ENSG00000132471

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254806 ENSG00000132471 HEK293_OSMI2_2hA HEK293_TMG_2hB WBP2 protein_coding protein_coding 84.63719 149.2365 47.59958 5.999762 0.7868248 -1.648374 76.53825 139.8661 38.4645 5.187542 1.2713 -1.862175 0.8848542 0.9374333 0.8081 -0.1293333 1.092048e-07 1.092048e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132471 E001 0.2924217 0.0290785164 2.203144e-02   17 75845534 75845698 165 - 0.361 0.000 -11.097
ENSG00000132471 E002 17.4522477 0.0016787349 4.748733e-01 6.136729e-01 17 75845699 75845708 10 - 1.219 1.138 -0.290
ENSG00000132471 E003 22.2096689 0.0032655410 7.814531e-01 8.595834e-01 17 75845709 75845719 11 - 1.236 1.251 0.053
ENSG00000132471 E004 52.2185936 0.0014556598 5.072538e-02 1.104571e-01 17 75845720 75845743 24 - 1.507 1.626 0.407
ENSG00000132471 E005 57.4478913 0.0024516079 4.966402e-02 1.085640e-01 17 75845744 75845746 3 - 1.549 1.667 0.404
ENSG00000132471 E006 124.3574406 0.0038274026 3.827027e-04 1.707735e-03 17 75845747 75845771 25 - 1.823 2.004 0.608
ENSG00000132471 E007 421.9008373 0.0010516772 2.512493e-10 4.135756e-09 17 75845772 75845836 65 - 2.360 2.530 0.565
ENSG00000132471 E008 1055.7049875 0.0007761339 1.438398e-17 6.919760e-16 17 75845837 75846034 198 - 2.769 2.925 0.520
ENSG00000132471 E009 1592.3566676 0.0008623108 1.952551e-09 2.739428e-08 17 75846035 75846322 288 - 3.002 3.095 0.309
ENSG00000132471 E010 586.6034694 0.0015577185 1.721047e-01 2.909335e-01 17 75846323 75846335 13 - 2.627 2.652 0.085
ENSG00000132471 E011 1128.3812224 0.0012400621 4.152262e-01 5.586196e-01 17 75846336 75846494 159 - 2.926 2.932 0.021
ENSG00000132471 E012 1073.0390870 0.0002907571 3.252120e-02 7.684495e-02 17 75846495 75846737 243 - 2.891 2.912 0.071
ENSG00000132471 E013 452.3698954 0.0001559357 7.395219e-01 8.291916e-01 17 75846738 75846772 35 - 2.536 2.531 -0.017
ENSG00000132471 E014 367.3547054 0.0011975770 9.102237e-01 9.469267e-01 17 75846773 75846787 15 - 2.448 2.440 -0.026
ENSG00000132471 E015 556.1715309 0.0004490125 3.731234e-02 8.605792e-02 17 75846908 75846984 77 - 2.666 2.611 -0.184
ENSG00000132471 E016 6.7282381 0.0028343149 1.405760e-01 2.488224e-01 17 75846985 75847099 115 - 0.944 0.733 -0.819
ENSG00000132471 E017 10.7848487 0.0050272921 6.442895e-05 3.530974e-04 17 75847100 75847486 387 - 1.282 0.838 -1.625
ENSG00000132471 E018 540.7317401 0.0009191264 1.216449e-01 2.222836e-01 17 75847487 75847559 73 - 2.648 2.600 -0.159
ENSG00000132471 E019 307.8018959 0.0002055929 1.205625e-01 2.207700e-01 17 75847560 75847574 15 - 2.407 2.355 -0.174
ENSG00000132471 E020 306.0401982 0.0001852773 1.309266e-01 2.354337e-01 17 75847575 75847597 23 - 2.404 2.353 -0.171
ENSG00000132471 E021 222.7771137 0.0001954714 4.077803e-01 5.513801e-01 17 75847598 75847609 12 - 2.255 2.218 -0.125
ENSG00000132471 E022 18.8129776 0.0113985295 1.901831e-02 4.937323e-02 17 75847610 75847795 186 - 1.375 1.128 -0.870
ENSG00000132471 E023 641.4294479 0.0001563370 2.839249e-01 4.241176e-01 17 75847796 75847930 135 - 2.677 2.684 0.024
ENSG00000132471 E024 27.8761570 0.0068133828 3.874239e-20 2.509275e-18 17 75847931 75848506 576 - 1.818 1.111 -2.443
ENSG00000132471 E025 9.7114933 0.0032887942 6.204652e-12 1.335590e-10 17 75848507 75848569 63 - 1.409 0.677 -2.715
ENSG00000132471 E026 721.4527091 0.0009660196 1.236733e-01 2.251886e-01 17 75848570 75848662 93 - 2.772 2.727 -0.149
ENSG00000132471 E027 0.6244956 0.0203302034 1.959071e-01 3.211111e-01 17 75848782 75849038 257 - 0.361 0.123 -1.991
ENSG00000132471 E028 4.3531439 0.0115822691 2.366298e-01 3.702773e-01 17 75849357 75849603 247 - 0.792 0.595 -0.822
ENSG00000132471 E029 1038.4393033 0.0021047534 1.215714e-03 4.693765e-03 17 75849604 75849739 136 - 2.967 2.877 -0.299
ENSG00000132471 E030 4.6823117 0.0100263147 1.656042e-01 2.824940e-01 17 75851200 75851567 368 - 0.835 0.613 -0.914
ENSG00000132471 E031 933.8975033 0.0047720654 8.835174e-05 4.672670e-04 17 75851568 75851676 109 - 2.965 2.820 -0.485
ENSG00000132471 E032 5.1283263 0.0032076704 2.454903e-03 8.628782e-03 17 75851677 75852350 674 - 1.004 0.577 -1.710
ENSG00000132471 E033 1.3253775 0.0099252024 2.771237e-01 4.166422e-01 17 75852656 75852820 165 - 0.469 0.259 -1.254
ENSG00000132471 E034 9.6283787 0.0202798525 1.554541e-02 4.172495e-02 17 75855124 75855179 56 - 1.165 0.847 -1.175
ENSG00000132471 E035 3.4215535 0.0051911870 3.265955e-01 4.700240e-01 17 75855180 75855238 59 - 0.689 0.517 -0.767
ENSG00000132471 E036 629.8976271 0.0041308948 9.051326e-06 6.077214e-05 17 75855239 75855476 238 - 2.807 2.644 -0.540
ENSG00000132471 E037 1.6241393 0.0091320969 4.559098e-01 5.963888e-01 17 75856262 75856507 246 - 0.217 0.363 1.011