ENSG00000132507

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336458 ENSG00000132507 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF5A protein_coding protein_coding 1887.695 3550.645 986.5242 90.60604 10.21387 -1.847644 1198.23846 2496.97767 514.25050 73.964267 23.205047 -2.279617 0.61397917 0.704366667 0.52096667 -0.1834000 2.268643e-03 6.95012e-47 FALSE TRUE
ENST00000573714 ENSG00000132507 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF5A protein_coding protein_coding 1887.695 3550.645 986.5242 90.60604 10.21387 -1.847644 70.04538 21.06669 61.98509 3.307166 4.087257 1.556505 0.05692917 0.005866667 0.06286667 0.0570000 2.489752e-26 6.95012e-47 FALSE TRUE
MSTRG.13559.15 ENSG00000132507 HEK293_OSMI2_2hA HEK293_TMG_2hB EIF5A protein_coding   1887.695 3550.645 986.5242 90.60604 10.21387 -1.847644 454.65219 747.49212 318.78675 114.964251 7.717609 -1.229441 0.23944583 0.209433333 0.32336667 0.1139333 5.810348e-02 6.95012e-47 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132507 E001 5.483223e-01 0.0206540838 5.754397e-01 7.010406e-01 17 7306800 7306937 138 + 0.212 0.126 -0.895
ENSG00000132507 E002 5.483223e-01 0.0206540838 5.754397e-01 7.010406e-01 17 7306938 7306978 41 + 0.212 0.126 -0.895
ENSG00000132507 E003 9.148515e-01 0.0167466809 2.879343e-01 4.284758e-01 17 7306979 7306984 6 + 0.000 0.266 12.620
ENSG00000132507 E004 1.281469e+00 0.0122175840 6.925144e-01 7.937392e-01 17 7306985 7306985 1 + 0.212 0.304 0.689
ENSG00000132507 E005 1.281469e+00 0.0122175840 6.925144e-01 7.937392e-01 17 7306986 7306987 2 + 0.212 0.304 0.689
ENSG00000132507 E006 1.246040e+01 0.0048446537 1.233436e-01 2.247288e-01 17 7306988 7306998 11 + 1.132 0.983 -0.543
ENSG00000132507 E007 1.019539e+02 0.0007093781 2.801841e-03 9.680484e-03 17 7306999 7307113 115 + 1.982 1.878 -0.348
ENSG00000132507 E008 5.810947e+01 0.0004702371 3.294315e-03 1.113367e-02 17 7307114 7307115 2 + 1.765 1.630 -0.457
ENSG00000132507 E009 1.860458e+01 0.3717379583 5.752780e-02 1.223791e-01 17 7307116 7307238 123 + 1.730 0.836 -3.169
ENSG00000132507 E010 1.382097e+01 0.0024759907 4.395611e-01 5.813082e-01 17 7307239 7307325 87 + 0.962 1.078 0.425
ENSG00000132507 E011 8.906534e+01 0.6579683128 2.226406e-01 3.535477e-01 17 7307326 7307350 25 + 2.097 1.758 -1.141
ENSG00000132507 E012 1.021147e+01 0.0017554326 3.323697e-01 4.760124e-01 17 7307351 7307409 59 + 1.018 0.925 -0.345
ENSG00000132507 E013 3.536547e+01 0.6528321282 8.424778e-01 9.018551e-01 17 7307410 7307448 39 + 0.931 1.516 2.078
ENSG00000132507 E014 3.899688e+02 0.0134396037 2.456481e-01 3.808185e-01 17 7307540 7307581 42 + 2.513 2.470 -0.141
ENSG00000132507 E015 4.731248e+02 0.0108596500 1.418387e-01 2.505517e-01 17 7307582 7307591 10 + 2.604 2.552 -0.174
ENSG00000132507 E016 6.133830e+02 0.0096186322 1.977387e-02 5.100898e-02 17 7307592 7307601 10 + 2.748 2.657 -0.303
ENSG00000132507 E017 6.845354e+02 0.0124733096 2.580060e-02 6.353215e-02 17 7307602 7307609 8 + 2.804 2.702 -0.337
ENSG00000132507 E018 1.484121e+03 0.0111989890 6.275937e-03 1.933579e-02 17 7307610 7307627 18 + 3.149 3.036 -0.377
ENSG00000132507 E019 1.419322e+03 0.0112544826 8.818561e-03 2.582947e-02 17 7307628 7307630 3 + 3.125 3.017 -0.359
ENSG00000132507 E020 1.944793e+03 0.0157753302 3.998387e-03 1.313774e-02 17 7307631 7307647 17 + 3.290 3.146 -0.481
ENSG00000132507 E021 9.411151e+03 0.0055260999 1.115484e-02 3.153823e-02 17 7307648 7307752 105 + 3.908 3.849 -0.195
ENSG00000132507 E022 4.886831e+00 0.0058725629 1.752145e-01 2.949596e-01 17 7307828 7307888 61 + 0.823 0.641 -0.746
ENSG00000132507 E023 3.333962e+01 0.0276486267 3.864359e-02 8.852479e-02 17 7307974 7307992 19 + 1.566 1.382 -0.635
ENSG00000132507 E024 3.490669e+02 0.0058211826 8.200766e-01 8.864727e-01 17 7307993 7308113 121 + 2.397 2.437 0.131
ENSG00000132507 E025 1.904051e+01 0.0035526771 2.692665e-01 4.077709e-01 17 7308114 7308133 20 + 1.067 1.210 0.510
ENSG00000132507 E026 5.363282e+01 0.0084169011 1.566948e-03 5.852225e-03 17 7308371 7308480 110 + 1.774 1.579 -0.661
ENSG00000132507 E027 7.070227e+01 0.0012609912 1.630381e-05 1.031943e-04 17 7308481 7308575 95 + 1.890 1.697 -0.651
ENSG00000132507 E028 6.896655e+01 0.0023182417 6.309842e-04 2.646931e-03 17 7309597 7309614 18 + 1.857 1.699 -0.536
ENSG00000132507 E029 2.224359e+04 0.0013972127 2.120048e-03 7.596542e-03 17 7309615 7309800 186 + 4.252 4.230 -0.071
ENSG00000132507 E030 1.347097e+02 0.0002621312 1.070390e-147 1.126568e-143 17 7309801 7310453 653 + 2.519 1.732 -2.636
ENSG00000132507 E031 2.260299e+04 0.0001554511 3.821543e-06 2.792917e-05 17 7311018 7311122 105 + 4.241 4.241 0.000
ENSG00000132507 E032 2.874177e+04 0.0003498088 3.713529e-02 8.573620e-02 17 7311350 7311481 132 + 4.336 4.348 0.037
ENSG00000132507 E033 2.042552e+02 0.0002752058 3.359411e-16 1.352381e-14 17 7311482 7311577 96 + 2.365 2.153 -0.707
ENSG00000132507 E034 1.895409e+04 0.0006127306 9.844285e-02 1.881336e-01 17 7311578 7311651 74 + 4.126 4.173 0.155
ENSG00000132507 E035 1.540041e+03 0.0006122588 2.356828e-04 1.115468e-03 17 7311784 7311821 38 + 3.000 3.090 0.300
ENSG00000132507 E036 4.193578e+04 0.0013460285 2.334032e-14 7.270229e-13 17 7311822 7312566 745 + 4.397 4.531 0.445