ENSG00000132613

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338779 ENSG00000132613 HEK293_OSMI2_2hA HEK293_TMG_2hB MTSS2 protein_coding protein_coding 41.36126 53.8131 36.38724 5.063883 0.9553714 -0.5643964 22.376394 33.926358 14.921499 2.1305543 0.4803685 -1.1844727 0.5272083 0.63600000 0.4102667 -0.22573333 0.0001115871 0.0001115871 FALSE TRUE
ENST00000576338 ENSG00000132613 HEK293_OSMI2_2hA HEK293_TMG_2hB MTSS2 protein_coding protein_coding 41.36126 53.8131 36.38724 5.063883 0.9553714 -0.5643964 8.769030 10.438571 9.130697 1.1732844 0.4851125 -0.1929296 0.2145625 0.19583333 0.2505667 0.05473333 0.2744037802 0.0001115871 FALSE FALSE
MSTRG.12920.3 ENSG00000132613 HEK293_OSMI2_2hA HEK293_TMG_2hB MTSS2 protein_coding   41.36126 53.8131 36.38724 5.063883 0.9553714 -0.5643964 4.877472 3.708110 6.072363 1.4580264 0.4211926 0.7100624 0.1230333 0.06456667 0.1674333 0.10286667 0.1337624260 0.0001115871 FALSE TRUE
MSTRG.12920.5 ENSG00000132613 HEK293_OSMI2_2hA HEK293_TMG_2hB MTSS2 protein_coding   41.36126 53.8131 36.38724 5.063883 0.9553714 -0.5643964 2.451306 2.415817 3.327160 0.5075244 0.3711250 0.4601505 0.0613250 0.04380000 0.0913000 0.04750000 0.0065165361 0.0001115871 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132613 E001 38.929194 0.0196166622 1.303578e-02 3.599618e-02 16 70661204 70661297 94 - 1.387 1.640 0.867
ENSG00000132613 E002 550.656232 0.0061791152 4.076408e-06 2.958410e-05 16 70661298 70661732 435 - 2.558 2.767 0.696
ENSG00000132613 E003 414.910071 0.0019810576 1.860177e-12 4.361988e-11 16 70661733 70661850 118 - 2.421 2.645 0.746
ENSG00000132613 E004 389.268950 0.0004179142 1.063140e-12 2.597145e-11 16 70661851 70661924 74 - 2.428 2.603 0.581
ENSG00000132613 E005 336.843983 0.0001579539 1.083585e-08 1.327569e-07 16 70661925 70661942 18 - 2.390 2.531 0.470
ENSG00000132613 E006 788.980936 0.0034817063 4.332744e-07 3.880053e-06 16 70661943 70662243 301 - 2.740 2.914 0.579
ENSG00000132613 E007 2255.757468 0.0007061992 2.477796e-02 6.141872e-02 16 70662244 70664449 2206 - 3.286 3.336 0.164
ENSG00000132613 E008 275.167107 0.0006481528 2.574757e-02 6.342136e-02 16 70664598 70664763 166 - 2.429 2.392 -0.125
ENSG00000132613 E009 341.752029 0.0030974454 5.635878e-02 1.203503e-01 16 70664920 70665096 177 - 2.527 2.488 -0.130
ENSG00000132613 E010 249.283468 0.0062498537 1.856056e-02 4.836514e-02 16 70665466 70665540 75 - 2.414 2.338 -0.253
ENSG00000132613 E011 10.315849 0.0098385256 3.822934e-02 8.777856e-02 16 70666461 70666612 152 - 1.159 0.946 -0.778
ENSG00000132613 E012 0.961867 0.2244268302 4.385490e-01 5.804210e-01 16 70668999 70669046 48 - 0.156 0.341 1.460
ENSG00000132613 E013 155.462352 0.0087837773 2.165735e-02 5.496429e-02 16 70674306 70674319 14 - 2.223 2.126 -0.324
ENSG00000132613 E014 272.879828 0.0021158662 4.077467e-04 1.804148e-03 16 70674320 70674432 113 - 2.460 2.372 -0.292
ENSG00000132613 E015 138.291855 0.0002641895 1.684005e-01 2.860971e-01 16 70674433 70674528 96 - 2.127 2.100 -0.091
ENSG00000132613 E016 191.683754 0.0006423364 1.076036e-03 4.221494e-03 16 70676881 70676948 68 - 2.299 2.222 -0.255
ENSG00000132613 E017 138.259923 0.0002313905 1.414780e-04 7.099081e-04 16 70676949 70676978 30 - 2.176 2.074 -0.343
ENSG00000132613 E018 221.488999 0.0002728619 6.471386e-05 3.544640e-04 16 70677792 70677899 108 - 2.368 2.283 -0.281
ENSG00000132613 E019 279.592064 0.0016389415 1.046815e-04 5.436291e-04 16 70678252 70678409 158 - 2.474 2.382 -0.307
ENSG00000132613 E020 13.017193 0.0016146661 1.019644e-01 1.934993e-01 16 70679110 70679248 139 - 1.208 1.070 -0.494
ENSG00000132613 E021 24.211142 0.0008318477 3.130278e-01 4.555495e-01 16 70679315 70679323 9 - 1.410 1.353 -0.198
ENSG00000132613 E022 219.857011 0.0001952884 2.074377e-11 4.099567e-10 16 70679630 70679704 75 - 2.404 2.255 -0.498
ENSG00000132613 E023 220.084354 0.0003284510 5.058909e-11 9.393269e-10 16 70679786 70679877 92 - 2.403 2.253 -0.500
ENSG00000132613 E024 206.474077 0.0052951908 2.914103e-06 2.186456e-05 16 70679971 70680055 85 - 2.393 2.219 -0.583
ENSG00000132613 E025 177.530814 0.0039769542 4.371812e-08 4.770341e-07 16 70680794 70680867 74 - 2.343 2.144 -0.664
ENSG00000132613 E026 126.838789 0.0024395761 3.408099e-07 3.118134e-06 16 70680964 70681025 62 - 2.188 2.006 -0.609
ENSG00000132613 E027 102.500079 0.0093505395 2.474720e-07 2.329697e-06 16 70685723 70686053 331 - 2.152 1.873 -0.938