ENSG00000132680

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368320 ENSG00000132680 HEK293_OSMI2_2hA HEK293_TMG_2hB KHDC4 protein_coding protein_coding 38.01075 22.69096 45.94546 1.478565 0.8802306 1.017483 9.937916 5.344273 7.541523 0.4076532 0.2597703 0.4960770 0.27071667 0.23686667 0.16443333 -0.07243333 0.0603646459 3.424781e-11 FALSE  
ENST00000368321 ENSG00000132680 HEK293_OSMI2_2hA HEK293_TMG_2hB KHDC4 protein_coding protein_coding 38.01075 22.69096 45.94546 1.478565 0.8802306 1.017483 12.294975 11.438662 20.684060 1.4633617 0.5923119 0.8540377 0.33990417 0.50040000 0.45030000 -0.05010000 0.5872620062 3.424781e-11 FALSE  
ENST00000465953 ENSG00000132680 HEK293_OSMI2_2hA HEK293_TMG_2hB KHDC4 protein_coding processed_transcript 38.01075 22.69096 45.94546 1.478565 0.8802306 1.017483 5.595050 1.629427 6.244223 0.1592796 0.2539110 1.9316394 0.13771667 0.07230000 0.13586667 0.06356667 0.0006920766 3.424781e-11    
MSTRG.2335.7 ENSG00000132680 HEK293_OSMI2_2hA HEK293_TMG_2hB KHDC4 protein_coding   38.01075 22.69096 45.94546 1.478565 0.8802306 1.017483 3.656584 2.143161 3.499268 0.3386617 0.6523089 0.7047141 0.09497917 0.09566667 0.07653333 -0.01913333 0.7501204759 3.424781e-11 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132680 E001 14.9392021 0.0266619744 6.352494e-03 1.953861e-02 1 155913045 155913081 37 - 1.311 0.985 -1.171
ENSG00000132680 E002 97.2157349 0.0003277668 2.471871e-05 1.501491e-04 1 155913082 155913137 56 - 1.911 2.079 0.565
ENSG00000132680 E003 107.4886617 0.0008561598 1.498450e-06 1.198653e-05 1 155913138 155913164 27 - 1.945 2.136 0.639
ENSG00000132680 E004 142.7883410 0.0002720754 8.232780e-12 1.737026e-10 1 155913165 155913205 41 - 2.049 2.270 0.739
ENSG00000132680 E005 163.4149701 0.0002165511 3.292487e-18 1.700059e-16 1 155913206 155913275 70 - 2.087 2.346 0.864
ENSG00000132680 E006 320.4058478 0.0021599255 1.231677e-13 3.454678e-12 1 155913276 155913445 170 - 2.391 2.625 0.779
ENSG00000132680 E007 709.4460884 0.0015483914 4.392087e-16 1.736368e-14 1 155913446 155914111 666 - 2.759 2.945 0.617
ENSG00000132680 E008 246.7702681 0.0002327650 1.509644e-02 4.070328e-02 1 155914112 155914216 105 - 2.362 2.435 0.243
ENSG00000132680 E009 286.6729113 0.0001854732 1.050478e-01 1.981579e-01 1 155914217 155914311 95 - 2.437 2.488 0.170
ENSG00000132680 E010 164.0149038 0.0016228812 7.677770e-01 8.499267e-01 1 155914312 155914320 9 - 2.206 2.231 0.084
ENSG00000132680 E011 197.7576386 0.0034096018 3.658625e-05 2.128406e-04 1 155914321 155914955 635 - 2.215 2.382 0.556
ENSG00000132680 E012 88.0395930 0.0004680716 9.622954e-01 9.802080e-01 1 155914956 155915201 246 - 1.940 1.954 0.046
ENSG00000132680 E013 26.2980365 0.0170035673 7.186492e-01 8.136811e-01 1 155915202 155915226 25 - 1.408 1.449 0.143
ENSG00000132680 E014 49.8184341 0.0023881734 5.571166e-01 6.856019e-01 1 155915227 155915369 143 - 1.680 1.725 0.153
ENSG00000132680 E015 51.9039288 0.0047654930 3.897461e-01 5.338046e-01 1 155915370 155915576 207 - 1.690 1.752 0.211
ENSG00000132680 E016 19.0525508 0.0010327230 2.511611e-01 3.873219e-01 1 155915577 155915589 13 - 1.247 1.352 0.369
ENSG00000132680 E017 32.7158334 0.0017003169 8.184234e-01 8.852240e-01 1 155915590 155915663 74 - 1.509 1.538 0.100
ENSG00000132680 E018 33.6161973 0.0006157018 3.300884e-01 4.736869e-01 1 155915664 155915755 92 - 1.554 1.511 -0.149
ENSG00000132680 E019 54.8941092 0.0030699719 1.778454e-01 2.984311e-01 1 155915756 155915872 117 - 1.766 1.705 -0.208
ENSG00000132680 E020 228.3036967 0.0001778759 4.727805e-04 2.055983e-03 1 155915873 155915964 92 - 2.388 2.321 -0.225
ENSG00000132680 E021 185.9304719 0.0014649586 2.801916e-02 6.805315e-02 1 155916625 155916709 85 - 2.293 2.238 -0.186
ENSG00000132680 E022 82.2538516 0.0126868248 9.583730e-02 1.841444e-01 1 155916710 155916737 28 - 1.959 1.852 -0.360
ENSG00000132680 E023 35.7825736 0.0005661794 1.151603e-05 7.544818e-05 1 155916738 155916942 205 - 1.654 1.398 -0.878
ENSG00000132680 E024 148.3395914 0.0015127308 1.124547e-02 3.175040e-02 1 155917499 155917672 174 - 2.203 2.129 -0.247
ENSG00000132680 E025 6.4820068 0.0097603595 2.389607e-01 3.729273e-01 1 155921239 155921374 136 - 0.787 0.948 0.620
ENSG00000132680 E026 61.2175646 0.0004168097 5.707370e-02 1.215947e-01 1 155921375 155921384 10 - 1.820 1.748 -0.243
ENSG00000132680 E027 94.1481787 0.0003353677 5.837015e-04 2.473786e-03 1 155921385 155921421 37 - 2.021 1.907 -0.383
ENSG00000132680 E028 154.3342046 0.0002500843 1.155924e-05 7.570573e-05 1 155921422 155921524 103 - 2.235 2.121 -0.381
ENSG00000132680 E029 81.7387570 0.0003971760 4.640244e-05 2.635133e-04 1 155921525 155921527 3 - 1.974 1.824 -0.505
ENSG00000132680 E030 137.7285758 0.0032030375 4.435180e-03 1.435852e-02 1 155921528 155921628 101 - 2.182 2.083 -0.334
ENSG00000132680 E031 122.2049363 0.0010114167 3.411198e-02 7.998134e-02 1 155921861 155921918 58 - 2.115 2.057 -0.195
ENSG00000132680 E032 2.6990086 0.0054578779 8.554044e-03 2.517458e-02 1 155921919 155922014 96 - 0.707 0.262 -2.310
ENSG00000132680 E033 110.1238255 0.0003024618 2.788904e-02 6.779535e-02 1 155923627 155923687 61 - 2.069 2.010 -0.200
ENSG00000132680 E034 195.0467607 0.0001889351 1.137819e-05 7.464120e-05 1 155925632 155925843 212 - 2.330 2.232 -0.329
ENSG00000132680 E035 0.9544932 0.0574509281 1.994950e-01 3.256030e-01 1 155926471 155926675 205 - 0.180 0.423 1.684
ENSG00000132680 E036 247.7292889 0.0003449513 1.139910e-11 2.350632e-10 1 155926676 155926839 164 - 2.452 2.303 -0.498
ENSG00000132680 E037 179.0794484 0.0003057661 2.559857e-10 4.206412e-09 1 155927104 155927156 53 - 2.317 2.157 -0.537
ENSG00000132680 E038 204.8990013 0.0002205183 9.978710e-11 1.760675e-09 1 155929296 155929375 80 - 2.372 2.221 -0.504
ENSG00000132680 E039 213.2704839 0.0001930230 2.172699e-10 3.614747e-09 1 155929712 155929840 129 - 2.385 2.241 -0.482
ENSG00000132680 E040 0.7374030 0.0157058319 3.653367e-01 5.096608e-01 1 155932273 155932714 442 - 0.306 0.150 -1.311
ENSG00000132680 E041 0.1472490 0.0428290877 7.492112e-01   1 155933584 155933632 49 - 0.099 0.000 -8.087
ENSG00000132680 E042 190.2371900 0.0042923124 2.698822e-04 1.257183e-03 1 155933633 155933849 217 - 2.332 2.190 -0.475
ENSG00000132680 E043 82.2852302 0.0040705436 2.289134e-05 1.399792e-04 1 155934336 155934413 78 - 1.993 1.785 -0.698