ENSG00000132470

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000200181 ENSG00000132470 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB4 protein_coding protein_coding 2.583041 5.417109 1.236888 0.4266714 0.2054775 -2.121852 0.21513049 0.4244071 0.1559985 0.08289736 0.01645446 -1.387877 0.10812917 0.07983333 0.1351667 0.05533333 0.4689521 0.0197926 FALSE TRUE
ENST00000578318 ENSG00000132470 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB4 protein_coding protein_coding 2.583041 5.417109 1.236888 0.4266714 0.2054775 -2.121852 0.80125081 2.0089257 0.3578818 0.32689890 0.21831882 -2.456274 0.26413750 0.36870000 0.2481667 -0.12053333 0.7131958 0.0197926   FALSE
ENST00000579211 ENSG00000132470 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB4 protein_coding retained_intron 2.583041 5.417109 1.236888 0.4266714 0.2054775 -2.121852 0.75660444 1.6367711 0.2531991 0.20456654 0.25319909 -2.645414 0.29093333 0.30236667 0.2674000 -0.03496667 0.4387194 0.0197926 FALSE FALSE
ENST00000583327 ENSG00000132470 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB4 protein_coding processed_transcript 2.583041 5.417109 1.236888 0.4266714 0.2054775 -2.121852 0.02366416 0.0000000 0.1893133 0.00000000 0.09812823 4.316966 0.01720417 0.00000000 0.1376333 0.13763333 0.0197926 0.0197926 FALSE FALSE
ENST00000584939 ENSG00000132470 HEK293_OSMI2_2hA HEK293_TMG_2hB ITGB4 protein_coding protein_coding 2.583041 5.417109 1.236888 0.4266714 0.2054775 -2.121852 0.75662637 1.3279639 0.2804952 0.09786585 0.14063619 -2.203453 0.29365417 0.24546667 0.2116000 -0.03386667 0.8499067 0.0197926 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132470 E001 0.0000000       17 75721328 75721458 131 +      
ENSG00000132470 E002 0.0000000       17 75721459 75721496 38 +      
ENSG00000132470 E003 0.0000000       17 75721497 75721508 12 +      
ENSG00000132470 E004 0.1482932 0.042472150 1.000000000   17 75721509 75721563 55 + 0.000 0.066 9.148
ENSG00000132470 E005 0.0000000       17 75721564 75721612 49 +      
ENSG00000132470 E006 0.1482932 0.042472150 1.000000000   17 75724694 75724695 2 + 0.000 0.066 11.425
ENSG00000132470 E007 0.1482932 0.042472150 1.000000000   17 75724696 75724703 8 + 0.000 0.066 11.425
ENSG00000132470 E008 0.1482932 0.042472150 1.000000000   17 75724704 75724782 79 + 0.000 0.066 11.425
ENSG00000132470 E009 0.0000000       17 75727195 75727277 83 +      
ENSG00000132470 E010 0.2965864 0.292793948 1.000000000   17 75727404 75727505 102 + 0.000 0.120 12.111
ENSG00000132470 E011 0.7717566 0.070351039 1.000000000 1.000000000 17 75727651 75727800 150 + 0.216 0.217 0.009
ENSG00000132470 E012 0.2934659 0.029311385 0.333115434   17 75727801 75727855 55 + 0.216 0.066 -1.979
ENSG00000132470 E013 0.3299976 0.027442404 1.000000000   17 75728377 75728473 97 + 0.000 0.123 12.292
ENSG00000132470 E014 0.1451727 0.043361167 0.116044825   17 75729265 75729377 113 + 0.216 0.000 -15.273
ENSG00000132470 E015 0.1451727 0.043361167 0.116044825   17 75729378 75729436 59 + 0.216 0.000 -15.273
ENSG00000132470 E016 0.8158510 0.521990543 0.770903054 0.852112531 17 75730241 75730504 264 + 0.217 0.185 -0.285
ENSG00000132470 E017 0.8158510 0.521990543 0.770903054 0.852112531 17 75730875 75730964 90 + 0.217 0.185 -0.285
ENSG00000132470 E018 0.6643356 0.751270019 1.000000000 1.000000000 17 75731246 75731368 123 + 0.000 0.188 12.567
ENSG00000132470 E019 0.0000000       17 75731812 75731819 8 +      
ENSG00000132470 E020 0.0000000       17 75731820 75731973 154 +      
ENSG00000132470 E021 0.2903454 0.299600574 0.044435375   17 75732163 75732239 77 + 0.359 0.000 -15.796
ENSG00000132470 E022 0.4720498 0.212870445 0.126564941 0.229362710 17 75733490 75733692 203 + 0.360 0.066 -2.970
ENSG00000132470 E023 0.4815130 0.020715844 0.600263052 0.721529084 17 75736051 75736154 104 + 0.216 0.123 -0.978
ENSG00000132470 E024 0.2998086 0.029222923 0.333482047   17 75736288 75736386 99 + 0.216 0.066 -1.980
ENSG00000132470 E025 0.1515154 0.042185656 0.116119788   17 75736565 75736694 130 + 0.216 0.000 -15.275
ENSG00000132470 E026 0.3729606 0.028356314 0.334465344 0.478207545 17 75737322 75737444 123 + 0.216 0.066 -1.974
ENSG00000132470 E027 0.3729606 0.028356314 0.334465344 0.478207545 17 75737538 75737644 107 + 0.216 0.066 -1.974
ENSG00000132470 E028 0.1515154 0.042185656 0.116119788   17 75739672 75739705 34 + 0.216 0.000 -15.275
ENSG00000132470 E029 0.5202097 0.020928935 0.089479380 0.174334610 17 75739880 75740071 192 + 0.360 0.066 -2.975
ENSG00000132470 E030 0.6653823 0.017260525 0.021819443 0.055300111 17 75740358 75740461 104 + 0.468 0.066 -3.560
ENSG00000132470 E031 0.0000000       17 75740462 75740498 37 +      
ENSG00000132470 E032 0.2966881 0.029078516 0.022837693   17 75740793 75740851 59 + 0.360 0.000 -16.132
ENSG00000132470 E033 0.1451727 0.043361167 0.116044825   17 75740982 75741005 24 + 0.216 0.000 -15.273
ENSG00000132470 E034 0.0000000       17 75741006 75741105 100 +      
ENSG00000132470 E035 0.1482932 0.042472150 1.000000000   17 75742341 75742423 83 + 0.000 0.066 11.425
ENSG00000132470 E036 0.5117019 0.023186018 0.563858386 0.691256696 17 75742424 75742489 66 + 0.000 0.174 12.770
ENSG00000132470 E037 0.0000000       17 75742490 75742581 92 +      
ENSG00000132470 E038 0.7331471 0.017267182 0.379453610 0.523727756 17 75742582 75742761 180 + 0.000 0.219 13.102
ENSG00000132470 E039 0.4031496 0.024708984 1.000000000 1.000000000 17 75743713 75743861 149 + 0.000 0.123 12.296
ENSG00000132470 E040 0.0000000       17 75746264 75746375 112 +      
ENSG00000132470 E041 0.6955713 0.017808398 0.201954149 0.328648436 17 75748841 75749045 205 + 0.360 0.123 -1.974
ENSG00000132470 E042 0.7644715 0.127036581 0.010320553 0.029557926 17 75750111 75750268 158 + 0.554 0.066 -3.971
ENSG00000132470 E043 0.7279398 0.285290686 0.002530586 0.008854713 17 75750680 75750860 181 + 0.624 0.000 -16.803
ENSG00000132470 E044 0.4407149 0.023573658 0.089294381 0.174069051 17 75750974 75751111 138 + 0.360 0.066 -2.979
ENSG00000132470 E045 0.0000000       17 75751813 75751848 36 +      
ENSG00000132470 E046 0.8888167 0.092722663 0.133192257 0.238576551 17 75752174 75752356 183 + 0.468 0.172 -1.999
ENSG00000132470 E047 0.8167960 0.015870382 0.337631930 0.481521247 17 75752446 75752577 132 + 0.360 0.174 -1.393
ENSG00000132470 E048 6.1370661 0.019103815 0.311797586 0.454307932 17 75753765 75753974 210 + 0.873 0.710 -0.646
ENSG00000132470 E049 1.7619252 0.008977171 0.505204556 0.641020492 17 75754483 75754575 93 + 0.468 0.332 -0.753
ENSG00000132470 E050 8.9049647 0.002402733 0.603741110 0.724460591 17 75754576 75754617 42 + 0.942 0.860 -0.312
ENSG00000132470 E051 19.7186990 0.001057053 0.902162699 0.941665291 17 75754618 75754815 198 + 1.217 1.189 -0.101
ENSG00000132470 E052 0.1515154 0.042185656 0.116119788   17 75755055 75755213 159 + 0.216 0.000 -15.275
ENSG00000132470 E053 13.7416837 0.001452877 0.498549351 0.635008867 17 75755701 75755850 150 + 1.123 1.035 -0.317
ENSG00000132470 E054 19.4471667 0.001203144 0.420207825 0.563433167 17 75756429 75756617 189 + 1.143 1.202 0.210
ENSG00000132470 E055 18.3116034 0.001318435 0.847768916 0.905474476 17 75756704 75756859 156 + 1.200 1.165 -0.125
ENSG00000132470 E056 14.6882983 0.017889642 0.680361636 0.784265527 17 75756943 75757038 96 + 1.054 1.091 0.133
ENSG00000132470 E057 18.0294832 0.016428481 0.351082701 0.495286766 17 75757039 75757107 69 + 1.078 1.174 0.344
ENSG00000132470 E058 19.2516557 0.001203144 0.140137733 0.248206589 17 75757200 75757310 111 + 1.078 1.207 0.460
ENSG00000132470 E059 0.9912127 0.152268653 1.000000000 1.000000000 17 75757311 75757415 105 + 0.216 0.224 0.068
ENSG00000132470 E060 28.8972428 0.005487493 0.034723211 0.081119309 17 75757416 75757625 210 + 1.218 1.383 0.578
ENSG00000132470 E061 16.0454981 0.025003573 0.136094251 0.242609978 17 75757626 75757818 193 + 0.973 1.147 0.634