK293_OSMI2_2hA HEK293_TMG_2hB SERINC3 protein_coding   51.76182 39.04706 59.75272 3.790971 0.9113491 0.6136625 9.023177 6.9306211 11.1603678 0.1596080 0.6665933 0.6865400 0.17790417 0.18016667 0.187166667 0.00700000 0.92570797 0.00194066 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132824 E001 1.2210915 0.0136425780 4.422759e-01 5.839357e-01 20 44479825 44480543 719 - 0.263 0.403 0.880
ENSG00000132824 E002 0.5901540 0.0206862458 4.732947e-01 6.122726e-01 20 44484931 44485720 790 - 0.263 0.140 -1.123
ENSG00000132824 E003 0.5869318 0.2755811615 8.356088e-01 8.971838e-01 20 44485721 44485764 44 - 0.191 0.241 0.428
ENSG00000132824 E004 2.3540668 0.0065791536 3.148874e-02 7.486005e-02 20 44494885 44494924 40 - 0.324 0.683 1.785
ENSG00000132824 E005 1.7682679 0.0082499020 8.300534e-02 1.642532e-01 20 44496221 44496221 1 - 0.263 0.566 1.687
ENSG00000132824 E006 2.0680765 0.0072438620 9.692147e-02 1.857867e-01 20 44496222 44496223 2 - 0.324 0.608 1.464
ENSG00000132824 E007 2.3980740 0.0064092947 3.130227e-02 7.448696e-02 20 44496224 44496229 6 - 0.324 0.683 1.785
ENSG00000132824 E008 2.3980740 0.0064092947 3.130227e-02 7.448696e-02 20 44496230 44496230 1 - 0.324 0.683 1.785
ENSG00000132824 E009 18.8309013 0.0010687889 5.062659e-08 5.452252e-07 20 44496231 44496288 58 - 1.040 1.488 1.578
ENSG00000132824 E010 47.9014303 0.0004771019 5.578583e-14 1.644129e-12 20 44496289 44496355 67 - 1.466 1.864 1.352
ENSG00000132824 E011 705.5081773 0.0041292814 3.619253e-04 1.626453e-03 20 44497441 44498923 1483 - 2.789 2.911 0.405
ENSG00000132824 E012 274.9238546 0.0001891762 8.443758e-05 4.490320e-04 20 44498924 44499231 308 - 2.478 2.401 -0.255
ENSG00000132824 E013 160.5492200 0.0002738977 6.895705e-01 7.914313e-01 20 44499232 44499304 73 - 2.203 2.224 0.070
ENSG00000132824 E014 764.2642087 0.0015089411 2.085605e-03 7.489273e-03 20 44499305 44500156 852 - 2.850 2.923 0.242
ENSG00000132824 E015 273.9286548 0.0001604043 4.836695e-01 6.217033e-01 20 44500157 44500257 101 - 2.445 2.440 -0.019
ENSG00000132824 E016 461.4843470 0.0008555800 1.463043e-02 3.966301e-02 20 44500258 44500434 177 - 2.639 2.698 0.197
ENSG00000132824 E017 567.3013772 0.0016801173 2.903590e-02 7.007700e-02 20 44501073 44501300 228 - 2.728 2.785 0.189
ENSG00000132824 E018 3.9117062 0.0052887037 2.885521e-01 4.291482e-01 20 44502358 44502437 80 - 0.757 0.608 -0.624
ENSG00000132824 E019 4.2899654 0.0077251572 1.825945e-01 3.044640e-01 20 44502438 44502581 144 - 0.797 0.608 -0.784
ENSG00000132824 E020 497.0234058 0.0015377219 2.216514e-01 3.523667e-01 20 44503815 44503995 181 - 2.682 2.716 0.115
ENSG00000132824 E021 322.4489440 0.0006920664 8.525469e-01 9.086291e-01 20 44504801 44504891 91 - 2.509 2.512 0.010
ENSG00000132824 E022 384.2595203 0.0004100970 6.588653e-01 7.678635e-01 20 44506827 44506996 170 - 2.588 2.588 -0.001
ENSG00000132824 E023 318.3479506 0.0009461353 5.154890e-01 6.501637e-01 20 44509891 44510028 138 - 2.510 2.502 -0.029
ENSG00000132824 E024 278.9707941 0.0025317645 2.908268e-01 4.316130e-01 20 44511289 44511368 80 - 2.461 2.430 -0.104
ENSG00000132824 E025 453.8083270 0.0035285095 1.741375e-03 6.412517e-03 20 44512801 44512994 194 - 2.701 2.601 -0.333
ENSG00000132824 E026 1.2876999 0.0102558644 2.658271e-01 4.039315e-01 20 44513559 44513614 56 - 0.263 0.464 1.199
ENSG00000132824 E027 191.8996191 0.0038109148 1.471434e-04 7.348135e-04 20 44513879 44513892 14 - 2.348 2.200 -0.492
ENSG00000132824 E028 392.4821305 0.0033848359 2.134118e-07 2.034533e-06 20 44513893 44514040 148 - 2.665 2.497 -0.560
ENSG00000132824 E029 1.4372538 0.1677507800 6.276211e-01 7.434096e-01 20 44519312 44519414 103 - 0.426 0.333 -0.531
ENSG00000132824 E030 246.7094116 0.0008125000 2.364404e-13 6.378034e-12 20 44521913 44522087 175 - 2.472 2.285 -0.623