ENSG00000132635

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000360652 ENSG00000132635 HEK293_OSMI2_2hA HEK293_TMG_2hB PCED1A protein_coding protein_coding 25.36416 36.35605 21.26373 2.739632 0.6796603 -0.7735189 14.597155 20.054548 13.610067 1.1454363 0.7547570 -0.55891493 0.58752083 0.5546000 0.6399667 0.08536667 3.325037e-01 1.703108e-12 FALSE TRUE
ENST00000474714 ENSG00000132635 HEK293_OSMI2_2hA HEK293_TMG_2hB PCED1A protein_coding protein_coding 25.36416 36.35605 21.26373 2.739632 0.6796603 -0.7735189 1.351008 4.594931 0.000000 1.2043632 0.0000000 -8.84703574 0.04000417 0.1260667 0.0000000 -0.12606667 1.703108e-12 1.703108e-12 FALSE FALSE
MSTRG.20272.10 ENSG00000132635 HEK293_OSMI2_2hA HEK293_TMG_2hB PCED1A protein_coding   25.36416 36.35605 21.26373 2.739632 0.6796603 -0.7735189 3.272355 3.254951 3.284182 0.8501365 0.4270274 0.01285912 0.13828750 0.0876000 0.1548333 0.06723333 1.807735e-01 1.703108e-12 FALSE TRUE
MSTRG.20272.7 ENSG00000132635 HEK293_OSMI2_2hA HEK293_TMG_2hB PCED1A protein_coding   25.36416 36.35605 21.26373 2.739632 0.6796603 -0.7735189 2.306864 3.905421 1.660896 0.5997127 0.9476476 -1.22854491 0.08146667 0.1064000 0.0754000 -0.03100000 7.601022e-01 1.703108e-12 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132635 E001 2.60579 0.0063629098 0.8080747851 0.878041158 20 2835314 2835320 7 - 0.501 0.537 0.170
ENSG00000132635 E002 10.76728 0.0017044304 0.3066651866 0.448849226 20 2835321 2835333 13 - 0.966 1.070 0.381
ENSG00000132635 E003 12.02062 0.0015234849 0.8434899889 0.902550963 20 2835334 2835336 3 - 1.074 1.087 0.050
ENSG00000132635 E004 34.68698 0.0008487317 0.2583819440 0.395626534 20 2835337 2835372 36 - 1.478 1.543 0.222
ENSG00000132635 E005 47.56889 0.0004989288 0.0364338179 0.084408814 20 2835373 2835391 19 - 1.578 1.687 0.368
ENSG00000132635 E006 381.11680 0.0016535982 0.0002110049 0.001010909 20 2835392 2835709 318 - 2.486 2.576 0.299
ENSG00000132635 E007 180.24439 0.0003018511 0.0009627964 0.003831185 20 2836039 2836110 72 - 2.163 2.250 0.293
ENSG00000132635 E008 263.25653 0.0003621004 0.0004249755 0.001869985 20 2836111 2836314 204 - 2.333 2.411 0.260
ENSG00000132635 E009 375.01469 0.0001947120 0.5739709937 0.699869749 20 2838232 2838478 247 - 2.537 2.542 0.014
ENSG00000132635 E010 287.86399 0.0001888809 0.2279899112 0.360029380 20 2838596 2838746 151 - 2.447 2.414 -0.108
ENSG00000132635 E011 207.69975 0.0002208049 0.7090115560 0.806504583 20 2838844 2838929 86 - 2.293 2.277 -0.054
ENSG00000132635 E012 157.52315 0.0002538867 0.4414434670 0.583085057 20 2838930 2839037 108 - 2.184 2.155 -0.098
ENSG00000132635 E013 90.63848 0.0005997014 0.6673688780 0.774636683 20 2839038 2839082 45 - 1.946 1.922 -0.080
ENSG00000132635 E014 187.48789 0.0002353536 0.0741429100 0.150170010 20 2839192 2839271 80 - 2.274 2.220 -0.182
ENSG00000132635 E015 135.20200 0.0029026649 0.0013195575 0.005042283 20 2839789 2839846 58 - 2.182 2.053 -0.432
ENSG00000132635 E016 119.82510 0.0040255658 0.0157191502 0.042104200 20 2839847 2839933 87 - 2.115 2.007 -0.361
ENSG00000132635 E017 31.61644 0.0389747040 0.1227591227 0.223894288 20 2839934 2840019 86 - 1.588 1.415 -0.594
ENSG00000132635 E018 250.09749 0.0070716492 0.0404226348 0.091796590 20 2840211 2840671 461 - 2.426 2.335 -0.304
ENSG00000132635 E019 18.90963 0.0147552621 0.4332207014 0.575633142 20 2840866 2841190 325 - 1.312 1.232 -0.280