ENSG00000132740

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000255078 ENSG00000132740 HEK293_OSMI2_2hA HEK293_TMG_2hB IGHMBP2 protein_coding protein_coding 22.73764 25.92907 16.03529 1.873234 1.434678 -0.6929768 9.2087170 12.948231 5.79960901 1.5381106 0.08245357 -1.1573558 0.39596667 0.49626667 0.367333333 -0.12893333 1.179151e-01 4.742506e-10 FALSE  
ENST00000539064 ENSG00000132740 HEK293_OSMI2_2hA HEK293_TMG_2hB IGHMBP2 protein_coding retained_intron 22.73764 25.92907 16.03529 1.873234 1.434678 -0.6929768 1.8314133 1.425088 1.53079102 0.3460255 0.13310714 0.1025316 0.08237500 0.05386667 0.095933333 0.04206667 7.579695e-02 4.742506e-10 FALSE  
ENST00000675755 ENSG00000132740 HEK293_OSMI2_2hA HEK293_TMG_2hB IGHMBP2 protein_coding processed_transcript 22.73764 25.92907 16.03529 1.873234 1.434678 -0.6929768 0.6750871 0.000000 0.90308985 0.0000000 0.18375520 6.5126849 0.03223750 0.00000000 0.058900000 0.05890000 4.742506e-10 4.742506e-10 FALSE  
ENST00000676173 ENSG00000132740 HEK293_OSMI2_2hA HEK293_TMG_2hB IGHMBP2 protein_coding processed_transcript 22.73764 25.92907 16.03529 1.873234 1.434678 -0.6929768 1.5835766 1.527919 1.28078796 0.1820748 0.30050479 -0.2527277 0.07350417 0.05936667 0.078400000 0.01903333 6.252945e-01 4.742506e-10 FALSE  
ENST00000676400 ENSG00000132740 HEK293_OSMI2_2hA HEK293_TMG_2hB IGHMBP2 protein_coding processed_transcript 22.73764 25.92907 16.03529 1.873234 1.434678 -0.6929768 3.6016287 2.875170 3.36380475 0.6746530 1.04091917 0.2257204 0.16352917 0.10830000 0.204500000 0.09620000 4.117380e-01 4.742506e-10    
MSTRG.5861.35 ENSG00000132740 HEK293_OSMI2_2hA HEK293_TMG_2hB IGHMBP2 protein_coding   22.73764 25.92907 16.03529 1.873234 1.434678 -0.6929768 0.5516646 1.692623 0.05796972 0.2125016 0.05796972 -4.6467231 0.02114583 0.06596667 0.003866667 -0.06210000 5.872728e-03 4.742506e-10 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132740 E001 0.6664265 0.0177264911 4.647662e-01 6.044790e-01 11 68903863 68903890 28 + 0.284 0.164 -1.009
ENSG00000132740 E002 1.2147488 0.0117374171 5.585624e-01 6.867818e-01 11 68903891 68903895 5 + 0.377 0.283 -0.592
ENSG00000132740 E003 7.1548883 0.0454990424 1.027372e-01 1.946675e-01 11 68903896 68903912 17 + 1.010 0.787 -0.850
ENSG00000132740 E004 16.2782079 0.0605704893 2.842376e-01 4.244543e-01 11 68903913 68903925 13 + 1.279 1.152 -0.452
ENSG00000132740 E005 18.0130646 0.0411869785 2.775006e-01 4.170699e-01 11 68903926 68903932 7 + 1.310 1.198 -0.395
ENSG00000132740 E006 46.1285021 0.0182845309 4.443430e-01 5.859181e-01 11 68903933 68903989 57 + 1.656 1.620 -0.123
ENSG00000132740 E007 57.0700699 0.0059688236 5.451937e-01 6.755952e-01 11 68903990 68904038 49 + 1.729 1.716 -0.046
ENSG00000132740 E008 0.1482932 0.0418537836 1.000000e+00   11 68904579 68904609 31 + 0.000 0.089 10.990
ENSG00000132740 E009 0.0000000       11 68905936 68905964 29 +      
ENSG00000132740 E010 58.1026688 0.0004921100 8.470716e-01 9.050236e-01 11 68906069 68906135 67 + 1.718 1.729 0.037
ENSG00000132740 E011 55.9588730 0.0008951287 7.166052e-01 8.122163e-01 11 68906136 68906200 65 + 1.706 1.708 0.007
ENSG00000132740 E012 47.7383419 0.0028758405 2.673770e-01 4.056878e-01 11 68906201 68906238 38 + 1.669 1.626 -0.147
ENSG00000132740 E013 3.4967063 0.0047036142 2.301367e-01 3.626291e-01 11 68906239 68906242 4 + 0.454 0.669 0.992
ENSG00000132740 E014 4.6969612 0.0431754677 5.399798e-01 6.711864e-01 11 68906243 68906384 142 + 0.784 0.706 -0.315
ENSG00000132740 E015 115.7473891 0.0011830534 4.395120e-02 9.829212e-02 11 68908145 68908337 193 + 2.056 2.001 -0.181
ENSG00000132740 E016 88.7702692 0.0003436025 1.186304e-02 3.320229e-02 11 68908534 68908631 98 + 1.959 1.880 -0.266
ENSG00000132740 E017 101.9649409 0.0003317075 1.813464e-04 8.837890e-04 11 68911440 68911545 106 + 2.043 1.926 -0.392
ENSG00000132740 E018 71.0272259 0.0054529283 4.851470e-03 1.551814e-02 11 68911546 68911603 58 + 1.898 1.766 -0.445
ENSG00000132740 E019 0.2214452 0.0373231006 1.000000e+00   11 68911604 68911992 389 + 0.000 0.090 11.031
ENSG00000132740 E020 0.2214452 0.0373231006 1.000000e+00   11 68911993 68912169 177 + 0.000 0.090 11.031
ENSG00000132740 E021 0.6986918 0.0166303466 7.624346e-01 8.460098e-01 11 68912940 68914184 1245 + 0.165 0.227 0.577
ENSG00000132740 E022 0.2955422 0.0291881369 5.858834e-01   11 68914185 68914267 83 + 0.165 0.090 -1.011
ENSG00000132740 E023 0.4815130 0.0219905606 9.822108e-01 9.929238e-01 11 68914268 68914350 83 + 0.165 0.164 -0.011
ENSG00000132740 E024 0.0000000       11 68914351 68914351 1 +      
ENSG00000132740 E025 0.0000000       11 68914685 68914709 25 +      
ENSG00000132740 E026 123.2364170 0.0004789188 4.712740e-02 1.040528e-01 11 68914823 68915017 195 + 2.080 2.032 -0.160
ENSG00000132740 E027 37.3083627 0.0075292102 2.050195e-01 3.324260e-01 11 68915018 68915023 6 + 1.584 1.517 -0.230
ENSG00000132740 E028 0.0000000       11 68917015 68917160 146 +      
ENSG00000132740 E029 0.0000000       11 68917161 68917163 3 +      
ENSG00000132740 E030 0.1482932 0.0418537836 1.000000e+00   11 68917164 68917301 138 + 0.000 0.089 10.990
ENSG00000132740 E031 0.0000000       11 68917522 68917552 31 +      
ENSG00000132740 E032 86.2970557 0.0021296360 2.485247e-01 3.841909e-01 11 68917736 68917883 148 + 1.920 1.889 -0.103
ENSG00000132740 E033 0.0000000       11 68926196 68926292 97 +      
ENSG00000132740 E034 0.0000000       11 68926293 68926365 73 +      
ENSG00000132740 E035 0.8576959 0.3047752747 3.739780e-01 5.184061e-01 11 68928921 68928997 77 + 0.379 0.167 -1.570
ENSG00000132740 E036 0.3332198 0.0284425108 5.855511e-01   11 68929071 68929143 73 + 0.165 0.090 -1.009
ENSG00000132740 E037 0.3634088 0.3411616817 5.890359e-01   11 68929144 68929182 39 + 0.000 0.165 11.205
ENSG00000132740 E038 97.6708325 0.0003246740 5.813617e-01 7.058993e-01 11 68929183 68929357 175 + 1.920 1.962 0.142
ENSG00000132740 E039 18.4208402 0.0010019782 7.366468e-05 3.977641e-04 11 68929500 68929601 102 + 1.436 1.141 -1.034
ENSG00000132740 E040 11.0104927 0.0016127909 5.429040e-01 6.735970e-01 11 68929734 68929747 14 + 0.969 1.054 0.314
ENSG00000132740 E041 20.3143244 0.0016577253 8.325342e-01 8.950594e-01 11 68929748 68929843 96 + 1.289 1.292 0.008
ENSG00000132740 E042 9.7998109 0.0017817553 6.453837e-01 7.574918e-01 11 68929844 68929891 48 + 0.947 1.017 0.261
ENSG00000132740 E043 33.9777089 0.0189633817 2.048263e-01 3.321783e-01 11 68929892 68930148 257 + 1.568 1.478 -0.309
ENSG00000132740 E044 32.8706960 0.0006450408 6.975946e-03 2.116039e-02 11 68930149 68930322 174 + 1.589 1.441 -0.509
ENSG00000132740 E045 22.2971488 0.0008501571 6.461401e-03 1.982401e-02 11 68930323 68930357 35 + 1.444 1.260 -0.637
ENSG00000132740 E046 31.0105335 0.0006729898 1.801606e-02 4.716751e-02 11 68930358 68930434 77 + 1.552 1.419 -0.456
ENSG00000132740 E047 35.2772141 0.0134149106 2.890414e-03 9.942268e-03 11 68932305 68932926 622 + 1.652 1.436 -0.737
ENSG00000132740 E048 10.9167723 0.0019949277 5.142480e-03 1.631653e-02 11 68932927 68932946 20 + 1.198 0.933 -0.963
ENSG00000132740 E049 22.2449389 0.0018970611 2.931248e-04 1.351759e-03 11 68932947 68933123 177 + 1.485 1.232 -0.879
ENSG00000132740 E050 15.4267437 0.0013487727 1.013177e-02 2.908805e-02 11 68933124 68933264 141 + 1.309 1.104 -0.729
ENSG00000132740 E051 7.3145706 0.0024863418 6.728369e-03 2.051682e-02 11 68933265 68933298 34 + 1.065 0.765 -1.139
ENSG00000132740 E052 99.6515198 0.0002894159 8.251421e-01 8.898593e-01 11 68933299 68933481 183 + 1.934 1.963 0.098
ENSG00000132740 E053 2.5034783 0.0073206963 3.786121e-01 5.229244e-01 11 68933682 68933794 113 + 0.377 0.547 0.867
ENSG00000132740 E054 97.0825000 0.0016953584 7.133386e-01 8.098576e-01 11 68933795 68933913 119 + 1.937 1.943 0.023
ENSG00000132740 E055 1.1801917 0.0236331951 8.425675e-01 9.019003e-01 11 68933914 68934072 159 + 0.284 0.332 0.312
ENSG00000132740 E056 0.6621601 0.0176723459 4.653403e-01 6.050606e-01 11 68934331 68934463 133 + 0.284 0.164 -1.008
ENSG00000132740 E057 106.5638874 0.0009565628 3.485963e-01 4.928324e-01 11 68934464 68934558 95 + 1.993 1.978 -0.049
ENSG00000132740 E058 1.9196841 0.0072576653 2.067709e-01 3.346814e-01 11 68934901 68934966 66 + 0.576 0.376 -1.010
ENSG00000132740 E059 1.6616927 0.0104576563 2.517222e-01 3.879894e-01 11 68934967 68934994 28 + 0.520 0.332 -1.008
ENSG00000132740 E060 67.6807054 0.0018150333 5.559463e-01 6.847162e-01 11 68935299 68935330 32 + 1.792 1.785 -0.025
ENSG00000132740 E061 108.1873594 0.0004030639 9.840164e-01 9.940860e-01 11 68935331 68935422 92 + 1.981 2.001 0.067
ENSG00000132740 E062 1.3683536 0.1946642087 4.020670e-01 5.457700e-01 11 68935851 68935881 31 + 0.455 0.286 -0.989
ENSG00000132740 E063 302.8295281 0.0001677383 2.479521e-01 3.835171e-01 11 68936237 68936783 547 + 2.402 2.448 0.155
ENSG00000132740 E064 83.1173767 0.0003180451 5.407587e-01 6.718549e-01 11 68936784 68936823 40 + 1.844 1.890 0.157
ENSG00000132740 E065 97.4962553 0.0003025321 3.882616e-01 5.323745e-01 11 68936824 68936922 99 + 1.908 1.962 0.183
ENSG00000132740 E066 110.9013699 0.0003162816 1.624255e-03 6.038508e-03 11 68936923 68937091 169 + 1.895 2.036 0.474
ENSG00000132740 E067 2.2035836 0.1344804978 8.483306e-01 9.058119e-01 11 68937740 68938181 442 + 0.454 0.487 0.164
ENSG00000132740 E068 149.6401870 0.0004786972 3.046914e-09 4.127780e-08 11 68938182 68938354 173 + 1.957 2.184 0.761
ENSG00000132740 E069 4.3375389 0.0036826869 6.877532e-01 7.900219e-01 11 68938658 68938844 187 + 0.712 0.670 -0.177
ENSG00000132740 E070 541.4750823 0.0081084870 1.930286e-05 1.201771e-04 11 68939534 68940602 1069 + 2.542 2.742 0.665