ENSG00000132549

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357162 ENSG00000132549 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13B protein_coding protein_coding 2.769589 1.445268 3.078137 0.07236166 0.09386105 1.085452 1.2141252 0.3798279 1.8352324 0.07025767 0.11667279 2.2428932 0.41157917 0.2626000 0.59566667 0.33306667 4.436914e-04 1.140056e-07 FALSE TRUE
ENST00000493587 ENSG00000132549 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13B protein_coding retained_intron 2.769589 1.445268 3.078137 0.07236166 0.09386105 1.085452 1.0484974 0.9994182 0.7592001 0.07376103 0.09951591 -0.3920931 0.43578750 0.6911333 0.24533333 -0.44580000 1.140056e-07 1.140056e-07 FALSE TRUE
ENST00000682358 ENSG00000132549 HEK293_OSMI2_2hA HEK293_TMG_2hB VPS13B protein_coding retained_intron 2.769589 1.445268 3.078137 0.07236166 0.09386105 1.085452 0.2251176 0.0000000 0.1810617 0.00000000 0.09135960 4.2559669 0.06005833 0.0000000 0.06023333 0.06023333 3.384947e-01 1.140056e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132549 E001 0.8846495 0.032228935 6.186194e-03 1.910403e-02 8 99013266 99013268 3 + 0.065 0.560 4.026
ENSG00000132549 E002 0.8846495 0.032228935 6.186194e-03 1.910403e-02 8 99013269 99013271 3 + 0.065 0.560 4.026
ENSG00000132549 E003 0.2965864 0.341667651 5.111889e-02   8 99013272 99013273 2 + 0.000 0.356 14.325
ENSG00000132549 E004 0.2965864 0.341667651 5.111889e-02   8 99013274 99013275 2 + 0.000 0.356 14.325
ENSG00000132549 E005 0.7384472 0.126279780 3.908349e-01 5.347810e-01 8 99013276 99013295 20 + 0.171 0.361 1.420
ENSG00000132549 E006 1.3370202 0.113213352 4.863142e-01 6.240846e-01 8 99013296 99013306 11 + 0.294 0.467 0.997
ENSG00000132549 E007 1.3370202 0.113213352 4.863142e-01 6.240846e-01 8 99013307 99013307 1 + 0.294 0.467 0.997
ENSG00000132549 E008 1.4885357 0.175467764 6.403641e-01 7.536173e-01 8 99013308 99013310 3 + 0.329 0.465 0.761
ENSG00000132549 E009 3.3448231 0.034675859 7.338133e-01 8.249782e-01 8 99013311 99013347 37 + 0.592 0.558 -0.152
ENSG00000132549 E010 9.8121263 0.001892677 2.495361e-01 3.853681e-01 8 99013760 99013935 176 + 0.987 0.879 -0.408
ENSG00000132549 E011 9.8235798 0.001735681 2.243310e-01 3.556061e-01 8 99038423 99038566 144 + 0.994 0.879 -0.435
ENSG00000132549 E012 0.0000000       8 99055926 99056040 115 +      
ENSG00000132549 E013 7.9434446 0.002524020 4.682304e-01 6.076548e-01 8 99096312 99096432 121 + 0.900 0.839 -0.232
ENSG00000132549 E014 4.5320146 0.003796305 1.009880e-01 1.919756e-01 8 99102953 99103058 106 + 0.729 0.473 -1.145
ENSG00000132549 E015 4.5278619 0.003967496 1.010863e-01 1.921236e-01 8 99103059 99103120 62 + 0.729 0.473 -1.145
ENSG00000132549 E016 9.5733176 0.003537897 7.915467e-02 1.581616e-01 8 99111098 99111279 182 + 0.994 0.796 -0.757
ENSG00000132549 E017 0.0000000       8 99113128 99114855 1728 +      
ENSG00000132549 E018 11.1950470 0.069650431 2.477174e-01 3.832530e-01 8 99115700 99115874 175 + 1.049 0.881 -0.627
ENSG00000132549 E019 11.2726642 0.001558966 8.409988e-02 1.659701e-01 8 99121177 99121445 269 + 1.054 0.879 -0.653
ENSG00000132549 E020 0.8909948 0.013613890 7.827240e-01 8.605129e-01 8 99121446 99121762 317 + 0.257 0.219 -0.299
ENSG00000132549 E021 6.8462814 0.111891354 1.910550e-01 3.150712e-01 8 99134632 99134727 96 + 0.880 0.627 -1.029
ENSG00000132549 E022 6.9100865 0.055536549 8.151604e-04 3.313442e-03 8 99135015 99135137 123 + 0.924 0.219 -3.500
ENSG00000132549 E023 8.1419034 0.006030855 1.997551e-04 9.627059e-04 8 99135596 99135733 138 + 0.980 0.364 -2.703
ENSG00000132549 E024 7.7297937 0.002470693 2.990979e-04 1.375955e-03 8 99136665 99136752 88 + 0.957 0.364 -2.619
ENSG00000132549 E025 0.1482932 0.042540216 1.196012e-01   8 99136753 99137068 316 + 0.000 0.219 14.178
ENSG00000132549 E026 8.2959862 0.002068908 9.913599e-04 3.928672e-03 8 99142974 99143165 192 + 0.973 0.473 -2.091
ENSG00000132549 E027 8.5751242 0.019593299 4.029781e-01 5.467834e-01 8 99147841 99148010 170 + 0.925 0.842 -0.318
ENSG00000132549 E028 0.0000000       8 99150754 99150822 69 +      
ENSG00000132549 E029 5.5470604 0.037329805 8.221383e-01 8.878380e-01 8 99156549 99156628 80 + 0.728 0.799 0.285
ENSG00000132549 E030 6.4005931 0.023506355 5.459087e-01 6.761780e-01 8 99156629 99156743 115 + 0.812 0.750 -0.246
ENSG00000132549 E031 7.8869252 0.018947769 5.981699e-01 7.198261e-01 8 99170039 99170163 125 + 0.881 0.842 -0.152
ENSG00000132549 E032 7.8392619 0.002061707 2.473200e-02 6.132647e-02 8 99192876 99193057 182 + 0.934 0.632 -1.208
ENSG00000132549 E033 0.5838113 0.482284783 7.671243e-01 8.494261e-01 8 99193058 99193385 328 + 0.171 0.215 0.413
ENSG00000132549 E034 0.0000000       8 99236271 99236392 122 +      
ENSG00000132549 E035 0.1482932 0.042540216 1.196012e-01   8 99240870 99241502 633 + 0.000 0.219 14.178
ENSG00000132549 E036 6.0753716 0.008756812 4.501815e-04 1.967326e-03 8 99274198 99274332 135 + 0.872 0.219 -3.298
ENSG00000132549 E037 5.6844124 0.005785879 5.973514e-03 1.853820e-02 8 99275081 99275208 128 + 0.833 0.364 -2.145
ENSG00000132549 E038 3.5398533 0.006663827 6.408858e-01 7.540288e-01 8 99275209 99275254 46 + 0.609 0.559 -0.223
ENSG00000132549 E039 6.6119217 0.002759629 7.154764e-01 8.113689e-01 8 99384208 99384317 110 + 0.812 0.796 -0.062
ENSG00000132549 E040 0.0000000       8 99389616 99389720 105 +      
ENSG00000132549 E041 2.9152544 0.005211377 5.225795e-01 6.563625e-01 8 99391557 99391559 3 + 0.491 0.632 0.647
ENSG00000132549 E042 7.9745163 0.049832810 2.626036e-01 4.003788e-01 8 99391560 99391704 145 + 0.909 0.753 -0.609
ENSG00000132549 E043 0.1515154 0.042869253 1.000000e+00   8 99391705 99392341 637 + 0.065 0.000 -12.539
ENSG00000132549 E044 0.1515154 0.042869253 1.000000e+00   8 99424267 99424532 266 + 0.065 0.000 -12.539
ENSG00000132549 E045 0.0000000       8 99429570 99429647 78 +      
ENSG00000132549 E046 0.2966881 0.027195464 1.000000e+00   8 99431521 99431536 16 + 0.121 0.000 -13.511
ENSG00000132549 E047 7.0732077 0.097341151 1.046060e-02 2.988762e-02 8 99431537 99431664 128 + 0.919 0.365 -2.471
ENSG00000132549 E048 8.3669627 0.001960649 1.242624e-04 6.334225e-04 8 99442401 99442635 235 + 0.987 0.364 -2.730
ENSG00000132549 E049 0.0000000       8 99442636 99442836 201 +      
ENSG00000132549 E050 0.1472490 0.042932775 1.000000e+00   8 99444120 99444261 142 + 0.065 0.000 -12.539
ENSG00000132549 E051 10.2977851 0.001737823 3.279466e-04 1.492648e-03 8 99467414 99467634 221 + 1.060 0.559 -1.998
ENSG00000132549 E052 9.7288363 0.001801487 1.338155e-04 6.758451e-04 8 99481599 99481802 204 + 1.042 0.473 -2.345
ENSG00000132549 E053 7.0184269 0.015651728 1.436712e-03 5.428631e-03 8 99501687 99501858 172 + 0.917 0.364 -2.467
ENSG00000132549 E054 0.1817044 0.038869519 1.194391e-01   8 99502030 99502835 806 + 0.000 0.219 14.199
ENSG00000132549 E055 4.7423110 0.003443460 4.659674e-01 6.055476e-01 8 99502836 99502950 115 + 0.716 0.632 -0.354
ENSG00000132549 E056 3.8137524 0.006783563 5.050476e-01 6.408771e-01 8 99507137 99507203 67 + 0.642 0.559 -0.368
ENSG00000132549 E057 0.2966881 0.027195464 1.000000e+00   8 99507770 99507911 142 + 0.121 0.000 -13.511
ENSG00000132549 E058 12.5561017 0.005157292 5.838013e-02 1.238515e-01 8 99511104 99511512 409 + 1.106 0.914 -0.708
ENSG00000132549 E059 7.9244059 0.004196221 5.942902e-02 1.256602e-01 8 99520899 99521010 112 + 0.934 0.693 -0.946
ENSG00000132549 E060 9.8072102 0.001753993 9.197137e-03 2.677809e-02 8 99556450 99556653 204 + 1.022 0.694 -1.273
ENSG00000132549 E061 7.2919572 0.003789242 4.120873e-03 1.348081e-02 8 99575658 99575784 127 + 0.917 0.473 -1.882
ENSG00000132549 E062 8.1794647 0.002381248 1.823062e-02 4.763644e-02 8 99577490 99577633 144 + 0.950 0.632 -1.268
ENSG00000132549 E063 0.0000000       8 99577634 99577785 152 +      
ENSG00000132549 E064 16.5440564 0.001058190 7.601133e-02 1.531309e-01 8 99641811 99642266 456 + 1.204 1.061 -0.515
ENSG00000132549 E065 9.4394584 0.002085723 7.690561e-02 1.545495e-01 8 99642267 99642498 232 + 0.994 0.796 -0.758
ENSG00000132549 E066 4.7170419 0.003609494 8.546485e-02 1.681559e-01 8 99661354 99661491 138 + 0.742 0.473 -1.197
ENSG00000132549 E067 13.1798780 0.021280282 2.080740e-01 3.361701e-01 8 99699525 99699932 408 + 1.101 0.982 -0.434
ENSG00000132549 E068 12.5022010 0.003002527 3.653690e-01 5.096797e-01 8 99717171 99717373 203 + 1.072 1.008 -0.234
ENSG00000132549 E069 11.8210221 0.005442443 8.401425e-01 9.001690e-01 8 99720345 99720552 208 + 1.022 1.085 0.230
ENSG00000132549 E070 3.1807371 0.007458063 1.522134e-01 2.646922e-01 8 99720863 99720867 5 + 0.609 0.364 -1.223
ENSG00000132549 E071 10.1267229 0.001745010 3.403907e-01 4.843567e-01 8 99720868 99721047 180 + 0.994 0.915 -0.297
ENSG00000132549 E072 10.7350964 0.037074450 7.949125e-01 8.690126e-01 8 99766774 99766970 197 + 1.002 1.008 0.022
ENSG00000132549 E073 11.3387509 0.018056049 5.243684e-01 6.579013e-01 8 99776775 99776956 182 + 1.028 0.981 -0.173
ENSG00000132549 E074 22.5094581 0.002695027 1.461458e-01 2.564479e-01 8 99778682 99779031 350 + 1.316 1.224 -0.320
ENSG00000132549 E075 14.2504020 0.001717225 1.890212e-01 3.125147e-01 8 99784315 99784476 162 + 1.138 1.035 -0.373
ENSG00000132549 E076 12.7266544 0.001398867 4.576416e-01 5.979518e-01 8 99809375 99809530 156 + 1.078 1.035 -0.156
ENSG00000132549 E077 15.4462499 0.001338560 9.769398e-02 1.869780e-01 8 99817540 99817803 264 + 1.172 1.035 -0.495
ENSG00000132549 E078 8.7573251 0.001858298 2.718328e-02 6.636561e-02 8 99818451 99818534 84 + 0.973 0.694 -1.091
ENSG00000132549 E079 12.4554875 0.001620284 6.560752e-02 1.360576e-01 8 99818713 99818888 176 + 1.095 0.915 -0.666
ENSG00000132549 E080 13.4390989 0.053348123 3.644642e-01 5.088221e-01 8 99819412 99819582 171 + 1.106 1.014 -0.334
ENSG00000132549 E081 14.4670186 0.030177724 4.684258e-01 6.078465e-01 8 99819921 99820122 202 + 1.084 1.210 0.449
ENSG00000132549 E082 13.8456295 0.002641383 1.126092e-01 2.093590e-01 8 99821294 99821482 189 + 1.041 1.241 0.716
ENSG00000132549 E083 11.5021562 0.002932968 4.659865e-01 6.055682e-01 8 99823832 99823978 147 + 0.987 1.108 0.442
ENSG00000132549 E084 14.7361468 0.003858371 2.944713e-01 4.355682e-01 8 99832369 99832652 284 + 1.078 1.225 0.526
ENSG00000132549 E085 12.3830093 0.001641842 9.236022e-01 9.558582e-01 8 99835197 99835324 128 + 1.035 1.085 0.182
ENSG00000132549 E086 15.1124212 0.003598254 9.078042e-01 9.454991e-01 8 99835539 99835738 200 + 1.123 1.151 0.101
ENSG00000132549 E087 11.1738967 0.002794090 6.969030e-01 7.971584e-01 8 99848776 99848894 119 + 1.015 1.008 -0.025
ENSG00000132549 E088 42.1647358 0.002429888 8.416627e-01 9.012329e-01 8 99853451 99854256 806 + 1.545 1.600 0.188
ENSG00000132549 E089 0.0000000       8 99854410 99854519 110 +      
ENSG00000132549 E090 15.0877042 0.001151172 4.261699e-01 5.690204e-01 8 99859304 99859480 177 + 1.106 1.224 0.420
ENSG00000132549 E091 15.4109186 0.023784722 4.689866e-01 6.083112e-01 8 99861776 99861946 171 + 1.117 1.239 0.434
ENSG00000132549 E092 2.1067732 0.009111886 6.093043e-03 1.885540e-02 8 99868057 99868288 232 + 0.257 0.748 2.512
ENSG00000132549 E093 16.0976184 0.002833013 2.509975e-01 3.871366e-01 8 99868289 99868465 177 + 1.123 1.272 0.532
ENSG00000132549 E094 11.1308791 0.002249528 2.801877e-02 6.805307e-02 8 99870785 99870887 103 + 0.934 1.207 0.994
ENSG00000132549 E095 14.4717269 0.001208952 4.045439e-01 5.482523e-01 8 99870888 99871447 560 + 1.084 1.207 0.440
ENSG00000132549 E096 26.3154533 0.001824249 1.029323e-04 5.355729e-04 8 99871448 99871697 250 + 1.269 1.592 1.114
ENSG00000132549 E097 134.0385556 0.007182219 4.428239e-24 4.427001e-22 8 99875418 99877613 2196 + 1.885 2.375 1.642