ENSG00000132466

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000330838 ENSG00000132466 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD17 protein_coding protein_coding 26.22049 19.71205 31.86087 3.619391 0.3451234 0.6924287 6.656512 4.7381563 6.905174 1.01268815 0.51161579 0.5423981 0.25467917 0.23870000 0.21680000 -0.0219000 7.316135e-01 5.2991e-11 FALSE TRUE
ENST00000358602 ENSG00000132466 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD17 protein_coding protein_coding 26.22049 19.71205 31.86087 3.619391 0.3451234 0.6924287 1.908128 2.8812053 1.542515 0.05482775 0.04812623 -0.8970643 0.07995833 0.15756667 0.04843333 -0.1091333 4.771747e-04 5.2991e-11 FALSE TRUE
ENST00000509867 ENSG00000132466 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD17 protein_coding protein_coding 26.22049 19.71205 31.86087 3.619391 0.3451234 0.6924287 5.423247 0.5768385 8.923508 0.35691606 0.61931023 3.9281915 0.19012500 0.03610000 0.27970000 0.2436000 4.831398e-02 5.2991e-11 FALSE TRUE
ENST00000510127 ENSG00000132466 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD17 protein_coding processed_transcript 26.22049 19.71205 31.86087 3.619391 0.3451234 0.6924287 1.973314 3.9513450 0.000000 2.01312558 0.00000000 -8.6298465 0.09041250 0.17556667 0.00000000 -0.1755667 1.177942e-01 5.2991e-11   FALSE
ENST00000558247 ENSG00000132466 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD17 protein_coding protein_coding 26.22049 19.71205 31.86087 3.619391 0.3451234 0.6924287 6.120348 6.2762036 6.861331 0.97275443 0.52170919 0.1284006 0.24013750 0.32353333 0.21553333 -0.1080000 2.691211e-02 5.2991e-11 FALSE TRUE
MSTRG.25018.12 ENSG00000132466 HEK293_OSMI2_2hA HEK293_TMG_2hB ANKRD17 protein_coding   26.22049 19.71205 31.86087 3.619391 0.3451234 0.6924287 1.845145 0.4574882 4.074058 0.06488401 0.20411329 3.1270017 0.06245000 0.02466667 0.12773333 0.1030667 5.299100e-11 5.2991e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_2hB HEK293_OSMI2_2hA log2fold_HEK293_OSMI2_2hA_HEK293_TMG_2hB
ENSG00000132466 E001 113.6288080 0.0111234998 1.363720e-17 6.578881e-16 4 73073376 73075237 1862 - 1.731 2.293 1.887
ENSG00000132466 E002 229.4717468 0.0056004880 2.983826e-27 3.944709e-25 4 73075238 73075685 448 - 2.077 2.576 1.666
ENSG00000132466 E003 134.7393886 0.0081130818 4.726177e-19 2.704198e-17 4 73075686 73075781 96 - 1.840 2.350 1.712
ENSG00000132466 E004 202.9959709 0.0063443907 1.936330e-22 1.621715e-20 4 73075782 73075855 74 - 2.039 2.519 1.604
ENSG00000132466 E005 602.6958942 0.0061409313 7.593659e-28 1.060911e-25 4 73075856 73076290 435 - 2.524 2.983 1.526
ENSG00000132466 E006 260.6559743 0.0030907501 1.204013e-24 1.270734e-22 4 73076940 73077104 165 - 2.210 2.593 1.277
ENSG00000132466 E007 135.1459003 0.0035769718 1.744194e-14 5.553484e-13 4 73077355 73077368 14 - 1.945 2.295 1.172
ENSG00000132466 E008 311.3705404 0.0019024383 3.284013e-24 3.334118e-22 4 73077369 73077533 165 - 2.324 2.645 1.070
ENSG00000132466 E009 345.9212846 0.0015812363 2.026436e-19 1.214496e-17 4 73078642 73078890 249 - 2.400 2.669 0.896
ENSG00000132466 E010 0.1472490 0.0433276866 7.461349e-01   4 73080721 73080810 90 - 0.097 0.000 -10.648
ENSG00000132466 E011 214.5423318 0.0012681310 3.333829e-14 1.015245e-12 4 73085249 73085365 117 - 2.203 2.455 0.841
ENSG00000132466 E012 168.1739431 0.0011003149 7.251708e-07 6.207927e-06 4 73085366 73085446 81 - 2.135 2.321 0.622
ENSG00000132466 E013 1148.5316382 0.0010388483 3.934775e-03 1.295929e-02 4 73090667 73092300 1634 - 3.019 3.099 0.268
ENSG00000132466 E014 175.8902906 0.0002030231 3.885397e-01 5.326171e-01 4 73094079 73094228 150 - 2.219 2.272 0.179
ENSG00000132466 E015 169.2524508 0.0003757087 5.548987e-02 1.188257e-01 4 73097117 73097272 156 - 2.236 2.211 -0.083
ENSG00000132466 E016 293.0987378 0.0004838823 2.778647e-01 4.174912e-01 4 73098073 73098520 448 - 2.461 2.466 0.017
ENSG00000132466 E017 2.0421565 0.0079744554 5.528683e-01 6.820997e-01 4 73100861 73101007 147 - 0.512 0.430 -0.413
ENSG00000132466 E018 4.7543996 0.0034714024 5.424494e-01 6.732094e-01 4 73101008 73101173 166 - 0.779 0.719 -0.243
ENSG00000132466 E019 96.6859266 0.0148118422 7.384777e-01 8.283492e-01 4 73102376 73102462 87 - 1.965 2.012 0.159
ENSG00000132466 E020 93.8191577 0.0055813230 6.396448e-01 7.529953e-01 4 73102463 73102547 85 - 1.971 1.976 0.015
ENSG00000132466 E021 2.1079336 0.0506050054 9.924332e-01 9.993541e-01 4 73102548 73102779 232 - 0.478 0.494 0.081
ENSG00000132466 E022 0.2214452 0.0448635601 3.121216e-01   4 73104003 73104080 78 - 0.000 0.154 10.837
ENSG00000132466 E023 10.6367086 0.0060296390 1.681237e-01 2.857576e-01 4 73112879 73112894 16 - 1.114 0.994 -0.438
ENSG00000132466 E024 33.3281289 0.0258091736 3.773798e-02 8.684490e-02 4 73112895 73113079 185 - 1.599 1.427 -0.592
ENSG00000132466 E025 12.4887246 0.0015699566 5.465942e-01 6.767528e-01 4 73113080 73113083 4 - 1.139 1.109 -0.108
ENSG00000132466 E026 49.0764835 0.0050090574 4.204452e-04 1.852762e-03 4 73113084 73113311 228 - 1.768 1.576 -0.651
ENSG00000132466 E027 154.2468690 0.0003807654 7.779983e-02 1.559446e-01 4 73113792 73113908 117 - 2.196 2.173 -0.077
ENSG00000132466 E028 143.3559269 0.0002122676 1.537276e-02 4.133418e-02 4 73115821 73115916 96 - 2.171 2.127 -0.148
ENSG00000132466 E029 184.8014288 0.0001879718 7.976664e-08 8.258581e-07 4 73118688 73118850 163 - 2.309 2.193 -0.389
ENSG00000132466 E030 187.3585486 0.0002183312 1.559282e-14 5.000022e-13 4 73120162 73120337 176 - 2.337 2.154 -0.610
ENSG00000132466 E031 210.3500428 0.0012197369 1.050338e-12 2.568190e-11 4 73120881 73121094 214 - 2.388 2.201 -0.625
ENSG00000132466 E032 204.1633993 0.0032841264 1.147779e-06 9.410280e-06 4 73121617 73121759 143 - 2.364 2.213 -0.505
ENSG00000132466 E033 186.2944664 0.0031109361 3.665863e-08 4.057293e-07 4 73124913 73125058 146 - 2.335 2.155 -0.600
ENSG00000132466 E034 172.8202077 0.0086882898 3.504381e-07 3.197642e-06 4 73125201 73125312 112 - 2.321 2.081 -0.803
ENSG00000132466 E035 171.1387155 0.0034160736 5.312655e-13 1.361378e-11 4 73135117 73135262 146 - 2.322 2.058 -0.883
ENSG00000132466 E036 55.0863636 0.0040415199 3.065148e-07 2.830529e-06 4 73135263 73135265 3 - 1.835 1.559 -0.935
ENSG00000132466 E037 248.6261114 0.0023030523 2.715985e-13 7.262318e-12 4 73139531 73140283 753 - 2.468 2.257 -0.703
ENSG00000132466 E038 109.3600074 0.0080749469 3.387384e-06 2.506855e-05 4 73141741 73141792 52 - 2.120 1.887 -0.782
ENSG00000132466 E039 107.9364021 0.0026982020 1.346510e-11 2.745881e-10 4 73141793 73141843 51 - 2.125 1.855 -0.908
ENSG00000132466 E040 153.8805827 0.0045706241 9.388194e-10 1.399233e-08 4 73142242 73142385 144 - 2.269 2.026 -0.813
ENSG00000132466 E041 131.3063822 0.0082007306 2.535273e-07 2.382203e-06 4 73142640 73142767 128 - 2.203 1.953 -0.835
ENSG00000132466 E042 106.6431002 0.0102557776 4.763282e-08 5.162116e-07 4 73144745 73144832 88 - 2.130 1.825 -1.023
ENSG00000132466 E043 118.7455906 0.0113324102 3.953257e-07 3.567535e-06 4 73146764 73146873 110 - 2.170 1.886 -0.952
ENSG00000132466 E044 147.8385372 0.0002849473 1.954859e-28 2.870869e-26 4 73147241 73147432 192 - 2.275 1.945 -1.105
ENSG00000132466 E045 176.6611674 0.0055126157 1.727775e-16 7.219272e-15 4 73148813 73149050 238 - 2.358 2.003 -1.187
ENSG00000132466 E046 114.8422361 0.0082053043 2.385947e-09 3.299829e-08 4 73151430 73151524 95 - 2.161 1.852 -1.035
ENSG00000132466 E047 161.2486926 0.0123760220 1.856235e-07 1.789611e-06 4 73153880 73154113 234 - 2.302 2.015 -0.960
ENSG00000132466 E048 146.9537633 0.0018300929 9.605221e-18 4.733820e-16 4 73155631 73155778 148 - 2.262 1.967 -0.990
ENSG00000132466 E049 148.3226510 0.0023134296 2.340654e-19 1.392682e-17 4 73156019 73156166 148 - 2.275 1.947 -1.098
ENSG00000132466 E050 128.0109924 0.0151368418 3.850141e-09 5.120736e-08 4 73161192 73161348 157 - 2.224 1.849 -1.256
ENSG00000132466 E051 0.4482035 0.0281251584 1.831470e-01 3.051408e-01 4 73168929 73169090 162 - 0.243 0.000 -12.489
ENSG00000132466 E052 104.7015382 0.0203393794 2.645831e-07 2.476383e-06 4 73177380 73177533 154 - 2.136 1.766 -1.245
ENSG00000132466 E053 3.5557755 0.0127139694 1.023924e-03 4.041183e-03 4 73222974 73223114 141 - 0.813 0.266 -2.705
ENSG00000132466 E054 43.0348240 0.0306511596 6.256914e-04 2.627405e-03 4 73258276 73258284 9 - 1.740 1.428 -1.066
ENSG00000132466 E055 101.4766983 0.0432662880 3.054284e-05 1.813871e-04 4 73258285 73258839 555 - 2.130 1.726 -1.358