ENSG00000132780

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350030 ENSG00000132780 HEK293_OSMI2_2hA HEK293_TMG_2hB NASP protein_coding protein_coding 299.5766 235.9777 370.027 5.064914 9.311697 0.6489579 41.88517 44.843040 51.83314 2.171746 4.883624 0.2089472 0.14662917 0.19023333 0.13960000 -0.050633333 5.081732e-02 8.224612e-13 FALSE TRUE
ENST00000351223 ENSG00000132780 HEK293_OSMI2_2hA HEK293_TMG_2hB NASP protein_coding protein_coding 299.5766 235.9777 370.027 5.064914 9.311697 0.6489579 66.13975 82.175153 54.43311 3.823390 2.904610 -0.5941284 0.23339167 0.34903333 0.14763333 -0.201400000 3.641139e-09 8.224612e-13 FALSE TRUE
ENST00000453748 ENSG00000132780 HEK293_OSMI2_2hA HEK293_TMG_2hB NASP protein_coding nonsense_mediated_decay 299.5766 235.9777 370.027 5.064914 9.311697 0.6489579 18.74531 16.254261 27.29768 1.824679 2.220807 0.7476017 0.06346250 0.06866667 0.07410000 0.005433333 8.817550e-01 8.224612e-13 FALSE TRUE
ENST00000464190 ENSG00000132780 HEK293_OSMI2_2hA HEK293_TMG_2hB NASP protein_coding retained_intron 299.5766 235.9777 370.027 5.064914 9.311697 0.6489579 66.64404 23.661824 100.83744 5.961826 2.073822 2.0909317 0.20700833 0.09940000 0.27313333 0.173733333 1.384755e-03 8.224612e-13 FALSE TRUE
ENST00000525515 ENSG00000132780 HEK293_OSMI2_2hA HEK293_TMG_2hB NASP protein_coding protein_coding 299.5766 235.9777 370.027 5.064914 9.311697 0.6489579 17.71228 9.041571 24.61435 1.597195 3.420966 1.4438453 0.05517917 0.03806667 0.06626667 0.028200000 1.208808e-01 8.224612e-13 FALSE FALSE
ENST00000528238 ENSG00000132780 HEK293_OSMI2_2hA HEK293_TMG_2hB NASP protein_coding protein_coding 299.5766 235.9777 370.027 5.064914 9.311697 0.6489579 44.39269 38.258761 55.32149 2.280396 5.008742 0.5319336 0.14830833 0.16200000 0.14933333 -0.012666667 7.844155e-01 8.224612e-13 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132780 E001 0.1472490 0.0428507916 5.045260e-01   1 45581985 45583319 1335 + 0.121 0.000 -9.082
ENSG00000132780 E002 0.9619818 0.0236327152 9.760225e-01 9.890270e-01 1 45583320 45583845 526 + 0.293 0.298 0.032
ENSG00000132780 E003 1.6304846 0.0109711766 9.684361e-01 9.842772e-01 1 45583846 45583912 67 + 0.416 0.423 0.033
ENSG00000132780 E004 0.1515154 0.0423934412 5.044515e-01   1 45583913 45583987 75 + 0.121 0.000 -9.096
ENSG00000132780 E005 0.0000000       1 45583988 45583988 1 +      
ENSG00000132780 E006 0.8481309 0.0143496066 6.356511e-01 7.498821e-01 1 45583989 45584040 52 + 0.216 0.298 0.619
ENSG00000132780 E007 0.8481309 0.0143496066 6.356511e-01 7.498821e-01 1 45584041 45584041 1 + 0.216 0.298 0.619
ENSG00000132780 E008 0.8481309 0.0143496066 6.356511e-01 7.498821e-01 1 45584042 45584044 3 + 0.216 0.298 0.619
ENSG00000132780 E009 66.5300399 0.0077704377 3.204317e-04 1.462520e-03 1 45584045 45584057 13 + 1.931 1.706 -0.758
ENSG00000132780 E010 106.0222690 0.0071227239 2.515732e-03 8.811572e-03 1 45584058 45584059 2 + 2.107 1.940 -0.561
ENSG00000132780 E011 119.6829734 0.0079687736 5.890544e-04 2.493576e-03 1 45584060 45584060 1 + 2.171 1.979 -0.644
ENSG00000132780 E012 233.7758795 0.0069106451 1.911874e-16 7.935993e-15 1 45584061 45584062 2 + 2.539 2.139 -1.335
ENSG00000132780 E013 384.4471663 0.0009914661 1.184694e-33 2.628065e-31 1 45584063 45584064 2 + 2.718 2.424 -0.978
ENSG00000132780 E014 873.5050501 0.0023377504 9.374706e-09 1.162538e-07 1 45584065 45584107 43 + 3.017 2.862 -0.519
ENSG00000132780 E015 1255.7902637 0.0024688895 8.271513e-08 8.537256e-07 1 45584108 45584205 98 + 3.169 3.026 -0.476
ENSG00000132780 E016 2.2957402 0.3009068542 8.503019e-01 9.071371e-01 1 45588651 45588948 298 + 0.553 0.476 -0.370
ENSG00000132780 E017 1059.8940200 0.0018921422 2.475346e-06 1.887861e-05 1 45591223 45591270 48 + 3.083 2.967 -0.383
ENSG00000132780 E018 5.5746465 0.0035636870 1.445140e-02 3.924844e-02 1 45594694 45594773 80 + 0.956 0.633 -1.288
ENSG00000132780 E019 50.1915176 0.0029351420 3.461605e-02 8.093032e-02 1 45600385 45600457 73 + 1.765 1.645 -0.406
ENSG00000132780 E020 1500.6241834 0.0010129755 2.366774e-04 1.119295e-03 1 45602255 45602365 111 + 3.211 3.143 -0.226
ENSG00000132780 E021 1.1770738 0.0108054696 2.878401e-02 6.956834e-02 1 45604917 45604935 19 + 0.512 0.124 -2.775
ENSG00000132780 E022 1057.1695479 0.0010028932 1.715332e-02 4.528050e-02 1 45604936 45604965 30 + 3.049 3.001 -0.158
ENSG00000132780 E023 1354.8732069 0.0011680590 4.903390e-03 1.566127e-02 1 45604966 45605016 51 + 3.161 3.104 -0.189
ENSG00000132780 E024 1272.5692534 0.0010732848 3.493681e-02 8.153485e-02 1 45606482 45606516 35 + 3.126 3.083 -0.144
ENSG00000132780 E025 1536.3212688 0.0017553611 2.807627e-01 4.206412e-01 1 45606517 45606591 75 + 3.200 3.172 -0.094
ENSG00000132780 E026 44.6875294 0.0006064428 1.138133e-34 2.736243e-32 1 45606592 45606680 89 + 1.911 1.171 -2.540
ENSG00000132780 E027 1736.4488500 0.0023658390 9.173824e-03 2.671767e-02 1 45607321 45607972 652 + 3.274 3.206 -0.229
ENSG00000132780 E028 1019.7582697 0.0002041087 2.003482e-02 5.156207e-02 1 45607973 45608337 365 + 3.025 2.994 -0.106
ENSG00000132780 E029 236.6896487 0.0027558648 5.392145e-65 6.465352e-62 1 45609300 45610553 1254 + 2.608 1.971 -2.126
ENSG00000132780 E030 111.8050171 0.0042438923 4.285045e-25 4.722575e-23 1 45610554 45610995 442 + 2.251 1.747 -1.694
ENSG00000132780 E031 535.2952787 0.0028081634 5.406800e-22 4.305599e-20 1 45610996 45613168 2173 + 2.863 2.566 -0.991
ENSG00000132780 E032 1519.8990869 0.0001485402 1.326229e-01 2.377417e-01 1 45613169 45613248 80 + 3.174 3.187 0.046
ENSG00000132780 E033 1570.1231765 0.0007842198 5.163388e-03 1.637300e-02 1 45614096 45614181 86 + 3.172 3.213 0.138
ENSG00000132780 E034 1614.1840588 0.0001406664 2.794070e-06 2.106024e-05 1 45614293 45614366 74 + 3.182 3.229 0.155
ENSG00000132780 E035 3.9617363 0.0067887420 2.101401e-01 3.387053e-01 1 45614963 45615012 50 + 0.591 0.773 0.769
ENSG00000132780 E036 1323.1295031 0.0009236747 1.109857e-04 5.723207e-04 1 45615013 45615058 46 + 3.084 3.151 0.222
ENSG00000132780 E037 2114.9548310 0.0002754929 6.783703e-09 8.632714e-08 1 45615059 45615201 143 + 3.291 3.352 0.203
ENSG00000132780 E038 2495.1329554 0.0002641563 5.915422e-14 1.737456e-12 1 45615305 45615471 167 + 3.355 3.430 0.249
ENSG00000132780 E039 11.8100840 0.0017281875 8.152036e-01 8.829613e-01 1 45615472 45615715 244 + 1.111 1.086 -0.087
ENSG00000132780 E040 1387.1272481 0.0004727691 1.065195e-12 2.601161e-11 1 45616337 45616393 57 + 3.086 3.185 0.328
ENSG00000132780 E041 1758.5561252 0.0009629538 8.878212e-08 9.100479e-07 1 45616626 45616700 75 + 3.194 3.284 0.297
ENSG00000132780 E042 1166.2208775 0.0030999203 6.051752e-03 1.874661e-02 1 45616701 45616703 3 + 3.022 3.101 0.264
ENSG00000132780 E043 19.8811978 0.0431792054 5.544092e-01 6.833917e-01 1 45617237 45617462 226 + 1.280 1.348 0.236
ENSG00000132780 E044 1152.3000948 0.0010311224 1.063793e-06 8.777542e-06 1 45617463 45617464 2 + 3.010 3.100 0.297
ENSG00000132780 E045 2149.0422824 0.0016466696 4.391783e-08 4.789099e-07 1 45617465 45617591 127 + 3.268 3.379 0.371
ENSG00000132780 E046 1530.1781491 0.0012229627 2.024262e-11 4.007633e-10 1 45618061 45618904 844 + 3.111 3.238 0.421