ENSG00000132694

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000361409 ENSG00000132694 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF11 protein_coding protein_coding 12.37314 12.69524 9.754938 0.5935835 0.4792568 -0.3797404 2.728602 1.5498504 2.6938771 0.43272764 0.4394500 0.7936219 0.22390417 0.11996667 0.27343333 0.153466667 0.032440449 0.009549395 FALSE TRUE
ENST00000368194 ENSG00000132694 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF11 protein_coding protein_coding 12.37314 12.69524 9.754938 0.5935835 0.4792568 -0.3797404 6.659251 8.5909154 5.0945769 0.28870244 0.1180211 -0.7526988 0.54567083 0.67843333 0.52413333 -0.154300000 0.009549395 0.009549395 FALSE TRUE
ENST00000461678 ENSG00000132694 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF11 protein_coding processed_transcript 12.37314 12.69524 9.754938 0.5935835 0.4792568 -0.3797404 1.042345 0.8935511 0.7279764 0.07924624 0.2755580 -0.2920314 0.08060417 0.07086667 0.07213333 0.001266667 0.973605676 0.009549395 FALSE TRUE
ENST00000487682 ENSG00000132694 HEK293_OSMI2_2hA HEK293_TMG_2hB ARHGEF11 protein_coding processed_transcript 12.37314 12.69524 9.754938 0.5935835 0.4792568 -0.3797404 1.482010 1.2235807 0.8350304 0.11171134 0.1266465 -0.5457770 0.11190417 0.09740000 0.08706667 -0.010333333 0.860177553 0.009549395 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132694 E001 0.1482932 0.0418758401 6.836245e-01   1 156934840 156934844 5 - 0.000 0.105 8.925
ENSG00000132694 E002 274.0924975 0.0115879488 4.661213e-09 6.115325e-08 1 156934845 156935523 679 - 2.175 2.524 1.164
ENSG00000132694 E003 170.5925590 0.0022758166 2.391475e-09 3.306508e-08 1 156935524 156935788 265 - 2.057 2.292 0.787
ENSG00000132694 E004 190.3138698 0.0009945687 9.811702e-12 2.046908e-10 1 156935789 156936058 270 - 2.111 2.337 0.754
ENSG00000132694 E005 163.4221497 0.0026043071 6.444060e-06 4.474446e-05 1 156936816 156937005 190 - 2.074 2.261 0.626
ENSG00000132694 E006 169.9987363 0.0021052624 1.632481e-07 1.591952e-06 1 156937249 156937496 248 - 2.079 2.284 0.685
ENSG00000132694 E007 97.9157192 0.0087163979 1.777394e-03 6.527516e-03 1 156938418 156938513 96 - 1.844 2.048 0.685
ENSG00000132694 E008 18.8177623 0.0409365294 1.747657e-01 2.944028e-01 1 156938514 156939148 635 - 1.371 1.211 -0.560
ENSG00000132694 E009 8.2764256 0.0419076924 2.226936e-01 3.535933e-01 1 156939149 156939285 137 - 1.044 0.881 -0.608
ENSG00000132694 E010 9.3824669 0.0191768831 1.107864e-03 4.329327e-03 1 156939286 156939547 262 - 1.207 0.827 -1.401
ENSG00000132694 E011 194.4811166 0.0016413005 8.646659e-06 5.828649e-05 1 156939548 156939910 363 - 2.168 2.330 0.539
ENSG00000132694 E012 0.8931848 0.0809596416 4.461525e-02 9.949178e-02 1 156939911 156940206 296 - 0.468 0.105 -2.831
ENSG00000132694 E013 127.4395494 0.0038637145 4.103105e-02 9.293984e-02 1 156940207 156940425 219 - 2.020 2.128 0.360
ENSG00000132694 E014 62.0993245 0.0005136666 4.053330e-01 5.490232e-01 1 156941372 156941433 62 - 1.745 1.798 0.181
ENSG00000132694 E015 82.1465146 0.0081157178 2.803811e-01 4.202471e-01 1 156941864 156941989 126 - 1.849 1.928 0.266
ENSG00000132694 E016 71.6079277 0.0003551035 3.366459e-01 4.805233e-01 1 156942690 156942780 91 - 1.807 1.863 0.190
ENSG00000132694 E017 71.5664657 0.0042555973 1.296810e-02 3.583696e-02 1 156943935 156944102 168 - 1.745 1.894 0.503
ENSG00000132694 E018 57.4934835 0.0012447010 1.061759e-01 1.998829e-01 1 156944358 156944433 76 - 1.687 1.783 0.326
ENSG00000132694 E019 83.6993572 0.0006600911 8.701581e-02 1.706174e-01 1 156945019 156945197 179 - 1.854 1.939 0.287
ENSG00000132694 E020 11.7148876 0.0015155294 5.670414e-04 2.410238e-03 1 156945198 156945631 434 - 1.256 0.938 -1.152
ENSG00000132694 E021 5.0372644 0.0032644690 7.650663e-01 8.479169e-01 1 156945908 156946044 137 - 0.780 0.752 -0.113
ENSG00000132694 E022 64.9048329 0.0003788671 8.345530e-01 8.964363e-01 1 156946045 156946162 118 - 1.785 1.809 0.081
ENSG00000132694 E023 78.3612726 0.0003390707 4.890178e-01 6.265162e-01 1 156946662 156946787 126 - 1.892 1.879 -0.045
ENSG00000132694 E024 62.5623829 0.0006316258 1.086059e-01 2.034778e-01 1 156946936 156947015 80 - 1.825 1.767 -0.196
ENSG00000132694 E025 83.0248495 0.0003630170 4.247923e-01 5.677333e-01 1 156947304 156947450 147 - 1.921 1.905 -0.056
ENSG00000132694 E026 96.3532506 0.0003006596 1.929701e-01 3.175110e-01 1 156947769 156947956 188 - 1.992 1.959 -0.110
ENSG00000132694 E027 61.0675179 0.0004290827 5.933403e-01 7.157555e-01 1 156948181 156948228 48 - 1.751 1.791 0.134
ENSG00000132694 E028 83.6455924 0.0003487701 2.430893e-01 3.778174e-01 1 156948319 156948498 180 - 1.927 1.896 -0.105
ENSG00000132694 E029 80.3132022 0.0008970532 1.920885e-03 6.979935e-03 1 156951573 156951699 127 - 1.960 1.847 -0.380
ENSG00000132694 E030 52.4815495 0.0036981857 1.654871e-03 6.137393e-03 1 156954892 156954921 30 - 1.809 1.650 -0.539
ENSG00000132694 E031 46.3433824 0.0005054127 1.108500e-04 5.717607e-04 1 156955703 156955723 21 - 1.768 1.585 -0.622
ENSG00000132694 E032 74.6143541 0.0005100643 5.340669e-04 2.287218e-03 1 156955724 156955799 76 - 1.935 1.806 -0.435
ENSG00000132694 E033 90.6779174 0.0079376436 4.354050e-02 9.753828e-02 1 156956420 156956564 145 - 2.000 1.904 -0.323
ENSG00000132694 E034 43.0537002 0.0169835430 4.177098e-01 5.610342e-01 1 156957792 156957815 24 - 1.651 1.604 -0.159
ENSG00000132694 E035 79.4833431 0.0044155248 1.239509e-01 2.256031e-01 1 156958742 156958864 123 - 1.924 1.861 -0.209
ENSG00000132694 E036 71.4012192 0.0003971356 3.331730e-03 1.123947e-02 1 156959046 156959142 97 - 1.907 1.798 -0.367
ENSG00000132694 E037 50.5009437 0.0004414687 5.690995e-05 3.161150e-04 1 156960418 156960460 43 - 1.802 1.618 -0.622
ENSG00000132694 E038 62.7439233 0.0004118672 4.930199e-05 2.782363e-04 1 156961677 156961775 99 - 1.884 1.717 -0.561
ENSG00000132694 E039 55.1568403 0.0004584382 4.163466e-06 3.015008e-05 1 156963203 156963304 102 - 1.847 1.643 -0.689
ENSG00000132694 E040 44.1886577 0.0007066531 1.417378e-07 1.398968e-06 1 156963520 156963594 75 - 1.788 1.526 -0.891
ENSG00000132694 E041 0.0000000       1 156963692 156963766 75 -      
ENSG00000132694 E042 0.1515154 0.0442747941 3.409613e-01   1 156967911 156967986 76 - 0.142 0.000 -10.215
ENSG00000132694 E043 59.3716925 0.0037768664 3.367256e-05 1.977852e-04 1 156967987 156968124 138 - 1.883 1.677 -0.696
ENSG00000132694 E044 47.5986202 0.0004903989 1.216219e-03 4.695232e-03 1 156969282 156969358 77 - 1.757 1.606 -0.510
ENSG00000132694 E045 39.9573444 0.0046514608 3.078080e-02 7.348594e-02 1 156969998 156970043 46 - 1.665 1.542 -0.421
ENSG00000132694 E046 33.0165154 0.0149633632 1.359020e-01 2.423562e-01 1 156971697 156971816 120 - 1.577 1.467 -0.377
ENSG00000132694 E047 0.9996463 0.0126797177 6.448527e-01 7.570891e-01 1 156971817 156971825 9 - 0.335 0.260 -0.501
ENSG00000132694 E048 50.3044095 0.0013981965 1.303352e-04 6.602702e-04 1 156976983 156977054 72 - 1.799 1.616 -0.621
ENSG00000132694 E049 72.3011269 0.0024323030 9.376367e-05 4.926435e-04 1 156978204 156978382 179 - 1.949 1.779 -0.571
ENSG00000132694 E050 45.4637305 0.0052934488 5.350807e-02 1.153945e-01 1 156979229 156979286 58 - 1.717 1.612 -0.355
ENSG00000132694 E051 45.0295633 0.0027322662 8.420650e-03 2.484027e-02 1 156980437 156980486 50 - 1.729 1.594 -0.459
ENSG00000132694 E052 57.0269149 0.0274861938 6.418745e-03 1.971070e-02 1 156984339 156984437 99 - 1.878 1.652 -0.765
ENSG00000132694 E053 54.8265564 0.0183897386 1.482319e-02 4.009380e-02 1 156986082 156986173 92 - 1.834 1.659 -0.591
ENSG00000132694 E054 70.4353642 0.0081493914 1.935724e-02 5.010755e-02 1 157044299 157044499 201 - 1.913 1.789 -0.417
ENSG00000132694 E055 112.9683420 0.0082975898 6.586860e-03 2.015181e-02 1 157044500 157045132 633 - 2.118 1.987 -0.439
ENSG00000132694 E056 71.6062770 0.0184406434 4.570363e-04 1.994797e-03 1 157045133 157045742 610 - 1.982 1.734 -0.833