ENSG00000132768

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000255108 ENSG00000132768 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH2 protein_coding protein_coding 78.97981 131.9099 51.85915 5.321307 1.481218 -1.346713 42.871882 71.087514 25.390291 4.4251518 2.4522675 -1.4849541 0.53468750 0.53793333 0.48793333 -0.0500000000 5.928588e-01 2.137369e-15 FALSE  
ENST00000459879 ENSG00000132768 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH2 protein_coding protein_coding 78.97981 131.9099 51.85915 5.321307 1.481218 -1.346713 6.272695 12.899056 4.613667 1.8263642 0.3473993 -1.4812741 0.07668333 0.09756667 0.08946667 -0.0081000000 8.839932e-01 2.137369e-15 FALSE  
ENST00000490861 ENSG00000132768 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH2 protein_coding retained_intron 78.97981 131.9099 51.85915 5.321307 1.481218 -1.346713 3.724179 2.966762 3.471297 0.1145129 0.1217196 0.2258810 0.05572917 0.02260000 0.06693333 0.0443333333 5.652399e-13 2.137369e-15 FALSE  
ENST00000527319 ENSG00000132768 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH2 protein_coding nonsense_mediated_decay 78.97981 131.9099 51.85915 5.321307 1.481218 -1.346713 4.161586 11.341801 0.000000 2.7791007 0.0000000 -10.1487055 0.03644583 0.08796667 0.00000000 -0.0879666667 2.137369e-15 2.137369e-15    
ENST00000527567 ENSG00000132768 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH2 protein_coding retained_intron 78.97981 131.9099 51.85915 5.321307 1.481218 -1.346713 3.429485 2.096638 3.638835 0.4097897 0.4549759 0.7924931 0.05275000 0.01580000 0.07070000 0.0549000000 1.407334e-06 2.137369e-15 FALSE  
MSTRG.1027.3 ENSG00000132768 HEK293_OSMI2_2hA HEK293_TMG_2hB DPH2 protein_coding   78.97981 131.9099 51.85915 5.321307 1.481218 -1.346713 4.301637 7.807615 2.957664 0.3776123 1.5027387 -1.3974008 0.05410833 0.05916667 0.05863333 -0.0005333333 8.827007e-01 2.137369e-15 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132768 E001 1.990848 0.0233337786 4.732943e-03 1.518599e-02 1 43968706 43968845 140 + 0.727 0.251 -2.469
ENSG00000132768 E002 9.436606 0.0017935587 6.242736e-02 1.307335e-01 1 43969927 43969990 64 + 1.093 0.894 -0.738
ENSG00000132768 E003 14.694207 0.0011852425 5.048033e-02 1.100184e-01 1 43969991 43969999 9 + 1.251 1.077 -0.622
ENSG00000132768 E004 36.459360 0.0005807831 3.127379e-02 7.443310e-02 1 43970000 43970007 8 + 1.591 1.464 -0.434
ENSG00000132768 E005 43.711181 0.0005072136 1.298353e-02 3.587229e-02 1 43970008 43970009 2 + 1.673 1.539 -0.458
ENSG00000132768 E006 94.886025 0.0025727277 1.811343e-02 4.737453e-02 1 43970010 43970022 13 + 1.982 1.883 -0.332
ENSG00000132768 E007 103.434731 0.0020788812 9.037284e-03 2.637157e-02 1 43970023 43970023 1 + 2.022 1.919 -0.347
ENSG00000132768 E008 125.048334 0.0005390454 1.846308e-04 8.976939e-04 1 43970024 43970024 1 + 2.118 1.994 -0.416
ENSG00000132768 E009 152.707482 0.0002643954 6.471184e-04 2.705806e-03 1 43970025 43970028 4 + 2.186 2.086 -0.333
ENSG00000132768 E010 307.104492 0.0010133728 6.367514e-01 7.507135e-01 1 43970029 43970066 38 + 2.394 2.419 0.082
ENSG00000132768 E011 344.950733 0.0015952774 7.863797e-01 8.631960e-01 1 43970067 43970104 38 + 2.449 2.468 0.066
ENSG00000132768 E012 207.284677 0.0015695586 1.952882e-01 3.203299e-01 1 43970105 43970109 5 + 2.268 2.236 -0.108
ENSG00000132768 E013 544.598709 0.0009444217 2.849494e-01 4.252457e-01 1 43970110 43970236 127 + 2.670 2.658 -0.040
ENSG00000132768 E014 351.762016 0.0003891102 7.111017e-01 8.081028e-01 1 43970237 43970270 34 + 2.468 2.470 0.008
ENSG00000132768 E015 251.045447 0.0009921703 8.920744e-01 9.350700e-01 1 43970271 43970278 8 + 2.318 2.325 0.025
ENSG00000132768 E016 257.845653 0.0026995780 3.619378e-01 5.063438e-01 1 43970279 43970295 17 + 2.350 2.331 -0.065
ENSG00000132768 E017 256.450755 0.0036915655 3.848276e-01 5.289829e-01 1 43970296 43970312 17 + 2.348 2.328 -0.068
ENSG00000132768 E018 199.307522 0.0019679616 4.284676e-01 5.712259e-01 1 43970313 43970314 2 + 2.235 2.219 -0.054
ENSG00000132768 E019 233.974772 0.0004854293 5.278710e-01 6.608267e-01 1 43970315 43970322 8 + 2.299 2.292 -0.023
ENSG00000132768 E020 538.645743 0.0002651425 3.390317e-01 4.829322e-01 1 43970596 43970708 113 + 2.658 2.651 -0.023
ENSG00000132768 E021 39.230764 0.0069764336 2.215142e-14 6.924952e-13 1 43970709 43970817 109 + 1.855 1.344 -1.743
ENSG00000132768 E022 22.569891 0.0084933028 1.980138e-14 6.236595e-13 1 43970818 43970869 52 + 1.678 1.050 -2.192
ENSG00000132768 E023 19.750580 0.0035668253 3.551850e-16 1.423498e-14 1 43970870 43970905 36 + 1.631 0.983 -2.278
ENSG00000132768 E024 32.549953 0.0055676819 9.469506e-09 1.173219e-07 1 43970906 43970965 60 + 1.716 1.318 -1.365
ENSG00000132768 E025 572.894799 0.0005047151 5.117287e-01 6.466899e-01 1 43970966 43971113 148 + 2.660 2.685 0.083
ENSG00000132768 E026 479.700585 0.0002138065 9.884735e-01 9.968460e-01 1 43971114 43971189 76 + 2.593 2.605 0.037
ENSG00000132768 E027 30.859993 0.0006686289 3.614592e-07 3.288702e-06 1 43971190 43971220 31 + 1.653 1.332 -1.100
ENSG00000132768 E028 42.588490 0.0005289423 1.772421e-16 7.389523e-15 1 43971221 43971386 166 + 1.858 1.418 -1.497
ENSG00000132768 E029 507.444536 0.0002914567 3.271534e-01 4.706124e-01 1 43971387 43971468 82 + 2.603 2.634 0.102
ENSG00000132768 E030 462.957391 0.0001532041 4.668445e-01 6.063796e-01 1 43971469 43971540 72 + 2.568 2.593 0.084
ENSG00000132768 E031 560.891085 0.0006250460 8.242218e-01 8.892769e-01 1 43971541 43971659 119 + 2.666 2.673 0.025
ENSG00000132768 E032 1247.757516 0.0001491300 4.680524e-01 6.074863e-01 1 43971660 43972070 411 + 3.003 3.023 0.068
ENSG00000132768 E033 964.285363 0.0004003322 5.016795e-01 6.378250e-01 1 43972158 43972334 177 + 2.889 2.912 0.075
ENSG00000132768 E034 402.452594 0.0009515231 2.551726e-01 3.920051e-01 1 43972415 43972427 13 + 2.495 2.536 0.135
ENSG00000132768 E035 2463.104485 0.0009739821 6.712461e-09 8.547795e-08 1 43972428 43973369 942 + 3.237 3.337 0.331