ENSG00000132485

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254821 ENSG00000132485 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRANB2 protein_coding protein_coding 69.73151 26.40084 114.1052 2.195778 2.861685 2.111289 27.742325 12.173226 42.175863 1.3422943 3.1647068 1.791863 0.41905833 0.4607000 0.36953333 -0.091166667 2.250758e-01 1.491314e-41 FALSE TRUE
ENST00000370920 ENSG00000132485 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRANB2 protein_coding protein_coding 69.73151 26.40084 114.1052 2.195778 2.861685 2.111289 13.580522 7.813694 22.375151 1.4214449 2.4076016 1.516620 0.21692917 0.2943000 0.19593333 -0.098366667 1.963111e-01 1.491314e-41 FALSE TRUE
ENST00000477096 ENSG00000132485 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRANB2 protein_coding processed_transcript 69.73151 26.40084 114.1052 2.195778 2.861685 2.111289 8.998962 2.933574 15.790425 0.3791781 0.9493215 2.424322 0.13658333 0.1102667 0.13856667 0.028300000 3.197855e-01 1.491314e-41   FALSE
ENST00000487510 ENSG00000132485 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRANB2 protein_coding processed_transcript 69.73151 26.40084 114.1052 2.195778 2.861685 2.111289 5.583407 2.287547 9.763674 0.3162300 0.7901768 2.088807 0.08132500 0.0878000 0.08563333 -0.002166667 1.000000e+00 1.491314e-41   FALSE
ENST00000611683 ENSG00000132485 HEK293_OSMI2_2hA HEK293_TMG_2hB ZRANB2 protein_coding protein_coding 69.73151 26.40084 114.1052 2.195778 2.861685 2.111289 10.917186 0.000000 19.651032 0.0000000 1.6375303 10.941123 0.09980833 0.0000000 0.17216667 0.172166667 1.491314e-41 1.491314e-41 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132485 E001 1.181224 0.2857546198 1.090495e-01 2.041454e-01 1 71063291 71063296 6 - 0.173 0.557 2.406
ENSG00000132485 E002 33.546470 0.0028758936 6.387354e-04 2.675655e-03 1 71063297 71063336 40 - 1.391 1.670 0.958
ENSG00000132485 E003 2234.831360 0.0067179573 9.721320e-05 5.090001e-04 1 71063337 71065042 1706 - 3.232 3.400 0.557
ENSG00000132485 E004 163.345754 0.0132514976 3.630824e-01 5.075063e-01 1 71065043 71065053 11 - 2.114 2.221 0.356
ENSG00000132485 E005 169.279882 0.0115934632 2.936266e-01 4.346951e-01 1 71065054 71065086 33 - 2.128 2.241 0.377
ENSG00000132485 E006 314.323763 0.0020636314 5.175904e-01 6.519479e-01 1 71065087 71065137 51 - 2.408 2.475 0.223
ENSG00000132485 E007 234.260370 0.0021864383 8.617043e-01 9.148326e-01 1 71065678 71065718 41 - 2.286 2.338 0.176
ENSG00000132485 E008 196.098359 0.0023260250 8.339205e-01 8.960017e-01 1 71065719 71065748 30 - 2.209 2.264 0.184
ENSG00000132485 E009 147.473387 0.0038207958 6.478210e-01 7.594398e-01 1 71065749 71065752 4 - 2.094 2.124 0.099
ENSG00000132485 E010 343.602268 0.0031111994 2.491312e-05 1.511422e-04 1 71065753 71066775 1023 - 2.487 2.385 -0.342
ENSG00000132485 E011 597.575748 0.0001032015 4.705069e-01 6.097394e-01 1 71066776 71066934 159 - 2.690 2.749 0.196
ENSG00000132485 E012 89.277826 0.0003231402 1.626689e-03 6.046249e-03 1 71066935 71067513 579 - 1.908 1.809 -0.335
ENSG00000132485 E013 422.081548 0.0005204391 3.541780e-02 8.245727e-02 1 71069276 71069362 87 - 2.530 2.623 0.309
ENSG00000132485 E014 44.548328 0.0031186808 8.691317e-01 9.198929e-01 1 71069363 71069600 238 - 1.574 1.608 0.115
ENSG00000132485 E015 490.485860 0.0006428562 9.937595e-01 1.000000e+00 1 71070827 71070996 170 - 2.609 2.655 0.155
ENSG00000132485 E016 457.125491 0.0021909398 1.094243e-01 2.047155e-01 1 71072121 71072255 135 - 2.590 2.587 -0.011
ENSG00000132485 E017 415.449073 0.0035617448 3.258428e-03 1.102734e-02 1 71072472 71072548 77 - 2.561 2.500 -0.205
ENSG00000132485 E018 486.432807 0.0006774348 1.211384e-08 1.471298e-07 1 71076795 71076877 83 - 2.634 2.549 -0.283
ENSG00000132485 E019 531.747280 0.0012432906 1.419974e-09 2.046168e-08 1 71078457 71078565 109 - 2.676 2.569 -0.356
ENSG00000132485 E020 383.177623 0.0002006051 1.150158e-12 2.792438e-11 1 71078656 71078708 53 - 2.536 2.418 -0.394
ENSG00000132485 E021 327.071277 0.0004009693 5.725422e-10 8.884134e-09 1 71080940 71081289 350 - 2.467 2.352 -0.382